O01704
Gene name |
rib-1 (F12F6.3) |
Protein name |
Exostosin-1 homolog |
Names |
Multiple exostoses homolog 1, Related to mammalian RIB protein 1 |
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_F12F6.3 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O01704
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O01704-F1 | Predicted | AlphaFoldDB |
No variants for O01704
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O01704 | |||||
No associated diseases with O01704
1 regional properties for O01704
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Exostosin, GT47 domain | 44 - 333 | IPR040911 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| enzyme binding | Binding to an enzyme, a protein with catalytic activity. |
| glycosyltransferase activity | Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| heparan sulfate proteoglycan biosynthetic process | The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues. |
| pharynx development | The biological process whose specific outcome is the progression of a pharynx from an initial condition to its mature state. The pharynx is the part of the digestive system immediately posterior to the mouth. |
| protein glycosylation | A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins. |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A5D7I4 | EXT1 | Exostosin-1 | Bos taurus (Bovine) | PR |
| Q16394 | EXT1 | Exostosin-1 | Homo sapiens (Human) | PR |
| P97464 | Ext1 | Exostosin-1 | Mus musculus (Mouse) | PR |
| Q10SX7 | Os03g0107900 | Probable glucuronosyltransferase Os03g0107900 | Oryza sativa subsp japonica (Rice) | PR |
| Q94AA9 | XGD1 | Xylogalacturonan beta-1,3-xylosyltransferase | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LFP3 | At5g11130/At5g11120 | Probable glycosyltransferase At5g11130 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q3EAR7 | At3g42180 | Probable glycosyltransferase At3g42180 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q5IGR8 | ext1a | Exostosin-1a | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q5IGR7 | ext1b | Exostosin-1b | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MQNVMKFHLV | IFMLFGSVRL | QNPTIERKQC | TMSNCFDFSK | CSTSKKVYIH | PMEKRFEESP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QSVIYSKILK | HFLESNHYTN | DPNEACIFLL | GIDTTDRDVR | SQNYVKNVND | YIESLDPSVW |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NNGRNHLIFN | FYHGTFPDYD | DHNLNFDTGE | AMIARASSSE | NNFIKVFDVS | LPLFHENHPY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EIKESKSERN | DDRIENQRKY | LVSFKGKRYV | YGIGSGTRNL | VHHLHNGDDI | VMVTTCKHNN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DWQVYQDDRC | QRDNDEYDRW | EYDELLANST | FCLVPRGRRL | GSFRFLETLR | SGCVPVVISD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SWILPFSETI | DWNSAAIVVA | ERDALSIPEL | LMSTSRRRVK | ELRESARNVY | DAYLRSIQVI |
| 370 | 380 | ||||
| SDHVLRIIFK | RIDNKIELED | HQ |