Q64511

PR
Gene name
Top2b
Protein name
DNA topoisomerase 2-beta
Names
DNA topoisomerase II, beta isozyme
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:21974
EC number
5.6.2.2: Enzymes altering nucleic acid conformation
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1289-1608 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q64511

Entry ID Method Resolution Chain Position Source
AF-Q64511-F1 Predicted AlphaFoldDB

44 variants for Q64511

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3404918274 19 A>V No EVA
rs231744053 32 D>E No EVA
rs3389321453 55 R>L No EVA
rs3389304272 64 E>D No EVA
rs3404918291 89 G>D No EVA
rs3389308826 104 N>K No EVA
rs3389279649 203 W>C No EVA
rs234127814 217 H>Y No EVA
rs49272973 252 A>V No EVA
rs3389304281 288 L>M No EVA
rs3389308707 305 R>K No EVA
rs3389233894 306 W>* No EVA
rs3389298712 326 I>F No EVA
rs3389289625 379 N>S No EVA
rs1132427678 391 T>P No EVA
rs1133021734 392 L>M No EVA
rs1134997830 396 S>R No EVA
rs3404534659 396 S>T No EVA
rs1131888896 398 G>R No EVA
rs1132945911 399 S>Y No EVA
rs3405061173 456 A>S No EVA
rs3389308634 477 L>I No EVA
rs3389270989 484 V>L No EVA
rs3389305399 494 P>L No EVA
rs3389312743 619 I>L No EVA
rs3389300846 756 L>Q No EVA
rs3389303452 766 Y>H No EVA
rs3389308825 868 G>V No EVA
rs3389312685 877 D>V No EVA
rs3389312690 888 M>V No EVA
rs3389232417 898 L>R No EVA
rs3389270977 900 N>Y No EVA
rs3389298683 925 V>E No EVA
rs3389298697 927 R>S No EVA
rs3389308674 1101 E>K No EVA
rs46976423 1168 S>A No EVA
rs3389308904 1188 E>G No EVA
rs3389305354 1191 E>G No EVA
rs3389305424 1209 G>R No EVA
rs3389316701 1262 F>I No EVA
rs13469722 1284 P>H No EVA
rs235426254 1503 I>V No EVA
rs3389312691 1550 K>N No EVA
rs3389232363 1551 P>L No EVA

No associated diseases with Q64511

5 regional properties for Q64511

Type Name Position InterPro Accession
domain TolB, N-terminal 24 - 121 IPR007195
repeat WD40-like beta propeller 199 - 223 IPR011659-1
repeat WD40-like beta propeller 237 - 272 IPR011659-2
repeat WD40-like beta propeller 281 - 315 IPR011659-3
repeat WD40-like beta propeller 369 - 396 IPR011659-4

Functions

Description
EC Number 5.6.2.2 Enzymes altering nucleic acid conformation
Subcellular Localization
  • Nucleus, nucleolus
  • Nucleus, nucleoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
heterochromatin A compact and highly condensed form of chromatin that is refractory to transcription.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
ribonucleoprotein complex A macromolecular complex that contains both RNA and protein molecules.

11 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
chromatin binding Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA topoisomerase activity Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA.
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2.
enzyme binding Binding to an enzyme, a protein with catalytic activity.
histone deacetylase binding Binding to histone deacetylase.
metal ion binding Binding to a metal ion.
protein C-terminus binding Binding to a protein C-terminus, the end of a peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
protein heterodimerization activity Binding to a nonidentical protein to form a heterodimer.
protein kinase C binding Binding to protein kinase C.

