AiPD: Autoinhibited Protein Database

Q8IZV5

Gene name	RDH10 (SDR16C4, UNQ9375/PRO34191)
Protein name	Retinol dehydrogenase 10
Names	Short chain dehydrogenase/reductase family 16C member 4
Species	Homo sapiens (Human)
KEGG Pathway	hsa:157506
EC number	1.1.1.300: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

291-341 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

291-341 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q8IZV5

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8IZV5-F1	Predicted				AlphaFoldDB

170 variants for Q8IZV5

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1257557137 CA371487544	3	I>F		No	ClinGen gnomAD
rs1397684527 CA371487546	3	I>T		No	ClinGen gnomAD
CA4782915 rs780951408	4	V>M		No	ClinGen ExAC gnomAD
rs773336664 CA4782918	5	V>A		No	ClinGen ExAC TOPMed gnomAD
rs769369174 CA4782917	5	V>L		No	ClinGen ExAC gnomAD
rs749230554 CA4782919	6	E>D		No	ClinGen ExAC gnomAD
CA371487562 rs1172340226	6	E>G		No	ClinGen gnomAD
TCGA novel	7	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA371487583 rs1428738168	9	V>A		No	ClinGen gnomAD
CA179316541 rs867212084 CA179316540	9	V>L		No	ClinGen TOPMed gnomAD
CA371487581 rs867212084	9	V>M		No	ClinGen TOPMed gnomAD
CA371487594 rs1270058134	11	T>I		No	ClinGen TOPMed gnomAD
CA371487602 rs774039054 COSM4151870	12	F>L	ovary [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs770812328 CA4782920	12	F>S		No	ClinGen ExAC gnomAD
rs759338480 CA4782922	13	K>R		No	ClinGen ExAC gnomAD
rs1347652724 CA371487611	14	V>M		No	ClinGen gnomAD
rs1190485689 CA371487648	19	V>L		No	ClinGen TOPMed gnomAD
rs1190485689 CA371487646	19	V>M		No	ClinGen TOPMed gnomAD
CA179316552 rs866198182	21	A>S		No	ClinGen Ensembl
CA4782923 rs768766057	21	A>V		No	ClinGen ExAC gnomAD
rs1370557423 CA371487666	22	A>V		No	ClinGen gnomAD
rs1021188367 CA179316562	24	R>G		No	ClinGen TOPMed gnomAD
TCGA novel	24	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA179316564 rs541277968	27	V>G		No	ClinGen Ensembl
rs533195986 CA4782927	27	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1390959398 CA371487699	28	R>P		No	ClinGen TOPMed
CA371487697 rs1174433789	28	R>W		No	ClinGen gnomAD
rs1168223467 CA371487706	29	P>L		No	ClinGen TOPMed
CA371487711 rs1399017399	30	K>R		No	ClinGen gnomAD
CA371487721 rs1346277234	31	E>D		No	ClinGen gnomAD
rs559905978 CA179316579	35	A>E		No	ClinGen Ensembl
CA371487759 rs1301381317	37	Q>R		No	ClinGen gnomAD
CA371487769 rs1586184746	38	V>G		No	ClinGen Ensembl
CA371487772 rs1586184747	39	C>G		No	ClinGen Ensembl
CA179316587 rs112690392	40	L>F		No	ClinGen gnomAD
rs112690392 CA371487779	40	L>V		No	ClinGen gnomAD
rs1415742333 CA371487784	41	I>V		No	ClinGen TOPMed
TCGA novel	42	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA371487807 rs1206589757	44	A>G		No	ClinGen TOPMed
CA371487844 rs1224840565	50	R>L		No	ClinGen TOPMed
CA4782931 rs755300818	52	F>L		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	56	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1447105996 CA371487899	59	R>H		No	ClinGen gnomAD
CA371487951 rs1379574486	68	I>V		No	ClinGen gnomAD
rs1468835590 CA371487967	70	T>A		No	ClinGen gnomAD
rs867559240 CA179316650	78	G>D		No	ClinGen TOPMed gnomAD
CA371488028 rs867559240	78	G>V		No	ClinGen TOPMed gnomAD
CA371488045 rs1415500519	81	R>C		No	ClinGen TOPMed
rs1402539012 CA371488069	84	Y>C		No	ClinGen gnomAD
CA371488073 rs1394484494	85	R>S		No	ClinGen gnomAD
CA371488079 rs1250496717	86	D>N		No	ClinGen TOPMed
CA4782938 rs771306889	88	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1236379418 CA371488100	89	A>S		No	ClinGen gnomAD
