Q5IGR8

PR
Gene name
ext1a
Protein name
Exostosin-1a
Names
Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase 1a, Multiple exostoses protein 1 homolog a
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
EC number
2.4.1.224: Hexosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-109 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5IGR8

Entry ID Method Resolution Chain Position Source
AF-Q5IGR8-F1 Predicted AlphaFoldDB

No variants for Q5IGR8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5IGR8

No associated diseases with Q5IGR8

2 regional properties for Q5IGR8

Type Name Position InterPro Accession
domain Glycosyl transferase 64 domain 464 - 713 IPR015338
domain Exostosin, GT47 domain 95 - 380 IPR040911

Functions

Description
EC Number 2.4.1.224 Hexosyltransferases
Subcellular Localization
  • Endoplasmic reticulum membrane ; Single-pass type II membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
integral component of endoplasmic reticulum membrane The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

6 GO annotations of molecular function

Name Definition
acetylglucosaminyltransferase activity Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar.
glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity Catalysis of the reaction: beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP-N-acetyl-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP.
glucuronosyltransferase activity Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
glycosyltransferase activity Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).
metal ion binding Binding to a metal ion.
N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity Catalysis of the reaction: N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP.

2 GO annotations of biological process

Name Definition
heparan sulfate proteoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues.
protein glycosylation A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A5D7I4 EXT1 Exostosin-1 Bos taurus (Bovine) PR
Q16394 EXT1 Exostosin-1 Homo sapiens (Human) PR
P97464 Ext1 Exostosin-1 Mus musculus (Mouse) PR
Q10SX7 Os03g0107900 Probable glucuronosyltransferase Os03g0107900 Oryza sativa subsp japonica (Rice) PR
O01704 rib-1 Exostosin-1 homolog Caenorhabditis elegans PR
Q94AA9 XGD1 Xylogalacturonan beta-1,3-xylosyltransferase Arabidopsis thaliana (Mouse-ear cress) PR
Q9LFP3 At5g11130/At5g11120 Probable glycosyltransferase At5g11130 Arabidopsis thaliana (Mouse-ear cress) PR
Q3EAR7 At3g42180 Probable glycosyltransferase At3g42180 Arabidopsis thaliana (Mouse-ear cress) PR
Q5IGR7 ext1b Exostosin-1b Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MQAKKRYLIL FSAGVCLILL FYLQGPASRR TPKRGDDPHP HWPHFSDPLR AFIPWDQTET
70 80 90 100 110 120
EDYNVRASPR HKRDDSTGAD KCRMDSCFDF ELCKRNGFKV YVYPQQKGEK ISESYQNILS
130 140 150 160 170 180
SIEGSRFYTS DPGQACLFVL NLDTLDRDQL SPQYVHNLKT KIQNLNLWNN GRNHLIFNLY
190 200 210 220 230 240
SGTWPDYTED LGFDIGQAML AKASISTESF RPNFDISIPL FSKDHPRTGG ERGFLKYNTI
250 260 270 280 290 300
PPFRKYMLVF KGKRYLTGIG SDTRNALYHI HNAEDVVLLT TCKHGKDWQK HKDARCDKDN
310 320 330 340 350 360
AEYDRYDYKE MLHNSTFCLV PRGRRLGSFR FLEALQAACV PVMLSNGWEL PFSEIIDWRT
370 380 390 400 410 420
AAVIGDERLL LQIPSTVRSI HQDRILSLRQ QTQFLWEAYF SSVEKIVLTT LEIIQDRVLQ
430 440 450 460 470 480
HSAHSTLMWN RLPGGLFTLP QYSSYLGDFP FFYALLGIKP HQKFTAVIHA VTPLVSQSQP
490 500 510 520 530 540
IFKLLVAVAK SQFCAQIMVL WNCDKPLPSK HRWPATSVPV IVIEGESKVM SSRFLPYENI
550 560 570 580 590 600
ITDAVLSLDE DTVLSTTEVD FAFTVWQSFP ERIVGYPARS HFWDSNKERW GYTSKWTNDY
610 620 630 640 650 660
SMVLTGAAFY HRYYNYLYTH YLPGSLKGLV DQLSNCEDIL MNFLVSAVTK MPPIKVTQKK
670 680 690 700 710 720
QYKETMMGQT SRASRWADPD HFAQRQTCMN KFASWFGTMP LVHSQMRLDP VLFRDQVSIL
RKKYRDIERL