AiPD: Autoinhibited Protein Database

Q14416

Gene name	GRM2
Protein name	Metabotropic glutamate receptor 2
Names	mGluR2
Species	Homo sapiens (Human)
KEGG Pathway	hsa:2912
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

459-535 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

459-535 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

26 structures for Q14416

Entry ID	Method	Resolution	Chain	Position	Source
4XAQ	X-ray	221 A	A/B	2-493	PDB
4XAS	X-ray	235 A	A/B	2-493	PDB
5CNI	X-ray	269 A	A/B	2-493	PDB
5CNJ	X-ray	265 A	A/B	2-493	PDB
5KZN	X-ray	280 A	A	1-562	PDB
5KZQ	X-ray	280 A	A	1-562	PDB
7E9G	EM	350 A	R/S	19-825	PDB
7EPA	EM	360 A	A/B	19-825	PDB
7EPB	EM	310 A	A/B	19-825	PDB
7EPD	EM	390 A	A	19-825	PDB
7MTQ	EM	365 A	A/B	18-872	PDB
7MTR	EM	330 A	A/B	18-872	PDB
7MTS	EM	320 A	A/B	18-872	PDB
8JCU	EM	280 A	2	19-872	PDB
8JCV	EM	340 A	2	19-872	PDB
8JCW	EM	300 A	2	19-872	PDB
8JCX	EM	300 A	2	19-872	PDB
8JCY	EM	290 A	2	19-872	PDB
8JCZ	EM	300 A	2	19-872	PDB
8JD0	EM	330 A	2	19-872	PDB
8JD1	EM	370 A	2	19-872	PDB
8JD2	EM	280 A	2	19-872	PDB
8JD3	EM	330 A	2	19-872	PDB
8JD4	EM	290 A	2	19-872	PDB
8JD5	EM	360 A	2	19-872	PDB
AF-Q14416-F1	Predicted				AlphaFoldDB

656 variants for Q14416

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA2424870 rs377743299	2	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1249903412 CA353047725	5	L>I		No	ClinGen TOPMed gnomAD
CA2424871 rs778180799	6	A>V		No	ClinGen ExAC gnomAD
CA353047793 rs1460463489	9	A>G		No	ClinGen TOPMed gnomAD
TCGA novel	9	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs748943012 CA2424875	10	L>V		No	ClinGen ExAC TOPMed gnomAD
rs75461739 CA2424876	12	L>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1297648430 CA353047846	14	W>*		No	ClinGen TOPMed
rs962481777 CA74700756	14	W>C		No	ClinGen gnomAD
CA353047865 rs1365229369	15	G>D		No	ClinGen gnomAD
COSM1209031 rs778755860 CA2424877	16	A>V	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA2424878 rs747960529	17	V>M		No	ClinGen ExAC gnomAD
CA2424879 rs200663159	18	A>T		No	ClinGen 1000Genomes ExAC gnomAD
CA2424880 rs773073246	19	E>Q		No	ClinGen ExAC gnomAD
rs973816668 CA74700823	23	K>R		No	ClinGen Ensembl
rs760789831 CA353047965	25	V>L		No	ClinGen ExAC TOPMed gnomAD
rs760789831 CA2424882	25	V>M		No	ClinGen ExAC TOPMed gnomAD
rs771168656 CA2424883	27	T>N		No	ClinGen ExAC TOPMed gnomAD
CA2424884 rs542779542	29	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs200623206 CA2424885	33	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2424888 rs763273102	41	H>Q		No	ClinGen ExAC gnomAD
CA353048073 rs1559691116	42	Q>K		No	ClinGen Ensembl
CA353048082 rs1441437444	43	K>E		No	ClinGen TOPMed
CA353048090 rs1380431669	43	K>N		No	ClinGen TOPMed
rs764610362 CA2424890	45	G>R		No	ClinGen ExAC TOPMed gnomAD
CA2424889 rs764610362	45	G>S		No	ClinGen ExAC TOPMed gnomAD
CA353048125 rs1343958363	46	P>L		No	ClinGen gnomAD
CA353048127 rs1275843222	47	A>P		No	ClinGen gnomAD
CA74700891 rs886572875	47	A>V		No	ClinGen TOPMed gnomAD
CA74700897 rs950828398	48	E>Q		No	ClinGen gnomAD
CA353048201 rs1362945908	52	P>S		No	ClinGen gnomAD
CA353048230 rs1222041644	54	N>S		No	ClinGen TOPMed gnomAD
rs770111317 CA2424891	56	H>D		No	ClinGen ExAC gnomAD
rs765886757 CA2424893	56	H>Q		No	ClinGen ExAC gnomAD
CA353048269 rs1282161649	57	R>C		No	ClinGen gnomAD
rs1577551017 CA353048281	58	G>S		No	ClinGen Ensembl
CA2424897 rs778471244	59	I>M		No	ClinGen ExAC TOPMed gnomAD
rs1246035621 CA353048318	60	Q>H		No	ClinGen gnomAD
rs1479358728 CA353048324	61	R>C		No	ClinGen TOPMed gnomAD
rs1280835404 CA353048329	61	R>H		No	ClinGen Ensembl
rs200502357 CA2424898	71	R>L		No	ClinGen 1000Genomes ExAC gnomAD
CA2424899 rs746951130	73	N>K		No	ClinGen ExAC gnomAD
rs1415280732 CA353048475	74	R>C		No	ClinGen gnomAD
rs776842043 CA2424901	76	P>L		No	ClinGen ExAC TOPMed gnomAD
CA2424903 rs770031669	77	H>Y		No	ClinGen ExAC gnomAD
rs775595117 CA2424904	78	L>M		No	ClinGen ExAC TOPMed gnomAD
CA2424906 rs764369500	79	L>V		No	ClinGen ExAC gnomAD
CA2424909 rs768079452	80	P>H		No	ClinGen ExAC gnomAD
CA2424908 rs762293607	80	P>T		No	ClinGen ExAC gnomAD
rs753314932 CA2424910	81	G>V		No	ClinGen ExAC gnomAD
rs1489834872 CA353048555	82	V>M		No	ClinGen TOPMed gnomAD
rs754495843 CA2424911	83	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA2424912 rs764896896	84	L>M		No	ClinGen ExAC gnomAD
CA353048595 rs1157742177	85	G>A		No	ClinGen TOPMed
rs916562998 CA74701008	86	A>S		No	ClinGen gnomAD
rs916562998 CA353048597	86	A>T		No	ClinGen gnomAD
CA2424914 rs758170042	88	I>V		No	ClinGen ExAC TOPMed gnomAD
CA2424916 rs773302322	90	D>N		No	ClinGen ExAC TOPMed gnomAD
CA2424917 rs370930855	91	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	92	C>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1196233477 CA353048742	97	H>D		No	ClinGen TOPMed
rs781340078 CA2424918	97	H>R		No	ClinGen ExAC gnomAD
CA2424919 rs745889223	98	A>V		No	ClinGen ExAC TOPMed gnomAD
CA353048776 rs1559691461	100	E>G		No	ClinGen Ensembl
CA353048784 rs1214262858	101	Q>K		No	ClinGen TOPMed
rs1448919180 CA353048788	101	Q>R		No	ClinGen gnomAD
CA74701032 rs763448953	105	F>L		No	ClinGen Ensembl
