A1L1W4

PR
Gene name
rdh10a (zgc:158459)
Protein name
Retinol dehydrogenase 10-A
Names
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:562840
EC number
1.1.1.300: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

55-126 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A1L1W4

Entry ID Method Resolution Chain Position Source
AF-A1L1W4-F1 Predicted AlphaFoldDB

No variants for A1L1W4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A1L1W4

No associated diseases with A1L1W4

1 regional properties for A1L1W4

Type Name Position InterPro Accession
conserved_site Short-chain dehydrogenase/reductase, conserved site 195 - 223 IPR020904

Functions

Description
EC Number 1.1.1.300 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Microsome membrane ; Single-pass membrane protein
  • Endoplasmic reticulum membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
lipid droplet An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.

2 GO annotations of molecular function

Name Definition
NADP-retinol dehydrogenase activity Catalysis of the reaction: all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+.
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.

1 GO annotations of biological process

Name Definition
retinoic acid biosynthetic process The chemical reactions and pathways resulting in the biosynthesis of retinoic acid, one of the three components that makes up vitamin A.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8HZT6 RDH10 Retinol dehydrogenase 10 Bos taurus (Bovine) PR
Q8IZV5 RDH10 Retinol dehydrogenase 10 Homo sapiens (Human) PR
Q8VCR2 Hsd17b13 17-beta-hydroxysteroid dehydrogenase 13 Mus musculus (Mouse) PR
Q05A13 Sdr16c6 Short-chain dehydrogenase/reductase family 16C member 6 Mus musculus (Mouse) PR
Q8VCH7 Rdh10 Retinol dehydrogenase 10 Mus musculus (Mouse) PR
Q80ZF7 Rdh10 Retinol dehydrogenase 10 Rattus norvegicus (Rat) PR
Q5XGF7 rdh10 Retinol dehydrogenase 10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q7T2D1 rdh10b Retinol dehydrogenase 10-B Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MNIFVEFFLV MLKVCWAIVM AGFKWLIRPK EKSVAGQVCV ITGAGGGLGR LFAKEFARRR
70 80 90 100 110 120
ATLVLWDINS HSNEETAEMV RQIYREQDNP MSKEGAVGGV EEVPPFQPQV YTYVLDVGKR
130 140 150 160 170 180
ESVYSTAEKV RREVGEVDLL INNAGVVSGH HLLECPDELI ERTMVVNCHA HFWTTKAFLP
190 200 210 220 230 240
KMLEMNHGHI VTVASSLGLF STAGVEDYCA SKFGAIGFHE SLSHEIQASE KDGIKMTLVC
250 260 270 280 290 300
PYLVDTGMFR GCRIRKEIEP FLPPLRPEFC VKQAMRAILT DQPMICTPRI VYMVNFMKSI
310 320 330
LPFEAIVCMY RFLGADKCMY PFLAQRKEAM NNNEAKNGI