AiPD: Autoinhibited Protein Database

Q4G0F5

Gene name	VPS26B
Protein name	Vacuolar protein sorting-associated protein 26B
Names	Vesicle protein sorting 26B
Species	Homo sapiens (Human)
KEGG Pathway	hsa:112936
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

270-336 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

270-336 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q4G0F5

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q4G0F5-F1	Predicted				AlphaFoldDB

217 variants for Q4G0F5

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs758627881 CA6372179	3	F>L		No	ClinGen ExAC gnomAD
rs1037338422 CA231245456	5	G>R		No	ClinGen Ensembl
rs1224117576 CA383493537	8	Q>R		No	ClinGen gnomAD
CA6372180 rs150789700	10	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6372181 rs747138489	11	E>A		No	ClinGen ExAC TOPMed gnomAD
CA383493556 rs1347279439	11	E>Q		No	ClinGen gnomAD
CA383493565 rs1591874303	12	V>G		No	ClinGen Ensembl
rs1050830778 CA231245466	12	V>M		No	ClinGen TOPMed
CA383493928 rs1272604488	14	I>M		No	ClinGen TOPMed gnomAD
CA383493930 rs1166160486	15	L>V		No	ClinGen TOPMed
rs377029699 CA231245468	16	L>P		No	ClinGen Ensembl
TCGA novel	18	D>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1480395792 CA383493948	18	D>H		No	ClinGen TOPMed gnomAD
rs1480395792 CA383493949	18	D>Y		No	ClinGen TOPMed gnomAD
CA231245470 rs886849125 COSM1317354	19	A>G	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated TOPMed
rs1200836115 CA383493957	19	A>S		No	ClinGen gnomAD
TCGA novel	21	S>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs74462513 CA231245472	21	S>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA383493991 rs1166887322	24	R>Q		No	ClinGen TOPMed gnomAD
rs1036512274 CA231245475	24	R>W		No	ClinGen TOPMed gnomAD
rs899357583 CA231245478	25	A>T		No	ClinGen TOPMed gnomAD
CA383494006 rs748498512	26	E>D		No	ClinGen ExAC gnomAD
CA383494010 rs1364775676	27	H>P		No	ClinGen TOPMed gnomAD
rs1364775676 CA383494011	27	H>R		No	ClinGen TOPMed gnomAD
CA6372186 rs371039042	30	E>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA383494032 rs371039042	30	E>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs762627075 CA6372187	31	D>N		No	ClinGen ExAC TOPMed gnomAD
CA6372189 rs773684939	32	G>R		No	ClinGen ExAC TOPMed gnomAD
CA6372191 rs759127190	33	K>E		No	ClinGen ExAC gnomAD
TCGA novel CA383494066 rs1290009980	33	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen TOPMed gnomAD NCI-TCGA
CA383494064 rs1290009980	33	K>T		No	ClinGen TOPMed gnomAD
CA6372192 rs373569374	34	K>E		No	ClinGen ESP ExAC gnomAD
rs752690816 CA383494087	34	K>N		No	ClinGen ExAC TOPMed gnomAD
rs1425956800 CA383494089	35	E>K		No	ClinGen TOPMed
CA383494148 rs1444718626	38	F>I		No	ClinGen gnomAD
rs1191826980 CA383494176	39	L>F		No	ClinGen gnomAD
rs1191826980 CA383494173	39	L>V		No	ClinGen gnomAD
CA383494212 rs1161334800	41	Y>C		No	ClinGen gnomAD
rs763813492 CA6372195 CA383494274	44	E>D		No	ClinGen ExAC gnomAD
rs1410702526 CA383494306	46	V>A		No	ClinGen TOPMed
rs753649611 CA6372196	47	S>A		No	ClinGen ExAC gnomAD
rs1381638621 CA383494331	48	G>W		No	ClinGen gnomAD
rs1317724622 CA383494360	50	V>L		No	ClinGen gnomAD
CA6372198 rs780349854	53	A>S		No	ClinGen ExAC gnomAD
CA383494419 rs780349854	53	A>T		No	ClinGen ExAC gnomAD
CA383494450 rs1313224434	55	K>Q		No	ClinGen gnomAD
rs1023897341 CA231245515	58	N>S		No	ClinGen TOPMed gnomAD
rs755131324 CA6372200	60	R>W		No	ClinGen ExAC gnomAD