CA353048860 rs1486056711	106	V>G		No	ClinGen gnomAD
rs769770570 CA2424920	106	V>L		No	ClinGen ExAC gnomAD
rs200055532 CA2424921	108	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs749496396 CA2424923	112	R>H		No	ClinGen ExAC TOPMed gnomAD
CA353048977 rs1559691526	113	G>A		No	ClinGen Ensembl
CA353048970 rs1257918617	113	G>S		No	ClinGen gnomAD
TCGA novel	114	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs768973589 CA2424924	115	D>H		No	ClinGen ExAC gnomAD
CA2424925 rs774667809	117	S>L		No	ClinGen ExAC gnomAD
CA353049084 rs1401547328	118	R>H		No	ClinGen TOPMed
rs762232162 CA2424926	119	H>R		No	ClinGen ExAC gnomAD
rs1391294099 CA353049169	123	D>N		No	ClinGen gnomAD
rs759017134 CA2424929	124	G>R		No	ClinGen ExAC gnomAD
CA74701096 rs751920600	125	S>C		No	ClinGen Ensembl
CA353049242 rs1451535340	126	Y>F		No	ClinGen TOPMed
CA74701105 rs902360993	126	Y>H		No	ClinGen Ensembl
CA2424930 rs764682062	127	A>E		No	ClinGen ExAC TOPMed gnomAD
rs1187968065 CA353049249	127	A>T		No	ClinGen gnomAD
CA2424931 COSM1566708 rs764682062	127	A>V	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs762488020 CA2424932	129	H>N		No	ClinGen ExAC gnomAD
rs145490430 CA2424933	129	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA353049319 rs1437336836	130	G>R		No	ClinGen gnomAD
CA2424934 rs751391242	130	G>V		No	ClinGen ExAC TOPMed gnomAD
rs370256711 CA2424935	132	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA74701129 rs113937841	133	P>L		No	ClinGen gnomAD
CA2424936 rs781211820	136	I>V		No	ClinGen ExAC gnomAD
TCGA novel	137	T>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs750361568 CA2424937	137	T>S		No	ClinGen ExAC gnomAD
rs142637496 COSM308397 CA2424938	138	G>S	kidney [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs1421896249 CA353049488	138	G>V		No	ClinGen TOPMed gnomAD
CA74701160 rs1007206033	140	I>T		No	ClinGen TOPMed
rs138359683 CA2424940	142	G>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA2424941 rs138359683	142	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs149255850 CA2424942	144	Y>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1482214769 CA353049618	146	D>A		No	ClinGen Ensembl
CA74701197 rs376659355	146	D>Y		No	ClinGen Ensembl
CA353049689 rs1428377888	150	Q>R		No	ClinGen gnomAD
CA353050729 rs1315877793	153	N>S		No	ClinGen TOPMed
rs1404174007 CA353050739	154	L>V		No	ClinGen gnomAD
CA74703675 rs561582268	155	L>W		No	ClinGen TOPMed
rs374419415 CA74703688	162	Q>H		No	ClinGen ESP
CA74703692 rs940254088	165	Y>N		No	ClinGen gnomAD
CA74703698 rs917235012	166	A>P		No	ClinGen Ensembl
rs1168857150 CA353050982	169	S>N		No	ClinGen TOPMed
TCGA novel	170	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1474852209 CA353051023	172	L>M		No	ClinGen TOPMed
CA2424965 rs777212616	177	R>C		No	ClinGen ExAC gnomAD
rs748682242 CA2424966	177	R>H		No	ClinGen ExAC TOPMed gnomAD
CA353051137 rs1250048007	180	Y>C		No	ClinGen gnomAD
TCGA novel	182	A>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	183	R>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2424969 rs761538024	183	R>C		No	ClinGen ExAC TOPMed gnomAD
rs1485116568 CA353051179 COSM212874	183	R>H	Variant assessed as Somatic; impact. urinary_tract breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
TCGA novel	184	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353051229 rs1209318778	187	P>L		No	ClinGen TOPMed
CA353051280 rs1423851237	191	Q>*		No	ClinGen gnomAD
CA353051299 rs1161472483	192	A>G		No	ClinGen gnomAD
CA353051316 rs1372121874	193	K>N		No	ClinGen gnomAD
CA2424970 COSM1046739 rs767321005	199	L>I	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1297290414 CA353051398	200	R>C		No	ClinGen TOPMed gnomAD
COSM1253801 rs372298669 CA2424971	200	R>H	Variant assessed as Somatic; 0.0 impact. oesophagus [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA2424973 rs766170364	201	F>L		No	ClinGen ExAC gnomAD
CA2424972 rs375302090	201	F>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs1577557442 CA353051475	205	T>P		No	ClinGen Ensembl
CA2424975 rs768195509	206	Y>*		No	ClinGen ESP ExAC gnomAD
rs755009271 CA2424976	206	Y>C		No	ClinGen ExAC
rs1559693974	206	Y>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA2424977 rs765321622	208	S>F		No	ClinGen ExAC gnomAD
rs367909421 CA2424978	211	A>V		No	ClinGen ESP ExAC gnomAD
CA2424980 rs778120250	213	E>D		No	ClinGen ExAC TOPMed gnomAD
rs747318511 CA2424981	214	G>D		No	ClinGen ExAC gnomAD
CA353051575 rs1205660271	214	G>S		No	ClinGen gnomAD
CA353051586 rs1177196948	215	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs143196180 CA2424984	218	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
rs1371898785 CA353051627	219	T>K		No	ClinGen TOPMed
CA353051655 rs1393957758	223	A>G		No	ClinGen TOPMed
rs770473805 CA2424986	229	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs770473805 CA2424985	229	R>P		No	ClinGen ExAC TOPMed gnomAD
CA353051704 rs1410388515	231	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1410388515 CA353051703	231	R>G		No	ClinGen TOPMed gnomAD
COSM1566707 rs147501226 CA2424989	231	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA gnomAD
