Q10663

PR
Gene name
icl-1 (gei-7, C05E4.9)
Protein name
Bifunctional glyoxylate cycle protein
Names
Gex-3-interacting protein 7
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_C05E4.9
EC number
2.3.3.9: Acyl groups converted into alkyl groups on transfer
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

386-473 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q10663

Entry ID Method Resolution Chain Position Source
AF-Q10663-F1 Predicted AlphaFoldDB

No variants for Q10663

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q10663

No associated diseases with Q10663

3 regional properties for Q10663

Type Name Position InterPro Accession
conserved_site Isocitrate lyase/phosphorylmutase, conserved site 188 - 193 IPR018523
conserved_site Malate synthase, conserved site 701 - 716 IPR019830
domain ICL/PEPM domain 53 - 366 IPR039556

Functions

Description
EC Number 2.3.3.9 Acyl groups converted into alkyl groups on transfer
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

2 GO annotations of molecular function

Name Definition
isocitrate lyase activity Catalysis of the reaction: isocitrate = glyoxylate + succinate.
malate synthase activity Catalysis of the reaction: acetyl-CoA + glyoxylate + H(2)O = (S)-malate + CoA + H(+).

3 GO annotations of biological process

Name Definition
determination of adult lifespan The pathways that regulate the duration of the adult phase of the life-cycle of an animal.
glyoxylate cycle A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate.
tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q12031 ICL2 Mitochondrial 2-methylisocitrate lyase ICL2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P28240 ICL1 Isocitrate lyase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P17069 Isocitrate lyase Gossypium hirsutum (Upland cotton) (Gossypium mexicanum) PR
P49296 Isocitrate lyase Cucumis sativus (Cucumber) PR
Q6Z6M4 ICL Isocitrate lyase Oryza sativa subsp japonica (Rice) PR
P45456 ICL1 Isocitrate lyase 1 Glycine max (Soybean) (Glycine hispida) PR
P45457 ICL2 Isocitrate lyase 2 Glycine max (Soybean) (Glycine hispida) PR
P28297 ICL Isocitrate lyase Arabidopsis thaliana (Mouse-ear cress) PR
P49297 Isocitrate lyase Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
10 20 30 40 50 60
MSSAAKNFYQ VVKSAPKGRF KGIKRDYTVE DVLKLRGSID IDYTLATRGA NKLWQLLHTE
70 80 90 100 110 120
PFVPALGAQT GNQAVQMVRA GLKAIYLSGW QVAADANSAG DMYPDQSLYP ANSGPELAKR
130 140 150 160 170 180
INRSLRRADQ IEACEAEDYL AQRDWYAPIV ADAEAGFGGA LNCFELMKAY IEAGAAGVHY
190 200 210 220 230 240
EDQLGSEKKC GHMGGKVLIP TAQHIRHLNA SRLAADVCGV PTIIVARTDA ESSRLLTSDI
250 260 270 280 290 300
DPRDHPYIDY EAGRTIEGFY RLKDSTAIQY CIDRAIQYAP YTDLIWMETS HPTIADAREF
310 320 330 340 350 360
AEGVHKQYPD KMFAYNCSPS FNWKKHLSPS QMEKFQKELG AMGFKYQFIT LAGYHANSYS
370 380 390 400 410 420
MFDLARNYKE KGMLAYSGLQ EGEFAAEKHG YTAVKHQREV GTGYFDAVSR AVTGGLSSTT
430 440 450 460 470 480
ALSGSTEEAQ FQTAVASQDE EILSLTAQNV AGDEKILTPD ALRFLHDLNT EFNPRRLRLL
490 500 510 520 530 540
SKRNQVQADI NNSLWFPDFN KETEVLRSDQ GWKGAEIPRD LQDRRVEITG PTDRKMVINA
550 560 570 580 590 600
MNSGANVFMA DFEDSNSPTW RNQLEGQINL YDAVRNNISY THPTTKKEYT LNEKHAVLKV
610 620 630 640 650 660
RPRGWHLPEK HVLIHNQPTS GSLFDFGLFV FHNAKALIAQ GSGPYFYLPK LQSAEEAQLW
670 680 690 700 710 720
ADVFKYTEDK LGLARGTIKC TVLIEHLLAS FQLHEIIHAL KDNIVGLNCG RWDYIFSYIK
730 740 750 760 770 780
TFQNHRKFLL PDRFQIGMTA PFMRNYSLEV IKACHLRGIH AMGGMAAQIP IKHDQVANDK
790 800 810 820 830 840
AFALVRADKE REATDGHDGT WVAHPGLVPL AKRVFDQMMP KPNQISKNLT RANCTKEDLT
850 860 870 880 890 900
VIPEGTRTEA GFRHNISVTL GYLDSWLRGT GCVPLYNLME DAATAEISRA QLWQWLHHDA
910 920 930 940 950 960
KLEDGRTIDA GLVKQTIAAE TERRLIRAGS VVNRIPEAAD LLEKFVTEEK MSDFLTTDAY
DRLVSEGY