Q3UVX5
PR
Gene name |
Grm5 (Gprc1e, Mglur5) |
Protein name |
Metabotropic glutamate receptor 5 |
Names |
mGluR5 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:108071 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q3UVX5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3UVX5-F1 | Predicted | AlphaFoldDB |
41 variants for Q3UVX5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3397964816 | 64 | Y>H | No | EVA | |
| rs3388904277 | 65 | G>R | No | EVA | |
| rs3388926973 | 65 | G>V | No | EVA | |
| rs3398051619 | 66 | I>F | No | EVA | |
| rs3398051679 | 70 | E>D | No | EVA | |
| rs3398134121 | 70 | E>K | No | EVA | |
| rs3398134148 | 72 | M>I | No | EVA | |
| rs3398277593 | 74 | H>L | No | EVA | |
| rs3388906628 | 101 | H>D | No | EVA | |
| rs3388923356 | 189 | R>S | No | EVA | |
| rs3388919474 | 193 | S>* | No | EVA | |
| rs3388925357 | 236 | K>R | No | EVA | |
| rs3388925400 | 292 | L>M | No | EVA | |
| rs3388922135 | 303 | S>T | No | EVA | |
| rs3388922137 | 311 | D>G | No | EVA | |
| rs3388912127 | 311 | D>Y | No | EVA | |
| rs3388928971 | 338 | D>G | No | EVA | |
| rs3398262474 | 349 | L>F | No | EVA | |
| rs3398206571 | 352 | P>H | No | EVA | |
| rs3398053739 | 353 | W>G | No | EVA | |
| rs3398206585 | 355 | Q>R | No | EVA | |
| rs3398206557 | 474 | G>* | No | EVA | |
| rs3397808996 | 475 | K>E | No | EVA | |
| rs1132574703 | 517 | G>* | No | EVA | |
| rs1133580037 | 518 | Q>H | No | EVA | |
| rs1133481134 | 518 | Q>L | No | EVA | |
| rs3388917510 | 522 | I>N | No | EVA | |
| rs3388922064 | 554 | G>E | No | EVA | |
| rs3398279710 | 612 | S>LLEDLTTGVSR* | No | EVA | |
| rs3388925839 | 740 | V>A | No | EVA | |
| rs3388919459 | 784 | W>* | No | EVA | |
| rs3388925921 | 801 | M>V | No | EVA | |
| rs3398262412 | 877 | Y>* | No | EVA | |
| rs3397808947 | 877 | Y>N | No | EVA | |
| rs3397819786 | 880 | R>M | No | EVA | |
| rs3388912188 | 941 | N>K | No | EVA | |
| rs3388897892 | 954 | S>N | No | EVA | |
| rs3398054637 | 1021 | L>P | No | EVA | |
| rs3398279740 | 1025 | A>P | No | EVA | |
| rs3398183177 | 1036 | P>S | No | EVA | |
| rs3388912189 | 1173 | S>F | No | EVA |
1 associated diseases with Q3UVX5
[MIM: 608443]: Intellectual developmental disorder, autosomal recessive 3 (MRT3)
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO:0000269|PubMed:16033914}. Note=The disease is caused by variants affecting the gene represented in this entry.
Without disease ID
- A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO:0000269|PubMed:16033914}. Note=The disease is caused by variants affecting the gene represented in this entry.
No regional properties for Q3UVX5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q3UVX5 | |||
13 GO annotations of cellular component
| Name | Definition |
|---|---|
| astrocyte projection | A prolongation or process extending from the soma of an astrocyte and wrapping around neurons. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| dendritic shaft | Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines. |
| dendritic spine | A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity. |
| glutamatergic synapse | A synapse that uses glutamate as a neurotransmitter. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| integral component of postsynaptic membrane | The component of the postsynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| postsynaptic density | An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. |
| postsynaptic density membrane | The membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated. |
| Schaffer collateral - CA1 synapse | A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell. |
9 GO annotations of molecular function
| Name | Definition |
|---|---|
| A2A adenosine receptor binding | Binding to an A2A adenosine receptor. |
| adenylate cyclase inhibiting G protein-coupled glutamate receptor activity | Combining with glutamate and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex to inhibit downstream adenylate cyclase activity. |
| G protein-coupled receptor activity | Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
| G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential | A G protein-coupled receptor activity occurring in the postsynaptic membrane that is part of a GPCR signaling pathway that positively regulates ion channel activity in the postsynaptic membrane. |
| glutamate receptor activity | Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| identical protein binding | Binding to an identical protein or proteins. |
| neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration | Any neurotransmitter receptor activity that is involved in regulating the concentration of calcium in the postsynaptic cytosol. |
| PLC activating G protein-coupled glutamate receptor activity | A G protein-coupled receptor that binds glutamate and is linked to the inositol 1,4,5-trisphosphate/calcium signaling system. |
| protein tyrosine kinase binding | Binding to protein tyrosine kinase. |
24 GO annotations of biological process
| Name | Definition |
|---|---|
| calcium-mediated signaling using intracellular calcium source | The series of molecular signals in which a cell uses calcium ions released from an intracellular store to convert a signal into a response. |
| cellular response to amyloid-beta | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a amyloid-beta stimulus. |
| chemical synaptic transmission | The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. |
| cognition | The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory. |
| desensitization of G protein-coupled receptor signaling pathway | The process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway after prolonged stimulation with an agonist of the pathway. |