rs147501226 CA2424988	231	R>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA gnomAD
CA353051707 rs1186452114	232	N>D		No	ClinGen TOPMed
rs1252642246 CA353051719	233	I>S		No	ClinGen TOPMed
CA353051715 rs1473835640	233	I>V		No	ClinGen TOPMed
rs760319854 CA2424990	234	C>Y		No	ClinGen ExAC gnomAD
rs766226233 CA2424991	237	T>I		No	ClinGen ExAC TOPMed gnomAD
rs776381737 CA2424992	238	S>L		No	ClinGen ExAC TOPMed gnomAD
rs765196767 CA2424994	242	G>S		No	ClinGen ExAC gnomAD
rs764159304 CA2424997	243	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA2424998 rs751842471	243	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs757517400 CA2424999	244	A>T		No	ClinGen ExAC
rs1280056924 CA353051791	245	M>I		No	ClinGen TOPMed
CA353051789 rs1263961713	245	M>T		No	ClinGen gnomAD
rs781600336 CA2425000	245	M>V		No	ClinGen ExAC gnomAD
rs746276808 CA2425001	247	R>C		No	ClinGen ExAC TOPMed gnomAD
rs746276808 CA2425002	247	R>G		No	ClinGen ExAC TOPMed gnomAD
rs755306821 CA2425003	247	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs755306821 CA74703931	247	R>P		No	ClinGen ExAC TOPMed gnomAD
CA2425005 rs117368814	248	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2425006 RCV000913640 rs141459351	248	A>V		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA353051835 rs1176762023	252	G>V		No	ClinGen gnomAD
CA74703948 rs62259684	254	V>M		No	ClinGen Ensembl
rs1467829905 CA353051848	255	R>*		No	ClinGen gnomAD
COSM1485355 rs759390511 CA2425010	255	R>Q	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA2425012 rs775416347	256	A>G		No	ClinGen ExAC gnomAD
rs145752808 CA353051852	256	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs145752808 CA2425011	256	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA353051860 rs1284240364	258	L>M		No	ClinGen gnomAD
rs752794186 CA74703976	259	Q>L		No	ClinGen Ensembl
CA353051881 rs1221775826	261	P>A		No	ClinGen gnomAD
rs757102865 CA74703980	263	A>G		No	ClinGen Ensembl
rs1447545792 CA353051902	264	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs767700581 CA2425017	265	V>M		No	ClinGen ExAC gnomAD
CA353051922 rs1199867200	268	L>V		No	ClinGen TOPMed gnomAD
rs1479216160 CA353051943	271	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA353051944 rs1160790431	271	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	275	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs754426900 CA2425021	275	A>V		No	ClinGen ExAC TOPMed gnomAD
CA2425023 rs777314733	276	R>Q	Variant assessed as Somatic; 9.307e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs368526510 CA2425022	276	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs1407202988 CA353051977	277	E>K		No	ClinGen gnomAD
rs1347949756 CA353051996	280	A>P		No	ClinGen TOPMed
rs1347949756 CA353051997	280	A>S		No	ClinGen TOPMed
rs749310386 CA2425024	281	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1435625253 CA353052025	284	R>C		No	ClinGen TOPMed gnomAD
rs1345121780 CA353052026	284	R>H		No	ClinGen TOPMed gnomAD
rs1435625253 CA353052023	284	R>S		No	ClinGen TOPMed gnomAD
rs1403293184 CA353052039	286	N>S		No	ClinGen gnomAD
rs1437774871 CA353052043	287	A>T		No	ClinGen TOPMed
CA74704011 rs973355460	287	A>V		No	ClinGen Ensembl
rs1281468627 CA353052053	288	S>I		No	ClinGen gnomAD
CA353052060 rs1223290687	289	F>S		No	ClinGen gnomAD
rs1223290687 CA353052059	289	F>Y		No	ClinGen gnomAD
CA353052065 rs1282141958	290	T>A		No	ClinGen TOPMed gnomAD
rs867491732 CA74704018	290	T>S		No	ClinGen Ensembl
CA74704023 rs950023743	291	W>L		No	ClinGen gnomAD
rs780875749 CA2425026	294	S>C		No	ClinGen ExAC gnomAD
rs780875749 CA74704032	294	S>G		No	ClinGen ExAC gnomAD
rs769611989 CA2425028	296	G>R		No	ClinGen ExAC gnomAD
TCGA novel	299	A>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1233065208 CA353052203	301	E>D		No	ClinGen gnomAD
rs762928999 CA2425030	302	S>N		No	ClinGen ExAC gnomAD
CA353052254 rs1164644562	306	G>D		No	ClinGen gnomAD
rs1427030701 CA353052252	306	G>S		No	ClinGen gnomAD
CA353052263 rs1173171943	307	S>N		No	ClinGen TOPMed
rs910071496 CA74704054	307	S>R		No	ClinGen TOPMed
rs1577558304 CA353052270	307	S>R		No	ClinGen Ensembl
rs570332974 CA2425033	308	E>D		No	ClinGen 1000Genomes ExAC gnomAD
CA2425032 rs774486355	308	E>G		No	ClinGen ExAC TOPMed gnomAD
CA353052277 rs774486355	308	E>V		No	ClinGen ExAC TOPMed gnomAD
rs143181148 CA2425034	315	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA353052372 rs1336565927	318	E>K		No	ClinGen gnomAD
rs750679418 CA2425035	320	A>G		No	ClinGen ExAC TOPMed gnomAD
CA353052398 rs1577558364	320	A>S		No	ClinGen Ensembl
rs761080290 CA2425036	321	S>A		No	ClinGen ExAC gnomAD
rs761080290 CA353052407	321	S>T		No	ClinGen ExAC gnomAD
rs1215023338 CA353052416	322	Y>D		No	ClinGen TOPMed
rs1290912697 CA353052437	324	I>V		No	ClinGen gnomAD
CA353052455 rs1445144291	325	S>R		No	ClinGen TOPMed
CA2425039 rs755478612	325	S>T		No	ClinGen ExAC gnomAD
TCGA novel	327	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1197327319 CA353052491	328	A>V		No	ClinGen TOPMed gnomAD
rs547069813 CA2425040	329	S>F		No	ClinGen ExAC gnomAD