CA231245519 rs200076063	61	L>P		No	ClinGen 1000Genomes
rs1591874499 CA383494573	62	E>G		No	ClinGen Ensembl
CA383494609 rs1224847997	65	G>S		No	ClinGen TOPMed
CA383494616 rs1205099881	66	I>L		No	ClinGen gnomAD
CA231245528 rs1035067092	70	F>L		No	ClinGen TOPMed
CA383494713 rs1181328153	71	I>F		No	ClinGen TOPMed gnomAD
TCGA novel	77	Y>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs746237444 CA6372244	77	Y>H		No	ClinGen ExAC gnomAD
CA383497334 rs1192969088	77	Y>S		No	ClinGen gnomAD
rs981973943 CA231250791	79	D>N		No	ClinGen TOPMed gnomAD
CA231250800 rs370978210	80	R>C		No	ClinGen ESP
CA6372247 rs746504494	80	R>H		No	ClinGen ExAC gnomAD
CA231250811 rs989206678	81	G>R		No	ClinGen gnomAD
CA231250817 rs913207297	83	H>Q		No	ClinGen TOPMed
CA383497464 rs1350956246	84	H>R		No	ClinGen gnomAD
CA6372249 rs776430967	85	E>D		No	ClinGen ExAC gnomAD
rs748053554 CA6372250	89	L>V		No	ClinGen ExAC TOPMed gnomAD
CA6372254 rs767817735	94	A>S		No	ClinGen ExAC TOPMed gnomAD
rs767817735 CA383497628	94	A>T		No	ClinGen ExAC TOPMed gnomAD
CA231250850 rs775689975	95	R>Q		No	ClinGen TOPMed
rs770181237 CA6372256	95	R>W		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	98	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6372257 rs764201176	99	I>N		No	ClinGen ExAC gnomAD
CA383497694 rs1591879725	100	T>P		No	ClinGen Ensembl
rs753875206 CA6372258	100	T>S		No	ClinGen ExAC gnomAD
CA383497720 rs1213634546	102	S>L		No	ClinGen TOPMed gnomAD
CA383497741 rs1565356498	104	A>T		No	ClinGen Ensembl
CA6372261 rs184697812	106	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA383497841 rs1591879753	110	T>P		No	ClinGen Ensembl
TCGA novel	111	H>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA383497878 rs1443067262	112	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
TCGA novel	113	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6372264 rs746733630	115	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	119	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6372268 rs769731323	120	T>A		No	ClinGen ExAC TOPMed gnomAD
CA383498029 rs1380092795	121	G>R		No	ClinGen gnomAD
CA383498043 rs1284564917	122	Q>*		No	ClinGen gnomAD
rs1381146508 CA383498055	123	N>D		No	ClinGen gnomAD
TCGA novel	127	R>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6372271 rs770915188	127	R>C		No	ClinGen ExAC gnomAD
rs997239900 CA231251016	127	R>H		No	ClinGen TOPMed
rs140389768 CA231254902	129	F>L		No	ClinGen ESP TOPMed
CA6372299 rs201072669	131	R>C		No	ClinGen ExAC gnomAD
rs1477409536 CA383499006	131	R>H		No	ClinGen gnomAD
CA6372300 rs751882827	132	A>V		No	ClinGen ExAC gnomAD
CA383499074 rs1426849194	135	S>R		No	ClinGen gnomAD
rs1464288071 CA383499100 COSM466588	137	R>C	kidney Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs147379113 CA6372302	139	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1043201395 CA231254941	141	V>F		No	ClinGen TOPMed gnomAD
CA383499172 rs1043201395	141	V>I		No	ClinGen TOPMed gnomAD
CA383499216 rs1343676735	143	K>N		No	ClinGen gnomAD
CA6372304 rs752358559	144	E>A		No	ClinGen ExAC gnomAD
CA383499247 rs1591882366	145	M>T		No	ClinGen Ensembl
CA383499243 rs1347357490	145	M>V		No	ClinGen gnomAD
CA6372307 rs372253863	147	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs982822432 CA231254965	150	H>P		No	ClinGen TOPMed gnomAD
rs1591882378 CA383499374	151	T>A		No	ClinGen Ensembl
rs1450485246 CA383499427	153	S>N		No	ClinGen gnomAD
