Q84MA5
Gene name |
CAT1 (AAT1, At4g21120, F7J7.60) |
Protein name |
Cationic amino acid transporter 1 |
Names |
Amino acid transporter 1 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G21120 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q84MA5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q84MA5-F1 | Predicted | AlphaFoldDB |
39 variants for Q84MA5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_4_11270352_G_A | 12 | R>Q | No | 1000Genomes | |
| ENSVATH06741149 | 18 | T>S | No | 1000Genomes | |
| tmp_4_11270404_A_T | 29 | Q>H | No | 1000Genomes | |
| tmp_4_11270416_T_A | 33 | N>K | No | 1000Genomes | |
| ENSVATH06741150 | 43 | S>T | No | 1000Genomes | |
| tmp_4_11270456_G_A | 47 | D>N | No | 1000Genomes | |
| ENSVATH06741151 | 49 | I>M | No | 1000Genomes | |
| tmp_4_11270507_G_A | 64 | A>T | No | 1000Genomes | |
| ENSVATH12101782 | 69 | E>Q | No | 1000Genomes | |
| tmp_4_11270579_A_G | 88 | I>V | No | 1000Genomes | |
| ENSVATH02898488 | 103 | H>N | No | 1000Genomes | |
| ENSVATH12101783 | 103 | H>Q | No | 1000Genomes | |
| ENSVATH14269785 | 150 | F>L | No | 1000Genomes | |
| ENSVATH06741194 | 174 | W>C | No | 1000Genomes | |
| ENSVATH02898509 | 184 | H>Y | No | 1000Genomes | |
| ENSVATH00527710 | 195 | K>R | No | 1000Genomes | |
| ENSVATH00527711 | 245 | I>V | No | 1000Genomes | |
| tmp_4_11272644_C_T | 249 | T>I | No | 1000Genomes | |
| tmp_4_11272665_A_T | 256 | Y>F | No | 1000Genomes | |
| ENSVATH06741195 | 258 | D>G | No | 1000Genomes | |
| ENSVATH06741196 | 279 | I>V | No | 1000Genomes | |
| tmp_4_11272889_C_T | 331 | P>S | No | 1000Genomes | |
| ENSVATH14269786 | 352 | A>T | No | 1000Genomes | |
| ENSVATH06741202 | 360 | T>A | No | 1000Genomes | |
| tmp_4_11273129_C_T | 380 | A>V | No | 1000Genomes | |
| tmp_4_11273238_A_T | 416 | K>N | No | 1000Genomes | |
| tmp_4_11273289_G_C | 433 | M>I | No | 1000Genomes | |
| ENSVATH14269787 | 437 | V>A | No | 1000Genomes | |
| ENSVATH02898515 | 448 | G>R | No | 1000Genomes | |
| ENSVATH06741206 | 467 | A>V | No | 1000Genomes | |
| tmp_4_11273401_G_A | 471 | A>T | No | 1000Genomes | |
| ENSVATH00527716 | 474 | V>L | No | 1000Genomes | |
| ENSVATH06741207 | 478 | L>S | No | 1000Genomes | |
| tmp_4_11273428_G_A | 480 | E>K | No | 1000Genomes | |
| tmp_4_11273504_C_T | 505 | P>L | No | 1000Genomes | |
| ENSVATH06741210 | 527 | A>T | No | 1000Genomes | |
| tmp_4_11273656_G_C | 556 | V>L | No | 1000Genomes | |
| ENSVATH06741211 | 588 | D>N | No | 1000Genomes | |
| ENSVATH00527718 | 591 | C>G | No | 1000Genomes |
No associated diseases with Q84MA5
1 regional properties for Q84MA5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cationic amino acid transporter, C-terminal | 513 - 562 | IPR029485 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| amino acid transmembrane transporter activity | Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. |
| L-glutamate transmembrane transporter activity | Enables the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid. |
| L-lysine transmembrane transporter activity | Enables the transfer of L-lysine from one side of a membrane to the other. L-lysine is 2,6-diaminohexanoic acid. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| amino acid transport | The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P30825 | SLC7A1 | High affinity cationic amino acid transporter 1 | Homo sapiens (Human) | PR |
| Q8WY07 | SLC7A3 | Cationic amino acid transporter 3 | Homo sapiens (Human) | PR |
| P70423 | Slc7a3 | Cationic amino acid transporter 3 | Mus musculus (Mouse) | PR |
| Q09143 | Slc7a1 | High affinity cationic amino acid transporter 1 | Mus musculus (Mouse) | PR |
| O08812 | Slc7a3 | Cationic amino acid transporter 3 | Rattus norvegicus (Rat) | PR |
| P30823 | Slc7a1 | High affinity cationic amino acid transporter 1 | Rattus norvegicus (Rat) | PR |
| Q9LZ20 | CAT6 | Cationic amino acid transporter 6, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q5PR34 | slc7a2 | Cationic amino acid transporter 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MASGGGDDGL | RRRGCSCTKD | DFLPEESFQS | MGNYLKALKE | TPSRFMDRIM | TRSLDSDEIN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EMKARSGHEM | KKTLTWWDLM | WFGIGAVIGS | GIFVLTGLEA | RNHSGPAVVL | SYVVSGVSAM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LSVFCYTEFA | VEIPVAGGSF | AYLRVELGDF | MAFIAAGNII | LEYVVGGAAV | ARSWTSYFAT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LLNHKPEDFR | IIVHKLGEDY | SHLDPIAVGV | CAIICVLAVV | GTKGSSRFNY | IASIIHMVVI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LFVIIAGFTK | ADVKNYSDFT | PYGVRGVFKS | AAVLFFAYIG | FDAVSTMAEE | TKNPGRDIPI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GLVGSMVVTT | VCYCLMAVTL | CLMQPYQQID | PDAPFSVAFS | AVGWDWAKYI | VAFGALKGMT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TVLLVGAIGQ | ARYMTHIARA | HMMPPWLAQV | NAKTGTPINA | TVVMLAATAL | IAFFTKLKIL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ADLLSVSTLF | IFMFVAVALL | VRRYYVTGET | STRDRNKFLV | FLGLILASST | ATAVYWALEE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EGWIGYCITV | PIWFLSTVAM | KFLVPQARAP | KIWGVPLVPW | LPSASIAINI | FLLGSIDTKS |
| 550 | 560 | 570 | 580 | 590 | |
| FVRFAIWTGI | LLIYYVLFGL | HATYDTAKAT | LKEKQALQKA | EEGGVVADNS | CSAT |