CA371488105 rs1278611059	90	A>T		No	ClinGen gnomAD
CA371488115 rs1586184864	91	D>A		No	ClinGen Ensembl
rs1229701671 CA371488111	91	D>N		No	ClinGen gnomAD
rs1586184869 CA371488132	94	A>S		No	ClinGen Ensembl
rs1214058857 CA371488140	95	L>P		No	ClinGen gnomAD
rs1334637507 CA371488138	95	L>V		No	ClinGen TOPMed
rs1230814069 CA371488151	97	A>P		No	ClinGen TOPMed
CA371488193 rs1370763586	101	E>G		No	ClinGen gnomAD
CA4782958 rs771894802	103	E>A		No	ClinGen ExAC gnomAD
CA4782959 rs771894802	103	E>G		No	ClinGen ExAC gnomAD
CA4782957 rs556672044	103	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
CA371488218 rs1414872613	105	L>Q		No	ClinGen gnomAD
CA371488224 rs1324680102	106	P>H		No	ClinGen gnomAD
CA4782962 rs770032148	107	H>N		No	ClinGen ExAC TOPMed gnomAD
rs770032148 CA4782961	107	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA4782964 rs145171413	108	C>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA371488234 rs145171413	108	C>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs774783285 CA4782965	109	N>D		No	ClinGen ExAC gnomAD
CA371488244 rs1279891122	109	N>I		No	ClinGen gnomAD
rs760053367 CA4782966	109	N>K		No	ClinGen ExAC gnomAD
rs1279891122 CA371488243	109	N>S		No	ClinGen gnomAD
CA4782968 rs776033179	111	Q>P		No	ClinGen ExAC gnomAD
TCGA novel	112	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4782969 rs761056077	113	F>Y		No	ClinGen ExAC gnomAD
CA4782973 rs764773069	124	N>K		No	ClinGen ExAC gnomAD
CA4782975 rs758352706	125	V>I		No	ClinGen ExAC gnomAD
rs1382657995 CA371488372	128	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA371488381 rs1296232402	130	E>K		No	ClinGen gnomAD
CA371488401 rs1436935711	132	V>A		No	ClinGen TOPMed gnomAD
CA4782978 rs754709622	133	R>C		No	ClinGen ExAC gnomAD
rs1316129347 CA371488404	133	R>H		No	ClinGen TOPMed
rs944302467 CA179318118	135	E>K		No	ClinGen TOPMed
CA4782980 rs749516657	136	V>F		No	ClinGen ExAC
CA4782981 COSM1101559 rs190882720	138	E>K	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA gnomAD
rs1259079034 CA371488463	143	V>I		No	ClinGen gnomAD
TCGA novel	144	N>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1586185939 CA371488490	146	A>V		No	ClinGen Ensembl
TCGA novel	147	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	150	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1464064107 CA371488676	173	H>N		No	ClinGen TOPMed
rs777077714	176	T>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs762042478 CA4783009	183	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1310116206 CA371541154	186	E>A		No	ClinGen gnomAD
rs1285293062 CA371541237	198	S>A		No	ClinGen gnomAD
rs868576051 CA179648566	198	S>F		No	ClinGen Ensembl
rs1213153197 CA371541245	199	L>F		No	ClinGen gnomAD
COSM1663878 rs1272790543 CA371541294	207	V>I	kidney [Cosmic]	No	ClinGen cosmic curated gnomAD
CA4783034 rs762557242	209	D>H		No	ClinGen ExAC gnomAD
rs1199360293 CA371541359	214	K>E		No	ClinGen gnomAD
rs867670086 CA179648761	221	H>Y		No	ClinGen Ensembl
TCGA novel	223	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM213004 CA371541456 rs1213492883	228	L>I	breast [Cosmic]	No	ClinGen cosmic curated gnomAD
TCGA novel	228	L>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM290835 CA179648762 rs973578810	229	K>R	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs1247354058 CA371541468	230	A>T		No	ClinGen gnomAD
rs758906627 CA4783037	231	A>T		No	ClinGen ExAC TOPMed gnomAD