8 GO annotations of biological process

Name Definition
axonogenesis De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells.
B cell differentiation The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.
DNA topological change The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
forebrain development The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).
neuron migration The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
positive regulation of single stranded viral RNA replication via double stranded DNA intermediate Any process that activates or increases the frequency, rate or extent of retroviral genome replication.
resolution of meiotic recombination intermediates The cleavage and rejoining of intermediates, such as Holliday junctions, formed during meiotic recombination to produce two intact molecules in which genetic material has been exchanged.
sister chromatid segregation The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P11388 TOP2A DNA topoisomerase 2-alpha Homo sapiens (Human) PR
Q02880 TOP2B DNA topoisomerase 2-beta Homo sapiens (Human) PR
Q01320 Top2a DNA topoisomerase 2-alpha Mus musculus (Mouse) PR
O46374 TOP2A DNA topoisomerase 2-alpha Sus scrofa (Pig) PR
P41516 Top2a DNA topoisomerase 2-alpha Rattus norvegicus (Rat) PR
Q23670 top-2 DNA topoisomerase 2 top-2 Caenorhabditis elegans PR
10 20 30 40 50 60
MAKSSLAGSD GALTWVNNAT KKEELETANK NDSTKKLSVE RVYQKKTQLE HILLRPDTYI
70 80 90 100 110 120
GSVEPLTQLM WVYDEDVGMN CREVTFVPGL YKIFDEILVN AADNKQRDKN MTCIKVSIDP
130 140 150 160 170 180
ESNIISIWNN GKGIPVVEHK VEKVYVPALI FGQLLTSSNY DDDEKKVTGG RNGYGAKLCN
190 200 210 220 230 240
IFSTKFTVET ACKEYKHSFK QTWMNNMMKT SEAKIKHFDG EDYTCITFQP DLSKFKMEKL
250 260 270 280 290 300
DKDIVALMTR RAYDLAGSCK GVKVMFNGKK LPVNGFRSYV DLYVKDKLDE TGVALKVIHE
310 320 330 340 350 360
LANERWDVCL TLSEKGFQQI SFVNSIATTK GGRHVDYVVD QVVSKLIEVV KKKNKAGVSV
370 380 390 400 410 420
KPFQVKNHIW VFINCLIENP TFDSQTKENM TLQPKSFGSK CQLSEKFFKA ASNCGIVESI
430 440 450 460 470 480
LNWVKFKAQT QLNKKCSSVK YSKIKGIPKL DDANDAGGKH SLECTLILTE GDSAKSLAVS
490 500 510 520 530 540
GLGVIGRDRY GVFPLRGKIL NVREASHKQI MENAEINNII KIVGLQYKKS YDDAESLKTL
550 560 570 580 590 600
RYGKIMIMTD QDQDGSHIKG LLINFIHHNW PSLLKHGFLE EFITPIVKAS KNKQELSFYS
610 620 630 640 650 660
IPEFDEWKKH IENQKAWKIK YYKGLGTSTA KEAKEYFADM ERHRILFRYA GPEDDAAITL
670 680 690 700 710 720
AFSKKKIDDR KEWLTNFMED RRQRRLHGLP EQFLYGTATK HLTYNDFINK ELILFSNSDN
730 740 750 760 770 780
ERSIPSLVDG FKPGQRKVLF TCFKRNDKRE VKVAQLAGSV AEMSAYHHGE QALMMTIVNL
790 800 810 820 830 840
AQNFVGSNNI NLLQPIGQFG TRLHGGKDAA SPRYIFTMLS SLARLLFPAV DDNLLKFLYD
850 860 870 880 890 900
DNQRVEPEWY IPIIPMVLIN GAEGIGTGWA CKLPNYDARE IVNNVRRMLE GLDPHPMLPN
910 920 930 940 950 960
YKNFKGTIQE LGQNQYAVSG EIFVVDRNTV EITELPVRTW TQVYKEQVLE PMLNGTDKTP
970 980 990 1000 1010 1020
ALISDYKEYH TDTTVKFVVK MTEEKLAQAE AAGLHKVFKL QTTLTCNSMV LFDHMGCLKK
1030 1040 1050 1060 1070 1080
YETVQDILKE FFDLRLSYYG LRKEWLVGML GAESTKLNNQ ARFILEKIQG KITIENRSKK
1090 1100 1110 1120 1130 1140
DLIQMLVQRG YESDPVKAWK EAQEKAAEEE DSQNQHDDSS SDSGTPSGPD FNYILNMSLW
1150 1160 1170 1180 1190 1200
SLTKEKVEEL IKQRDTKGRE VNDLKRKSPS DLWKEDLAAF VEELDKVEAQ EREDILAGMS
1210 1220 1230 1240 1250 1260
GKAIKGKVGK PKVKKLQLEE TMPSPYGRRI VPEITAMKAD ASRKLLKKKK GDPDTTVVKV
1270 1280 1290 1300 1310 1320
EFDEEFSGTP AEGTGEETLT PSAPVNKGPK PKREKKEPGT RVRKTPTSTG KTNAKKVKKR
1330 1340 1350 1360 1370 1380
NPWSDDESKS ESDLEEAEPV VIPRDSLLRR AAAERPKYTF DFSEEEDDDA AAADDSNDLE
1390 1400 1410 1420 1430 1440
ELKVKASPIT NDGEDEFVPS DGLDKDEYAF SSGKSKATPE KSSNDKKSQD FGNLFSFPSY
1450 1460 1470 1480 1490 1500
SQKSEDDSAK FDSNEEDTAS VFAPSFGLKQ TDKLPSKTVA AKKGKPPSDT APKAKRAPKQ
1510 1520 1530 1540 1550 1560
KKIVETINSD SDSEFGIPKK TTTPKGKGRG AKKRKASGSE NEGDYNPGRK PSKTASKKPK
1570 1580 1590 1600 1610
KTSFDQDSDV DIFPSDFTSE PPALPRTGRA RKEVKYFAES DEEEDVDFAM FN