Q803D2

PR
Gene name
pafah1b1b (lis1a)
Protein name
Lissencephaly-1 homolog B
Names
Platelet-activating factor acetylhydrolase IB subunit alpha b
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:394247
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-129 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q803D2

Entry ID Method Resolution Chain Position Source
AF-Q803D2-F1 Predicted AlphaFoldDB

No variants for Q803D2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q803D2

No associated diseases with Q803D2

9 regional properties for Q803D2

Type Name Position InterPro Accession
repeat WD40 repeat 97 - 410 IPR001680
domain LIS1 homology motif 7 - 39 IPR006594
conserved_site WD40 repeat, conserved site 165 - 179 IPR019775-1
conserved_site WD40 repeat, conserved site 207 - 221 IPR019775-2
conserved_site WD40 repeat, conserved site 311 - 325 IPR019775-3
conserved_site WD40 repeat, conserved site 395 - 409 IPR019775-4
repeat G-protein beta WD-40 repeat 123 - 137 IPR020472-1
repeat G-protein beta WD-40 repeat 165 - 179 IPR020472-2
repeat G-protein beta WD-40 repeat 311 - 325 IPR020472-3

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytoskeleton
  • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
  • Localizes to the plus end of microtubules and to the centrosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

10 GO annotations of cellular component

Name Definition
1-alkyl-2-acetylglycerophosphocholine esterase complex An enzyme complex composed of two catalytic alpha subunits, which form a catalytic dimer, and a non-catalytic, regulatory beta subunit; the catalytic dimer may be an alpha1/alpha1 or alpha2/alpha2 homodimer, or an alpha1/alpha2 heterodimer. Modulates the action of platelet-activating factor (PAF).
axon cytoplasm Any cytoplasm that is part of a axon.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic microtubule Any microtubule in the cytoplasm of a cell.
kinetochore A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
microtubule associated complex Any multimeric complex connected to a microtubule.
microtubule organizing center An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.
neuron projection A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
nuclear envelope The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).

3 GO annotations of molecular function

Name Definition
dynein complex binding Binding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity.
microtubule plus-end binding Binding to the plus end of a microtubule.
protein heterodimerization activity Binding to a nonidentical protein to form a heterodimer.

12 GO annotations of biological process

Name Definition
apical protein localization Any process in which a protein is transported to, or maintained in, apical regions of the cell.
brain morphogenesis The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
establishment of mitotic spindle orientation A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures.
germ cell development The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.
microtubule organizing center organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow.
microtubule sliding The movement of one microtubule along another microtubule.
nuclear migration The directed movement of the nucleus to a specific location within a cell.
photoreceptor cell maintenance Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light.
reelin-mediated signaling pathway The series of molecular signals initiated by the binding of reelin (a secreted glycoprotein) to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
retrograde axonal transport The directed movement of organelles or molecules along microtubules from the cell periphery toward the cell body in nerve cell axons.
vesicle transport along microtubule The directed movement of a vesicle along a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination.

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P43033 PAFAH1B1 Platelet-activating factor acetylhydrolase IB subunit beta Bos taurus (Bovine) PR
B0LSW3 PAFAH1B1 Platelet-activating factor acetylhydrolase IB subunit beta Felis catus (Cat) (Felis silvestris catus) PR
Q9PTR5 PAFAH1B1 Lissencephaly-1 homolog Gallus gallus (Chicken) PR
Q5IS43 PAFAH1B1 Platelet-activating factor acetylhydrolase IB subunit alpha Pan troglodytes (Chimpanzee) PR
Q7KNS3 Lis-1 Lissencephaly-1 homolog Drosophila melanogaster (Fruit fly) PR
Q96DN5 TBC1D31 TBC1 domain family member 31 Homo sapiens (Human) PR
P43034 PAFAH1B1 Platelet-activating factor acetylhydrolase IB subunit beta Homo sapiens (Human) PR
P63005 Pafah1b1 Platelet-activating factor acetylhydrolase IB subunit beta Mus musculus (Mouse) PR
Q9GL51 PAFAH1B1 Platelet-activating factor acetylhydrolase IB subunit alpha Sus scrofa (Pig) PR
P63004 Pafah1b1 Platelet-activating factor acetylhydrolase IB subunit alpha Rattus norvegicus (Rat) PR
Q6NZH4 pafah1b1 Lissencephaly-1 homolog Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q7T394 pafah1b1a Lissencephaly-1 homolog A Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MVLSQRQRDE LNRAIADYLR SNGYEEAYST FKKEAELDVN DELDKKFAGL LEKKWTSVIR
70 80 90 100 110 120
LQKKVMELES KLNEAKEEIT LGGPVGQKRD PKEWIPRPPE KYALSGHRSP VTRVIFHPVF
130 140 150 160 170 180
SLMVSASEDA TIKVWDYEAG DFERTLKGHT DSVQDISFDQ TGKLLASCSA DMTIKLWDFQ
190 200 210 220 230 240
GFECIRTMHG HDHNVSSVAI MPNGDHIVSA SRDKTMKMWE VATGYCVKTF TGHREWVRMV
250 260 270 280 290 300
RPNQDGTLLA SCSNDQTVRV WVVATKECKA ELREHEHVVE CISWAPESAH PTISEATGSE
310 320 330 340 350 360
NKKSGKPGPF LLSGSRDKTI KMWDISTGMC LMTLVGHDNW VRGVLFHPGG RFVVSCADDK
370 380 390 400
TLRIWDYKNK RCMKTLSAHE HFVTSLDFHK ASPYVVTGSV DQTVKVWECR