P40336
PR
Gene name |
Vps26a (Vps26) |
Protein name |
Vacuolar protein sorting-associated protein 26A |
Names |
H<beta>58 protein, H beta 58, Vesicle protein sorting 26A, mVPS26 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:30930 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for P40336
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 4P2A | X-ray | 270 A | A | 9-327 | PDB |
| 6VAC | EM | 570 A | B | 1-327 | PDB |
| 7U6F | EM | 490 A | B3 | 1-327 | PDB |
| AF-P40336-F1 | Predicted | AlphaFoldDB |
19 variants for P40336
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389046403 | 14 | I>V | No | EVA | |
| rs260467185 | 23 | T>A | No | EVA | |
| rs3389046393 | 25 | K>I | No | EVA | |
| rs3389099223 | 69 | R>S | No | EVA | |
| rs3401229033 | 78 | L>V | No | EVA | |
| rs3401228988 | 79 | F>Y | No | EVA | |
| rs3401235606 | 82 | K>M | No | EVA | |
| rs3401321937 | 84 | N>I | No | EVA | |
| rs3401235593 | 86 | H>L | No | EVA | |
| rs3412094160 | 116 | K>R | No | EVA | |
| rs3389091125 | 152 | H>R | No | EVA | |
| rs3389102770 | 168 | V>M | No | EVA | |
| rs3389104370 | 212 | I>M | No | EVA | |
| rs3389112599 | 215 | E>V | No | EVA | |
| rs3389105776 | 217 | T>S | No | EVA | |
| rs3389095863 | 223 | T>S | No | EVA | |
| rs3389109047 | 229 | T>I | No | EVA | |
| rs3389102538 | 297 | K>I | No | EVA | |
| rs3389104424 | 321 | S>Y | No | EVA |
No associated diseases with P40336
No regional properties for P40336
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P40336 | |||
9 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| early endosome | A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. |
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| endosome membrane | The lipid bilayer surrounding an endosome. |
| lysosome | A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. |
| retromer complex | A conserved hetero-pentameric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. The budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p. The mammalian complex shows slight variation in composition compared to yeast, and comprises SNX1 or SNX2, SNX5 or SNX6, VPS26A or VPS26B, VPS29, and VPS35. |
| retromer, cargo-selective complex | The trimeric subcomplex of the retromer, believed to be closely associated with the membrane. This trimeric complex is responsible for recognizing and binding to cargo molecules. The complex comprises three Vps proteins in both yeast and mammalian cells: Vps35p, Vps29p, and Vps26p in yeast, and VPS35, VPS29 and VPS26A or VPS26B in mammals. |
| tubular endosome | A network of fine tubules in the vicinity of the Golgi complex and around the centriole. |
| vesicle | Any small, fluid-filled, spherical organelle enclosed by membrane. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| endocytic recycling | The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. |
| intracellular protein transport | The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. |
| retrograde transport, endosome to Golgi | The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q0VD53 | VPS26A | Vacuolar protein sorting-associated protein 26A | Bos taurus (Bovine) | PR |
| Q4G0F5 | VPS26B | Vacuolar protein sorting-associated protein 26B | Homo sapiens (Human) | PR |
| O75436 | VPS26A | Vacuolar protein sorting-associated protein 26A | Homo sapiens (Human) | PR |
| Q8C0E2 | Vps26b | Vacuolar protein sorting-associated protein 26B | Mus musculus (Mouse) | PR |
| Q6AY86 | Vps26a | Vacuolar protein sorting-associated protein 26A | Rattus norvegicus (Rat) | PR |
| O01258 | vps-26 | Vacuolar protein sorting-associated protein 26 | Caenorhabditis elegans | PR |
| Q5BKM4 | vps26b | Vacuolar protein sorting-associated protein 26B | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q28HT6 | vps26a | Vacuolar protein sorting-associated protein 26A | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q6DH23 | vps26bl | Vacuolar protein sorting-associated protein 26B-like | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q6TNP8 | vps26a | Vacuolar protein sorting-associated protein 26A | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSFLGGFFGP | ICEIDVALND | GETRKMAEMK | TEDGKVEKHY | LFYDGESVSG | KVNLAFKQPG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KRLEHQGIRI | EFVGQIELFN | DKSNTHEFVN | LVKELALPGE | LTQSRSYDFE | FMQVEKPYES |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YIGANVRLRY | FLKVTIVRRL | TDLVKEYDLI | VHQLATYPDV | NNSIKMEVGI | EDCLHIEFEY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NKSKYHLKDV | IVGKIYFLLV | RIKIQHMELQ | LIKKEITGIG | PSTTTETETI | AKYEIMDGAP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VKGESIPIRL | FLAGYDPTPT | MRDVNKKFSV | RYFLNLVLVD | EEDRRYFKQQ | EIILWRKAPE |
| 310 | 320 | ||||
| KLRKQRTNFH | QRFESPDSQA | SAEQPEM |