Q8CDZ2

PR
Gene name
Mettl21e
Protein name
Protein-lysine methyltransferase METTL21E
Names
Methyltransferase-like protein 21E
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:403183
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-57 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8CDZ2

Entry ID Method Resolution Chain Position Source
AF-Q8CDZ2-F1 Predicted AlphaFoldDB

7 variants for Q8CDZ2

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388466971 42 T>I No EVA
rs3389908059 64 Y>H No EVA
rs3389895503 65 G>D No EVA
rs213720934 152 A>S No EVA
rs3389907337 201 R>I No EVA
rs33503707 225 S>R No EVA
rs3388467078 227 P>H No EVA

No associated diseases with Q8CDZ2

No regional properties for Q8CDZ2

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q8CDZ2

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

1 GO annotations of molecular function

Name Definition
protein-lysine N-methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate.

2 GO annotations of biological process

Name Definition
peptidyl-lysine methylation The methylation of peptidyl-lysine to form either the mono-, di- or trimethylated derivative.
peptidyl-lysine trimethylation The methylation of peptidyl-lysine to form peptidyl-N6,N6,N6-trimethyl-L-lysine.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q12367 RKM5 Ribosomal lysine N-methyltransferase 5 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
A6QP81 METTL21C Protein-lysine methyltransferase METTL21C Bos taurus (Bovine) PR
Q58DC7 METTL21E Protein-lysine methyltransferase METTL21E Bos taurus (Bovine) PR
Q5VZV1 METTL21C Protein-lysine methyltransferase METTL21C Homo sapiens (Human) PR
A6NDL7 METTL21EP Putative methyltransferase-like protein 21E pseudogene Homo sapiens (Human) PR
Q8BLU2 Mettl21c Protein-lysine methyltransferase METTL21C Mus musculus (Mouse) PR
A7IQW5 C42C1.13 Protein-lysine methyltransferase C42C1.13 Caenorhabditis elegans PR
10 20 30 40 50 60
MDLTVTHITH KETYKEPRDD DDDKQVVAEI MARSFIPTLI TTIPWEGFHF AGHEIQITEG
70 80 90 100 110 120
KDCYGAFVWP SALVLCYFLE THAKQYNMVD KNVIEIGAGT GLVSIVASLL GARVIATDLP
130 140 150 160 170 180
ELLGNLQYNI SRNTKMKCKH LPQVKELSWG VALDRNFPRS SNNFDYILAA DVVYAHPFLE
190 200 210 220 230 240
ELLMTFDHLC KETTIILWAM RFRLEKENKF VDKFKELFDL EEISSFPSLN IKLYKAMKKN
RRSA