Q9LTC0
Gene name |
PBL19 (At5g47070, K14A3.2) |
Protein name |
Probable serine/threonine-protein kinase PBL19 |
Names |
PBS1-like protein 19 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G47070 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
235-242 (Activation loop from InterPro)
Target domain |
86-369 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
253-260 (Activation loop from InterPro)
Target domain |
86-369 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q9LTC0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9LTC0-F1 | Predicted | AlphaFoldDB |
25 variants for Q9LTC0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_5_19120445_C_A | 28 | E>D | No | 1000Genomes | |
| ENSVATH12599705 | 41 | S>N | No | 1000Genomes | |
| ENSVATH03379441 | 75 | S>T | No | 1000Genomes | |
| ENSVATH07359975 | 149 | V>A | No | 1000Genomes | |
| tmp_5_19119632_G_C | 202 | A>G | No | 1000Genomes | |
| ENSVATH03379419 | 227 | D>N | No | 1000Genomes | |
| ENSVATH00716333 | 245 | D>E | No | 1000Genomes | |
| ENSVATH12599642 | 292 | R>S | No | 1000Genomes | |
| tmp_5_19118988_C_T | 310 | V>I | No | 1000Genomes | |
| tmp_5_19118969_T_C | 316 | D>G | No | 1000Genomes | |
| tmp_5_19118919_G_A | 333 | P>S | No | 1000Genomes | |
| ENSVATH07359967 | 351 | N>T | No | 1000Genomes | |
| ENSVATH00716326 | 352 | D>E | No | 1000Genomes | |
| tmp_5_19118857_T_G | 353 | K>N | No | 1000Genomes | |
| tmp_5_19118843_A_G | 358 | M>T | No | 1000Genomes | |
| tmp_5_19118839_T_G | 359 | E>D | No | 1000Genomes | |
| ENSVATH00716325 | 360 | I>L | No | 1000Genomes | |
| ENSVATH07359966 | 361 | V>L | No | 1000Genomes | |
| ENSVATH12599639 | 367 | K>M | No | 1000Genomes | |
| tmp_5_19118798_T_A | 373 | D>V | No | 1000Genomes | |
| ENSVATH03379414 | 374 | S>N | No | 1000Genomes | |
| ENSVATH12599638 | 379 | M>I | No | 1000Genomes | |
| tmp_5_19118768_G_A | 383 | T>M | No | 1000Genomes | |
| ENSVATH07359964 | 394 | Q>* | No | 1000Genomes | |
| tmp_5_19118708_A_C | 403 | L>W | No | 1000Genomes |
No associated diseases with Q9LTC0
10 regional properties for Q9LTC0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Receptor L-domain | 56 - 166 | IPR000494-1 |
| domain | Receptor L-domain | 353 - 472 | IPR000494-2 |
| domain | Protein kinase domain | 709 - 966 | IPR000719 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 711 - 964 | IPR001245 |
| domain | Furin-like cysteine-rich domain | 182 - 332 | IPR006211 |
| repeat | Furin-like repeat | 180 - 220 | IPR006212-1 |
| repeat | Furin-like repeat | 223 - 266 | IPR006212-2 |
| repeat | Furin-like repeat | 490 - 595 | IPR006212-3 |
| repeat | Furin-like repeat | 607 - 642 | IPR006212-4 |
| domain | Growth factor receptor domain 4 | 499 - 629 | IPR032778 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| plastid | Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| innate immune response | Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
25 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q6XUX0 | DSTYK | Dual serine/threonine and tyrosine protein kinase | Gallus gallus (Chicken) | PR |
| Q9Y616 | IRAK3 | Interleukin-1 receptor-associated kinase 3 | Homo sapiens (Human) | PR |
| P53667 | LIMK1 | LIM domain kinase 1 | Homo sapiens (Human) | PR |
| P53671 | LIMK2 | LIM domain kinase 2 | Homo sapiens (Human) | PR |
| Q8K4B2 | Irak3 | Interleukin-1 receptor-associated kinase 3 | Mus musculus (Mouse) | PR |
| Q8CFA1 | Irak2 | Interleukin-1 receptor-associated kinase-like 2 | Mus musculus (Mouse) | PR |
| O54785 | Limk2 | LIM domain kinase 2 | Mus musculus (Mouse) | PR |
| Q4QQS0 | Irak2 | Interleukin-1 receptor-associated kinase-like 2 | Rattus norvegicus (Rat) | PR |
| Q9ASQ5 | CRCK3 | Calmodulin-binding receptor-like cytoplasmic kinase 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8LPS5 | SERK5 | Somatic embryogenesis receptor kinase 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RWW0 | ALE2 | Receptor-like serine/threonine-protein kinase ALE2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P93050 | BSH | Probable LRR receptor-like serine/threonine-protein kinase RKF3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LRP3 | At3g17420 | Probable receptor-like protein kinase At3g17420 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LSV3 | WAKL16 | Putative wall-associated receptor kinase-like 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9STF0 | LECRKS3 | Receptor like protein kinase S.3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SCZ4 | FER | Receptor-like protein kinase FERONIA | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M342 | WAKL15 | Wall-associated receptor kinase-like 15 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LYN6 | At3g56050 | Probable inactive receptor-like protein kinase At3g56050 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8VZJ9 | CRCK2 | Calmodulin-binding receptor-like cytoplasmic kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q0WNY5 | WAKL18 | Wall-associated receptor kinase-like 18 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94C25 | At5g20050 | Probable receptor-like protein kinase At5g20050 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FLW0 | At5g24010 | Probable receptor-like protein kinase At5g24010 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q3E8W4 | ANX2 | Receptor-like protein kinase ANXUR2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FIL7 | CRCK1 | Calmodulin-binding receptor-like cytoplasmic kinase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P43293 | PBL11 | Probable serine/threonine-protein kinase PBL11 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNCLFLFKSK | KPRKQQKDNN | KNKRKGKELL | QNSAPELTNR | SETSSFNLQT | PRSLPSPRSI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KDLYTEREQN | LRVFSYEELS | KATYVFSRKL | VIGEGGFGIV | YKGKILSNGD | SSDPPLVVAI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KKLNRQGLQG | HKQWLAEVQF | LGVVNHPNVV | KLIGYCSEDG | ETGIERLLVY | EYMSNRSLED |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HLFPRRSHTL | PWKKRLEIML | GAAEGLTYLH | DLKVIYRDFK | SSNVLLDDQF | CPKLSDFGLA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| REGPDGDNTH | VTTARVGTHG | YAAPEYVQTG | HLRLKSDVYS | FGVVLYEIIT | GRRTIERNKP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VAERRLLDWV | KEYPADSQRF | SMIVDPRLRN | NYPAAGARSL | AKLADLCLKK | NDKERPTMEI |
| 370 | 380 | 390 | 400 | ||
| VVERLKKIIE | ESDSEDYPMA | TTTTKESSQV | RRRQVAKPEK | QSLRGVSVRG |