CA2425041 rs559122958	332	Q>H		No	ClinGen 1000Genomes ExAC gnomAD
rs570829609 CA2425043	333	S>N		No	ClinGen 1000Genomes ExAC gnomAD
rs1037147478 CA74704098	333	S>R		No	ClinGen TOPMed gnomAD
CA353052538 rs1234465899	333	S>R		No	ClinGen TOPMed
rs1385154627 CA353052577	337	W>C		No	ClinGen TOPMed gnomAD
rs376518304 CA2425045	339	N>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA2425047 rs755817901	341	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs534825087 CA2425046	341	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA2425048 rs779795830	343	P>R		No	ClinGen ExAC gnomAD
CA353052623 rs1394900152	344	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA353052633 rs1454981492	345	F>L		No	ClinGen TOPMed gnomAD
COSM1253802 CA2425049 rs749107956	346	R>C	Variant assessed as Somatic; 0.0 impact. oesophagus [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
COSM1424297 CA2425050 rs200432452	346	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA2425052 rs748192650	354	R>C		No	ClinGen ExAC TOPMed gnomAD
rs772309023 CA2425053	354	R>H		No	ClinGen ExAC TOPMed gnomAD
rs773518679 CA2425054	356	S>G		No	ClinGen ExAC TOPMed gnomAD
rs148285622 CA353052725	358	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2425056 rs148285622	358	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2425055 rs760955228	358	R>W		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	360	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2425057 rs777046936	360	R>G		No	ClinGen ExAC gnomAD
rs1461431300 CA353052736	360	R>Q		No	ClinGen gnomAD
rs143495329 CA353052755	363	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs143495329 CA2425059	363	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2425060 rs753145566	363	A>V		No	ClinGen ExAC gnomAD
rs376625340 CA2425061	365	H>Q		No	ClinGen ESP ExAC gnomAD
CA74704226 rs556933149	365	H>Y		No	ClinGen 1000Genomes TOPMed
rs755762716 CA2425064	366	S>C		No	ClinGen ExAC gnomAD
rs755762716 CA353052791	366	S>F		No	ClinGen ExAC gnomAD
rs749977509 CA2425063	366	S>P		No	ClinGen ExAC gnomAD
rs1408573308 CA353052798	367	L>P		No	ClinGen gnomAD
CA353052793 rs1166418690	367	L>V		No	ClinGen gnomAD
rs200117897 CA2425066	368	R>Q		No	ClinGen 1000Genomes ESP ExAC gnomAD
CA2425065 rs369626642	368	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA2425067 rs775879013	371	P>T		No	ClinGen ExAC TOPMed gnomAD
rs778870495 CA353052868	373	E>D		No	ClinGen ExAC TOPMed gnomAD
CA2425069 rs748058333	374	Q>E		No	ClinGen ExAC gnomAD
rs748058333 CA2425070	374	Q>K		No	ClinGen ExAC gnomAD
rs773393762 CA2425071	379	M>T		No	ClinGen ExAC TOPMed gnomAD
CA74704321 rs1017104434	380	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs144039519 CA74704346	382	V>A		No	ClinGen ESP TOPMed gnomAD
rs961808916 CA74704349	383	N>K		No	ClinGen Ensembl
CA2425072 rs747151575	385	V>A		No	ClinGen ExAC gnomAD
rs144377567 CA353053046	386	Y>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs776728919 CA2425074	387	A>T		No	ClinGen ExAC gnomAD
CA353053069 rs1260658344	388	M>T		No	ClinGen gnomAD
rs1024952885 CA353053079	389	A>S		No	ClinGen gnomAD
rs1024952885 CA74704360	389	A>T		No	ClinGen gnomAD
rs376573547 CA2425075	389	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA2425076 rs765548083	391	A>T		No	ClinGen ExAC gnomAD
CA2425077 rs775975235	391	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1431741087 CA353053117	392	L>F		No	ClinGen gnomAD
TCGA novel	394	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1415631335 CA353053172	395	M>I		No	ClinGen TOPMed
CA353053161 rs1175837979	395	M>V		No	ClinGen TOPMed gnomAD
CA2425078 rs200511797	397	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs1455392394 CA353053195	397	R>H		No	ClinGen gnomAD
CA2425082 rs765950059	402	N>S		No	ClinGen ExAC gnomAD
rs1577559058 CA353053313	404	T>P		No	ClinGen Ensembl
rs1013970344 CA74704443	405	R>G		No	ClinGen TOPMed gnomAD
CA353053333 rs142465014	405	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA2425086 rs142465014	405	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1013970344 CA353053330	405	R>W		No	ClinGen TOPMed gnomAD
rs1559694931 CA543055075	407	C>*		No	ClinGen Ensembl
CA353053399 rs758404626 CA353053397	408	D>E		No	ClinGen ExAC gnomAD
CA2425088 rs777912992	409	A>T		No	ClinGen ExAC gnomAD
CA2425089 rs747024908	409	A>V		No	ClinGen ExAC TOPMed gnomAD
CA2425093 rs746059445	411	R>L		No	ClinGen ExAC TOPMed gnomAD
rs746059445 CA2425092	411	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA2425091 rs781432416	411	R>W		No	ClinGen ExAC TOPMed gnomAD
CA74704503 rs910162089	413	V>G		No	ClinGen TOPMed gnomAD
CA2425095 rs763369132	415	G>R		No	ClinGen ExAC TOPMed gnomAD
CA2425096 rs540373636	416	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA353053540 rs1366011485	416	R>H		No	ClinGen gnomAD
CA2425097 COSM1046744 rs561666712	417	R>C	endometrium [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs116567227 CA2425098	417	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs200731148 CA2425100	418	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA74704577 rs1051160429	419	Y>C		No	ClinGen TOPMed