TCGA novel	153	S>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1474217216 CA383499547	158	L>P		No	ClinGen gnomAD
CA383499625 rs1161546577	161	S>C		No	ClinGen gnomAD
CA383499610 rs1431433967	161	S>P		No	ClinGen TOPMed gnomAD
rs781475558 CA6372312	163	K>R		No	ClinGen ExAC TOPMed gnomAD
CA6372313 rs748256651	164	M>I		No	ClinGen ExAC gnomAD
rs1453730530 CA383499768	169	E>K		No	ClinGen TOPMed
CA6372316 rs773229617	171	C>S		No	ClinGen ExAC gnomAD
CA6372315 rs773229617	171	C>Y		No	ClinGen ExAC gnomAD
CA6372317 rs771398178	176	F>S		No	ClinGen ExAC gnomAD
rs1343265147 CA383500031	179	N>S		No	ClinGen TOPMed gnomAD
rs1301209173 CA383500046	180	K>E		No	ClinGen TOPMed
CA6372318 rs774888517	181	S>C		No	ClinGen ExAC gnomAD
rs759932615 CA6372319	182	K>R		No	ClinGen ExAC TOPMed gnomAD
CA383501857 rs1458969286	187	D>G		No	ClinGen gnomAD
rs764777364 CA6372345	189	I>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1397001036 CA383501918	193	I>V		No	ClinGen gnomAD
rs763466532 CA6372350	200	I>L		No	ClinGen ExAC TOPMed gnomAD
rs1330620735 CA383502019	202	I>L		No	ClinGen gnomAD
CA6372351 rs777959091	202	I>M		No	ClinGen ExAC gnomAD
CA383502098 rs1255082256	207	I>V		No	ClinGen gnomAD
rs374370712 CA6372352	208	D>G		No	ClinGen ESP ExAC gnomAD
rs1248193556 CA383502140	209	I>V		No	ClinGen gnomAD
CA383502212 rs1182833830	212	R>Q		No	ClinGen gnomAD
CA231259759 rs1051455685	213	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA383502265 rs772426075	215	T>K		No	ClinGen ExAC TOPMed gnomAD
CA6372356 rs772426075	215	T>M		No	ClinGen ExAC TOPMed gnomAD
rs1346736700 CA383502325	218	G>V		No	ClinGen TOPMed
CA6372359 rs769205837	220	N>S		No	ClinGen ExAC gnomAD
CA383502374 rs769205837	220	N>T		No	ClinGen ExAC gnomAD
rs1351755902 CA383502397	221	V>M		No	ClinGen gnomAD
CA231259808 rs111401005	225	N>S		No	ClinGen Ensembl
CA6372361 rs761503499	227	T>M		No	ClinGen ExAC TOPMed gnomAD
rs1398683727 CA383502543	228	I>T		No	ClinGen TOPMed
CA231259817 rs991788426	230	K>M		No	ClinGen TOPMed
CA383502565 rs1249386226	230	K>Q		No	ClinGen gnomAD
rs766206737 CA6372365	232	E>K		No	ClinGen ExAC gnomAD
rs751572708 CA6372366	233	I>S		No	ClinGen ExAC gnomAD
CA231259824 rs898962728	237	A>S		No	ClinGen TOPMed
rs898962728 CA383502753	237	A>T		No	ClinGen TOPMed
TCGA novel	240	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1420035360 CA383503086	242	E>Q		No	ClinGen TOPMed
CA383503149 COSM687166 rs1392483854	245	P>L	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
TCGA novel	247	R>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6372382 rs770542325	249	F>L		No	ClinGen ExAC gnomAD
rs1363976307 CA383503264	251	A>T		No	ClinGen gnomAD
CA6372384 rs759419191	251	A>V		No	ClinGen ExAC gnomAD
CA6372387 rs760510761	252	G>R		No	ClinGen ExAC gnomAD
rs1591488133 CA383503293	253	Y>D		No	ClinGen Ensembl
rs758550271 CA6372390	255	L>V		No	ClinGen ExAC TOPMed gnomAD
rs766420440 CA6372391	256	T>M		No	ClinGen ExAC TOPMed gnomAD
CA383503457 rs1244134308	259	M>I		No	ClinGen gnomAD
CA383503442 rs1209657435	259	M>L		No	ClinGen gnomAD
CA383503469 rs1472034375	260	R>Q		No	ClinGen gnomAD
CA383503468 rs1565359334	260	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA231261050 rs768146294	262	I>S		No	ClinGen Ensembl
CA383503524 rs1591488150	263	N>S		No	ClinGen Ensembl
rs751714973 CA6372392	265	K>R		No	ClinGen ExAC TOPMed gnomAD
rs1415136107 CA383503644	267	S>F		No	ClinGen gnomAD
