Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q7KNS3

Entry ID Method Resolution Chain Position Source
AF-Q7KNS3-F1 Predicted AlphaFoldDB

No variants for Q7KNS3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7KNS3

No associated diseases with Q7KNS3

13 regional properties for Q7KNS3

Type Name Position InterPro Accession
repeat WD40 repeat 97 - 180 IPR001680-1
repeat WD40 repeat 182 - 263 IPR001680-2
repeat WD40 repeat 266 - 411 IPR001680-3
domain LIS1 homology motif 9 - 41 IPR006594
conserved_site WD40 repeat, conserved site 123 - 137 IPR019775-1
conserved_site WD40 repeat, conserved site 165 - 179 IPR019775-2
conserved_site WD40 repeat, conserved site 208 - 222 IPR019775-3
conserved_site WD40 repeat, conserved site 312 - 326 IPR019775-4
conserved_site WD40 repeat, conserved site 354 - 368 IPR019775-5
conserved_site WD40 repeat, conserved site 396 - 410 IPR019775-6
repeat G-protein beta WD-40 repeat 123 - 137 IPR020472-1
repeat G-protein beta WD-40 repeat 312 - 326 IPR020472-2
repeat G-protein beta WD-40 repeat 354 - 368 IPR020472-3

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytoskeleton
  • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
  • Cytoplasm, cytoskeleton, spindle pole
  • Chromosome, centromere, kinetochore
  • Localizes to the plus end of microtubules
  • Also localizes to the mitotic spindle poles from late prophase through to telophase and to kinetochore microtubules in metaphase
  • Localization to kinetochore microtubules is reduced in anaphase and telophase
  • In oocytes, it concentrates in the cortex from stage 5 of oogenesis
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

16 GO annotations of cellular component

Name Definition
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
axon cytoplasm Any cytoplasm that is part of a axon.
cell cortex The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
centrosome A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
cytoplasmic microtubule Any microtubule in the cytoplasm of a cell.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
dendrite A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
dynactin complex A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach.
dynein complex Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity.
growth cone The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
kinetochore A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
microtubule associated complex Any multimeric complex connected to a microtubule.
neuron projection A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
nuclear envelope The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
spindle pole Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.

2 GO annotations of molecular function

Name Definition
dynein complex binding Binding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity.
microtubule plus-end binding Binding to the plus end of a microtubule.

47 GO annotations of biological process

Name Definition
axo-dendritic transport The directed movement of organelles or molecules along microtubules in neuron projections.
axonal transport The directed movement of organelles or molecules along microtubules in axons.
border follicle cell migration The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster.
brain morphogenesis The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
centrosome localization Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell.
centrosome separation The process in which duplicated centrosome components move away from each other. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle.
chorion-containing eggshell pattern formation The regionalization process that gives rise to the structural pattern of a chorion-containing eggshell such as those found in insects.
clathrin-dependent endocytosis involved in vitellogenesis A clathrin-mediated endocytosis process whereby yolk proteins are internalized and trafficked through the endocytic pathway for yolk deposition.
cytoplasmic transport, nurse cell to oocyte The directed movement of cytoplasmic constituents synthesized in the nurse cells to the oocyte.
dendrite development The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure.
dendrite morphogenesis The process in which the anatomical structures of a dendrite are generated and organized.
establishment of mitotic spindle orientation A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures.
female germ-line cyst formation Formation of a group of interconnected cells derived from a single female gonial founder cell.
fusome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome, a large intracellular spectrin-rich structure found in insect germline cells and mammalian hematopoietic cells.
germ cell development The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.
germarium-derived cystoblast division The four rounds of incomplete mitosis undergone by a cystoblast to form a 16-cell cyst of interconnected cells within a germarium. Within the cyst, one cell differentiates into an oocyte while the rest become nurse cells. An example of this process is found in Drosophila melanogaster.
germarium-derived oocyte differentiation The process in which one relatively unspecialized immature cystocyte of the germ-line cyst in the germarium acquires the specialized features of an oocyte. An example of this process can be found in Drosophila melanogaster.
germarium-derived oocyte fate determination The cell fate determination process in which a germarium-derived cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this is found in Drosophila melanogaster.
intracellular mRNA localization Any process in which mRNA is transported to, or maintained in, a specific location within the cell.
intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
kinetochore organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
microtubule organizing center organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow.
microtubule sliding The movement of one microtubule along another microtubule.
muscle cell cellular homeostasis The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state.
mushroom body development The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells.
neuroblast proliferation The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron.
nuclear migration The directed movement of the nucleus to a specific location within a cell.
nuclear migration along microtubule The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins.
nucleus localization Any process in which the nucleus is transported to, and/or maintained in, a specific location within the cell.
oocyte fate determination The process in which a cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed.
oocyte nucleus migration involved in oocyte dorsal/ventral axis specification The directed movement of the oocyte nucleus within the cell as part of the establishment and maintenance of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster.
oogenesis The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
ovarian fusome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome of ovarian cells, an organelle derived from the spectrosome. It anchors the mitotic spindle pole to provide orientation during cystoblast cell divisions.
photoreceptor cell axon guidance The chemotaxis process that directs the migration of a photoreceptor cell axon growth cone to its target in the optic lobe in response to a combination of attractive and repulsive cues.
positive regulation of axonogenesis Any process that activates or increases the frequency, rate or extent of axonogenesis.
positive regulation of BMP signaling pathway Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity.
positive regulation of mitotic metaphase/anaphase transition Any process that activates or increases the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.
protein localization Any process in which a protein is transported to, or maintained in, a specific location.
protein localization to kinetochore Any process in which a protein is transported to, or maintained at, the kinetochore.
regulation of dendrite morphogenesis Any process that modulates the frequency, rate or extent of dendrite morphogenesis.
retrograde axonal transport The directed movement of organelles or molecules along microtubules from the cell periphery toward the cell body in nerve cell axons.
rhabdomere development The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments.
spermatogenesis The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.
spindle assembly The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart.
stem cell population maintenance The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types.
transport along microtubule The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity.
vesicle transport along microtubule The directed movement of a vesicle along a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination.

