A6QP81
Gene name |
METTL21C |
Protein name |
Protein-lysine methyltransferase METTL21C |
Names |
Methyltransferase-like protein 21C |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:519447 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A6QP81
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A6QP81-F1 | Predicted | AlphaFoldDB |
47 variants for A6QP81
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs473207132 | 2 | D>A | No | EVA | |
| rs473207132 | 2 | D>G | No | EVA | |
| rs438585078 | 2 | D>Y | No | EVA | |
| rs440579331 | 3 | A>G | No | EVA | |
| rs475010606 | 4 | C>W | No | EVA | |
| rs454869743 | 5 | L>P | No | EVA | |
| rs476070889 | 6 | S>R | No | EVA | |
| rs452698100 | 6 | S>T | No | EVA | |
| rs467048967 | 7 | S>A | No | EVA | |
| rs467048967 | 7 | S>P | No | EVA | |
| rs467048967 | 7 | S>T | No | EVA | |
| rs519344244 | 8 | E>K | No | EVA | |
| rs446491339 | 9 | Q>P | No | EVA | |
| rs436120471 | 10 | Q>H | No | EVA | |
| rs467370537 | 11 | P>R | No | EVA | |
| rs481886963 | 12 | R>P | No | EVA | |
| rs445160614 | 14 | L>Q | No | EVA | |
| rs445160614 | 14 | L>R | No | EVA | |
| rs516983120 | 15 | D>E | No | EVA | |
| rs479595820 | 15 | D>G | No | EVA | |
| rs459573256 | 16 | E>* | No | EVA | |
| rs440465671 | 16 | E>G | No | EVA | |
| rs475078586 | 17 | G>V | No | EVA | |
| rs461467800 | 18 | P>L | No | EVA | |
| rs461467800 | 18 | P>R | No | EVA | |
| rs444348313 | 19 | S>G | No | EVA | |
| rs475853796 | 19 | S>I | No | EVA | |
| rs444348313 | 19 | S>R | No | EVA | |
| rs475853796 | 19 | S>T | No | EVA | |
| rs722127772 | 21 | P>L | No | EVA | |
| rs453413027 | 31 | T>S | No | EVA | |
| rs436612641 | 32 | S>R | No | EVA | |
| rs467409818 | 33 | K>* | No | EVA | |
| rs450576296 | 33 | K>R | No | EVA | |
| rs436734802 | 35 | P>R | No | EVA | |
| rs445136237 | 37 | D>Y | No | EVA | |
| rs718350479 | 86 | P>L | No | EVA | |
| rs475465421 | 113 | G>W | No | EVA | |
| rs467323975 | 128 | A>T | No | EVA | |
| rs456891941 | 143 | Q>E | No | EVA | |
| rs436807524 | 143 | Q>L | No | EVA | |
| rs445199262 | 150 | T>A | No | EVA | |
| rs474543556 | 177 | T>K | No | EVA | |
| rs479656810 | 186 | S>P | No | EVA | |
| rs797434892 | 194 | F>L | No | EVA | |
| rs457451602 | 214 | W>R | No | EVA | |
| rs437204658 | 246 | S>L | No | EVA |
No associated diseases with A6QP81
No regional properties for A6QP81
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for A6QP81 | |||
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| heat shock protein binding | Binding to a heat shock protein, a protein synthesized or activated in response to heat shock. |
| protein-lysine N-methyltransferase activity | Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| peptidyl-lysine methylation | The methylation of peptidyl-lysine to form either the mono-, di- or trimethylated derivative. |
| peptidyl-lysine trimethylation | The methylation of peptidyl-lysine to form peptidyl-N6,N6,N6-trimethyl-L-lysine. |
| protein methylation | The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q12367 | RKM5 | Ribosomal lysine N-methyltransferase 5 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q58DC7 | METTL21E | Protein-lysine methyltransferase METTL21E | Bos taurus (Bovine) | PR |
| Q2KIJ2 | METTL18 | Histidine protein methyltransferase 1 homolog | Bos taurus (Bovine) | PR |
| Q5VZV1 | METTL21C | Protein-lysine methyltransferase METTL21C | Homo sapiens (Human) | PR |
| Q8BLU2 | Mettl21c | Protein-lysine methyltransferase METTL21C | Mus musculus (Mouse) | PR |
| Q8CDZ2 | Mettl21e | Protein-lysine methyltransferase METTL21E | Mus musculus (Mouse) | PR |
| A7IQW5 | C42C1.13 | Protein-lysine methyltransferase C42C1.13 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDACLSSEQQ | PRPLDEGPSP | PDNEALHTDG | TSKRPGDSNE | IEASLRSLQK | FVPTNYASYT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QEYYRFVGKK | IVIQESIESY | GAVVWPGAMA | LCQYLEEHTE | ELNLRGAKIL | EIGAGPGLVS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IVASILGAQV | TATDLPDVLG | NLQYNLLKNT | LNCTTYLPEV | KELVWGEGLE | QSFPKSTLYY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DYVLASDVVY | HHYFLDKLLA | TMVYLCQPGT | VLLWANKFRF | STDYEFLDKF | KQVFDTTLLA |
| 250 | |||||
| ESQESSIKLF | KGILKWD |