Q4KM84

PR
Gene name
Mettl18
Protein name
Histidine protein methyltransferase 1 homolog
Names
Methyltransferase-like protein 18
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:304928
EC number
2.1.1.85: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-113 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4KM84

Entry ID Method Resolution Chain Position Source
AF-Q4KM84-F1 Predicted AlphaFoldDB

No variants for Q4KM84

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4KM84

No associated diseases with Q4KM84

No regional properties for Q4KM84

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q4KM84

Functions

Description
EC Number 2.1.1.85 Methyltransferases
Subcellular Localization
  • Cytoplasm, cytosol
  • Nucleus
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

2 GO annotations of molecular function

Name Definition
heat shock protein binding Binding to a heat shock protein, a protein synthesized or activated in response to heat shock.
protein-L-histidine N-tele-methyltransferase activity Catalysis of the reaction: L-histidyl- + S-adenosyl-L-methionine = N(tele)-methyl-L-histidyl-

5 GO annotations of biological process

Name Definition
peptidyl-histidine methylation, to form tele-methylhistidine The methylation of peptidyl-L-histidine to form peptidyl-L-1'-methyl-L-histidine (otherwise known as tau-methylhistidine, tele-methylhistidine).
peptidyl-lysine monomethylation The methylation of peptidyl-lysine to form peptidyl-N6-methyl-L-lysine.
regulation of ribosome biogenesis Any process that modulates the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits.
regulation of rRNA processing Any process that modulates the frequency, rate or extent of rRNA processing.
regulation of translation Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2KIJ2 METTL18 Histidine protein methyltransferase 1 homolog Bos taurus (Bovine) PR
O95568 METTL18 Histidine protein methyltransferase 1 homolog Homo sapiens (Human) PR
10 20 30 40 50 60
MAFQFNFSIE EDLENKLTSL DDGTCVLKSQ KGKEDKNQST ELPGLPQDRL WKCSSLGSAA
70 80 90 100 110 120
SSEDTDSPPS TADRSGVPEA CEKQPSLKPA KEHVIPKDCD QVLENKVLEM LPGSQHVSTA
130 140 150 160 170 180
VVKTISLKEK FPGENIVSQS FSSHSDLIPG VYEGGLKIWE CTFDLMTYFT KAKVKFAGQK
190 200 210 220 230 240
VLDLGCGSGL LGITASKGGA REVHFQDYNG LVIDEVTLPN VVANVPLQGD SNGINEPAGK
250 260 270 280 290 300
RQRKSEVAQE TCKCRLFSGE WAEFCKLVLS EKLFVKYDLI LTSETIYNPD YYSTLHETLL
310 320 330 340 350 360
RLLSRNGRVL LASKAHYFGV GGGVHLFQKF VEEKGVFETR TLEVIDEGLK RFLMEMTFKC
PS