AiPD: Autoinhibited Protein Database

O75436

Gene name	VPS26A
Protein name	Vacuolar protein sorting-associated protein 26A
Names	Vesicle protein sorting 26A, hVPS26
Species	Homo sapiens (Human)
KEGG Pathway	hsa:9559
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

186-260 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

186-260 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

7 structures for O75436

Entry ID	Method	Resolution	Chain	Position	Source
2FAU	X-ray	210 A	A	1-327	PDB
5F0J	X-ray	270 A	B	2-326	PDB
5F0L	X-ray	320 A	B	1-317	PDB
5F0M	X-ray	310 A	B	1-321	PDB
5F0P	X-ray	278 A	B	1-321	PDB
7BLO	EM	950 A	F/J	8-301	PDB
AF-O75436-F1	Predicted				AlphaFoldDB

185 variants for O75436

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA376893979 rs1589345013	3	F>V		No	ClinGen Ensembl
rs1301071638 CA376893988	4	L>V		No	ClinGen gnomAD
CA376894011 rs1465377629	6	G>D		No	ClinGen TOPMed
CA376894045 rs1307810851	8	F>L		No	ClinGen gnomAD
CA5530143 rs749526946	10	P>T		No	ClinGen ExAC gnomAD
CA5530145 rs774573506	11	I>T		No	ClinGen ExAC gnomAD
rs377001222 CA5530144	11	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs764160350 CA5530147	15	D>G		No	ClinGen ExAC gnomAD
rs1253070221 CA376894161	15	D>N		No	ClinGen gnomAD
rs761790872 CA5530149	16	I>M		No	ClinGen ExAC TOPMed gnomAD
CA5530148 rs369058494	16	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA376894190 rs1245431319	16	I>V		No	ClinGen gnomAD
CA5530150 rs765001100	18	L>P		No	ClinGen ExAC gnomAD
CA376894273 rs1455830020	20	D>V		No	ClinGen gnomAD
rs762518958 CA5530152	25	K>R		No	ClinGen ExAC TOPMed gnomAD
rs1196378145 CA376894411	26	M>V		No	ClinGen TOPMed
rs1337418243 CA376894494	29	M>V		No	ClinGen TOPMed gnomAD
rs1258452194 CA376894526	30	K>E		No	ClinGen TOPMed
rs756506511 CA209199723	33	D>G		No	ClinGen Ensembl
CA5530154 rs551583478	35	K>R		No	ClinGen 1000Genomes ExAC gnomAD
CA209199727 rs966829298	36	V>I		No	ClinGen TOPMed gnomAD
rs1234748450 CA376894664	37	E>K		No	ClinGen gnomAD
rs1211225357 CA376894719	39	H>P		No	ClinGen TOPMed gnomAD
CA5530155 rs754443768	39	H>Y		No	ClinGen ExAC gnomAD
rs1252090102 CA376894734	40	Y>N		No	ClinGen gnomAD
CA5530156 rs531340970	40	Y>S		No	ClinGen ExAC TOPMed gnomAD
CA376894763 rs1266095956	41	L>F		No	ClinGen TOPMed gnomAD
CA376894761 rs1266095956	41	L>V		No	ClinGen TOPMed gnomAD
CA5530157 rs753248739	42	F>V		No	ClinGen ExAC gnomAD
rs778064238 CA5530159	43	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs756626968 CA5530158	43	Y>H		No	ClinGen ExAC gnomAD
COSM427816 rs1461148219 CA376894845	45	G>R	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA5530162 rs779238987	48	V>I		No	ClinGen ExAC TOPMed gnomAD
CA5530163 rs746061052	49	S>A		No	ClinGen ExAC TOPMed gnomAD
CA5530182 rs772420433	52	V>G		No	ClinGen ExAC gnomAD
rs780285465 CA5530183 CA376900103	53	N>K		No	ClinGen ExAC gnomAD
rs1250967855 CA376900108	54	L>V		No	ClinGen gnomAD
CA5530184 rs377072735	55	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA5530185 rs769643163	56	F>V		No	ClinGen ExAC gnomAD
rs949166466 CA209202806	57	K>E		No	ClinGen Ensembl
rs773159591 CA5530186	57	K>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	58	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1461673696 CA376900302	64	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA376900330 rs1163548816	65	H>N		No	ClinGen gnomAD
CA5530187 rs762767775	67	G>R		No	ClinGen ExAC gnomAD
rs1456830993 CA376900465	70	I>F		No	ClinGen gnomAD
TCGA novel	72	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA376900542 rs1303309822	73	V>I		No	ClinGen TOPMed
CA5530188 rs770760473	75	Q>H		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	76	I>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA376900768 rs1170554878	77	E>G		No	ClinGen gnomAD
rs1355579428 CA376900786	78	L>P		No	ClinGen gnomAD
rs1429715760 CA376900792	79	F>L		No	ClinGen gnomAD
CA5530197 rs757829843	80	N>S		No	ClinGen ExAC
