A0JNC1

PR
Gene name
CDS2
Protein name
Phosphatidate cytidylyltransferase 2
Names
CDP-DAG synthase 2, CDP-DG synthase 2, CDP-diacylglycerol synthase 2, CDS 2, CDP-diglyceride pyrophosphorylase 2, CDP-diglyceride synthase 2, CTP:phosphatidate cytidylyltransferase 2
Species
Bos taurus (Bovine)
KEGG Pathway
bta:614834
EC number
2.7.7.41: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-89 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A0JNC1

Entry ID Method Resolution Chain Position Source
AF-A0JNC1-F1 Predicted AlphaFoldDB

47 variants for A0JNC1

Variant ID(s) Position Change Description Diseaes Association Provenance
rs454889185 3 E>V No EVA
rs475011691 5 R>S No EVA
rs449482365 25 A>P No EVA
rs440753026 54 V>L No EVA
rs477587442 57 R>T No EVA
rs471257316 72 R>I No EVA
rs450881852 125 F>I No EVA
rs41696120 126 R>T No EVA
rs456924507 133 L>R No EVA
rs473797164 172 T>P No EVA
rs452874295 174 Y>N No EVA
rs473158594 176 T>K No EVA
rs438353650 177 G>R No EVA
rs449621360 214 V>A No EVA
rs452840757 214 V>I No EVA
rs470283414 223 I>N No EVA
rs476063711 255 S>A No EVA
rs447913440 304 C>F No EVA
rs470023073 344 T>P No EVA
rs435486215 353 G>A No EVA
rs465976592 355 F>L No EVA
rs479516578 377 G>R No EVA
rs134773952 384 D>A No EVA
rs439581866 406 P>T No EVA
rs458650764 408 K>Q No EVA
rs481928832 414 L>V No EVA
rs461096129 419 D>E No EVA
rs481309218 420 Q>P No EVA
rs446484721 424 I>L No EVA
rs466703077 427 T>P No EVA
rs445683821 430 S>C No EVA
rs445683821 430 S>F No EVA
rs469629012 433 T>A No EVA
rs438290287 434 D>G No EVA
rs455264544 435 K>N No EVA
rs434199420 437 M>I No EVA
rs468743884 437 M>R No EVA
rs454046015 439 T>P No EVA
rs470932130 439 T>R No EVA
rs456384426 440 A>P No EVA
rs456384426 440 A>S No EVA
rs461279526 441 A>D No EVA
rs444288731 441 A>S No EVA
rs440247250 443 E>D No EVA
rs481260398 443 E>G No EVA
rs460205544 445 K>R No EVA
rs477102055 446 K>K No EVA

No associated diseases with A0JNC1

No regional properties for A0JNC1

Type Name Position InterPro Accession
No domain, repeats, and functional sites for A0JNC1

Functions

Description
EC Number 2.7.7.41 Nucleotidyltransferases
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name Definition
phosphatidate cytidylyltransferase activity Catalysis of the reaction: CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

2 GO annotations of biological process

Name Definition
CDP-diacylglycerol biosynthetic process The chemical reactions and pathways resulting in the formation of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate.
lipid droplet formation A process that results in the assembly, arrangement of constituent parts of a lipid droplet.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P38221 CDS1 Phosphatidate cytidylyltransferase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P56079 Cds Phosphatidate cytidylyltransferase, photoreceptor-specific Drosophila melanogaster (Fruit fly) PR
Q92903 CDS1 Phosphatidate cytidylyltransferase 1 Homo sapiens (Human) PR
O95674 CDS2 Phosphatidate cytidylyltransferase 2 Homo sapiens (Human) PR
P98191 Cds1 Phosphatidate cytidylyltransferase 1 Mus musculus (Mouse) PR
Q99L43 Cds2 Phosphatidate cytidylyltransferase 2 Mus musculus (Mouse) PR
O35052 Cds1 Phosphatidate cytidylyltransferase 1 Rattus norvegicus (Rat) PR
Q91XU8 Cds2 Phosphatidate cytidylyltransferase 2 Rattus norvegicus (Rat) PR
Q1PE48 CDS3 Phosphatidate cytidylyltransferase 3 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MTELRQRVAR EPEAPPEDKE SESEAKADGE TASDSESRVE AVTQPPSADD TPEVLNRALS
70 80 90 100 110 120
NLSSRWKNWW VRGILTLAMI AFFFIIIYLG PMVLMMIVMC VQIKCFHEII TIGYNVYHSY
130 140 150 160 170 180
DLPWFRTLSW YFLLCVNYFF YGETVTDYFF TLVQREEPLR ILSKYHRFIS FTLYLTGFCM
190 200 210 220 230 240
FVLSLVKKHY RLQFYMFGWT HVTLLIVVTQ SHLVIHNLFE GMIWFIVPIS CVICNDIMAY
250 260 270 280 290 300
MFGFFFGRTP LIKLSPKKTW EGFIGGFFAT VVFGLLLSYV MSGYRCFVCP VEYNNDTNSF
310 320 330 340 350 360
TVDCEPSGLF RLQEYNIPGV IQSIIGWKTV RMYPFQIHSI ALSTFASLIG PFGGFFASGF
370 380 390 400 410 420
KRAFKIKDFA NTIPGHGGIM DRFDCQYLMA TFVNVYIASF IRGPNPSKLV QQFLTLRPDQ
430 440
QLHIFNTLKS HLTDKGMLTA ATEDK