CA383503672 rs1217512115	268	V>A		No	ClinGen TOPMed
rs146620670 CA6372394	270	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA6372393 rs146620670	270	Y>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA6372395 rs748502635	276	L>P		No	ClinGen ExAC
rs542416560 CA6372397	277	I>L		No	ClinGen 1000Genomes ExAC gnomAD
CA6372398 rs748905855	277	I>T		No	ClinGen ExAC TOPMed gnomAD
rs1555057911 CA383503946	279	E>D		No	ClinGen Ensembl
rs1303263162 CA383503991	282	R>Q		No	ClinGen gnomAD
rs1447042634 COSM1676606 CA383503988	282	R>W	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated gnomAD
COSM1232372 CA383504024 rs1381214559	283	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
TCGA novel	288	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA231261420 rs909350877	290	V>A		No	ClinGen Ensembl
rs745367343 CA6372420	291	V>A		No	ClinGen ExAC gnomAD
CA6372422 rs774980807	292	L>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs879813172 CA231261422	294	R>Q		No	ClinGen TOPMed gnomAD
TCGA novel	294	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1427612035 CA383504718	297	D>V		No	ClinGen gnomAD
CA383504725 rs1268037400	298	I>N		No	ClinGen TOPMed
rs776450098 CA6372425 COSM1475278	299	V>I	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA6372428 rs138823375	300	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA6372427 rs138823375	300	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA6372426 rs541989590	300	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	301	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs767640193 CA6372430	302	S>N		No	ClinGen ExAC
CA383504755 rs1347990005	303	M>I		No	ClinGen TOPMed
CA6372431 rs752838639	303	M>L		No	ClinGen ExAC gnomAD
CA383504753 rs1591488342	303	M>T		No	ClinGen Ensembl
CA6372432 rs751395535 COSM1352758	304	S>T	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs764547459 CA383504774	306	Q>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs764547459 CA6372433	306	Q>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	307	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA383504792 rs1555057961	309	I>V		No	ClinGen Ensembl
CA6372436 COSM925182 rs778529826	313	R>C	Variant assessed as Somatic; 4.644e-05 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA231261468 rs568925080	313	R>H		No	ClinGen gnomAD
rs758058105 CA383504830	315	E>*		No	ClinGen ExAC TOPMed gnomAD
rs758058105 CA6372438	315	E>K		No	ClinGen ExAC TOPMed gnomAD
rs746535728 CA383504839	316	G>A		No	ClinGen ExAC gnomAD
rs773295674 CA6372439	316	G>C		No	ClinGen ExAC gnomAD
CA6372440 rs746535728	316	G>V		No	ClinGen ExAC gnomAD
rs1187696711 CA383504851	318	T>I		No	ClinGen gnomAD
CA231261516 rs938347654	319	S>F		No	ClinGen Ensembl
rs201480019 CA6372443	320	L>P		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	323	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6372446 rs759776381	324	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA6372445 rs773146019	324	R>W		No	ClinGen ExAC TOPMed gnomAD
rs368644780 CA6372447	325	T>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA383504888 rs1396919780	325	T>I		No	ClinGen gnomAD
CA383504884 rs368644780	325	T>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1368264193 CA383504905	328	Q>*		No	ClinGen gnomAD
TCGA novel	332	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1263608625 CA383504942	333	N>S		No	ClinGen TOPMed
CA6372452 rs754369033	334	C>R		No	ClinGen ExAC gnomAD