rs765764274 CA5530198	85	T>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	85	T>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs370434579 CA5530200	88	F>Y		No	ClinGen ESP ExAC gnomAD
CA5530201 rs780375401	90	N>S		No	ClinGen ExAC gnomAD
rs1003466774 CA209202960	92	V>M		No	ClinGen Ensembl
CA5530202 rs747087916	93	K>E		No	ClinGen ExAC gnomAD
rs1033563897 CA209202963	93	K>T		No	ClinGen Ensembl
CA376901158 rs1445877800	99	G>V		No	ClinGen gnomAD
rs959249968 CA209202966	101	L>M		No	ClinGen Ensembl
CA5530204 rs570302033	102	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5530203 rs755123253	102	T>P		No	ClinGen ExAC gnomAD
CA376901186 rs755123253	102	T>S		No	ClinGen ExAC gnomAD
CA5530206 rs749304996	104	S>G		No	ClinGen ExAC gnomAD
CA5530207 rs200895265	104	S>T		No	ClinGen ESP ExAC gnomAD
rs538754101 CA5530208	108	D>G		No	ClinGen 1000Genomes ExAC gnomAD
CA376901275 rs538754101	108	D>V		No	ClinGen 1000Genomes ExAC gnomAD
CA376901344 rs1424592061	112	M>I		No	ClinGen TOPMed
CA376901338 rs991869628	112	M>K		No	ClinGen TOPMed
rs991869628 CA209202974	112	M>T		No	ClinGen TOPMed
rs745601645 CA5530209	112	M>V		No	ClinGen ExAC gnomAD
rs771731408 CA5530210	114	V>A		No	ClinGen ExAC gnomAD
rs1186559540 CA376901367	114	V>I		No	ClinGen gnomAD
TCGA novel	115	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs775250912 CA5530211	117	P>L		No	ClinGen ExAC gnomAD
rs1236643139 CA376901432	119	E>K		No	ClinGen TOPMed
CA376901446 rs920379499	120	S>P		No	ClinGen gnomAD
rs920379499 CA209202978	120	S>T		No	ClinGen gnomAD
rs139473850 CA5530216	122	I>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs758798075 CA376902746	123	G>R		No	ClinGen ExAC TOPMed gnomAD
rs758798075 CA5530218	123	G>S		No	ClinGen ExAC TOPMed gnomAD
rs141829214 CA5530220	125	N>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs141829214 CA376902779	125	N>T		No	ClinGen ESP ExAC TOPMed gnomAD
COSM337223 rs755142402 CA5530221	127	R>C	lung Variant assessed as Somatic; 4.643e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA5530222 rs146283722	127	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA376902805 rs755142402	127	R>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	132	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA376903025 rs1333163304	133	K>I		No	ClinGen TOPMed
CA5530241 rs11552064	134	V>L		No	ClinGen ExAC gnomAD
rs11552064 CA209203143	134	V>M		No	ClinGen ExAC gnomAD
rs1267035519 CA376903078	136	I>M		No	ClinGen gnomAD
CA5530242 rs766824852	136	I>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1415970021 CA376903161	141	T>I		No	ClinGen TOPMed
CA5530243 rs751865858	143	L>V		No	ClinGen ExAC TOPMed gnomAD
CA376903258 rs1273313939	145	K>E		No	ClinGen gnomAD
CA209203153 rs939408231	146	E>A		No	ClinGen TOPMed gnomAD
rs939408231 CA209203154	146	E>G		No	ClinGen TOPMed gnomAD
rs767573724 CA5530245	150	I>T		No	ClinGen ExAC TOPMed gnomAD
CA5530247 rs756143729	152	H>R		No	ClinGen ExAC gnomAD
rs1221613496 CA376903550	158	P>L		No	ClinGen gnomAD
CA209203159 rs761116648	158	P>S		No	ClinGen ExAC gnomAD
CA5530248 rs761116648	158	P>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA209203163 rs930625934	160	V>I		No	ClinGen gnomAD
rs750421403 CA5530249	162	N>S		No	ClinGen ExAC gnomAD
rs1167161130 CA376903711	164	I>V		No	ClinGen TOPMed gnomAD
rs1391615701 CA376903898	170	I>V		No	ClinGen gnomAD
rs758267772 CA5530250	173	C>F		No	ClinGen ExAC TOPMed gnomAD
CA5530252 rs746723931	176	I>T		No	ClinGen ExAC gnomAD
rs1293359768 CA376904375	183	S>*		No	ClinGen gnomAD
rs886334051 CA209203169	184	K>T		No	ClinGen Ensembl
TCGA novel	190	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA209203898 rs903531427	204	I>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA5530270 rs779807557	206	H>Y		No	ClinGen ExAC gnomAD
rs751402642 CA5530271	207	M>T		No	ClinGen ExAC gnomAD
CA376904990 rs1241932737	207	M>V		No	ClinGen gnomAD
CA209203902 rs535991806	212	I>M		No	ClinGen Ensembl