CA74704579 rs1040311920	420	K>M		No	ClinGen Ensembl
CA353053627 rs1305593820	421	D>G		No	ClinGen gnomAD
rs759078547 CA2425101	422	F>L		No	ClinGen ExAC TOPMed gnomAD
rs765006135 CA2425102	423	V>L		No	ClinGen ExAC gnomAD
CA353053670 rs901784927	425	N>D		No	ClinGen TOPMed gnomAD
rs901784927 CA74704591	425	N>H		No	ClinGen TOPMed gnomAD
CA353053687 rs1222210595	426	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA353053703 rs1263915391	427	K>R		No	ClinGen gnomAD
CA2425124 rs751444280	430	A>V		No	ClinGen ExAC gnomAD
CA2425126 rs267599885	433	R>C		No	ClinGen ExAC gnomAD
rs750416610 CA2425127	433	R>H		No	ClinGen ExAC TOPMed gnomAD
CA353055027 rs1263793256	438	H>Q		No	ClinGen gnomAD
CA2425129 rs756224286	438	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA2425130 RCV000897454 rs143654927	439	N>S		No	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
rs747340682 CA74705605	442	R>C		No	ClinGen Ensembl
CA353055072 rs1207998527	442	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1207998527 CA353055073	442	R>L		No	ClinGen gnomAD
CA2425131 rs749536463	445	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA2425132 rs369993012	445	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs867493876 CA74705608	448	D>N		No	ClinGen Ensembl
rs769103089 CA2425133	452	R>C		No	ClinGen ExAC gnomAD
rs748577145 CA2425134	452	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs773781389 CA2425136	458	Y>C		No	ClinGen ExAC gnomAD
rs745305728 CA2425137	460	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs769372609 CA2425138	460	R>H		No	ClinGen ExAC TOPMed gnomAD
rs769372609 CA74705639	460	R>L		No	ClinGen ExAC TOPMed gnomAD
rs769372609 CA353055357	460	R>P		No	ClinGen ExAC TOPMed gnomAD
CA353055422 rs1347446235	463	S>N		No	ClinGen gnomAD
CA2425139 rs200690482	465	R>C	Variant assessed as Somatic; 4.623e-05 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs762669966 CA2425140	465	R>H		No	ClinGen ExAC TOPMed gnomAD
rs201541353 CA2425141	467	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA2425142 rs774276991	467	R>H		No	ClinGen ExAC gnomAD
CA2425143 rs761686344	470	K>N		No	ClinGen ExAC TOPMed gnomAD
rs750406225 CA2425145	475	A>T		No	ClinGen ExAC gnomAD
rs1471199029 CA353055694	477	G>A		No	ClinGen TOPMed
rs766426808 CA2425147	480	L>V		No	ClinGen ExAC gnomAD
rs753958370 CA2425148	482	T>P		No	ClinGen ExAC gnomAD
rs1490772324 CA353055939	484	L>P		No	ClinGen gnomAD
TCGA novel	488	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1178203294 CA353056146	489	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs971114872 CA74705745	490	P>L		No	ClinGen TOPMed gnomAD
TCGA novel	491	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1236060259 CA353056229	492	A>T		No	ClinGen TOPMed
rs1047701514 CA74705787	493	G>A		No	ClinGen Ensembl
rs577518979 CA353056297	493	G>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2425151 rs577518979	493	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs577518979 CA2425150	493	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2425156 rs199514469	497	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2425155 rs199514469	497	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2425157 rs146589478	499	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2425158 rs61729077	499	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs774155600 CA2425160	502	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1239395806 CA353056782	506	Q>R		No	ClinGen gnomAD
TCGA novel	508	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353056834 rs1442086062	508	E>V		No	ClinGen TOPMed
rs1349881504 CA353056913	510	K>E		No	ClinGen TOPMed
rs1361409511 CA353056926	511	S>C		No	ClinGen TOPMed gnomAD
TCGA novel	512	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353057059 rs1449445350	514	P>L		No	ClinGen TOPMed gnomAD
CA353057056 rs1449445350	514	P>R		No	ClinGen TOPMed gnomAD
rs753899005 CA353057109	516	E>*		No	ClinGen ExAC TOPMed gnomAD
rs753899005 CA2425166	516	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1214436734 CA353057279	521	L>F		No	ClinGen Ensembl
CA2425167 rs202090485	524	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA74705869 rs202090485	524	P>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	527	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2425169 TCGA novel rs752990956	528	Y>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC TOPMed NCI-TCGA
rs1164543830 CA353057478	529	E>G		No	ClinGen gnomAD
CA353057451 rs1448260111	529	E>K		No	ClinGen TOPMed
CA2425170 rs758637715	530	Y>*		No	ClinGen ExAC TOPMed gnomAD
rs1403765782 CA353057510	531	R>*		No	ClinGen gnomAD
rs368722269 CA2425171	531	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA2425174 rs781768671	534	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA2425175 rs374519341	535	F>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs768317110 CA2425176	537	C>R		No	ClinGen ExAC gnomAD
CA353057679 rs1283338456	537	C>Y		No	ClinGen gnomAD
rs201981098 CA2425179	538	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201981098 CA2425178	538	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA74705957 rs943731376	541	G>V		No	ClinGen TOPMed gnomAD
