O08812

PR
Gene name
Slc7a3 (Atrc3, Cat3)
Protein name
Cationic amino acid transporter 3
Names
CAT-3, CAT3, Cationic amino acid transporter y+, Solute carrier family 7 member 3
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:29485
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-58 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O08812

Entry ID Method Resolution Chain Position Source
AF-O08812-F1 Predicted AlphaFoldDB

No variants for O08812

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O08812

No associated diseases with O08812

5 regional properties for O08812

Type Name Position InterPro Accession
domain TolB, N-terminal 23 - 127 IPR007195
repeat WD40-like beta propeller 208 - 240 IPR011659-1
repeat WD40-like beta propeller 249 - 284 IPR011659-2
repeat WD40-like beta propeller 293 - 328 IPR011659-3
repeat WD40-like beta propeller 339 - 370 IPR011659-4

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

5 GO annotations of molecular function

Name Definition
amino acid transmembrane transporter activity Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group.
basic amino acid transmembrane transporter activity Enables the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have side chains with a positive charge at pH 7.3.
L-arginine transmembrane transporter activity Enables the transfer of L-arginine from one side of a membrane to the other.
L-lysine transmembrane transporter activity Enables the transfer of L-lysine from one side of a membrane to the other. L-lysine is 2,6-diaminohexanoic acid.
L-ornithine transmembrane transporter activity Enables the transfer of L-ornithine from one side of a membrane to the other. L-ornithine is 2,5-diaminopentanoic acid.

11 GO annotations of biological process

Name Definition
amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
basic amino acid transmembrane transport The directed movement of basic amino acids from one side of a membrane to the other.
L-arginine import across plasma membrane The directed movement of L-arginine from outside of a cell, across the plasma membrane and into the cytosol.
L-arginine transmembrane transport The directed movement of L-arginine across a membrane.
L-lysine import across plasma membrane The directed movement of L-lysine from outside of a cell, across the plasma membrane and into the cytosol.
L-lysine transmembrane transport The directed movement of L-lysine across a membrane.
L-ornithine import across plasma membrane The directed movement of L-ornithine from outside of a cell, across the plasma membrane and into the cytosol.
L-ornithine transmembrane transport The directed movement of L-ornithine across a membrane.
lysine transport The directed movement of lysine, 2,6-diaminohexanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
ornithine transport The directed movement of ornithine, 2,5-diaminopentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
regulation of TOR signaling Any process that modulates the frequency, rate or extent of TOR signaling.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P30825 SLC7A1 High affinity cationic amino acid transporter 1 Homo sapiens (Human) PR
Q8WY07 SLC7A3 Cationic amino acid transporter 3 Homo sapiens (Human) PR
Q09143 Slc7a1 High affinity cationic amino acid transporter 1 Mus musculus (Mouse) PR
P70423 Slc7a3 Cationic amino acid transporter 3 Mus musculus (Mouse) PR
P30823 Slc7a1 High affinity cationic amino acid transporter 1 Rattus norvegicus (Rat) PR
Q84MA5 CAT1 Cationic amino acid transporter 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LZ20 CAT6 Cationic amino acid transporter 6, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
Q5PR34 slc7a2 Cationic amino acid transporter 2 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MLWQALRRFG QKLVRRRLLE LGMGETRLAR CLSTLDLVAL GVGSTLGAGV YVLAGEVAKE
70 80 90 100 110 120
KAGPSIVICF LVAALSSVLA GLCYAEFGAR VPGSGSAYLY SYVTVGELWA FTTGWNLILS
130 140 150 160 170 180
YVIGTASVAR AWSSAFDNLI GNHISQTLKG TILLNMPHVL AEYPDFFALA LVLLLTGLLV
190 200 210 220 230 240
LGANESGLVT KVFTGMNLLV LGFVIISGFI KGELRNWKLT KEDYCLTMSE SNGTCSLDSM
250 260 270 280 290 300
GSGGFMPFGL EGILRGAATC FYAFVGFDCI ATTGEEAQNP QRSIPMGIVI SLSICFLAYF
310 320 330 340 350 360
GVSSALTLMM PYYKLQPESP LPEAFTYVGW EPARYLVAIG SLCALSTSLL GSMFPMPRVI
370 380 390 400 410 420
YAMAEDGLLF RVLARVHNGT HTPIVATVVS GVIAAFMAFL FELTDLVDLM SIGTLLAYSL
430 440 450 460 470 480
VSICVLILRY QPDQEMKNGE EEVELQEERT LEAEKLTVQA LFCQVDSIPT LLSGRIVYVC
490 500 510 520 530 540
SSLLAVLLTV LCLVLTWWTT PLHSGDPVWV TVVVLILGLI LGISGVIWRQ PQNRTPLHFK
550 560 570 580 590 600
VPVVPLLPLV SIFVNVYLMM QMTADTWARF GVWMLIGFAI YFGYGIQHSV EEVKNHQTLP
610
KTRPQTIDLD LTTSCVHSI