Q6Z6M4

PR
Gene name
ICL
Protein name
Isocitrate lyase
Names
ICL, Isocitrase, Isocitratase
Species
Oryza sativa subsp japonica (Rice)
KEGG Pathway
osa:4343441
EC number
4.1.3.1: Oxo-acid-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-49 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6Z6M4

Entry ID Method Resolution Chain Position Source
AF-Q6Z6M4-F1 Predicted AlphaFoldDB

No variants for Q6Z6M4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6Z6M4

No associated diseases with Q6Z6M4

2 regional properties for Q6Z6M4

Type Name Position InterPro Accession
conserved_site Isocitrate lyase/phosphorylmutase, conserved site 211 - 216 IPR018523
domain ICL/PEPM domain 70 - 489 IPR039556

Functions

Description
EC Number 4.1.3.1 Oxo-acid-lyases
Subcellular Localization
  • Glyoxysome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
glyoxysome A specialized form of peroxisome that contains the enzymes of the glyoxylate pathway. The glyoxysome is found in some plant cells, notably the cells of germinating seeds.

2 GO annotations of molecular function

Name Definition
isocitrate lyase activity Catalysis of the reaction: isocitrate = glyoxylate + succinate.
metal ion binding Binding to a metal ion.

2 GO annotations of biological process

Name Definition
glyoxylate cycle A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate.
tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q12031 ICL2 Mitochondrial 2-methylisocitrate lyase ICL2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P28240 ICL1 Isocitrate lyase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P17069 Isocitrate lyase Gossypium hirsutum (Upland cotton) (Gossypium mexicanum) PR
P49296 Isocitrate lyase Cucumis sativus (Cucumber) PR
Q10663 icl-1 Bifunctional glyoxylate cycle protein Caenorhabditis elegans PR
P45456 ICL1 Isocitrate lyase 1 Glycine max (Soybean) (Glycine hispida) PR
P45457 ICL2 Isocitrate lyase 2 Glycine max (Soybean) (Glycine hispida) PR
P28297 ICL Isocitrate lyase Arabidopsis thaliana (Mouse-ear cress) PR
P49297 Isocitrate lyase Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
10 20 30 40 50 60
MSSPFSVPSL IMEEEGRFEA EVAEVEAWWG TDRFRLTKRP YTARDVALLR GTLRQSYASG
70 80 90 100 110 120
DMAKKLWRTL RAHQANGTAS RTFGALDPVQ VAMMAKHLDT VYVSGWQCSS THTSTNEPGP
130 140 150 160 170 180
DLADYPYDTV PNKVEHLFFA QLYHDRKQRE ARMSMSRAER AHEPYVDYLK PIIADGDTGF
190 200 210 220 230 240
GGATATVKLC KLFVERGAAG VHLEDQSSVT KKCGHMAGKV LVAVSEHVNR LVAARLQFDI
250 260 270 280 290 300
MGVETVLVAR TDAVAATLIQ TNVDARDHQF ILGATNPRLR NRSLAAVLSD AMSAGKNGRE
310 320 330 340 350 360
LQAIEDEWLA TAQLKTFSDC VRDAIASLNA TDADKQRKLQ EWSAATSHDK CVPLEQARDI
370 380 390 400 410 420
AAGLGVTSLF WDWDLPRTRE GFYRFRGSVA AAVVRGRAFA PHADVLWMET SSPNIAECTA
430 440 450 460 470 480
FAEGVRAASP GAMLAYNLSP SFNWDASGMT DADMSEFIPR VARLGYVWQF ITLAGFHADA
490 500 510 520 530 540
LVTDTFARDF ARRGMLAYVE RIQREERSNG VETLQHQKWS GANFYDRVLK TVQGGISSTA
550 560 570
AMGKGVTEEQ FKGSWTGPGS ESSSHVLAKS RM