Q93ZS4
PR
Gene name |
NIK3 (At1g60800, F8A5.31) |
Protein name |
Protein NSP-INTERACTING KINASE 3 |
Names |
LRR receptor-like serine/threonine-protein kinase NIK3 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G60800 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q93ZS4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q93ZS4-F1 | Predicted | AlphaFoldDB |
31 variants for Q93ZS4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_1_22386916_A_G | 6 | F>L | No | 1000Genomes | |
| ENSVATH05014017 | 7 | V>M | No | 1000Genomes | |
| tmp_1_22386883_C_T | 17 | V>I | No | 1000Genomes | |
| ENSVATH05014015 | 22 | I>V | No | 1000Genomes | |
| tmp_1_22386847_G_A | 29 | P>S | No | 1000Genomes | |
| tmp_1_22386398_T_G | 51 | K>N | No | 1000Genomes | |
| ENSVATH05013991 | 129 | L>F | No | 1000Genomes | |
| ENSVATH00108729 | 140 | A>V | No | 1000Genomes | |
| tmp_1_22385961_G_C | 142 | L>V | No | 1000Genomes | |
| ENSVATH13673515 | 146 | K>N | No | 1000Genomes | |
| ENSVATH05013971 | 223 | D>G | No | 1000Genomes | |
| ENSVATH13673480 | 232 | T>N | No | 1000Genomes | |
| tmp_1_22385252_C_G | 251 | V>L | No | 1000Genomes | |
| ENSVATH05013967 | 265 | R>C | No | 1000Genomes | |
| tmp_1_22385011_G_C | 302 | N>K | No | 1000Genomes | |
| ENSVATH14369223 | 302 | N>T | No | 1000Genomes | |
| tmp_1_22384970_T_A | 316 | Y>F | No | 1000Genomes | |
| ENSVATH05013952 | 319 | H>N | No | 1000Genomes | |
| tmp_1_22384914_T_G | 335 | N>H | No | 1000Genomes | |
| ENSVATH05013948 | 360 | R>P | No | 1000Genomes | |
| ENSVATH05013944 | 394 | E>Q | No | 1000Genomes | |
| ENSVATH13673446 | 520 | V>G | No | 1000Genomes | |
| tmp_1_22383909_G_T | 531 | Q>K | No | 1000Genomes | |
| tmp_1_22383769_G_C | 577 | D>E | No | 1000Genomes | |
| ENSVATH05013913 | 582 | R>K | No | 1000Genomes | |
| tmp_1_22383731_G_A | 590 | T>I | No | 1000Genomes | |
| ENSVATH00108723 | 593 | H>Y | No | 1000Genomes | |
| ENSVATH05013912 | 600 | P>Q | No | 1000Genomes | |
| ENSVATH01414334 | 602 | M>K | No | 1000Genomes | |
| ENSVATH01414331 | 620 | S>T | No | 1000Genomes | |
| ENSVATH13673445 | 622 | V>I | No | 1000Genomes |
No associated diseases with Q93ZS4
5 regional properties for Q93ZS4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 301 - 584 | IPR000719 |
| repeat | Leucine-rich repeat | 99 - 158 | IPR001611 |
| active_site | Serine/threonine-protein kinase, active site | 424 - 436 | IPR008271 |
| domain | Leucine-rich repeat-containing N-terminal, plant-type | 33 - 71 | IPR013210 |
| binding_site | Protein kinase, ATP binding site | 307 - 329 | IPR017441 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| coreceptor activity | Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| anther development | The process whose specific outcome is the progression of the anther over time, from its formation to the mature structure. |
| defense response | Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. |
| homeostasis of number of meristem cells | Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in the meristem. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
44 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P46197 | NPR2 | Atrial natriuretic peptide receptor 2 | Bos taurus (Bovine) | PR |
| P0C0K6 | EPHB6 | Ephrin type-B receptor 6 | Pan troglodytes (Chimpanzee) | SS |
| P04629 | NTRK1 | High affinity nerve growth factor receptor | Homo sapiens (Human) | EV |
| Q16288 | NTRK3 | NT-3 growth factor receptor | Homo sapiens (Human) | SS |
| Q16620 | NTRK2 | BDNF/NT-3 growth factors receptor | Homo sapiens (Human) | EV |
| O15146 | MUSK | Muscle, skeletal receptor tyrosine-protein kinase | Homo sapiens (Human) | EV |
| P09581 | Csf1r | Macrophage colony-stimulating factor 1 receptor | Mus musculus (Mouse) | SS |
| P21803 | Fgfr2 | Fibroblast growth factor receptor 2 | Mus musculus (Mouse) | SS |
| P16092 | Fgfr1 | Fibroblast growth factor receptor 1 | Mus musculus (Mouse) | SS |
| Q03142 | Fgfr4 | Fibroblast growth factor receptor 4 | Mus musculus (Mouse) | PR |
| P05622 | Pdgfrb | Platelet-derived growth factor receptor beta | Mus musculus (Mouse) | SS |
| Q00342 | Flt3 | Receptor-type tyrosine-protein kinase FLT3 | Mus musculus (Mouse) | SS |
| Q61006 | Musk | Muscle, skeletal receptor tyrosine-protein kinase | Mus musculus (Mouse) | SS |
| P55144 | Tyro3 | Tyrosine-protein kinase receptor TYRO3 | Mus musculus (Mouse) | SS |
| Q00993 | Axl | Tyrosine-protein kinase receptor UFO | Mus musculus (Mouse) | PR |
| Q60805 | Mertk | Tyrosine-protein kinase Mer | Mus musculus (Mouse) | SS |
