A7IQW5

PR
Gene name
C42C1.13
Protein name
Protein-lysine methyltransferase C42C1.13
Names
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_C42C1.13
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-47 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A7IQW5

Entry ID Method Resolution Chain Position Source
AF-A7IQW5-F1 Predicted AlphaFoldDB

No variants for A7IQW5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A7IQW5

No associated diseases with A7IQW5

2 regional properties for A7IQW5

Type Name Position InterPro Accession
domain Spo11/DNA topoisomerase VI, subunit A, N-terminal 88 - 141 IPR013049
domain Topoisomerase 6 subunit A/Spo11, TOPRIM domain 198 - 353 IPR034136

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

1 GO annotations of molecular function

Name Definition
protein-lysine N-methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate.

2 GO annotations of biological process

Name Definition
peptidyl-lysine methylation The methylation of peptidyl-lysine to form either the mono-, di- or trimethylated derivative.
peptidyl-lysine trimethylation The methylation of peptidyl-lysine to form peptidyl-N6,N6,N6-trimethyl-L-lysine.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q12367 RKM5 Ribosomal lysine N-methyltransferase 5 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
A6QP81 METTL21C Protein-lysine methyltransferase METTL21C Bos taurus (Bovine) PR
Q58DC7 METTL21E Protein-lysine methyltransferase METTL21E Bos taurus (Bovine) PR
Q5VZV1 METTL21C Protein-lysine methyltransferase METTL21C Homo sapiens (Human) PR
A6NDL7 METTL21EP Putative methyltransferase-like protein 21E pseudogene Homo sapiens (Human) PR
Q8BLU2 Mettl21c Protein-lysine methyltransferase METTL21C Mus musculus (Mouse) PR
Q8CDZ2 Mettl21e Protein-lysine methyltransferase METTL21E Mus musculus (Mouse) PR
10 20 30 40 50 60
MAESEEYARV ISFNNDHDEL IIYQETVTDV GGVIWDSALM TIHYFFKYPK PFEGKKVLEL
70 80 90 100 110 120
GSGTGVGGIA LAALGADVII TDLPERLALI EKNVEANRKL TGNRIKVQVL DWTKDRIPEG
130 140 150 160 170 180
LDMVLAIDCV YYNSTIDPLI TLLNDCDAKE IMVVSEERDI GEAHLAQKSF FKDIQKFFRL
190 200
ELIPQKELDE DYCADDIIIG KLIRNV