CA5530274 rs747866317	213	K>Q		No	ClinGen ExAC gnomAD
rs1482238753 CA376905141	213	K>R		No	ClinGen gnomAD
CA5530276 rs777425474	219	I>T		No	ClinGen ExAC gnomAD
CA376905908 rs1199482638	221	P>S		No	ClinGen Ensembl
CA376905917 rs1188025822	222	S>N		No	ClinGen gnomAD
CA376905925 rs1415122948	223	T>I		No	ClinGen TOPMed
CA376905929 rs1564687946	224	T>I		No	ClinGen Ensembl
rs754928740 CA5530292	230	I>V		No	ClinGen ExAC TOPMed gnomAD
CA5530293 rs200224687	231	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1464224286 CA376906036	239	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs890031204 CA209204488	240	P>A		No	ClinGen TOPMed
TCGA novel	241	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5530315 rs763949492	244	E>D		No	ClinGen ExAC gnomAD
rs1472083039 CA376906101	248	I>V		No	ClinGen TOPMed gnomAD
TCGA novel	249	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	252	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs139296312 CA209204894	256	D>E		No	ClinGen ESP TOPMed
CA376906158 rs1180203433	256	D>G		No	ClinGen gnomAD
CA376906154 rs1396111916	256	D>N		No	ClinGen gnomAD
CA5530317 rs756932420	262	R>G		No	ClinGen ExAC gnomAD
rs1294566979 CA376906195	262	R>K		No	ClinGen TOPMed gnomAD
CA376906200 rs1390666347	263	D>N		No	ClinGen gnomAD
rs778293181 CA5530318	265	N>T		No	ClinGen ExAC gnomAD
TCGA novel	267	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs745327075 CA5530319	271	R>S		No	ClinGen ExAC TOPMed gnomAD
CA5530320 rs758927563	273	F>L		No	ClinGen ExAC gnomAD
TCGA novel	274	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA209204900 rs202140781	274	L>F		No	ClinGen Ensembl
rs1209685299 CA376906293	276	L>V		No	ClinGen TOPMed
TCGA novel	277	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs780503376 CA5530321	279	V>A		No	ClinGen ExAC gnomAD
rs1286524259 CA376906324	281	E>K		No	ClinGen gnomAD
CA209204904 rs930937771	283	D>N		No	ClinGen TOPMed
rs372476544 CA5530323	284	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA376906368 rs1472930362	285	R>K		No	ClinGen gnomAD
CA5530340 rs752120668	292	I>R		No	ClinGen ExAC
CA376906826 rs1380901915	292	I>V		No	ClinGen TOPMed
rs1422574293 CA376906859	295	W>R		No	ClinGen gnomAD
rs1170955052 CA376906874	296	R>K		No	ClinGen gnomAD
CA376906887 rs1336432413	297	K>*		No	ClinGen TOPMed
CA5530341 rs755470681	298	A>S		No	ClinGen ExAC TOPMed gnomAD
rs1429457228 CA376906905	298	A>V		No	ClinGen TOPMed gnomAD
TCGA novel	301	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1564690165 CA376907002	306	R>I		No	ClinGen Ensembl
rs1275817167 CA376907005	306	R>S		No	ClinGen TOPMed gnomAD
CA5530344 rs61750775	308	N>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs202188193 CA209205343	309	F>S		No	ClinGen Ensembl
rs769927610 CA5530345	309	F>V		No	ClinGen ExAC gnomAD
CA5530346 rs778015981	311	Q>*		No	ClinGen ExAC gnomAD
CA209205344 COSM919864 rs552011189	312	R>*	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes NCI-TCGA TOPMed
rs749489086 CA5530348	312	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA376907089 rs1312391462	314	E>Q		No	ClinGen TOPMed gnomAD
CA376907102 rs1209065643	315	S>P		No	ClinGen TOPMed gnomAD
CA376907126 rs1465812106	317	E>G		No	ClinGen gnomAD
TCGA novel	317	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA376907143 rs1446470625	319	Q>K		No	ClinGen TOPMed
CA376907151 rs1483650289	319	Q>R		No	ClinGen gnomAD
rs1221924576 CA376907165	320	A>P		No	ClinGen TOPMed gnomAD
rs774557106 CA5530350	321	S>F		No	ClinGen ExAC gnomAD
rs760694189 CA5530351	322	A>T		No	ClinGen ExAC gnomAD
rs776313365 CA376907193	323	E>*		No	ClinGen ExAC TOPMed gnomAD
CA5530353 rs776313365	323	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1415251215 CA376907202	324	Q>*		No	ClinGen gnomAD
rs1357659788 CA376907229	326	E>K		No	ClinGen TOPMed gnomAD
CA376907231 rs1357659788	326	E>Q		No	ClinGen TOPMed gnomAD
rs140007940 COSM1348770 CA5530355	327	M>I	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD

