Q8C0E2
Gene name |
Vps26b |
Protein name |
Vacuolar protein sorting-associated protein 26B |
Names |
Vesicle protein sorting 26B |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:69091 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
5 structures for Q8C0E2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2R51 | X-ray | 210 A | A | 7-336 | PDB |
| 3LH8 | X-ray | 260 A | A/B | 7-336 | PDB |
| 3LH9 | X-ray | 240 A | A/B | 7-336 | PDB |
| 3LHA | X-ray | 280 A | A/B | 7-336 | PDB |
| AF-Q8C0E2-F1 | Predicted | AlphaFoldDB |
21 variants for Q8C0E2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389024934 | 17 | N>I | No | EVA | |
| rs3389029161 | 49 | K>T | No | EVA | |
| rs3388981426 | 73 | Q>H | No | EVA | |
| rs3399371783 | 90 | V>L | No | EVA | |
| rs3399910875 | 91 | K>E | No | EVA | |
| rs3399912041 | 91 | K>N | No | EVA | |
| rs3400028331 | 92 | D>N | No | EVA | |
| rs3389024875 | 123 | N>D | No | EVA | |
| rs3399992091 | 159 | N>K | No | EVA | |
| rs3389029165 | 173 | H>R | No | EVA | |
| rs3389031991 | 180 | K>* | No | EVA | |
| rs3389029146 | 235 | D>E | No | EVA | |
| rs3389029505 | 237 | A>T | No | EVA | |
| rs3389024917 | 247 | R>G | No | EVA | |
| rs3389005858 | 262 | I>V | No | EVA | |
| rs3389034384 | 264 | K>M | No | EVA | |
| rs3389024878 | 288 | Q>L | No | EVA | |
| rs3389024876 | 293 | W>* | No | EVA | |
| rs3389019317 | 294 | R>W | No | EVA | |
| rs3389019252 | 295 | K>* | No | EVA | |
| rs3389031950 | 321 | G>D | No | EVA |
No associated diseases with Q8C0E2
No regional properties for Q8C0E2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q8C0E2 | |||
Functions
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| early endosome | A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. |
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| late endosome | A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. |
| phagocytic vesicle | A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis. |
| retromer complex | A conserved hetero-pentameric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. The budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p. The mammalian complex shows slight variation in composition compared to yeast, and comprises SNX1 or SNX2, SNX5 or SNX6, VPS26A or VPS26B, VPS29, and VPS35. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to interferon-gamma | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far. |
| intracellular protein transport | The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. |
| retrograde transport, endosome to Golgi | The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q0VD53 | VPS26A | Vacuolar protein sorting-associated protein 26A | Bos taurus (Bovine) | PR |
| O75436 | VPS26A | Vacuolar protein sorting-associated protein 26A | Homo sapiens (Human) | PR |
| Q4G0F5 | VPS26B | Vacuolar protein sorting-associated protein 26B | Homo sapiens (Human) | PR |
| P40336 | Vps26a | Vacuolar protein sorting-associated protein 26A | Mus musculus (Mouse) | PR |
| Q6AY86 | Vps26a | Vacuolar protein sorting-associated protein 26A | Rattus norvegicus (Rat) | PR |
| O01258 | vps-26 | Vacuolar protein sorting-associated protein 26 | Caenorhabditis elegans | PR |
| Q28HT6 | vps26a | Vacuolar protein sorting-associated protein 26A | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q5BKM4 | vps26b | Vacuolar protein sorting-associated protein 26B | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q6TNP8 | vps26a | Vacuolar protein sorting-associated protein 26A | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q6DH23 | vps26bl | Vacuolar protein sorting-associated protein 26B-like | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSFFGFGQSV | EVEILLNDAE | SRKRAEHKTE | DGKKEKYFLF | YDGETVSGKV | SLSLKNPNKR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LEHQGIKIEF | IGQIELYYDR | GNHHEFVSLV | KDLARPGEIT | QSQAFDFEFT | HVEKPYESYT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GQNVKLRYFL | RATISRRLND | VVKEMDIVVH | TLSTYPELNS | SIKMEVGIED | CLHIEFEYNK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SKYHLKDVIV | GKIYFLLVRI | KIKHMEIDII | KRETTGTGPN | VYHENDTIAK | YEIMDGAPVR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GESIPIRLFL | AGYELTPTMR | DINKKFSVRY | YLNLVLIDEE | ERRYFKQQEV | VLWRKGDIVR |
| 310 | 320 | 330 | |||
| KSMSHQAAIA | SQRFEGTTSL | GEVRTPGQLS | DNNSRQ |