CA371541478 rs1338693025	231	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA179648763 rs920379933	232	E>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	237	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs752567318 CA4783039	241	V>I		No	ClinGen ExAC gnomAD
rs1427297238 CA371541571	245	L>F		No	ClinGen TOPMed gnomAD
rs1399039554 CA371541602	250	M>V		No	ClinGen gnomAD
CA4783040 rs760588808	254	C>W		No	ClinGen ExAC gnomAD
rs950256022 CA179648767	255	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA371541645 rs1586197356	256	I>N		No	ClinGen Ensembl
CA4783084 rs563952870	258	K>E		No	ClinGen 1000Genomes ExAC gnomAD
CA179648895 rs771788342	260	I>F		No	ClinGen gnomAD
rs1368646440 CA371541687	260	I>M		No	ClinGen gnomAD
CA179648896 rs1009581987	260	I>T		No	ClinGen TOPMed
rs771788342 CA371541684	260	I>V		No	ClinGen gnomAD
TCGA novel	262	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs531103692 CA4783085	263	F>L		No	ClinGen 1000Genomes ExAC gnomAD
CA371541716 rs1349973397	265	P>S		No	ClinGen gnomAD
TCGA novel	266	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA371541782 rs1270578090	274	K>N		No	ClinGen gnomAD
rs1333140987 CA371541785	275	Q>E		No	ClinGen gnomAD
CA371541786 rs1221366050	275	Q>P		No	ClinGen gnomAD
CA179648897 rs1019217425	277	M>V		No	ClinGen TOPMed
TCGA novel	281	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA371541830 rs1488623669	281	L>P		No	ClinGen gnomAD
CA371541856 rs1248929043	285	P>S		No	ClinGen gnomAD
rs1210602500 CA371541898	291	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs752747246 CA4783089	291	R>H		No	ClinGen ExAC gnomAD
CA371541910 rs1350655030	293	M>T		No	ClinGen gnomAD
CA371541909 rs1163872682	293	M>V		No	ClinGen gnomAD
rs1368522051 CA371541920	294	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA371541930 rs756117140	295	I>M		No	ClinGen ExAC TOPMed gnomAD
CA371541934 rs1369953562	296	V>A		No	ClinGen gnomAD
rs74821757 CA4783091	296	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	298	F>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA179648906 rs200175538	302	I>F		No	ClinGen Ensembl
TCGA novel	305	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	308	V>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4783107 rs775770627	308	V>I		No	ClinGen ExAC
CA4783108 rs760815013	310	C>S		No	ClinGen ExAC TOPMed gnomAD
CA4783109 rs764131251	311	M>I		No	ClinGen ExAC gnomAD
rs754396419 CA4783110	313	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1228455605 CA371542061	313	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs952815322 CA179648909	322	Y>S		No	ClinGen Ensembl
rs867201149 CA179648910	323	P>F		No	ClinGen Ensembl
TCGA novel	325	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs750758856 CA4783115	327	Q>K		No	ClinGen ExAC gnomAD
CA4783117 rs758733414	328	R>K		No	ClinGen ExAC gnomAD
rs1186493564 CA371542167	328	R>S		No	ClinGen gnomAD
CA4783120 rs779629054	329	K>N		No	ClinGen ExAC gnomAD
CA4783122 rs754573984	330	Q>E		No	ClinGen ExAC gnomAD
rs754573984 CA4783121	330	Q>K		No	ClinGen ExAC gnomAD
rs201868320 CA4783123	331	A>D		No	ClinGen ExAC gnomAD
rs1413985262 CA371542199	333	N>K		No	ClinGen gnomAD
CA371542207 rs1177423874	334	N>K		No	ClinGen gnomAD
rs1361470732 CA371542215	335	N>K		No	ClinGen gnomAD
CA371542217 rs1433319993	336	E>K		No	ClinGen gnomAD
rs1435292027 CA371542228	337	A>E		No	ClinGen gnomAD
CA371542225 rs1366415775	337	A>T		No	ClinGen gnomAD
TCGA novel	339	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	339	N>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4783125 rs777696135	339	N>T		No	ClinGen ExAC gnomAD