CA2425181 rs760442768	542	L>P		No	ClinGen ExAC gnomAD
rs867459164 CA74705975	543	G>D		No	ClinGen Ensembl
TCGA novel	549	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353058091 rs1292084801	549	S>R		No	ClinGen TOPMed gnomAD
CA353058248 rs1414848074	554	F>L		No	ClinGen TOPMed
CA74706020 rs892607705	555	E>G		No	ClinGen TOPMed
CA2425184 rs759568400	555	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA74706028 rs1009674616	556	L>P		No	ClinGen TOPMed
TCGA novel	557	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs765319491 CA2425185	560	Y>S		No	ClinGen ExAC gnomAD
COSM3696173 rs752765574 CA2425186	562	R>C	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA2425187 rs763200463	562	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA353058563 rs1247673315	564	G>R		No	ClinGen TOPMed gnomAD
rs375725804 CA2425189	565	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	571	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353058808 rs1270471815	571	P>S		No	ClinGen gnomAD
rs1216260604 CA353058867	572	V>A		No	ClinGen gnomAD
rs781752079 CA2425191	574	I>V		No	ClinGen ExAC gnomAD
CA2425193 rs756734768	575	A>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	575	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA74706088 rs1033638729	578	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA74706096 rs915020572	579	A>T		No	ClinGen TOPMed
CA353059171 rs1477593946	582	T>A		No	ClinGen gnomAD
rs771740410 CA2425196	583	L>V		No	ClinGen ExAC gnomAD
CA353059273 rs1559696661	584	F>L		No	ClinGen Ensembl
TCGA novel	585	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353059338 rs1470328425	587	G>A		No	ClinGen gnomAD
rs368726639 CA74706113	588	V>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs368726639 CA2425198	588	V>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA2425197 rs777303416	588	V>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	589	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353059415 rs1210284323	590	V>M		No	ClinGen gnomAD
rs370866853 CA2425200	591	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA2425199 rs772536931	591	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1397802948 CA353059466	592	H>R		No	ClinGen gnomAD
rs745779468 CA2425202	593	N>K		No	ClinGen ExAC gnomAD
CA353059496 rs1559696701	593	N>S		No	ClinGen Ensembl
CA353059489 rs1559696701	593	N>T		No	ClinGen Ensembl
rs1345668335 CA353059587	595	T>A		No	ClinGen gnomAD
rs775633409 CA2425204	595	T>I		No	ClinGen ExAC gnomAD
rs1255931374 CA353059617	596	P>T		No	ClinGen gnomAD
rs1207289934 CA353059727	599	K>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs764313817 CA2425206	601	S>P		No	ClinGen ExAC gnomAD
CA2425208 rs762223150	603	R>Q		No	ClinGen ExAC gnomAD
CA2425207 rs774472043	603	R>W		No	ClinGen ExAC gnomAD
CA353059996 rs1433907291	609	L>V		No	ClinGen gnomAD
CA353060007 rs1559696788	610	L>P		No	ClinGen Ensembl
CA353060011 rs1375864960	611	G>S		No	ClinGen gnomAD
rs756685870 CA2425211	612	G>S		No	ClinGen ExAC gnomAD
rs766855976 CA2425212	613	V>I		No	ClinGen ExAC gnomAD
rs1051984893 CA353060210	619	M>L		No	ClinGen gnomAD
CA74706258 rs1051984893	619	M>V		No	ClinGen gnomAD
rs1304643908 CA353060237	620	T>N		No	ClinGen gnomAD
CA2425214 rs757850729	622	I>F		No	ClinGen ExAC gnomAD
CA353060298 rs1298502170	622	I>M		No	ClinGen gnomAD
TCGA novel	622	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	623	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs777442467 CA2425215	625	A>G		No	ClinGen ExAC gnomAD
CA2425216 rs746682496	629	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1294240913 CA353060520	634	L>S		No	ClinGen gnomAD
CA2425219 rs780930849	635	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA353060530 rs1488891900	635	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs745726555 CA2425220 COSM1046747	636	R>C	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs150657954 CA2425221	636	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA2425222 rs775297052	639	L>F		No	ClinGen ExAC gnomAD
rs1379599393 CA353060624	640	G>A		No	ClinGen gnomAD
CA2425223 rs199941778	642	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	644	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2425224 rs768645189	645	V>I		No	ClinGen ExAC gnomAD
rs774622434 CA353060735	646	C>F		No	ClinGen ExAC TOPMed gnomAD
rs774622434 CA2425225	646	C>S		No	ClinGen ExAC TOPMed gnomAD
CA2425226 rs762096466	648	S>P		No	ClinGen ExAC gnomAD
CA2425228 rs773700618	649	A>V		No	ClinGen ExAC gnomAD
rs1376741910 CA353060864	652	T>I		No	ClinGen gnomAD
CA353060879 rs1238436104	653	K>T		No	ClinGen gnomAD
CA353060888 rs1577563349	654	T>P		No	ClinGen Ensembl
rs1322578540 CA353060908	655	N>S		No	ClinGen gnomAD
CA74706397 rs375087136	656	R>C		No	ClinGen ESP
rs767625940 COSM1424300 CA74706405	656	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs767625940 CA74706419	656	R>L		No	ClinGen gnomAD
CA353060936 rs1481691100	658	A>T		No	ClinGen gnomAD
TCGA novel	658	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs754332134 CA2425231	659	R>C		No	ClinGen ExAC gnomAD
