Q8VCR2
Gene name |
Hsd17b13 (Scdr9) |
Protein name |
17-beta-hydroxysteroid dehydrogenase 13 |
Names |
17-beta-HSD 13, Alcohol dehydrogenase PAN1B-like, Short-chain dehydrogenase/reductase 9 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:243168 |
EC number |
1.1.1.62: With NAD(+) or NADP(+) as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8VCR2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8VCR2-F1 | Predicted | AlphaFoldDB |
10 variants for Q8VCR2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs32030041 | 13 | V>I | No | EVA | |
| rs229864413 | 25 | F>L | No | EVA | |
| rs3388760660 | 81 | R>S | No | EVA | |
| rs3388768039 | 82 | K>N | No | EVA | |
| rs3388777745 | 82 | K>R | No | EVA | |
| rs3395279593 | 174 | C>S | No | EVA | |
| rs3395977998 | 185 | Y>F | No | EVA | |
| rs32029831 | 200 | T>S | No | EVA | |
| rs13471966 | 212 | Q>K | No | EVA | |
| rs3689574 | 266 | S>F | No | EVA |
No associated diseases with Q8VCR2
No regional properties for Q8VCR2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q8VCR2 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 1.1.1.62 | With NAD(+) or NADP(+) as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| lipid droplet | An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. |
| steroid dehydrogenase activity | Catalysis of an oxidation-reduction (redox) reaction in which one substrate is a sterol derivative. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| positive regulation of lipid biosynthetic process | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8HZT6 | RDH10 | Retinol dehydrogenase 10 | Bos taurus (Bovine) | PR |
| Q8IZV5 | RDH10 | Retinol dehydrogenase 10 | Homo sapiens (Human) | PR |
| Q8VCH7 | Rdh10 | Retinol dehydrogenase 10 | Mus musculus (Mouse) | PR |
| Q05A13 | Sdr16c6 | Short-chain dehydrogenase/reductase family 16C member 6 | Mus musculus (Mouse) | PR |
| Q80ZF7 | Rdh10 | Retinol dehydrogenase 10 | Rattus norvegicus (Rat) | PR |
| Q5XGF7 | rdh10 | Retinol dehydrogenase 10 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| A1L1W4 | rdh10a | Retinol dehydrogenase 10-A | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q7T2D1 | rdh10b | Retinol dehydrogenase 10-B | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNLILEFLLL | VGVIIYSYLE | SLVKFFIPRR | RKSVTGQTVL | ITGAGHGIGR | LTAYEFAKQK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SRLVLWDINK | RGVEETADKC | RKLGAVVHVF | VVDCSNRAEI | YNSVDQVKRE | VGDVEIVVNN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AGAIYPADLL | SAKDEEITKT | FEVNILGHFW | IIKALLPSML | RRNSGHIVTV | ASVCGHGVIP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YLIPYCSSKF | AAVGFHRALT | AELDTLGKTG | IQTSCLCPVF | VNTGFTKNPS | TRLWPVLEPE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EVARSLINGI | LTNKKMIFVP | SYINISLILE | KGPGFSSKHP | HGGSQQPVTP | IPGDLTPSSD |
| FLKH |