Q2KIJ2
Gene name |
METTL18 |
Protein name |
Histidine protein methyltransferase 1 homolog |
Names |
Methyltransferase-like protein 18 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:783955 |
EC number |
2.1.1.85: Methyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q2KIJ2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q2KIJ2-F1 | Predicted | AlphaFoldDB |
No variants for Q2KIJ2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q2KIJ2 | |||||
No associated diseases with Q2KIJ2
No regional properties for Q2KIJ2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q2KIJ2 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.1.1.85 | Methyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| protein-L-histidine N-tele-methyltransferase activity | Catalysis of the reaction: L-histidyl- + S-adenosyl-L-methionine = N(tele)-methyl-L-histidyl- |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| peptidyl-histidine methylation, to form tele-methylhistidine | The methylation of peptidyl-L-histidine to form peptidyl-L-1'-methyl-L-histidine (otherwise known as tau-methylhistidine, tele-methylhistidine). |
| peptidyl-lysine monomethylation | The methylation of peptidyl-lysine to form peptidyl-N6-methyl-L-lysine. |
| regulation of ribosome biogenesis | Any process that modulates the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits. |
| regulation of rRNA processing | Any process that modulates the frequency, rate or extent of rRNA processing. |
| regulation of translation | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q58DC7 | METTL21E | Protein-lysine methyltransferase METTL21E | Bos taurus (Bovine) | PR |
| A6QP81 | METTL21C | Protein-lysine methyltransferase METTL21C | Bos taurus (Bovine) | PR |
| O95568 | METTL18 | Histidine protein methyltransferase 1 homolog | Homo sapiens (Human) | PR |
| Q4KM84 | Mettl18 | Histidine protein methyltransferase 1 homolog | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTFQFNFTIE | DHLEDELTSL | GDGALALHSS | KESLVSERQK | GTHRDKKCST | EQSDLLQDHL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| WEHKSERNEA | PSQDPDSSFG | AANSSSNLEP | HEEKPCLKVA | KEHAVPKDLK | KVLENKVTET |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LPGLQHVNIS | IMKTTLLKEN | FPGENIISKS | FSSHSDLISG | VYEGGLKIWE | CTFDLLAYLT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KAKVKFAGKK | VLDLGCGSGL | LGIMALKGGA | KEIHFQDYNS | VVIDEVTLPN | VVANSTLEDE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ENDVNEPDVK | RLRRSTVAQE | LCKCRFFSGE | WSEFCKLVLS | SEKLFEKYDL | ILTSETIYNP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DYYVPLHQTF | LRLLDKNGQV | LLASKVHYFG | VGGGTHLFQK | FVEERNVFET | RTLEIIDEGL |
| 370 | |||||
| KRCLIEMTFK | YPT |