Q8LPS5
PR
Gene name |
SERK5 (At2g13800, F13J11.15) |
Protein name |
Somatic embryogenesis receptor kinase 5 |
Names |
AtSERK5, Somatic embryogenesis receptor-like kinase 5 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT2G13800 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8LPS5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8LPS5-F1 | Predicted | AlphaFoldDB |
63 variants for Q8LPS5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH01768509 | 3 | H>Q | No | 1000Genomes | |
| ENSVATH00227051 | 8 | G>R | No | 1000Genomes | |
| ENSVATH00227052 | 18 | F>L | No | 1000Genomes | |
| ENSVATH01768510 | 20 | S>F | No | 1000Genomes | |
| ENSVATH01768511 | 23 | T>I | No | 1000Genomes | |
| tmp_2_5753345_G_A | 24 | G>R | No | 1000Genomes | |
| ENSVATH01768512 | 25 | K>N | No | 1000Genomes | |
| ENSVATH01768513 | 26 | T>A | No | 1000Genomes | |
| ENSVATH07852052 | 26 | T>R | No | 1000Genomes | |
| tmp_2_5753518_A_G | 35 | R>G | No | 1000Genomes | |
| ENSVATH00227058 | 44 | T>A | No | 1000Genomes | |
| tmp_2_5753560_CA_TA,C | 49 | Q>* | No | 1000Genomes | |
| tmp_2_5753562_A_T | 49 | Q>H | No | 1000Genomes | |
| ENSVATH13031460 | 51 | W>* | No | 1000Genomes | |
| tmp_2_5753576_C_G | 54 | T>S | No | 1000Genomes | |
| ENSVATH14406518 | 55 | H>Y | No | 1000Genomes | |
| ENSVATH01768526 | 73 | T>I | No | 1000Genomes | |
| ENSVATH05441675 | 80 | A>V | No | 1000Genomes | |
| ENSVATH05441676 | 87 | V>E | No | 1000Genomes | |
| tmp_2_5753740_G_T | 87 | V>L | No | 1000Genomes | |
| ENSVATH05441678 | 88 | P>S | No | 1000Genomes | |
| ENSVATH05441679 | 89 | Q>* | No | 1000Genomes | |
| ENSVATH01768535 | 102 | F>I | No | 1000Genomes | |
| ENSVATH07852055 | 109 | E>K | No | 1000Genomes | |
| ENSVATH00227064 | 150 | Y>H | No | 1000Genomes | |
| tmp_2_5754800_C_T | 163 | T>I | No | 1000Genomes | |
| ENSVATH05441700 | 166 | P>L | No | 1000Genomes | |
| ENSVATH05441703 | 178 | S>C | No | 1000Genomes | |
| ENSVATH14406520 | 184 | N>S | No | 1000Genomes | |
| ENSVATH05441704 | 189 | Q>* | No | 1000Genomes | |
| ENSVATH01768573 | 192 | S>C | No | 1000Genomes | |
| ENSVATH01768573 | 192 | S>F | No | 1000Genomes | |
| tmp_2_5754970_A_T | 193 | M>L | No | 1000Genomes | |
| tmp_2_5755062_T_A | 197 | N>K | No | 1000Genomes | |
| tmp_2_5755065_T_G | 198 | N>K | No | 1000Genomes | |
| ENSVATH00227066 | 200 | L>F | No | 1000Genomes | |
| ENSVATH01768576 | 207 | P>H | No | 1000Genomes | |
| ENSVATH01768576 | 207 | P>L | No | 1000Genomes | |
| tmp_2_5755626_G_A | 217 | A>T | No | 1000Genomes | |
| ENSVATH01768585 | 224 | A>V | No | 1000Genomes | |
| ENSVATH05441715 | 226 | A>P | No | 1000Genomes | |
| tmp_2_5755690_G_A | 238 | R>K | No | 1000Genomes | |
| tmp_2_5755700_G_C | 241 | Q>H | No | 1000Genomes | |
| ENSVATH05441721 | 254 | E>K | No | 1000Genomes | |
| ENSVATH07852081 | 256 | Y>H | No | 1000Genomes | |
| tmp_2_5755882_A_C | 274 | K>N | No | 1000Genomes | |
| tmp_2_5755891_A_T | 277 | K>N | No | 1000Genomes | |
| tmp_2_5755893_G_A | 278 | R>K | No | 1000Genomes | |
| tmp_2_5755908_A_G | 283 | K>R | No | 1000Genomes | |
| ENSVATH14406522 | 285 | R>G | No | 1000Genomes | |
| ENSVATH01768590 | 285 | R>P | No | 1000Genomes | |
| tmp_2_5755920_G_T | 287 | G>V | No | 1000Genomes | |
| ENSVATH07852082 | 288 | I>K | No | 1000Genomes | |
| ENSVATH07852083 | 289 | L>V | No | 1000Genomes | |
| ENSVATH00227070 | 297 | D>G | No | 1000Genomes | |
| tmp_2_5755953_C_A | 298 | T>N | No | 1000Genomes | |
| ENSVATH01768593 | 306 | N>K | No | 1000Genomes | |
| ENSVATH13031534 | 309 | R>H | No | 1000Genomes | |
| ENSVATH01768595 | 347 | L>I | No | 1000Genomes | |
| ENSVATH05441725 | 401 | L>M | No | 1000Genomes | |
| ENSVATH01768611 | 401 | L>R | No | 1000Genomes | |
| ENSVATH01768629 | 580 | G>S | No | 1000Genomes | |
| tmp_2_5757048_C_T | 597 | P>S | No | 1000Genomes |
No associated diseases with Q8LPS5
13 regional properties for Q8LPS5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Receptor L-domain | 52 - 172 | IPR000494-1 |
| domain | Receptor L-domain | 367 - 485 | IPR000494-2 |
| domain | Protein kinase domain | 722 - 989 | IPR000719 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 724 - 977 | IPR001245 |
| domain | Furin-like cysteine-rich domain | 191 - 344 | IPR006211 |
| repeat | Furin-like repeat | 190 - 231 | IPR006212-1 |
| repeat | Furin-like repeat | 233 - 281 | IPR006212-2 |
| repeat | Furin-like repeat | 503 - 609 | IPR006212-3 |
