P70423
PR
Gene name |
Slc7a3 (Atrc3, Cat3) |
Protein name |
Cationic amino acid transporter 3 |
Names |
CAT-3, CAT3, Cationic amino acid transporter y+, Solute carrier family 7 member 3 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:11989 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P70423
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P70423-F1 | Predicted | AlphaFoldDB |
48 variants for P70423
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389570168 | 10 | G>S | No | EVA | |
| rs3389537397 | 54 | A>V | No | EVA | |
| rs3389526795 | 76 | S>T | No | EVA | |
| rs3411181984 | 113 | T>P | No | EVA | |
| rs3411297265 | 114 | G>S | No | EVA | |
| rs3389567864 | 128 | V>L | No | EVA | |
| rs3389567864 | 128 | V>M | No | EVA | |
| rs3389537353 | 129 | A>D | No | EVA | |
| rs3389579153 | 129 | A>S | No | EVA | |
| rs3389570112 | 130 | R>Q | No | EVA | |
| rs3389567890 | 136 | F>S | No | EVA | |
| rs232980378 | 152 | I>V | No | EVA | |
| rs212133393 | 155 | K>N | No | EVA | |
| rs3389573796 | 159 | V>F | No | EVA | |
| rs3411454160 | 177 | G>R | No | EVA | |
| rs3389581965 | 190 | T>S | No | EVA | |
| rs254601009 | 202 | S>G | No | EVA | |
| rs3389570855 | 219 | L>H | No | EVA | |
| rs3389567897 | 222 | E>D | No | EVA | |
| rs3389581997 | 242 | S>F | No | EVA | |
| rs243591431 | 257 | A>T | No | EVA | |
| rs3389564859 | 263 | A>S | No | EVA | |
| rs3408805893 | 285 | P>H | No | EVA | |
| rs244592742 | 286 | M>L | No | EVA | |
| rs29083736 | 293 | F>S | No | EVA | |
| rs3411565170 | 316 | H>Q | No | EVA | |
| rs3410488884 | 317 | P>A | No | EVA | |
| rs3411509837 | 319 | S>G | No | EVA | |
| rs3409882329 | 320 | P>S | No | EVA | |
| rs3408805904 | 321 | L>Q | No | EVA | |
| rs3411454185 | 322 | P>A | No | EVA | |
| rs3411896251 | 322 | P>H | No | EVA | |
| rs3389564768 | 327 | Y>* | No | EVA | |
| rs3413114240 | 343 | C>S | No | EVA | |
| rs3389570196 | 347 | T>S | No | EVA | |
| rs245722951 | 360 | M>I | No | EVA | |
| rs3389564732 | 397 | M>L | No | EVA | |
| rs3389579200 | 418 | H>R | No | EVA | |
| rs3389573816 | 426 | L>H | No | EVA | |
| rs3389564843 | 431 | Q>L | No | EVA | |
| rs3389570840 | 434 | Q>R | No | EVA | |
| rs3389570813 | 438 | S>N | No | EVA | |
| rs3389579218 | 469 | T>P | No | EVA | |
| rs3411668683 | 498 | T>R | No | EVA | |
| rs3411296651 | 509 | V>I | No | EVA | |
| rs3389519067 | 521 | A>V | No | EVA | |
| rs3389570890 | 527 | W>C | No | EVA | |
| rs3411297260 | 548 | L>V | No | EVA |
No associated diseases with P70423
1 regional properties for P70423
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cationic amino acid transporter, C-terminal | 538 - 588 | IPR029485 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| amino acid transmembrane transporter activity | Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. |
| basic amino acid transmembrane transporter activity | Enables the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have side chains with a positive charge at pH 7.3. |
| L-arginine transmembrane transporter activity | Enables the transfer of L-arginine from one side of a membrane to the other. |
| L-lysine transmembrane transporter activity | Enables the transfer of L-lysine from one side of a membrane to the other. L-lysine is 2,6-diaminohexanoic acid. |
| L-ornithine transmembrane transporter activity | Enables the transfer of L-ornithine from one side of a membrane to the other. L-ornithine is 2,5-diaminopentanoic acid. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| amino acid transport | The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| L-arginine import across plasma membrane | The directed movement of L-arginine from outside of a cell, across the plasma membrane and into the cytosol. |
| L-arginine transmembrane transport | The directed movement of L-arginine across a membrane. |
| L-lysine import across plasma membrane | The directed movement of L-lysine from outside of a cell, across the plasma membrane and into the cytosol. |
| L-ornithine import across plasma membrane | The directed movement of L-ornithine from outside of a cell, across the plasma membrane and into the cytosol. |
| L-ornithine transmembrane transport | The directed movement of L-ornithine across a membrane. |
| lysine transport | The directed movement of lysine, 2,6-diaminohexanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| ornithine transport | The directed movement of ornithine, 2,5-diaminopentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| regulation of TOR signaling | Any process that modulates the frequency, rate or extent of TOR signaling. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P30825 | SLC7A1 | High affinity cationic amino acid transporter 1 | Homo sapiens (Human) | PR |
| Q8WY07 | SLC7A3 | Cationic amino acid transporter 3 | Homo sapiens (Human) | PR |
| Q09143 | Slc7a1 | High affinity cationic amino acid transporter 1 | Mus musculus (Mouse) | PR |
| P30823 | Slc7a1 | High affinity cationic amino acid transporter 1 | Rattus norvegicus (Rat) | PR |
| O08812 | Slc7a3 | Cationic amino acid transporter 3 | Rattus norvegicus (Rat) | PR |
| Q84MA5 | CAT1 | Cationic amino acid transporter 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LZ20 | CAT6 | Cationic amino acid transporter 6, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q5PR34 | slc7a2 | Cationic amino acid transporter 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLWQALRRFG | QKLVRRRVLE | LGMGETRLAR | CLSTLDLVAL | GVGSTLGAGV | YVLAGEVAKD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KAGPSIVICF | LVAALSSVLA | GLCYAEFGAR | VPGSGSAYLY | SYVTVGELWA | FTTGWNLILS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YVIGTASVAR | AWSSAFDNLI | GNHISRTLKG | TILLKMPHVL | AEYPDFFALA | LVLLLTGLLV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LGASKSALVT | KVFTGMNLLV | LSFVIISGFI | KGELRNWKLT | KEDYCLTMSE | SNGTCSLDSM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GSGGFMPFGL | EGILRGAATC | FYAFVGFDCI | ATTGEEAQNP | QRSIPMGIVI | SMFICFLAYF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GVSSALTLMM | PYYKLHPESP | LPEAFSYVGW | EPARYLVAIG | SLCALSTSLL | GSMFPMPRVM |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YSMAEDGLLF | RVLAKVHSVT | HIPIVATLVS | GVIAAFMAFL | FELTDLVDLM | SIGTLLAHSL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VSICVLILRY | QPDQEMKSVE | EEMELQEETL | EAEKLTVQAL | FCPVNSIPTL | LSGRVVYVCS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SLLAVLLTVL | CLVLTWWTTP | LRSGDPVWVT | VVVLILGLIL | AISGVIWRQP | QNRTPLHFKV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| PAVPLLPLVS | IFVNVYLMMQ | MTAGTWARFG | IWMLIGFAIY | FGYGIQHSMK | EVKNHQTLPK |
| 610 | |||||
| TRAQTIDLDL | TTSCVHSI |