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P43033 PAFAH1B1 Platelet-activating factor acetylhydrolase IB subunit beta Bos taurus (Bovine) PR
B0LSW3 PAFAH1B1 Platelet-activating factor acetylhydrolase IB subunit beta Felis catus (Cat) (Felis silvestris catus) PR
Q9PTR5 PAFAH1B1 Lissencephaly-1 homolog Gallus gallus (Chicken) PR
Q5IS43 PAFAH1B1 Platelet-activating factor acetylhydrolase IB subunit alpha Pan troglodytes (Chimpanzee) PR
Q96DN5 TBC1D31 TBC1 domain family member 31 Homo sapiens (Human) PR
P43034 PAFAH1B1 Platelet-activating factor acetylhydrolase IB subunit beta Homo sapiens (Human) PR
P63005 Pafah1b1 Platelet-activating factor acetylhydrolase IB subunit beta Mus musculus (Mouse) PR
Q9GL51 PAFAH1B1 Platelet-activating factor acetylhydrolase IB subunit alpha Sus scrofa (Pig) PR
P63004 Pafah1b1 Platelet-activating factor acetylhydrolase IB subunit alpha Rattus norvegicus (Rat) PR
Q6NZH4 pafah1b1 Lissencephaly-1 homolog Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q7T394 pafah1b1a Lissencephaly-1 homolog A Danio rerio (Zebrafish) (Brachydanio rerio) PR
Q803D2 pafah1b1b Lissencephaly-1 homolog B Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MKMVLSQRQR EELNQAIADY LGSNGYADSL ETFRKEADLS TEVEKKFGGL LEKKWTSVIR
70 80 90 100 110 120
LQKKVMELEA KLTEAEKEVI EGAPTKNKRT PGEWIPRPPE KFSLTGHRAS ITRVIFHPIF
130 140 150 160 170 180
ALMVSASEDA TIRIWDFETG EYERSLKGHT DSVQDVAFDA QGKLLASCSA DLSIKLWDFQ
190 200 210 220 230 240
QSYECIKTMH GHDHNVSSVA FVPAGDYVLS ASRDRTIKMW EVATGYCVKT YTGHREWVRM
250 260 270 280 290 300
VRVHIEGSIF ATCSNDQTIR VWLTNSKDCK VELRDHEHTV ECIAWAPEAA ASAINEAAGA
310 320 330 340 350 360
DNKKGHHQGP FLASGSRDKT IRIWDVSVGL CLLTLSGHDN WVRGLAFHPG GKYLVSASDD
370 380 390 400 410
KTIRVWDLRN KRCMKTLYAH QHFCTSIDFH KAHPYVISGS VDQTVKVWEC R