C0LGG3

PR
Gene name
At1g51820 (F19C24.23, T14L22.3)
Protein name
Probable LRR receptor-like serine/threonine-protein kinase At1g51820
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G51820
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

14-90 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

720-727 (Activation loop from InterPro)

Target domain

578-851 (Protein kinase domain)

Relief mechanism

Assay

738-745 (Activation loop from InterPro)

Target domain

578-851 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for C0LGG3

Entry ID Method Resolution Chain Position Source
AF-C0LGG3-F1 Predicted AlphaFoldDB

206 variants for C0LGG3

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH04936882 21 Q>* No 1000Genomes
ENSVATH04936877 44 Q>E No 1000Genomes
tmp_1_19241652_T_A 44 Q>H No 1000Genomes
ENSVATH04936876 50 T>I No 1000Genomes
ENSVATH04936876 50 T>K No 1000Genomes
ENSVATH14291028 50 T>P No 1000Genomes
tmp_1_19241624_C_T 54 D>N No 1000Genomes
ENSVATH00093286 55 L>F No 1000Genomes
ENSVATH04936874 62 G>S No 1000Genomes
tmp_1_19241591_C_T 65 A>T No 1000Genomes
ENSVATH04936873 66 K>I No 1000Genomes
tmp_1_19241515_T_A 90 Y>F No 1000Genomes
tmp_1_19241505_A_T 93 N>K No 1000Genomes
ENSVATH04936870 94 V>F No 1000Genomes
ENSVATH04936870 94 V>I No 1000Genomes
ENSVATH01347525 96 S>R No 1000Genomes
tmp_1_19241495_C_T 97 D>N No 1000Genomes
ENSVATH01347524 101 L>* No 1000Genomes
tmp_1_19241470_G_A 105 T>I No 1000Genomes
ENSVATH01347521 108 Y>N No 1000Genomes
tmp_1_19241459_C_T 109 G>R No 1000Genomes
ENSVATH04936867 114 L>F No 1000Genomes
ENSVATH01347520 116 V>I No 1000Genomes
tmp_1_19241411_C_A 125 G>C No 1000Genomes
tmp_1_19241371_A_T 138 I>K No 1000Genomes
ENSVATH01347516 143 L>H No 1000Genomes
ENSVATH01347517 143 L>I No 1000Genomes
ENSVATH01347515 146 R>K No 1000Genomes
ENSVATH04936865 148 N>I No 1000Genomes
tmp_1_19241317_T_A 156 K>M No 1000Genomes
tmp_1_19241314_G_A 157 T>M No 1000Genomes
tmp_1_19241312_C_A 158 G>* No 1000Genomes
tmp_1_19241293_A_T 164 I>K No 1000Genomes
ENSVATH04936864 173 K>M No 1000Genomes
ENSVATH13511500 185 K>T No 1000Genomes
tmp_1_19241227_T_C 186 Y>C No 1000Genomes
tmp_1_19241224_A_G 187 L>S No 1000Genomes
ENSVATH04936863 190 G>V No 1000Genomes
ENSVATH04936862 195 S>L No 1000Genomes
ENSVATH13511499 197 T>S No 1000Genomes
tmp_1_19241188_A_T 199 I>K No 1000Genomes
ENSVATH01347469 208 R>H No 1000Genomes
tmp_1_19240342_C_G 210 W>C No 1000Genomes
ENSVATH04936831 215 D>H No 1000Genomes
ENSVATH01347468
ENSVATH07644602
 218 W>* No 1000Genomes
ENSVATH01347468 218 W>L No 1000Genomes
ENSVATH01347467 225 L>F No 1000Genomes
ENSVATH01347467 225 L>I No 1000Genomes
ENSVATH13511414 226 K>* No 1000Genomes
tmp_1_19240281_T_G 231 I>L No 1000Genomes
ENSVATH01347465 242 K>R No 1000Genomes
ENSVATH04936830 245 T>R No 1000Genomes
ENSVATH04936829 246 P>R No 1000Genomes
ENSVATH01347464 256 T>I No 1000Genomes
ENSVATH04936828 265 Q>* No 1000Genomes
tmp_1_19240172_T_C 267 Y>C No 1000Genomes
ENSVATH13511413 271 H>D No 1000Genomes
