A6NDL7

PR
Gene name
METTL21EP (METTL21CP1)
Protein name
Putative methyltransferase-like protein 21E pseudogene
Names
Species
Homo sapiens (Human)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

8-80 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A6NDL7

Entry ID Method Resolution Chain Position Source
AF-A6NDL7-F1 Predicted AlphaFoldDB

No variants for A6NDL7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A6NDL7

No associated diseases with A6NDL7

No regional properties for A6NDL7

Type Name Position InterPro Accession
No domain, repeats, and functional sites for A6NDL7

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

1 GO annotations of molecular function

Name Definition
protein-lysine N-methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate.

2 GO annotations of biological process

Name Definition
peptidyl-lysine methylation The methylation of peptidyl-lysine to form either the mono-, di- or trimethylated derivative.
peptidyl-lysine trimethylation The methylation of peptidyl-lysine to form peptidyl-N6,N6,N6-trimethyl-L-lysine.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q12367 RKM5 Ribosomal lysine N-methyltransferase 5 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q58DC7 METTL21E Protein-lysine methyltransferase METTL21E Bos taurus (Bovine) PR
Q96G04 EEF2KMT Protein-lysine N-methyltransferase EEF2KMT Homo sapiens (Human) PR
Q5VZV1 METTL21C Protein-lysine methyltransferase METTL21C Homo sapiens (Human) PR
O95568 METTL18 Histidine protein methyltransferase 1 homolog Homo sapiens (Human) PR
Q8CDZ2 Mettl21e Protein-lysine methyltransferase METTL21E Mus musculus (Mouse) PR
A7IQW5 C42C1.13 Protein-lysine methyltransferase C42C1.13 Caenorhabditis elegans PR
10 20 30 40 50 60
MIHFNLLETQ LTPLASFQEI MKKTSIYHLP SFHYLMDSEA QEDTREAYDD KQVVTEIMAR
70 80 90 100 110 120
CFIPTLITTT SWESFHFIGH EIRITEAMDC YGAVVWPSAL VLCYFLETNA KQYNMVDKNV
130 140 150 160 170 180
IEIGAGTGLV SIVASLLGAH VTATDLPELL GNLQYNISRN TKMKSKHLPQ VKELSWGVAL
190 200 210 220 230 240
DTNFPRSSNN FDYILAADVV YAHPFLEELL ITFDHLCKET TIILWAMKFR LEKENKFVDR
250 260 270
FKELFDLEEI SSFPSLNIKL YKAVKKNRRS V