P45457

PR
Gene name
ICL2
Protein name
Isocitrate lyase 2
Names
ICL 2, Isocitrase 2, Isocitratsysase 2
Species
Glycine max (Soybean) (Glycine hispida)
KEGG Pathway
EC number
4.1.3.1: Oxo-acid-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

94-170 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P45457

Entry ID Method Resolution Chain Position Source
AF-P45457-F1 Predicted AlphaFoldDB

No variants for P45457

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P45457

No associated diseases with P45457

2 regional properties for P45457

Type Name Position InterPro Accession
conserved_site Isocitrate lyase/phosphorylmutase, conserved site 193 - 198 IPR018523
domain ICL/PEPM domain 48 - 239 IPR039556

Functions

Description
EC Number 4.1.3.1 Oxo-acid-lyases
Subcellular Localization
  • Glyoxysome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
glyoxysome A specialized form of peroxisome that contains the enzymes of the glyoxylate pathway. The glyoxysome is found in some plant cells, notably the cells of germinating seeds.

2 GO annotations of molecular function

Name Definition
isocitrate lyase activity Catalysis of the reaction: isocitrate = glyoxylate + succinate.
metal ion binding Binding to a metal ion.

2 GO annotations of biological process

Name Definition
glyoxylate cycle A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate.
tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q12031 ICL2 Mitochondrial 2-methylisocitrate lyase ICL2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P28240 ICL1 Isocitrate lyase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P17069 Isocitrate lyase Gossypium hirsutum (Upland cotton) (Gossypium mexicanum) PR
P49296 Isocitrate lyase Cucumis sativus (Cucumber) PR
Q6Z6M4 ICL Isocitrate lyase Oryza sativa subsp japonica (Rice) PR
Q10663 icl-1 Bifunctional glyoxylate cycle protein Caenorhabditis elegans PR
P45456 ICL1 Isocitrate lyase 1 Glycine max (Soybean) (Glycine hispida) PR
P28297 ICL Isocitrate lyase Arabidopsis thaliana (Mouse-ear cress) PR
P49297 Isocitrate lyase Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
10 20 30 40 50 60
EAEVAEVQAW WNSERFRLTK RPYTARDVVS LRGNLRQTYA SNEMAKKLWC LLKNHQANGT
70 80 90 100 110 120
ASRTFGALDP VQVTQMAKHL DTIYVSGWQC SATHTTSNEP GPDLADYPYD TVPNKVEHLF
130 140 150 160 170 180
FAQQYHDRKQ REERMRMSRE ERARTPYVDY LRPIIADGDT GFGGTTATVK LCKLFVERGA
190 200 210 220 230 240
AGIHIEDQSS VTKKCGHMAG KVLVAISEHI NRLVAARLQF DVMGVETVLV ARTDAEAANL
250 260 270 280 290 300
IQSNIDTRDH QFILGVTNPN LKGKSLATLM QQGMAAGKSG AELQALEDEW LSKAQLKTLS
310 320 330 340 350 360
EAVVEAIERQ NIGEEEKRRK LNEWMHHSSY ERCLSNEEGR EIAEKLGVRN LFWDWDLPRT
370 380 390 400 410 420
REGFYRFKGS VIASVVRGWA FSPHADVIWM ETASPNVIEC TQFSEGVRSK HPQMMLGYNL
430 440 450 460 470 480
SPSFNWDASG MSDEQMRDFI PKIAKLGYVW QFITVGGLHS NALITSTFAR DFANRGMLAY
490 500 510 520 530 540
VERIQREERN NGVDTLAHQK WAGANYYDRY LKTVQGGVAS TAAMGKGVTE EQFKESWTRP
550
GAVEIDRGSI VVAKARM