No associated diseases with Q4G0F5

No regional properties for Q4G0F5

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q4G0F5

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Membrane; Peripheral membrane protein Early endosome Late endosome	Localizes to early and late endosomal structures (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

7 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
early endosome	A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
endosome	A vacuole to which materials ingested by endocytosis are delivered.
late endosome	A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
phagocytic vesicle	A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
retromer complex	A conserved hetero-pentameric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. The budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p. The mammalian complex shows slight variation in composition compared to yeast, and comprises SNX1 or SNX2, SNX5 or SNX6, VPS26A or VPS26B, VPS29, and VPS35.
retromer, cargo-selective complex	The trimeric subcomplex of the retromer, believed to be closely associated with the membrane. This trimeric complex is responsible for recognizing and binding to cargo molecules. The complex comprises three Vps proteins in both yeast and mammalian cells: Vps35p, Vps29p, and Vps26p in yeast, and VPS35, VPS29 and VPS26A or VPS26B in mammals.

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

4 GO annotations of biological process

Name	Definition
cellular response to interferon-gamma	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far.
intracellular protein transport	The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
regulation of macroautophagy	Any process that modulates the frequency, rate or extent of macroautophagy.
retrograde transport, endosome to Golgi	The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport.

10 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q0VD53	VPS26A	Vacuolar protein sorting-associated protein 26A	Bos taurus (Bovine)	PR
O75436	VPS26A	Vacuolar protein sorting-associated protein 26A	Homo sapiens (Human)	PR
P40336	Vps26a	Vacuolar protein sorting-associated protein 26A	Mus musculus (Mouse)	PR
Q8C0E2	Vps26b	Vacuolar protein sorting-associated protein 26B	Mus musculus (Mouse)	PR
Q6AY86	Vps26a	Vacuolar protein sorting-associated protein 26A	Rattus norvegicus (Rat)	PR
O01258	vps-26	Vacuolar protein sorting-associated protein 26	Caenorhabditis elegans	PR
Q28HT6	vps26a	Vacuolar protein sorting-associated protein 26A	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q5BKM4	vps26b	Vacuolar protein sorting-associated protein 26B	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q6TNP8	vps26a	Vacuolar protein sorting-associated protein 26A	Danio rerio (Zebrafish) (Brachydanio rerio)	PR
Q6DH23	vps26bl	Vacuolar protein sorting-associated protein 26B-like	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MSFFGFGQSV	EVEILLNDAE	SRKRAEHKTE	DGKKEKYFLF	YDGETVSGKV	SLALKNPNKR
70	80	90	100	110	120
LEHQGIKIEF	IGQIELYYDR	GNHHEFVSLV	KDLARPGEIT	QSQAFDFEFT	HVEKPYESYT
130	140	150	160	170	180
GQNVKLRYFL	RATISRRLND	VVKEMDIVVH	TLSTYPELNS	SIKMEVGIED	CLHIEFEYNK
190	200	210	220	230	240
SKYHLKDVIV	GKIYFLLVRI	KIKHMEIDII	KRETTGTGPN	VYHENDTIAK	YEIMDGAPVR
250	260	270	280	290	300
GESIPIRLFL	AGYELTPTMR	DINKKFSVRY	YLNLVLIDEE	ERRYFKQQEV	VLWRKGDIVR
310	320	330
KSMSHQAAIA	SQRFEGTTSL	GEVRTPSQLS	DNNCRQ