Q5XGF7

PR
Gene name
rdh10
Protein name
Retinol dehydrogenase 10
Names
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KEGG Pathway
xtr:496504
EC number
1.1.1.300: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

57-129 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5XGF7

Entry ID Method Resolution Chain Position Source
AF-Q5XGF7-F1 Predicted AlphaFoldDB

No variants for Q5XGF7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5XGF7

No associated diseases with Q5XGF7

2 regional properties for Q5XGF7

Type Name Position InterPro Accession
domain Fibronectin type III 11 - 121 IPR003961
domain Interferon/interleukin receptor domain 123 - 218 IPR015373

Functions

Description
EC Number 1.1.1.300 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Microsome membrane ; Single-pass membrane protein
  • Endoplasmic reticulum membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
lipid droplet An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.

2 GO annotations of molecular function

Name Definition
NADP-retinol dehydrogenase activity Catalysis of the reaction: all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+.
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.

1 GO annotations of biological process

Name Definition
retinoic acid biosynthetic process The chemical reactions and pathways resulting in the biosynthesis of retinoic acid, one of the three components that makes up vitamin A.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8HZT6 RDH10 Retinol dehydrogenase 10 Bos taurus (Bovine) PR
Q8IZV5 RDH10 Retinol dehydrogenase 10 Homo sapiens (Human) PR
Q8VCR2 Hsd17b13 17-beta-hydroxysteroid dehydrogenase 13 Mus musculus (Mouse) PR
Q05A13 Sdr16c6 Short-chain dehydrogenase/reductase family 16C member 6 Mus musculus (Mouse) PR
Q8VCH7 Rdh10 Retinol dehydrogenase 10 Mus musculus (Mouse) PR
Q80ZF7 Rdh10 Retinol dehydrogenase 10 Rattus norvegicus (Rat) PR
A1L1W4 rdh10a Retinol dehydrogenase 10-A Danio rerio (Zebrafish) (Brachydanio rerio) PR
Q7T2D1 rdh10b Retinol dehydrogenase 10-B Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MHIVLEFFLV TFKVLWAFVL AAAKWLVRPK DKSVAGQVCL ITGAGSGLGR LFALEFARRR
70 80 90 100 110 120
AQLVLWDINS QSNEETAEMV RSIYRELEAE DSARRAGNAT EEEVQPCCNF QVYTYTCDVG
130 140 150 160 170 180
KRESVYSTAE RVRREVGDVY LLLNNAGVVS GHHLLECPDE LIERTMMVNC HAHFWTTKAF
190 200 210 220 230 240
LPKMMEMNHG HIVSVASSLG LFSTAGVEDY CASKFGVVGF HESLSHELKA ADKDGIKTTL
250 260 270 280 290 300
VCPYLVDTGM FRGCRIRKEI EPFLPPLKPD YCVKQAMRAI LTDQPMICTP RLMYIVTCMK
310 320 330 340
SILPFEAVVC MYRFLGADKC MYPFIAQRKQ ATNNNEAKNG I