| G protein-coupled glutamate receptor signaling pathway | A G protein-coupled receptor signaling pathway initiated by glutamate binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. |
| learning | Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience. |
| learning or memory | The acquisition and processing of information and/or the storage and retrieval of this information over time. |
| locomotory behavior | The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions. |
| negative regulation of locomotion | Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism. |
| positive regulation of long-term neuronal synaptic plasticity | A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers. |
| positive regulation of MAPK cascade | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. |
| positive regulation of protein tyrosine kinase activity | Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity. |
| postsynaptic modulation of chemical synaptic transmission | Any process, acting in the postsynapse that results in modulation of chemical synaptic transmission. |
| protein kinase C-activating G protein-coupled receptor signaling pathway | The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG). |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of DNA-templated transcription | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
| regulation of intracellular calcium activated chloride channel activity | Any process that modulates the frequency, rate or extent of intracellular calcium activated chloride channel activity. |
| regulation of long-term neuronal synaptic plasticity | A process that modulates long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers. |
| regulation of protein phosphorylation | Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein. |
| regulation of synaptic transmission, glutamatergic | Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. |
| regulation of translational elongation | Any process that modulates the frequency, rate, extent or accuracy of translational elongation. |
| synapse organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). |
| trans-synaptic signaling by endocannabinoid, modulating synaptic transmission | Cell-cell signaling between presynapse and postsynapse, via the release and reception of endocannabinoid ligands, that modulates the synaptic transmission properties of the synapse. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O00222 | GRM8 | Metabotropic glutamate receptor 8 | Homo sapiens (Human) | PR |
| Q14416 | GRM2 | Metabotropic glutamate receptor 2 | Homo sapiens (Human) | PR |
| P41180 | CASR | Extracellular calcium-sensing receptor | Homo sapiens (Human) | PR |
| P47743 | Grm8 | Metabotropic glutamate receptor 8 | Mus musculus (Mouse) | PR |
| Q14BI2 | Grm2 | Metabotropic glutamate receptor 2 | Mus musculus (Mouse) | PR |
| Q9QYS2 | Grm3 | Metabotropic glutamate receptor 3 | Mus musculus (Mouse) | PR |
| P31422 | Grm3 | Metabotropic glutamate receptor 3 | Rattus norvegicus (Rat) | PR |
| P31421 | Grm2 | Metabotropic glutamate receptor 2 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVLLLILSVL | LLKEDVRGSA | QSSERRVVAH | MPGDIIIGAL | FSVHHQPTVD | KVHERKCGAV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| REQYGIQRVE | AMLHTLERIN | SDPTLLPNIT | LGCEIRDSCW | HSAVALEQSI | EFIRDSLISS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EEEEGLVRCV | DGSSSFRSKK | PIVGVIGPGS | SSVAIQVQNL | LQLFNIPQIA | YSATSMDLSD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KTLFKYFMRV | VPSDAQQARA | MVDIVKRYNW | TYVSAVHTEG | NYGESGMEAF | KDMSAKEGIC |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IAHSYKIYSN | AGEQSFDKLL | KKLRSHLPKA | RVVACFCEGM | TVRGLLMAMR | RLGLAGEFLL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LGSDGWADRY | DVTDGYQREA | VGGITIKLQS | PDVKWFDDYY | LKLRPETNLR | NPWFQEFWQH |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RFQCRLEGFA | QENSKYNKTC | NSSLTLRTHH | VQDSKMGFVI | NAIYSMAYGL | HNMQMSLCPG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| YAGLCDAMKP | IDGRKLLDSL | MKTNFTGVSG | DMILFDENGD | SPGRYEIMNF | KEMGKDYFDY |
| 490 | 500 | 510 | 520 | 530 | 540 |
| INVGSWDNGE | LKMDDDEVWS | KKNNIIRSVC | SEPCEKGQIK | VIRKGEVSCC | WTCTPCKENE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| YVFDEYTCKA | CQLGSWPTDD | LTGCDLIPVQ | YLRWGDPEPI | AAVVFACLGL | LATLFVTVIF |
| 610 | 620 | 630 | 640 | 650 | 660 |
| IIYRDTPVVK | SSSRELCYII | LAGICLGYLC | TFCLIAKPKQ | IYCYLQRIGI | GLSPAMSYSA |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LVTKTNRIAR | ILAGSKKKIC | TKKPRFMSAC | AQLVIAFILI | CIQLGIIVAL | FIMEPPDIMH |
| 730 | 740 | 750 | 760 | 770 | 780 |
| DYPSIREVYL | ICNTTNLGVV | TPLGYNGLLI | LSCTFYAFKT | RNVPANFNEA | KYIAFTMYTT |
| 790 | 800 | 810 | 820 | 830 | 840 |
| CIIWLAFVPI | YFGSNYKIIT | MCFSVSLSAT | VALGCMFVPK | VYIILAKPER | NVRSAFTTST |
| 850 | 860 | 870 | 880 | 890 | 900 |
| VVRMHVGDGK | SSSAASRSSS | LVNLWKRRGS | SGETLRYKDR | RLAQHKSEIE | CFTPKGSMGN |
| 910 | 920 | 930 | 940 | 950 | 960 |
| GGRATMSSSN | GKSVTWAQNE | KSTRGQHLWQ | RLSVHINKKE | NPNQTAVIKP | FPKSTESRGQ |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| GAGAGGGSGP | GAAGAGSAGC | TATGGPEPPD | AGPKALYDVA | EAEERFPAAA | RPRSPSPIST |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| LSHLAGSAGR | TDDDAPSLHS | ETAARSSSSQ | GSLMEQISSV | VTRFTANITE | LNSMMLSTAA |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| APGPPGTPIC | SSYLIPKEIQ | LPTTMTTFAE | IQPLPAIEVT | GGAQPATGPS | PAQETPAGAE |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| AAPGKPDLEE | LVALTPPSPF | RDSVDSGSTT | PNSPVSESAL | CIPSSPKYDT | LIIRDYTQSS |
| SSL |