O01258

PR
Gene name
vps-26 (T20D3.7)
Protein name
Vacuolar protein sorting-associated protein 26
Names
VPS26 protein homolog
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_T20D3.7
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

270-356 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O01258

Entry ID Method Resolution Chain Position Source
AF-O01258-F1 Predicted AlphaFoldDB

No variants for O01258

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O01258

No associated diseases with O01258

No regional properties for O01258

Type Name Position InterPro Accession
No domain, repeats, and functional sites for O01258

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endosome A vacuole to which materials ingested by endocytosis are delivered.
retromer complex A conserved hetero-pentameric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. The budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p. The mammalian complex shows slight variation in composition compared to yeast, and comprises SNX1 or SNX2, SNX5 or SNX6, VPS26A or VPS26B, VPS29, and VPS35.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

2 GO annotations of biological process

Name Definition
intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
retrograde transport, endosome to Golgi The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport.

10 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q0VD53 VPS26A Vacuolar protein sorting-associated protein 26A Bos taurus (Bovine) PR
Q4G0F5 VPS26B Vacuolar protein sorting-associated protein 26B Homo sapiens (Human) PR
O75436 VPS26A Vacuolar protein sorting-associated protein 26A Homo sapiens (Human) PR
P40336 Vps26a Vacuolar protein sorting-associated protein 26A Mus musculus (Mouse) PR
Q8C0E2 Vps26b Vacuolar protein sorting-associated protein 26B Mus musculus (Mouse) PR
Q6AY86 Vps26a Vacuolar protein sorting-associated protein 26A Rattus norvegicus (Rat) PR
Q28HT6 vps26a Vacuolar protein sorting-associated protein 26A Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q5BKM4 vps26b Vacuolar protein sorting-associated protein 26B Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q6TNP8 vps26a Vacuolar protein sorting-associated protein 26A Danio rerio (Zebrafish) (Brachydanio rerio) PR
Q6DH23 vps26bl Vacuolar protein sorting-associated protein 26B-like Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MAMLFGFGQS AEIQIRLSNE DTRKIVKARG DDGNMHDHFL YYDGESVTGT VHVNLKKANH
70 80 90 100 110 120
KFEHQGIRIE FIGQIEVYYD RGNQQDFISL TRELARPGDL TQNAQFPFEF NNVEKPFETY
130 140 150 160 170 180
MGTNVKLRYF LRVTVIRRLT DLTKELDLVV HALSSYPDND KSIKMEVGIE DCLHIEFEYN
190 200 210 220 230 240
KNKYHLQDVI VGKIYFLLVR IKIKYMEIAI LKTEVVGSGP NTFKESETVA KFEIMDGAPV
250 260 270 280 290 300
RGESIPIRLF LAGYDLAPSM RDVGKKFSVK YFLNLVLVDE EDRRYFKQQE VTLWRKADKV
310 320 330 340 350
MRRPGTEDDE EEKQTTSIPG TQKFTAPAPV EHPKPESPRS DPKSGSTSPD DNSDSS