No associated diseases with O75436

No regional properties for O75436

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for O75436

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Endosome membrane ; Peripheral membrane protein Early endosome	Localizes to tubular profiles adjacent to endosomes (PubMed:15078903) Predominantly found in early not late endosomes (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

9 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
early endosome	A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
endosome	A vacuole to which materials ingested by endocytosis are delivered.
endosome membrane	The lipid bilayer surrounding an endosome.
lysosome	A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
retromer complex	A conserved hetero-pentameric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. The budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p. The mammalian complex shows slight variation in composition compared to yeast, and comprises SNX1 or SNX2, SNX5 or SNX6, VPS26A or VPS26B, VPS29, and VPS35.
retromer, cargo-selective complex	The trimeric subcomplex of the retromer, believed to be closely associated with the membrane. This trimeric complex is responsible for recognizing and binding to cargo molecules. The complex comprises three Vps proteins in both yeast and mammalian cells: Vps35p, Vps29p, and Vps26p in yeast, and VPS35, VPS29 and VPS26A or VPS26B in mammals.
tubular endosome	A network of fine tubules in the vicinity of the Golgi complex and around the centriole.
vesicle	Any small, fluid-filled, spherical organelle enclosed by membrane.

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

4 GO annotations of biological process

Name	Definition
endocytic recycling	The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins.
intracellular protein transport	The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
regulation of macroautophagy	Any process that modulates the frequency, rate or extent of macroautophagy.
retrograde transport, endosome to Golgi	The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport.

10 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q0VD53	VPS26A	Vacuolar protein sorting-associated protein 26A	Bos taurus (Bovine)	PR
Q4G0F5	VPS26B	Vacuolar protein sorting-associated protein 26B	Homo sapiens (Human)	PR
Q8C0E2	Vps26b	Vacuolar protein sorting-associated protein 26B	Mus musculus (Mouse)	PR
P40336	Vps26a	Vacuolar protein sorting-associated protein 26A	Mus musculus (Mouse)	PR
Q6AY86	Vps26a	Vacuolar protein sorting-associated protein 26A	Rattus norvegicus (Rat)	PR
O01258	vps-26	Vacuolar protein sorting-associated protein 26	Caenorhabditis elegans	PR
Q5BKM4	vps26b	Vacuolar protein sorting-associated protein 26B	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q28HT6	vps26a	Vacuolar protein sorting-associated protein 26A	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q6DH23	vps26bl	Vacuolar protein sorting-associated protein 26B-like	Danio rerio (Zebrafish) (Brachydanio rerio)	PR
Q6TNP8	vps26a	Vacuolar protein sorting-associated protein 26A	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MSFLGGFFGP	ICEIDIVLND	GETRKMAEMK	TEDGKVEKHY	LFYDGESVSG	KVNLAFKQPG
70	80	90	100	110	120
KRLEHQGIRI	EFVGQIELFN	DKSNTHEFVN	LVKELALPGE	LTQSRSYDFE	FMQVEKPYES
130	140	150	160	170	180
YIGANVRLRY	FLKVTIVRRL	TDLVKEYDLI	VHQLATYPDV	NNSIKMEVGI	EDCLHIEFEY
190	200	210	220	230	240
NKSKYHLKDV	IVGKIYFLLV	RIKIQHMELQ	LIKKEITGIG	PSTTTETETI	AKYEIMDGAP
250	260	270	280	290	300
VKGESIPIRL	FLAGYDPTPT	MRDVNKKFSV	RYFLNLVLVD	EEDRRYFKQQ	EIILWRKAPE
310	320
KLRKQRTNFH	QRFESPESQA	SAEQPEM