Q12031

PR
Gene name
ICL2 (YPR006C, LPZ6C, YP9723.06C)
Protein name
Mitochondrial 2-methylisocitrate lyase ICL2
Names
Methylisocitrate lyase
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YPR006C
EC number
4.1.3.30: Oxo-acid-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-119 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q12031

Entry ID Method Resolution Chain Position Source
AF-Q12031-F1 Predicted AlphaFoldDB

8 variants for Q12031

Variant ID(s) Position Change Description Diseaes Association Provenance
s16-568976 6 N>K No SGRP
s16-568863 44 F>S No SGRP
s16-568831 55 E>Q No SGRP
s16-568387 203 M>L No SGRP
s16-568027 323 A>T No SGRP
s16-568009 329 K>Q No SGRP
s16-567776 406 M>I No SGRP
s16-567576 473 D>G No SGRP

No associated diseases with Q12031

2 regional properties for Q12031

Type Name Position InterPro Accession
conserved_site Isocitrate lyase/phosphorylmutase, conserved site 211 - 216 IPR018523
domain ICL/PEPM domain 66 - 489 IPR039556

Functions

Description
EC Number 4.1.3.30 Oxo-acid-lyases
Subcellular Localization
  • Mitochondrion matrix
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

2 GO annotations of molecular function

Name Definition
isocitrate lyase activity Catalysis of the reaction: isocitrate = glyoxylate + succinate.
methylisocitrate lyase activity Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate.

1 GO annotations of biological process

Name Definition
propionate catabolic process, 2-methylcitrate cycle The chemical reactions and pathways resulting in the breakdown of propionate that occurs in the 2-methylcitrate cycle.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P28240 ICL1 Isocitrate lyase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P17069 Isocitrate lyase Gossypium hirsutum (Upland cotton) (Gossypium mexicanum) PR
Q6Z6M4 ICL Isocitrate lyase Oryza sativa subsp japonica (Rice) PR
Q10663 icl-1 Bifunctional glyoxylate cycle protein Caenorhabditis elegans PR
P45457 ICL2 Isocitrate lyase 2 Glycine max (Soybean) (Glycine hispida) PR
P45456 ICL1 Isocitrate lyase 1 Glycine max (Soybean) (Glycine hispida) PR
P28297 ICL Isocitrate lyase Arabidopsis thaliana (Mouse-ear cress) PR
P49297 Isocitrate lyase Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
10 20 30 40 50 60
MITMINNKTF NRKTTGTLKK LVLSSDKSLR RSFNGASSTK DFVFSESSKV EEWWESARFK
70 80 90 100 110 120
NISRPYSATD VVKHRGSLPA NTSIYPSSYQ ARKLFNLLEE NFKNGTPLHT LGVIDPVQMS
130 140 150 160 170 180
QLARCRNIKV AYISGWACSS TLVGSTNEVS PDFGDYPYDT VPNQVERIFK AQQLHDRKAF
190 200 210 220 230 240
LEASIKGSTP VDYLKPIIAD ADMGHGGPTT VMKVAKLFAE KGAAGIHLED QMVGGKRCGH
250 260 270 280 290 300
LSGAVLVPTA THLMRLISTR FQWDIMGTEN LVIARTDSCN GKLLSSSSDP RDHEFIRGII
310 320 330 340 350 360
RDNVVPWSEK LIEMEDKKIP NSAIADMEKE WYHENELFTF EEALEKQFTA SEFESYKEKK
370 380 390 400 410 420
EDLMVNKLGR AYLSLREMKL LAQEVTPLKK IIFDWDAPRT KEGYYMFNGC IEAAIRRSLV
430 440 450 460 470 480
FAPYSDMIWL ETKTPDLEQA RSFSRKIHKQ LPATKLVYNL SPSFNWSAHG FDDKALKSFV
490 500 510 520 530 540
WDLAKEGFTL QLVSLAGLHS DGVSFWELAN SFQSDGMKAY VEKVQKREKE TNCDIMTHQL
550 560 570
WSGAEYVDSL MKVVQNGASS QTLSTSGESF TETQF