Q12367
Gene name |
RKM5 |
Protein name |
Ribosomal lysine N-methyltransferase 5 |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YLR137W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q12367
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q12367-F1 | Predicted | AlphaFoldDB |
11 variants for Q12367
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s12-417290 | 95 | R>H | No | SGRP | |
| s12-417299 | 98 | R>K | No | SGRP | |
| s12-417374 | 123 | S>N | No | SGRP | |
| s12-417446 | 147 | K>M | No | SGRP | |
| s12-417466 | 154 | V>I | No | SGRP | |
| s12-417490 | 162 | G>S | No | SGRP | |
| s12-417709 | 235 | D>N | No | SGRP | |
| s12-417834 | 276 | I>M | No | SGRP | |
| s12-417910 | 302 | K>E | No | SGRP | |
| s12-417944 | 313 | T>N | No | SGRP | |
| s12-417973 | 323 | V>M | No | SGRP |
No associated diseases with Q12367
No regional properties for Q12367
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q12367 | |||
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| protein-lysine N-methyltransferase activity | Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate. |
| S-adenosylmethionine-dependent methyltransferase activity | Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| peptidyl-lysine methylation | The methylation of peptidyl-lysine to form either the mono-, di- or trimethylated derivative. |
| protein methylation | The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q58DC7 | METTL21E | Protein-lysine methyltransferase METTL21E | Bos taurus (Bovine) | PR |
| A6QP81 | METTL21C | Protein-lysine methyltransferase METTL21C | Bos taurus (Bovine) | PR |
| Q5VZV1 | METTL21C | Protein-lysine methyltransferase METTL21C | Homo sapiens (Human) | PR |
| A6NDL7 | METTL21EP | Putative methyltransferase-like protein 21E pseudogene | Homo sapiens (Human) | PR |
| Q8CDZ2 | Mettl21e | Protein-lysine methyltransferase METTL21E | Mus musculus (Mouse) | PR |
| Q8BLU2 | Mettl21c | Protein-lysine methyltransferase METTL21C | Mus musculus (Mouse) | PR |
| A7IQW5 | C42C1.13 | Protein-lysine methyltransferase C42C1.13 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAFKLWLLDE | ETIYEHVFER | YTQLEGQSGK | LAQDLGIQDR | RGGVLEITFE | PSGLEGGRKK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KRVRRRNKAS | SVEEDQNVAV | DSYHVSVGQS | ISSLRSSRDN | GNSTTGYVLW | STTPFFINWL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LYSTSAAPFR | LGSQVEVTCG | SSCEGHKLEL | PRLVDLTGAD | RGKRGILELG | AGISGILPVI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LGNFVDTYVS | TDQKGILNKL | KDNIMENLSQ | LTRKRCISRS | LRLELPTVEP | VGDADITAAS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LPSKSTLHLE | VAALDWEKIN | LQDKKTHSLH | PELSLIGETC | SSVYVIAMDV | IYNEYLIDPF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LKTLKQLKHW | LQTTYNLQFH | VLVGIHLRSQ | EVTTLFLEKA | IIEYDFTVYD | IVDQVIQESR |
| FNFYLIT |