P43293
Gene name |
PBL11 |
Protein name |
Probable serine/threonine-protein kinase PBL11 |
Names |
PBS1-like protein 11 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G02290 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
220-227 (Activation loop from InterPro)
Target domain |
68-353 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
238-245 (Activation loop from InterPro)
Target domain |
68-353 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for P43293
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P43293-F1 | Predicted | AlphaFoldDB |
21 variants for P43293
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_5_471859_C_T | 28 | G>E | No | 1000Genomes | |
| ENSVATH03007456 | 34 | T>N | No | 1000Genomes | |
| ENSVATH03007455 | 35 | A>T | No | 1000Genomes | |
| tmp_5_471772_C_T | 57 | S>N | No | 1000Genomes | |
| ENSVATH00601554 | 90 | S>A | No | 1000Genomes | |
| ENSVATH03007440 | 177 | T>M | No | 1000Genomes | |
| tmp_5_470965_A_T | 224 | L>* | No | 1000Genomes | |
| ENSVATH10499297 | 282 | K>T | No | 1000Genomes | |
| tmp_5_470658_G_A | 300 | T>I | No | 1000Genomes | |
| ENSVATH06908011 | 327 | V>I | No | 1000Genomes | |
| ENSVATH06908010 | 333 | I>L | No | 1000Genomes | |
| ENSVATH10499296 | 350 | M>I | No | 1000Genomes | |
| ENSVATH00601544 | 350 | M>L | No | 1000Genomes | |
| ENSVATH03007434 | 360 | S>P | No | 1000Genomes | |
| tmp_5_470469_T_C | 363 | Q>R | No | 1000Genomes | |
| ENSVATH06908007 | 369 | S>I | No | 1000Genomes | |
| tmp_5_470445_T_G | 371 | D>A | No | 1000Genomes | |
| ENSVATH06908006 | 371 | D>E | No | 1000Genomes | |
| ENSVATH03007433 | 373 | I>N | No | 1000Genomes | |
| ENSVATH06908005 | 374 | I>N | No | 1000Genomes | |
| ENSVATH06908004 | 379 | Q>R | No | 1000Genomes |
No associated diseases with P43293
4 regional properties for P43293
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 68 - 353 | IPR000719 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 72 - 349 | IPR001245 |
| active_site | Serine/threonine-protein kinase, active site | 199 - 211 | IPR008271 |
| binding_site | Protein kinase, ATP binding site | 74 - 106 | IPR017441 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| defense response | Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
42 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9Y616 | IRAK3 | Interleukin-1 receptor-associated kinase 3 | Homo sapiens (Human) | PR |
| P53667 | LIMK1 | LIM domain kinase 1 | Homo sapiens (Human) | PR |
| P53671 | LIMK2 | LIM domain kinase 2 | Homo sapiens (Human) | PR |
| Q8K4B2 | Irak3 | Interleukin-1 receptor-associated kinase 3 | Mus musculus (Mouse) | PR |
| Q8CFA1 | Irak2 | Interleukin-1 receptor-associated kinase-like 2 | Mus musculus (Mouse) | PR |
| O54785 | Limk2 | LIM domain kinase 2 | Mus musculus (Mouse) | PR |
| Q4QQS0 | Irak2 | Interleukin-1 receptor-associated kinase-like 2 | Rattus norvegicus (Rat) | PR |
| Q9ASQ5 | CRCK3 | Calmodulin-binding receptor-like cytoplasmic kinase 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LSV3 | WAKL16 | Putative wall-associated receptor kinase-like 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9STF0 | LECRKS3 | Receptor like protein kinase S.3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SCZ4 | FER | Receptor-like protein kinase FERONIA | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M342 | WAKL15 | Wall-associated receptor kinase-like 15 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LYN6 | At3g56050 | Probable inactive receptor-like protein kinase At3g56050 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8VZJ9 | CRCK2 | Calmodulin-binding receptor-like cytoplasmic kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q0WNY5 | WAKL18 | Wall-associated receptor kinase-like 18 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94C25 | At5g20050 | Probable receptor-like protein kinase At5g20050 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FLW0 | At5g24010 | Probable receptor-like protein kinase At5g24010 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FIL7 | CRCK1 | Calmodulin-binding receptor-like cytoplasmic kinase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGG3 | At1g51820 | Probable LRR receptor-like serine/threonine-protein kinase At1g51820 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGI2 | At1g67720 | Probable LRR receptor-like serine/threonine-protein kinase At1g67720 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGW2 | PAM74 | Probable LRR receptor-like serine/threonine-protein kinase PAM74 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P43298 | TMK1 | Receptor protein kinase TMK1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P93050 | BSH | Probable LRR receptor-like serine/threonine-protein kinase RKF3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q3E8W4 | ANX2 | Receptor-like protein kinase ANXUR2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8LPS5 | SERK5 | Somatic embryogenesis receptor kinase 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RWW0 | ALE2 | Receptor-like serine/threonine-protein kinase ALE2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RWZ5 | SD25 | G-type lectin S-receptor-like serine/threonine-protein kinase SD2-5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FN93 | At5g59680 | Probable LRR receptor-like serine/threonine-protein kinase At5g59680 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FN94 | At5g59670 | Receptor-like protein kinase At5g59670 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LIG2 | At3g21340 | Receptor-like protein kinase At3g21340 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LPZ9 | SD113 | G-type lectin S-receptor-like serine/threonine-protein kinase SD1-13 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LRP3 | At3g17420 | Probable receptor-like protein kinase At3g17420 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M2S4 | LECRKS4 | L-type lectin-domain containing receptor kinase S.4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SNA3 | At3g46340 | Putative receptor-like protein kinase At3g46340 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZQR3 | At2g14510 | Leucine-rich repeat receptor-like serine/threonine-protein kinase At2g14510 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LTC0 | PBL19 | Probable serine/threonine-protein kinase PBL19 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SXB4 | At1g11300 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g11300 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q84JQ4 | PRK2 | Pollen receptor-like kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q93ZS4 | NIK3 | Protein NSP-INTERACTING KINASE 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94AG2 | SERK1 | Somatic embryogenesis receptor kinase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64477 | At2g19130 | G-type lectin S-receptor-like serine/threonine-protein kinase At2g19130 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9XIC7 | SERK2 | Somatic embryogenesis receptor kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGGCFSNRIK | TDIASSTWLS | SKFLSRDGSK | GSSTASFSYM | PRTEGEILQN | ANLKNFSLSE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LKSATRNFRP | DSVVGEGGFG | CVFKGWIDES | SLAPSKPGTG | IVIAVKRLNQ | EGFQGHREWL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AEINYLGQLD | HPNLVKLIGY | CLEEEHRLLV | YEFMTRGSLE | NHLFRRGTFY | QPLSWNTRVR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MALGAARGLA | FLHNAQPQVI | YRDFKASNIL | LDSNYNAKLS | DFGLARDGPM | GDNSHVSTRV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MGTQGYAAPE | YLATGHLSVK | SDVYSFGVVL | LELLSGRRAI | DKNQPVGEHN | LVDWARPYLT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NKRRLLRVMD | PRLQGQYSLT | RALKIAVLAL | DCISIDAKSR | PTMNEIVKTM | EELHIQKEAS |
| 370 | 380 | ||||
| KEQQNPQISI | DNIINKSPQA | VNYPRPSIM |