| Q3UFB7 | Ntrk1 | High affinity nerve growth factor receptor | Mus musculus (Mouse) | SS |
| Q61851 | Fgfr3 | Fibroblast growth factor receptor 3 | Mus musculus (Mouse) | PR |
| P24786 | NTRK3 | NT-3 growth factor receptor | Sus scrofa (Pig) | SS |
| Q8LPS5 | SERK5 | Somatic embryogenesis receptor kinase 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94AG2 | SERK1 | Somatic embryogenesis receptor kinase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9XIC7 | SERK2 | Somatic embryogenesis receptor kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q3E8W4 | ANX2 | Receptor-like protein kinase ANXUR2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P43298 | TMK1 | Receptor protein kinase TMK1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M2S4 | LECRKS4 | L-type lectin-domain containing receptor kinase S.4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P93050 | BSH | Probable LRR receptor-like serine/threonine-protein kinase RKF3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FN94 | At5g59670 | Receptor-like protein kinase At5g59670 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SXB4 | At1g11300 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g11300 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q84JQ4 | PRK2 | Pollen receptor-like kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGI2 | At1g67720 | Probable LRR receptor-like serine/threonine-protein kinase At1g67720 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGG3 | At1g51820 | Probable LRR receptor-like serine/threonine-protein kinase At1g51820 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FN93 | At5g59680 | Probable LRR receptor-like serine/threonine-protein kinase At5g59680 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SNA3 | At3g46340 | Putative receptor-like protein kinase At3g46340 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LPZ9 | SD113 | G-type lectin S-receptor-like serine/threonine-protein kinase SD1-13 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9ZQR3 | At2g14510 | Leucine-rich repeat receptor-like serine/threonine-protein kinase At2g14510 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64477 | At2g19130 | G-type lectin S-receptor-like serine/threonine-protein kinase At2g19130 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LIG2 | At3g21340 | Receptor-like protein kinase At3g21340 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RWW0 | ALE2 | Receptor-like serine/threonine-protein kinase ALE2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RWZ5 | SD25 | G-type lectin S-receptor-like serine/threonine-protein kinase SD2-5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGW2 | PAM74 | Probable LRR receptor-like serine/threonine-protein kinase PAM74 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P43293 | PBL11 | Probable serine/threonine-protein kinase PBL11 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LRP3 | At3g17420 | Probable receptor-like protein kinase At3g17420 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGX1 | At5g65240 | Probable LRR receptor-like serine/threonine-protein kinase At5g65240 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O13146 | epha3 | Ephrin type-A receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEGVRFVVWR | LGFLVFVWFF | DISSATLSPT | GVNYEVTALV | AVKNELNDPY | KVLENWDVNS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VDPCSWRMVS | CTDGYVSSLD | LPSQSLSGTL | SPRIGNLTYL | QSVVLQNNAI | TGPIPETIGR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LEKLQSLDLS | NNSFTGEIPA | SLGELKNLNY | LRLNNNSLIG | TCPESLSKIE | GLTLVDISYN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NLSGSLPKVS | ARTFKVIGNA | LICGPKAVSN | CSAVPEPLTL | PQDGPDESGT | RTNGHHVALA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FAASFSAAFF | VFFTSGMFLW | WRYRRNKQIF | FDVNEQYDPE | VSLGHLKRYT | FKELRSATNH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FNSKNILGRG | GYGIVYKGHL | NDGTLVAVKR | LKDCNIAGGE | VQFQTEVETI | SLALHRNLLR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LRGFCSSNQE | RILVYPYMPN | GSVASRLKDN | IRGEPALDWS | RRKKIAVGTA | RGLVYLHEQC |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DPKIIHRDVK | AANILLDEDF | EAVVGDFGLA | KLLDHRDSHV | TTAVRGTVGH | IAPEYLSTGQ |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SSEKTDVFGF | GILLLELITG | QKALDFGRSA | HQKGVMLDWV | KKLHQEGKLK | QLIDKDLNDK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| FDRVELEEIV | QVALLCTQFN | PSHRPKMSEV | MKMLEGDGLA | ERWEATQNGT | GEHQPPPLPP |
| 610 | 620 | 630 | |||
| GMVSSSPRVR | YYSDYIQESS | LVVEAIELSG | PR |