COSM731158 CA353060954 rs1237497654	659	R>H	lung Variant assessed as Somatic; 0.0 impact. endometrium [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs754332134 CA353060948	659	R>S		No	ClinGen ExAC gnomAD
rs763484854 CA2425233	660	I>L		No	ClinGen ExAC gnomAD
rs756895347 CA2425235	662	G>S		No	ClinGen ExAC TOPMed gnomAD
rs370399429 CA2425237	663	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1463942896 CA353061034	664	A>S		No	ClinGen TOPMed
CA2425241 rs768679400	665	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs749163251 CA2425240	665	R>W		No	ClinGen ExAC TOPMed gnomAD
CA2425243 rs748298088	666	E>D		No	ClinGen ExAC gnomAD
rs1411242991 CA353061085	666	E>G		No	ClinGen TOPMed
rs779131411 CA2425242	666	E>Q		No	ClinGen ExAC gnomAD
rs906652049 CA74706510	667	G>S		No	ClinGen TOPMed
COSM1424301 rs1310863744 CA353061111	668	A>T	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs773571589 CA2425245	669	Q>E		No	ClinGen ExAC TOPMed gnomAD
rs761059008 CA2425246	669	Q>P		No	ClinGen ExAC gnomAD
CA353061145 rs1266544666	670	R>Q		No	ClinGen TOPMed
rs371492960 CA2425247	670	R>W	Variant assessed as Somatic; 0.0001875 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs777098269 CA2425248 COSM1734802	672	R>C	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA74706558 rs1033532418	672	R>H		No	ClinGen TOPMed gnomAD
CA74706589 rs959264006	673	F>L		No	ClinGen Ensembl
TCGA novel	673	F>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs759925615 CA2425249	676	P>S		No	ClinGen ExAC gnomAD
CA2425250 rs765796581	677	A>T		No	ClinGen ExAC TOPMed gnomAD
CA353061276 rs1179847823	679	Q>*		No	ClinGen gnomAD
CA2425251 rs751052753	680	V>M		No	ClinGen ExAC TOPMed gnomAD
CA74706597 rs557596073	681	A>T		No	ClinGen Ensembl
CA353061316 rs1477920982	681	A>V		No	ClinGen gnomAD
TCGA novel	683	C>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs61729081 CA2425252	685	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1470653636 CA353061381	686	L>F		No	ClinGen gnomAD
rs767120248 CA2425253	687	I>T		No	ClinGen ExAC gnomAD
CA74706644 rs534111871	687	I>V		No	ClinGen 1000Genomes
rs750102423 CA2425254	688	S>L		No	ClinGen ExAC gnomAD
CA74706687 rs138903693	689	G>D		No	ClinGen ESP TOPMed gnomAD
rs878951004 CA74706693	690	Q>K		No	ClinGen Ensembl
TCGA novel	691	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs201258235 RCV000896986 CA2425256	692	L>F		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
CA2425257 rs373228394	694	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs376437410 CA2425258	695	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA2425260 rs567499268	696	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs772307294 CA2425261	696	A>V		No	ClinGen ExAC gnomAD
rs778091926 CA353061647	697	W>*		No	ClinGen ExAC TOPMed gnomAD
rs778091926 CA2425262	697	W>C		No	ClinGen ExAC TOPMed gnomAD
CA353061687 rs1577563946	699	V>G		No	ClinGen Ensembl
CA353061713 rs1577563956	700	V>G		No	ClinGen Ensembl
TCGA novel	700	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs910832522 CA74706775	701	E>V		No	ClinGen Ensembl
rs747177404 CA2425263	703	P>L		No	ClinGen ExAC gnomAD
CA2425265 rs776851906	705	T>I		No	ClinGen ExAC gnomAD
rs369362488 CA2425266	706	G>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA74706793 rs920589578	707	K>N		No	ClinGen gnomAD
CA353061846 rs1174545644	708	E>*		No	ClinGen gnomAD
TCGA novel	708	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1362884990 CA353061874	709	T>I		No	ClinGen TOPMed gnomAD
CA2425267 rs770226519	711	P>L		No	ClinGen ExAC gnomAD
rs761266932 COSM191109 CA2425269	712	E>K	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA2425271 rs144237630	713	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs376746549 CA2425270	713	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs920948177 CA74706823	714	R>Q		No	ClinGen TOPMed gnomAD
CA74706822 rs140096454	714	R>W		No	ClinGen ESP TOPMed gnomAD
CA2425272 rs760240410	715	E>G		No	ClinGen ExAC gnomAD
CA2425274 rs372842577	716	V>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs372842577 CA2425273	716	V>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs1354237637 CA353062006	716	V>L		No	ClinGen gnomAD
CA2425275 rs754809245	717	V>G		No	ClinGen ExAC gnomAD
rs752703391 CA2425277	718	T>R		No	ClinGen ExAC TOPMed gnomAD
rs1369319594 CA353062060	719	L>P		No	ClinGen gnomAD
CA2425278 rs758458084	720	R>C		No	ClinGen ExAC TOPMed gnomAD
CA353062081 rs1190044104	720	R>H		No	ClinGen gnomAD
CA353062084 rs1190044104	720	R>L		No	ClinGen gnomAD
rs777964450 CA2425279	724	R>C		No	ClinGen ExAC gnomAD
rs1440714610 CA353062160	724	R>H		No	ClinGen TOPMed gnomAD
CA353062152 rs777964450	724	R>S		No	ClinGen ExAC gnomAD
rs151188856 CA74706940	725	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA TOPMed gnomAD
CA74706942 rs929411504	725	D>V		No	ClinGen Ensembl
rs376993642 CA74706950	726	A>P		No	ClinGen Ensembl
TCGA novel	727	S>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353062254 rs1407249080	728	M>V		No	ClinGen gnomAD
CA2425282 rs757404681	730	G>A		No	ClinGen ExAC gnomAD