tmp_1_19240146_GA_CA,G 276 Q>E No 1000Genomes
ENSVATH01347461 277 A>V No 1000Genomes
ENSVATH07644601 278 L>I No 1000Genomes
tmp_1_19240139_A_C 278 L>R No 1000Genomes
ENSVATH07644601 278 L>V No 1000Genomes
tmp_1_19240133_G_A 280 A>V No 1000Genomes
ENSVATH04936827 293 E>A No 1000Genomes
ENSVATH04936826 298 P>T No 1000Genomes
ENSVATH14290949 303 P>A No 1000Genomes
tmp_1_19240013_C_T 320 G>E No 1000Genomes
tmp_1_19239990_T_A 328 K>* No 1000Genomes
ENSVATH01347455 333 T>R No 1000Genomes
tmp_1_19239966_G_A 336 P>S No 1000Genomes
ENSVATH01347451 337 L>* No 1000Genomes
tmp_1_19239960_G_C 338 L>V No 1000Genomes
tmp_1_19239941_A_G 344 F>S No 1000Genomes
ENSVATH13511410 345 T>N No 1000Genomes
ENSVATH01347445 356 E>G No 1000Genomes
ENSVATH01347444 357 N>D No 1000Genomes
ENSVATH01347444 357 N>Y No 1000Genomes
tmp_1_19239898_A_T 358 D>E No 1000Genomes
ENSVATH13511409 360 A>T No 1000Genomes
ENSVATH01347434 367 G>D No 1000Genomes
ENSVATH01347432 371 L>F No 1000Genomes
ENSVATH01347433 371 L>M No 1000Genomes
tmp_1_19239748_A_T 381 C>S No 1000Genomes
tmp_1_19239739_TG_AG,T 384 K>* No 1000Genomes
ENSVATH13511408 385 Q>L No 1000Genomes
ENSVATH13511407 386 L>F No 1000Genomes
ENSVATH00093281 394 K>N No 1000Genomes
tmp_1_19239582_A_C 409 L>* No 1000Genomes
ENSVATH04936817 419 T>M No 1000Genomes
ENSVATH14290946 433 L>F No 1000Genomes
tmp_1_19239366_C_T 440 G>E No 1000Genomes
tmp_1_19239367_C_T 440 G>R No 1000Genomes
tmp_1_19239364_C_T 441 E>K No 1000Genomes
ENSVATH01347409 448 D>E No 1000Genomes
ENSVATH14290945 448 D>N No 1000Genomes
ENSVATH13511355 464 G>D No 1000Genomes
tmp_1_19239171_T_A 474 K>N No 1000Genomes
ENSVATH04936813 475 G>R No 1000Genomes
ENSVATH01347398 476 M>I No 1000Genomes
ENSVATH13511354 479 N>T No 1000Genomes
ENSVATH01347394 480 V>L No 1000Genomes
ENSVATH04936810 481 E>K No 1000Genomes
ENSVATH04936809 482 G>R No 1000Genomes
ENSVATH01347392 487 L>V No 1000Genomes
tmp_1_19239045_T_C 490 T>A No 1000Genomes
tmp_1_19239041_C_T 491 G>D No 1000Genomes
ENSVATH00093280 492 S>Y No 1000Genomes
ENSVATH01347391 495 K>N No 1000Genomes
ENSVATH01347390 497 K>R No 1000Genomes
tmp_1_19239014_C_T 500 G>E No 1000Genomes
ENSVATH13511344 513 S>L No 1000Genomes
ENSVATH13511343 518 A>V No 1000Genomes
ENSVATH01347388 521 I>V No 1000Genomes
tmp_1_19238942_A_G 524 L>S No 1000Genomes
ENSVATH13511342 527 F>L No 1000Genomes
ENSVATH01347387 527 F>S No 1000Genomes
ENSVATH01347384 534 R>K No 1000Genomes
ENSVATH13511341 535 S>P No 1000Genomes
tmp_1_19238906_G_A 536 P>L No 1000Genomes
ENSVATH04936803 552 R>S No 1000Genomes
ENSVATH13511335 557 S>F No 1000Genomes
ENSVATH04936802 564 K>I No 1000Genomes
tmp_1_19238716_T_A 565 N>Y No 1000Genomes
ENSVATH13511322 574 V>A No 1000Genomes
ENSVATH13511320 580 F>I No 1000Genomes
tmp_1_19238626_C_T 595 G>S No 1000Genomes
ENSVATH04936800 599 G>S No 1000Genomes
tmp_1_19238591_C_G 606 K>N No 1000Genomes
ENSVATH01347379 610 H>D No 1000Genomes
ENSVATH01347377 618 Q>E No 1000Genomes
ENSVATH04936799 618 Q>L No 1000Genomes