| active_site | Tyrosine-protein kinase, active site | 843 - 855 | IPR008266 |
| binding_site | Protein kinase, ATP binding site | 728 - 755 | IPR017441 |
| domain | Tyrosine-protein kinase, catalytic domain | 722 - 978 | IPR020635 |
| domain | Growth factor receptor domain 4 | 512 - 644 | IPR032778 |
| domain | Epidermal growth factor receptor-like, transmembrane-juxtamembrane segment | 656 - 690 | IPR049328 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| identical protein binding | Binding to an identical protein or proteins. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| signaling receptor binding | Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
| transmembrane receptor protein serine/threonine kinase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
64 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P0C0K6 | EPHB6 | Ephrin type-B receptor 6 | Pan troglodytes (Chimpanzee) | SS |
| Q9Y616 | IRAK3 | Interleukin-1 receptor-associated kinase 3 | Homo sapiens (Human) | PR |
| P53667 | LIMK1 | LIM domain kinase 1 | Homo sapiens (Human) | PR |
| P53671 | LIMK2 | LIM domain kinase 2 | Homo sapiens (Human) | PR |
| O15146 | MUSK | Muscle, skeletal receptor tyrosine-protein kinase | Homo sapiens (Human) | EV |
| P04629 | NTRK1 | High affinity nerve growth factor receptor | Homo sapiens (Human) | EV |
| Q16288 | NTRK3 | NT-3 growth factor receptor | Homo sapiens (Human) | SS |
| Q16620 | NTRK2 | BDNF/NT-3 growth factors receptor | Homo sapiens (Human) | EV |
| Q8K4B2 | Irak3 | Interleukin-1 receptor-associated kinase 3 | Mus musculus (Mouse) | PR |
| Q8CFA1 | Irak2 | Interleukin-1 receptor-associated kinase-like 2 | Mus musculus (Mouse) | PR |
| O54785 | Limk2 | LIM domain kinase 2 | Mus musculus (Mouse) | PR |
| P55144 | Tyro3 | Tyrosine-protein kinase receptor TYRO3 | Mus musculus (Mouse) | SS |
| Q61006 | Musk | Muscle, skeletal receptor tyrosine-protein kinase | Mus musculus (Mouse) | SS |
| Q00993 | Axl | Tyrosine-protein kinase receptor UFO | Mus musculus (Mouse) | PR |
| Q60805 | Mertk | Tyrosine-protein kinase Mer | Mus musculus (Mouse) | SS |
| Q3UFB7 | Ntrk1 | High affinity nerve growth factor receptor | Mus musculus (Mouse) | SS |
| P09581 | Csf1r | Macrophage colony-stimulating factor 1 receptor | Mus musculus (Mouse) | SS |
| P21803 | Fgfr2 | Fibroblast growth factor receptor 2 | Mus musculus (Mouse) | SS |
| P16092 | Fgfr1 | Fibroblast growth factor receptor 1 | Mus musculus (Mouse) | SS |
| Q03142 | Fgfr4 | Fibroblast growth factor receptor 4 | Mus musculus (Mouse) | PR |
| P05622 | Pdgfrb | Platelet-derived growth factor receptor beta | Mus musculus (Mouse) | SS |
| Q00342 | Flt3 | Receptor-type tyrosine-protein kinase FLT3 | Mus musculus (Mouse) | SS |
| Q61851 | Fgfr3 | Fibroblast growth factor receptor 3 | Mus musculus (Mouse) | PR |
| P24786 | NTRK3 | NT-3 growth factor receptor | Sus scrofa (Pig) | SS |
| Q4QQS0 | Irak2 | Interleukin-1 receptor-associated kinase-like 2 | Rattus norvegicus (Rat) | PR |
| P35739 | Ntrk1 | High affinity nerve growth factor receptor | Rattus norvegicus (Rat) | SS |
| Q03351 | Ntrk3 | NT-3 growth factor receptor | Rattus norvegicus (Rat) | SS |
| Q63604 | Ntrk2 | BDNF/NT-3 growth factors receptor | Rattus norvegicus (Rat) | SS |
| Q9ASQ5 | CRCK3 | Calmodulin-binding receptor-like cytoplasmic kinase 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LSV3 | WAKL16 | Putative wall-associated receptor kinase-like 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9STF0 | LECRKS3 | Receptor like protein kinase S.3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SCZ4 | FER | Receptor-like protein kinase FERONIA | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M342 | WAKL15 | Wall-associated receptor kinase-like 15 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LYN6 | At3g56050 | Probable inactive receptor-like protein kinase At3g56050 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8VZJ9 | CRCK2 | Calmodulin-binding receptor-like cytoplasmic kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q0WNY5 | WAKL18 | Wall-associated receptor kinase-like 18 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94C25 | At5g20050 | Probable receptor-like protein kinase At5g20050 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FLW0 | At5g24010 | Probable receptor-like protein kinase At5g24010 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LTC0 | PBL19 | Probable serine/threonine-protein kinase PBL19 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FIL7 | CRCK1 | Calmodulin-binding receptor-like cytoplasmic kinase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGG3 | At1g51820 | Probable LRR receptor-like serine/threonine-protein kinase At1g51820 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGI2 | At1g67720 | Probable LRR receptor-like serine/threonine-protein kinase At1g67720 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGW2 | PAM74 | Probable LRR receptor-like serine/threonine-protein kinase PAM74 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P43293 | PBL11 | Probable serine/threonine-protein kinase PBL11 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P43298 | TMK1 | Receptor protein kinase TMK1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P93050 | BSH | Probable LRR receptor-like serine/threonine-protein kinase RKF3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q3E8W4 | ANX2 | Receptor-like protein kinase ANXUR2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RWW0 | ALE2 | Receptor-like serine/threonine-protein kinase ALE2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RWZ5 | SD25 | G-type lectin S-receptor-like serine/threonine-protein kinase SD2-5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FN93 | At5g59680 | Probable LRR receptor-like serine/threonine-protein kinase At5g59680 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FN94 | At5g59670 | Receptor-like protein kinase At5g59670 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LIG2 | At3g21340 | Receptor-like protein kinase At3g21340 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LPZ9 | SD113 | G-type lectin S-receptor-like serine/threonine-protein kinase SD1-13 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LRP3 | At3g17420 | Probable receptor-like protein kinase At3g17420 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M2S4 | LECRKS4 | L-type lectin-domain containing receptor kinase S.4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SNA3 | At3g46340 | Putative receptor-like protein kinase At3g46340 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZQR3 | At2g14510 | Leucine-rich repeat receptor-like serine/threonine-protein kinase At2g14510 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q93ZS4 | NIK3 | Protein NSP-INTERACTING KINASE 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94AG2 | SERK1 | Somatic embryogenesis receptor kinase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9XIC7 | SERK2 | Somatic embryogenesis receptor kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SXB4 | At1g11300 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g11300 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q84JQ4 | PRK2 | Pollen receptor-like kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64477 | At2g19130 | G-type lectin S-receptor-like serine/threonine-protein kinase At2g19130 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| C0LGX1 | At5g65240 | Probable LRR receptor-like serine/threonine-protein kinase At5g65240 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEHGSSRGFI | WLILFLDFVS | RVTGKTQVDA | LIALRSSLSS | GDHTNNILQS | WNATHVTPCS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| WFHVTCNTEN | SVTRLDLGSA | NLSGELVPQL | AQLPNLQYLE | LFNNNITGEI | PEELGDLMEL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VSLDLFANNI | SGPIPSSLGK | LGKLRFLRLY | NNSLSGEIPR | SLTALPLDVL | DISNNRLSGD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IPVNGSFSQF | TSMSFANNKL | RPRPASPSPS | PSGTSAAIVV | GVAAGAALLF | ALAWWLRRKL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QGHFLDVPAE | EDPEVYLGQF | KRFSLRELLV | ATEKFSKRNV | LGKGRFGILY | KGRLADDTLV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AVKRLNEERT | KGGELQFQTE | VEMISMAVHR | NLLRLRGFCM | TPTERLLVYP | YMANGSVASC |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LRERPEGNPA | LDWPKRKHIA | LGSARGLAYL | HDHCDQKIIH | LDVKAANILL | DEEFEAVVGD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FGLAKLMNYN | DSHVTTAVRG | TIGHIAPEYL | STGKSSEKTD | VFGYGVMLLE | LITGQKAFDL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ARLANDDDIM | LLDWVKEVLK | EKKLESLVDA | ELEGKYVETE | VEQLIQMALL | CTQSSAMERP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KMSEVVRMLE | GDGLAERWEE | WQKEEMPIHD | FNYQAYPHAG | TDWLIPYSNS | LIENDYPSGP |
| R |