No associated diseases with Q8IZV5

1 regional properties for Q8IZV5

Type	Name	Position	InterPro Accession
conserved_site	Short-chain dehydrogenase/reductase, conserved site	197 - 225	IPR020904

Functions

		Description
EC Number	1.1.1.300	With NAD(+) or NADP(+) as acceptor
Subcellular Localization	Microsome membrane ; Single-pass membrane protein Endoplasmic reticulum membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
lipid droplet	An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.

3 GO annotations of molecular function

Name	Definition
NAD-retinol dehydrogenase activity	Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+.
NADP-retinol dehydrogenase activity	Catalysis of the reaction: all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+.
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.

17 GO annotations of biological process

Name	Definition
bud elongation involved in lung branching	The process in which a bud in the lung grows out from the point where it is formed.
ear development	The process whose specific outcome is the progression of the ear over time, from its formation to the mature structure. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals.
embryonic camera-type eye development	The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure.
embryonic forelimb morphogenesis	The process, occurring in the embryo, by which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human.
embryonic viscerocranium morphogenesis	The process in which the anatomical structures of the viscerocranium are generated and organized during the embryonic phase. The viscerocranium is the part of the skull comprising the facial bones.
gonad development	The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones.
in utero embryonic development	The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
metanephros development	The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine.
neural crest cell development	The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.
nose development	The process whose specific outcome is the progression of the nose over time, from its formation to the mature structure. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity).
positive regulation of retinoic acid biosynthetic process	Any process that activates or increases the frequency, rate or extent of retinoic acid biosynthetic process.
primary lung bud formation	The morphogenetic process in which the foregut region specified to become the lung forms the initial left and right buds.
retinal metabolic process	The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A.
retinoic acid biosynthetic process	The chemical reactions and pathways resulting in the biosynthesis of retinoic acid, one of the three components that makes up vitamin A.
retinoid metabolic process	The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity.
retinol metabolic process	The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A.
visual perception	The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.

8 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8HZT6	RDH10	Retinol dehydrogenase 10	Bos taurus (Bovine)	PR
Q8VCR2	Hsd17b13	17-beta-hydroxysteroid dehydrogenase 13	Mus musculus (Mouse)	PR
Q05A13	Sdr16c6	Short-chain dehydrogenase/reductase family 16C member 6	Mus musculus (Mouse)	PR
Q8VCH7	Rdh10	Retinol dehydrogenase 10	Mus musculus (Mouse)	PR
Q80ZF7	Rdh10	Retinol dehydrogenase 10	Rattus norvegicus (Rat)	PR
Q5XGF7	rdh10	Retinol dehydrogenase 10	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
A1L1W4	rdh10a	Retinol dehydrogenase 10-A	Danio rerio (Zebrafish) (Brachydanio rerio)	PR
Q7T2D1	rdh10b	Retinol dehydrogenase 10-B	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MNIVVEFFVV	TFKVLWAFVL	AAARWLVRPK	EKSVAGQVCL	ITGAGSGLGR	LFALEFARRR
70	80	90	100	110	120
ALLVLWDINT	QSNEETAGMV	RHIYRDLEAA	DAAALQAGNG	EEEILPHCNL	QVFTYTCDVG
130	140	150	160	170	180
KRENVYLTAE	RVRKEVGEVS	VLVNNAGVVS	GHHLLECPDE	LIERTMMVNC	HAHFWTTKAF
190	200	210	220	230	240
LPTMLEINHG	HIVTVASSLG	LFSTAGVEDY	CASKFGVVGF	HESLSHELKA	AEKDGIKTTL
250	260	270	280	290	300
VCPYLVDTGM	FRGCRIRKEI	EPFLPPLKPD	YCVKQAMKAI	LTDQPMICTP	RLMYIVTFMK
310	320	330	340
SILPFEAVVC	MYRFLGADKC	MYPFIAQRKQ	ATNNNEAKNG	I