ENSVATH01347363 624 E>D No 1000Genomes
ENSVATH01347362 625 L>I No 1000Genomes
tmp_1_19238436_G_C 627 L>V No 1000Genomes
tmp_1_19238426_T_G 630 H>P No 1000Genomes
ENSVATH04936796 631 H>D No 1000Genomes
ENSVATH14290916 636 G>R No 1000Genomes
ENSVATH01347357 641 C>* No 1000Genomes
tmp_1_19238393_C_A 641 C>F No 1000Genomes
tmp_1_19238391_C_T 642 D>N No 1000Genomes
ENSVATH01347355 643 E>G No 1000Genomes
ENSVATH01347356 643 E>Q No 1000Genomes
ENSVATH13511316 644 G>E No 1000Genomes
ENSVATH01347354 645 D>E No 1000Genomes
tmp_1_19238382_C_T 645 D>N No 1000Genomes
ENSVATH13511315 647 L>M No 1000Genomes
ENSVATH01347353 649 L>F No 1000Genomes
ENSVATH01347352 663 M>L No 1000Genomes
tmp_1_19238324_G_A 664 S>L No 1000Genomes
ENSVATH01347345 668 N>K No 1000Genomes
tmp_1_19238222_C_A 669 R>L No 1000Genomes
tmp_1_19238211_T_G 673 N>H No 1000Genomes
ENSVATH04936790 685 A>G No 1000Genomes
ENSVATH04936789 686 Q>K No 1000Genomes
ENSVATH04936787 695 C>Y No 1000Genomes
ENSVATH04936784 709 I>L No 1000Genomes
ENSVATH14290893 711 L>F No 1000Genomes
ENSVATH14290892 717 A>T No 1000Genomes
ENSVATH04936783 724 L>F No 1000Genomes
tmp_1_19237974_C_T 726 R>K No 1000Genomes
ENSVATH01347324 729 L>P No 1000Genomes
tmp_1_19237963_T_C 730 I>V No 1000Genomes
ENSVATH04936782 735 H>Y No 1000Genomes
ENSVATH04936781 736 V>G No 1000Genomes
tmp_1_19237935_A_G 739 V>A No 1000Genomes
tmp_1_19237933_C_T 740 V>I No 1000Genomes
ENSVATH01347319 742 G>E No 1000Genomes
ENSVATH13511272 745 G>R No 1000Genomes
ENSVATH04936779 747 L>I No 1000Genomes
ENSVATH04936778 750 E>G No 1000Genomes
ENSVATH01347313 752 H>Y No 1000Genomes
tmp_1_19237807_C_T 753 R>K No 1000Genomes
ENSVATH04936777 765 S>N No 1000Genomes
ENSVATH01347308 769 L>V No 1000Genomes
ENSVATH01347306 773 I>L No 1000Genomes
ENSVATH01347305 775 T>I No 1000Genomes
tmp_1_19237736_G_C 777 R>G No 1000Genomes
ENSVATH01347303 778 H>L No 1000Genomes
ENSVATH01347301 784 R>H No 1000Genomes
ENSVATH01347299 790 G>A No 1000Genomes
ENSVATH04936776 791 E>K No 1000Genomes
ENSVATH01347297 795 V>E No 1000Genomes
ENSVATH01347298 795 V>L No 1000Genomes
ENSVATH01347295 803 Q>H No 1000Genomes
ENSVATH01347296 803 Q>K No 1000Genomes
tmp_1_19237639_C_T 809 S>N No 1000Genomes
ENSVATH07644577 810 L>F No 1000Genomes
ENSVATH07644576 813 D>N No 1000Genomes
ENSVATH07644575 817 G>C No 1000Genomes
tmp_1_19237606_C_T 820 W>* No 1000Genomes
tmp_1_19237588_G_A 826 A>V No 1000Genomes
ENSVATH14290890 828 S>N No 1000Genomes
ENSVATH01347290 832 H>P No 1000Genomes
tmp_1_19237545_C_G 840 M>I No 1000Genomes
ENSVATH04936770 850 C>* No 1000Genomes
tmp_1_19237505_C_T 854 E>K No 1000Genomes
tmp_1_19237498_G_A 856 A>V No 1000Genomes
ENSVATH04936769 864 M>I No 1000Genomes
tmp_1_19237464_C_A 867 K>N No 1000Genomes
tmp_1_19237462_C_T 868 S>N No 1000Genomes
ENSVATH07644564 877 G>D No 1000Genomes
tmp_1_19237436_C_T 877 G>S No 1000Genomes
ENSVATH00093279 882 P>R No 1000Genomes
tmp_1_19237416_G_C 883 N>K No 1000Genomes
tmp_1_19237417_T_G 883 N>T No 1000Genomes
ENSVATH04936765 885 R>Q No 1000Genomes

