Q09143
PR
Gene name |
Slc7a1 |
Protein name |
High affinity cationic amino acid transporter 1 |
Names |
CAT-1, CAT1, Ecotropic retroviral leukemia receptor, Ecotropic retrovirus receptor, ERR, EcoR, Solute carrier family 7 member 1, System Y+ basic amino acid transporter |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:11987 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q09143
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q09143-F1 | Predicted | AlphaFoldDB |
31 variants for Q09143
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388818863 | 2 | G>C | No | EVA | |
| rs3388807290 | 36 | D>Y | No | EVA | |
| rs3388796451 | 48 | A>V | No | EVA | |
| rs3388802630 | 81 | G>C | No | EVA | |
| rs3395657288 | 91 | V>L | No | EVA | |
| rs3396338225 | 92 | P>T | No | EVA | |
| rs3388807764 | 117 | L>M | No | EVA | |
| rs3396129361 | 223 | N>I | No | EVA | |
| rs3396434798 | 223 | N>Y | No | EVA | |
| rs3388781499 | 230 | D>Y | No | EVA | |
| rs3388807780 | 234 | K>E | No | EVA | |
| rs3388781459 | 244 | G>R | No | EVA | |
| rs3388799456 | 268 | T>A | No | EVA | |
| rs3388796442 | 274 | N>T | No | EVA | |
| rs3396359920 | 276 | Q>* | No | EVA | |
| rs3396537162 | 276 | Q>EWPSGGS* | No | EVA | |
| rs3388812601 | 296 | G>V | No | EVA | |
| rs3396356199 | 315 | P>Q | No | EVA | |
| rs3396434816 | 325 | W>R | No | EVA | |
| rs3396338159 | 330 | Y>C | No | EVA | |
| rs3396218135 | 334 | I>N | No | EVA | |
| rs3396365262 | 339 | A>V | No | EVA | |
| rs3388799492 | 394 | F>S | No | EVA | |
| rs3388799535 | 395 | L>I | No | EVA | |
| rs3388813129 | 408 | G>D | No | EVA | |
| rs3411762409 | 443 | L>P | No | EVA | |
| rs45727037 | 494 | G>S | No | EVA | |
| rs52545907 | 498 | A>T | No | EVA | |
| rs233432164 | 551 | F>L | No | EVA | |
| rs249035926 | 573 | Q>H | No | EVA | |
| rs3388791924 | 596 | Y>* | No | EVA |
No associated diseases with Q09143
6 regional properties for Q09143
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Twin-arginine translocation pathway, signal sequence | 1 - 34 | IPR006311 |
| domain | TolB, N-terminal | 39 - 145 | IPR007195 |
| repeat | WD40-like beta propeller | 257 - 289 | IPR011659-1 |
| repeat | WD40-like beta propeller | 298 - 333 | IPR011659-2 |
| repeat | WD40-like beta propeller | 342 - 373 | IPR011659-3 |
| repeat | WD40-like beta propeller | 385 - 415 | IPR011659-4 |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| basal plasma membrane | The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| basolateral plasma membrane | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| amino acid transmembrane transporter activity | Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. |
| basic amino acid transmembrane transporter activity | Enables the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have side chains with a positive charge at pH 7.3. |
| L-arginine transmembrane transporter activity | Enables the transfer of L-arginine from one side of a membrane to the other. |
| L-histidine transmembrane transporter activity | Enables the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid. |
| L-lysine transmembrane transporter activity | Enables the transfer of L-lysine from one side of a membrane to the other. L-lysine is 2,6-diaminohexanoic acid. |
| L-ornithine transmembrane transporter activity | Enables the transfer of L-ornithine from one side of a membrane to the other. L-ornithine is 2,5-diaminopentanoic acid. |
| virus receptor activity | Combining with a virus component and mediating entry of the virus into the cell. |
11 GO annotations of biological process
| Name | Definition |
|---|---|
| amino acid import across plasma membrane | The directed movement of an amino acid from outside of a cell, across the plasma membrane and into the cytosol. |
| amino acid transport | The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| L-amino acid transport | The directed movement of L-enantiomer amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| L-arginine import across plasma membrane | The directed movement of L-arginine from outside of a cell, across the plasma membrane and into the cytosol. |
| L-arginine transmembrane transport | The directed movement of L-arginine across a membrane. |
| L-histidine import across plasma membrane | The directed movement of L-histidine from outside of a cell, across the plasma membrane and into the cytosol. |
| L-ornithine transmembrane transport | The directed movement of L-ornithine across a membrane. |
| lysine transport | The directed movement of lysine, 2,6-diaminohexanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| ornithine transport | The directed movement of ornithine, 2,5-diaminopentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| positive regulation of T cell proliferation | Any process that activates or increases the rate or extent of T cell proliferation. |
| regulation of TOR signaling | Any process that modulates the frequency, rate or extent of TOR signaling. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8WY07 | SLC7A3 | Cationic amino acid transporter 3 | Homo sapiens (Human) | PR |
| P30825 | SLC7A1 | High affinity cationic amino acid transporter 1 | Homo sapiens (Human) | PR |
| P70423 | Slc7a3 | Cationic amino acid transporter 3 | Mus musculus (Mouse) | PR |
| O08812 | Slc7a3 | Cationic amino acid transporter 3 | Rattus norvegicus (Rat) | PR |
| P30823 | Slc7a1 | High affinity cationic amino acid transporter 1 | Rattus norvegicus (Rat) | PR |
| Q84MA5 | CAT1 | Cationic amino acid transporter 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LZ20 | CAT6 | Cationic amino acid transporter 6, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q5PR34 | slc7a2 | Cationic amino acid transporter 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGCKNLLGLG | QQMLRRKVVD | CSREESRLSR | CLNTYDLVAL | GVGSTLGAGV | YVLAGAVARE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NAGPAIVISF | LIAALASVLA | GLCYGEFGAR | VPKTGSAYLY | SYVTVGELWA | FITGWNLILS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YIIGTSSVAR | AWSATFDELI | GKPIGEFSRQ | HMALNAPGVL | AQTPDIFAVI | IIIILTGLLT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LGVKESAMVN | KIFTCINVLV | LCFIVVSGFV | KGSIKNWQLT | EKNFSCNNND | TNVKYGEGGF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MPFGFSGVLS | GAATCFYAFV | GFDCIATTGE | EVKNPQKAIP | VGIVASLLIC | FIAYFGVSAA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LTLMMPYFCL | DIDSPLPGAF | KHQGWEEAKY | AVAIGSLCAL | STSLLGSMFP | MPRVIYAMAE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DGLLFKFLAK | INNRTKTPVI | ATVTSGAIAA | VMAFLFELKD | LVDLMSIGTL | LAYSLVAACV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LVLRYQPEQP | NLVYQMARTT | EELDRVDQNE | LVSASESQTG | FLPVAEKFSL | KSILSPKNVE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PSKFSGLIVN | ISAGLLAALI | ITVCIVAVLG | REALAEGTLW | AVFVMTGSVL | LCMLVTGIIW |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RQPESKTKLS | FKVPFVPVLP | VLSIFVNIYL | MMQLDQGTWV | RFAVWMLIGF | TIYFGYGIWH |
| 610 | 620 | ||||
| SEEASLAAGQ | AKTPDSNLDQ | CK |