P28297
Gene name |
ICL |
Protein name |
Isocitrate lyase |
Names |
ALP, Aspergillopeptidase B, Aspergillus proteinase B, Elastase, Elastinolytic serine proteinase, Oryzin, ICL, Isocitrase, Isocitratsysase |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G21720 |
EC number |
4.1.3.1: Oxo-acid-lyases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P28297
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P28297-F1 | Predicted | AlphaFoldDB |
18 variants for P28297
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_3_7655863_G_A | 4 | S>F | No | 1000Genomes | |
| ENSVATH05880260 | 5 | F>L | No | 1000Genomes | |
| ENSVATH10835500 | 30 | S>I | No | 1000Genomes | |
| ENSVATH05880237 | 164 | P>S | No | 1000Genomes | |
| tmp_3_7654641_A_G | 165 | F>S | No | 1000Genomes | |
| ENSVATH05880229 | 310 | G>S | No | 1000Genomes | |
| ENSVATH10835399 | 311 | S>L | No | 1000Genomes | |
| ENSVATH05880228 | 312 | A>S | No | 1000Genomes | |
| tmp_3_7654147_G_T | 330 | L>I | No | 1000Genomes | |
| ENSVATH00338700 | 340 | S>N | No | 1000Genomes | |
| ENSVATH05880214 | 349 | E>D | No | 1000Genomes | |
| tmp_3_7653754_G_T | 369 | L>I | No | 1000Genomes | |
| ENSVATH13961952 | 414 | D>E | No | 1000Genomes | |
| tmp_3_7653573_G_A | 429 | T>I | No | 1000Genomes | |
| tmp_3_7653565_C_T | 432 | V>I | No | 1000Genomes | |
| tmp_3_7653505_G_T | 452 | Q>K | No | 1000Genomes | |
| tmp_3_7652861_C_G | 553 | E>D | No | 1000Genomes | |
| tmp_3_7652800_A_G | 574 | S>P | No | 1000Genomes |
No associated diseases with P28297
Functions
| Description | ||
|---|---|---|
| EC Number | 4.1.3.1 | Oxo-acid-lyases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| glyoxysome | A specialized form of peroxisome that contains the enzymes of the glyoxylate pathway. The glyoxysome is found in some plant cells, notably the cells of germinating seeds. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| isocitrate lyase activity | Catalysis of the reaction: isocitrate = glyoxylate + succinate. |
| metal ion binding | Binding to a metal ion. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| glyoxylate cycle | A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate. |
| tricarboxylic acid cycle | A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q12031 | ICL2 | Mitochondrial 2-methylisocitrate lyase ICL2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P28240 | ICL1 | Isocitrate lyase | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P17069 | Isocitrate lyase | Gossypium hirsutum (Upland cotton) (Gossypium mexicanum) | PR | |
| P49296 | Isocitrate lyase | Cucumis sativus (Cucumber) | PR | |
| Q6Z6M4 | ICL | Isocitrate lyase | Oryza sativa subsp japonica (Rice) | PR |
| Q10663 | icl-1 | Bifunctional glyoxylate cycle protein | Caenorhabditis elegans | PR |
| P45456 | ICL1 | Isocitrate lyase 1 | Glycine max (Soybean) (Glycine hispida) | PR |
| P45457 | ICL2 | Isocitrate lyase 2 | Glycine max (Soybean) (Glycine hispida) | PR |
| P49297 | Isocitrate lyase | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAASFSVPSM | IMEEEGRFEA | EVAEVQTWWS | SERFKLTRRP | YTARDVVALR | GHLKQGYASN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EMAKKLWRTL | KSHQANGTAS | RTFGALDPVQ | VTMMAKHLDT | IYVSGWQCSS | THTSTNEPGP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DLADYPYDTV | PNKVEHLFFA | QQYHDRKQRE | ARMSMSREER | TKTPFVDYLK | PIIADGDTGF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GGTTATVKLC | KLFVERGAAG | VHIEDQSSVT | KKCGHMAGKV | LVAVSEHINR | LVAARLQFDV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MGTETVLVAR | TDAVAATLIQ | SNIDARDHQF | ILGATNPSLR | GKSLSSLLAE | GMTVGKNGPA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LQSIEDQWLG | SAGLMTFSEA | VVQAIKRMNL | NENEKNQRLS | EWLTHARYEN | CLSNEQGRVL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AAKLGVTDLF | WDWDLPRTRE | GFYRFQGSVA | AAVVRGWAFA | QIADIIWMET | ASPDLNECTQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FAEGIKSKTP | EVMLAYNLSP | SFNWDASGMT | DQQMVEFIPR | IARLGYCWQF | ITLAGFHADA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LVVDTFAKDY | ARRGMLAYVE | RIQREERTHG | VDTLAHQKWS | GANYYDRYLK | TVQGGISSTA |
| 550 | 560 | 570 | |||
| AMGKGVTEEQ | FKESWTRPGA | DGMGEGTSLV | VAKSRM |