No associated diseases with C0LGG3

5 regional properties for C0LGG3

Type Name Position InterPro Accession
domain Protein kinase domain 578 - 851 IPR000719
repeat Leucine-rich repeat 405 - 462 IPR001611
active_site Serine/threonine-protein kinase, active site 699 - 711 IPR008271
binding_site Protein kinase, ATP binding site 584 - 606 IPR017441
domain Malectin-like domain 29 - 346 IPR024788

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

1 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.

28 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P20594 NPR2 Atrial natriuretic peptide receptor 2 Homo sapiens (Human) PR
Q03145 Epha2 Ephrin type-A receptor 2 Mus musculus (Mouse) PR
Q60750 Epha1 Ephrin type-A receptor 1 Mus musculus (Mouse) SS
Q924U5 Tesk2 Dual specificity testis-specific protein kinase 2 Rattus norvegicus (Rat) PR
P43293 PBL11 Probable serine/threonine-protein kinase PBL11 Arabidopsis thaliana (Mouse-ear cress) PR
Q3E8W4 ANX2 Receptor-like protein kinase ANXUR2 Arabidopsis thaliana (Mouse-ear cress) PR
Q8LPS5 SERK5 Somatic embryogenesis receptor kinase 5 Arabidopsis thaliana (Mouse-ear cress) PR
C0LGW2 PAM74 Probable LRR receptor-like serine/threonine-protein kinase PAM74 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FN93 At5g59680 Probable LRR receptor-like serine/threonine-protein kinase At5g59680 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FN94 At5g59670 Receptor-like protein kinase At5g59670 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LIG2 At3g21340 Receptor-like protein kinase At3g21340 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SNA3 At3g46340 Putative receptor-like protein kinase At3g46340 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZQR3 At2g14510 Leucine-rich repeat receptor-like serine/threonine-protein kinase At2g14510 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LPZ9 SD113 G-type lectin S-receptor-like serine/threonine-protein kinase SD1-13 Arabidopsis thaliana (Mouse-ear cress) SS
P43298 TMK1 Receptor protein kinase TMK1 Arabidopsis thaliana (Mouse-ear cress) PR
C0LGI2 At1g67720 Probable LRR receptor-like serine/threonine-protein kinase At1g67720 Arabidopsis thaliana (Mouse-ear cress) PR
Q8RWW0 ALE2 Receptor-like serine/threonine-protein kinase ALE2 Arabidopsis thaliana (Mouse-ear cress) PR
P93050 BSH Probable LRR receptor-like serine/threonine-protein kinase RKF3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LRP3 At3g17420 Probable receptor-like protein kinase At3g17420 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M2S4 LECRKS4 L-type lectin-domain containing receptor kinase S.4 Arabidopsis thaliana (Mouse-ear cress) PR
Q8RWZ5 SD25 G-type lectin S-receptor-like serine/threonine-protein kinase SD2-5 Arabidopsis thaliana (Mouse-ear cress) PR
O64556 At2g19230 Putative leucine-rich repeat receptor-like serine/threonine-protein kinase At2g19230 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SXB4 At1g11300 G-type lectin S-receptor-like serine/threonine-protein kinase At1g11300 Arabidopsis thaliana (Mouse-ear cress) PR
Q84JQ4 PRK2 Pollen receptor-like kinase 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q93ZS4 NIK3 Protein NSP-INTERACTING KINASE 3 Arabidopsis thaliana (Mouse-ear cress) PR
Q94AG2 SERK1 Somatic embryogenesis receptor kinase 1 Arabidopsis thaliana (Mouse-ear cress) PR
O64477 At2g19130 G-type lectin S-receptor-like serine/threonine-protein kinase At2g19130 Arabidopsis thaliana (Mouse-ear cress) SS
Q9XIC7 SERK2 Somatic embryogenesis receptor kinase 2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MERHFVFIAT YLLIFHLVQA QNQTGFISVD CGLSLLESPY DAPQTGLTYT SDADLVASGK
70 80 90 100 110 120
TGRLAKEFEP LVDKPTLTLR YFPEGVRNCY NLNVTSDTNY LIKATFVYGN YDGLNVGPNF
130 140 150 160 170 180
NLYLGPNLWT TVSSNDTIEE IILVTRSNSL QVCLVKTGIS IPFINMLELR PMKKNMYVTQ
190 200 210 220 230 240
SGSLKYLFRG YISNSSTRIR FPDDVYDRKW YPLFDDSWTQ VTTNLKVNTS ITYELPQSVM
250 260 270 280 290 300
AKAATPIKAN DTLNITWTVE PPTTQFYSYV HIAEIQALRA NETREFNVTL NGEYTFGPFS
310 320 330 340 350 360
PIPLKTASIV DLSPGQCDGG RCILQVVKTL KSTLPPLLNA IEAFTVIDFP QMETNENDVA
370 380 390 400 410 420
GIKNVQGTYG LSRISWQGDP CVPKQLLWDG LNCKNSDIST PPIITSLDLS SSGLTGIITQ
430 440 450 460 470 480
AIKNLTHLQI LDLSDNNLTG EVPEFLADIK SLLVINLSGN NLSGSVPPSL LQKKGMKLNV
490 500 510 520 530 540
EGNPHILCTT GSCVKKKEDG HKKKSVIVPV VASIASIAVL IGALVLFLIL RKKRSPKVEG
550 560 570 580 590 600
PPPSYMQASD GRLPRSSEPA IVTKNRRFSY SQVVIMTNNF QRILGKGGFG MVYHGFVNGT
610 620 630 640 650 660
EQVAVKILSH SSSQGYKQFK AEVELLLRVH HKNLVGLVGY CDEGDNLALI YEYMANGDLK
670 680 690 700 710 720
EHMSGTRNRF ILNWGTRLKI VIESAQGLEY LHNGCKPPMV HRDVKTTNIL LNEHFEAKLA
730 740 750 760 770 780
DFGLSRSFLI EGETHVSTVV AGTPGYLDPE YHRTNWLTEK SDVYSFGILL LEIITNRHVI
790 800 810 820 830 840
DQSREKPHIG EWVGVMLTKG DIQSIMDPSL NEDYDSGSVW KAVELAMSCL NHSSARRPTM
850 860 870 880
SQVVIELNEC LASENARGGA SRDMESKSSI EVSLTFGTEV SPNAR