rs200057736 CA74706975	731	S>L		No	ClinGen TOPMed gnomAD
rs1239194699 CA353062407	732	L>P		No	ClinGen gnomAD
CA2425285 rs770169519	734	Y>N		No	ClinGen ExAC gnomAD
CA2425286 rs775884779	735	N>S		No	ClinGen ExAC gnomAD
rs1199921366 CA353062544	736	V>G		No	ClinGen gnomAD
rs769218538 CA2425288	736	V>M		No	ClinGen ExAC gnomAD
CA353062582 rs1240580406	737	L>F		No	ClinGen gnomAD
rs1487990203 CA353062647	739	I>L		No	ClinGen TOPMed
COSM1209030 rs145802255 CA2425290	740	A>T	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs1047004122 CA74707065	740	A>V		No	ClinGen TOPMed gnomAD
CA353062747 rs1403679566	743	T>M		No	ClinGen TOPMed gnomAD
TCGA novel	746	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353062880 rs1400968257	748	K>N		No	ClinGen gnomAD
rs765098461 CA2425294	749	T>A		No	ClinGen ExAC TOPMed gnomAD
rs1295999820 CA353062897	749	T>I		No	ClinGen TOPMed
COSM259045 CA353062899 rs1329180037	750	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs371451244 CA2425295	750	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs371451244 CA2425296	750	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA2425297 rs764150215	751	K>T		No	ClinGen ExAC gnomAD
rs1577564582 CA353063028	754	E>A		No	ClinGen Ensembl
rs1353742972 CA353063032	754	E>D		No	ClinGen gnomAD
TCGA novel	755	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	755	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353063039 rs1219972779	755	N>Y		No	ClinGen gnomAD
rs746082458 CA2425301	758	E>G		No	ClinGen ExAC gnomAD
CA353063171 rs1171946408	758	E>K		No	ClinGen TOPMed
CA353063319 rs1444553813	762	I>T		No	ClinGen gnomAD
rs1047717477 CA74707134	762	I>V		No	ClinGen TOPMed
CA353063339 rs1421487734	763	G>V		No	ClinGen TOPMed
rs1189895243 CA353063375	764	F>C		No	ClinGen TOPMed
rs1237148165 CA353063389	765	T>P		No	ClinGen gnomAD
rs1559697699 CA353063511	769	T>I		No	ClinGen Ensembl
CA74707172 rs1021963271	771	I>V		No	ClinGen Ensembl
rs1424468056 CA353063594	772	I>L		No	ClinGen gnomAD
rs769097741 CA2425305	775	A>S		No	ClinGen ExAC gnomAD
CA2425306 rs774929914	775	A>V		No	ClinGen ExAC gnomAD
rs746464200 CA2425307	776	F>L		No	ClinGen ExAC gnomAD
CA74707245 rs999298194	781	Y>C		No	ClinGen gnomAD
rs765045190 CA2425311	783	T>P		No	ClinGen ExAC gnomAD
rs775411773 CA2425312	784	S>F		No	ClinGen ExAC gnomAD
CA2425314 rs540567050	785	S>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs751539636 CA2425315	787	Y>D		No	ClinGen ExAC gnomAD
rs201347255 CA2425317	788	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA2425316 rs757192965	788	R>W		No	ClinGen ExAC gnomAD
CA353065419 rs1198164157	793	T>I		No	ClinGen gnomAD
CA353065429 rs1393184263	794	M>K		No	ClinGen gnomAD
CA353065431 rs1393184263	794	M>T		No	ClinGen gnomAD
CA2425336 rs138493587	796	V>A		No	ClinGen ESP ExAC TOPMed gnomAD
COSM1424303 rs200496822 CA2425335	796	V>M	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA2425337 rs760751956	800	L>F		No	ClinGen ExAC gnomAD
rs1294887398 CA353065583	802	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA353065630 rs1577566849	804	V>A		No	ClinGen Ensembl
rs1323492175 CA353065621	804	V>L		No	ClinGen gnomAD
CA353065627 rs1323492175	804	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1369338396 CA353065679	806	L>F		No	ClinGen gnomAD
CA353065694 rs1242805088	807	G>A		No	ClinGen gnomAD
rs1310390431 CA353065725	809	L>R		No	ClinGen gnomAD
CA2425340 rs149853208	811	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA353065914 rs1220543480	818	L>F		No	ClinGen TOPMed
rs778437566 CA2425344	819	F>S		No	ClinGen ExAC gnomAD
CA353065948 rs1251071228	820	Q>*		No	ClinGen gnomAD
rs769459008 CA2425346	822	Q>R		No	ClinGen ExAC gnomAD
rs1237382757 CA353065992	823	K>E		No	ClinGen gnomAD
rs748919543 CA2425348	825	V>M		No	ClinGen ExAC gnomAD
rs768260967 CA2425349	826	V>F		No	ClinGen ExAC gnomAD
rs774182963 CA2425350	828	H>P		No	ClinGen ExAC
rs149365368 CA2425351	829	R>Q		No	ClinGen ESP ExAC gnomAD
rs1456971698 CA353066178	829	R>W		No	ClinGen TOPMed gnomAD
CA2425352 rs771981750	830	A>T		No	ClinGen ExAC TOPMed gnomAD
CA2425353 rs773167971	830	A>V		No	ClinGen ExAC TOPMed gnomAD
rs766421021 CA2425355	831	P>H		No	ClinGen ExAC TOPMed gnomAD
CA353066219 rs1376714522	831	P>T		No	ClinGen TOPMed gnomAD
CA2425356 rs200949604	832	T>P		No	ClinGen ExAC gnomAD
CA2425357 rs759795814	833	S>N		No	ClinGen ExAC gnomAD
rs765431473 CA2425358	833	S>R		No	ClinGen ExAC gnomAD
CA2425360 rs374246449	834	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2425359 rs374246449	834	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs764654881 CA2425361	834	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA353066371 rs1185504590	837	S>N		No	ClinGen TOPMed
rs975323042 CA74708597	839	A>P		No	ClinGen gnomAD
rs148453920 CA2425362	842	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA74708620 rs930969051	845	S>G		No	ClinGen Ensembl
rs982835926 CA74708629	846	L>F		No	ClinGen Ensembl
CA2425363 rs757881094	847	G>D		No	ClinGen ExAC
rs757826006 CA2425380	851	G>D		No	ClinGen ExAC TOPMed gnomAD
rs1360173079 CA353066722	852	S>P		No	ClinGen TOPMed gnomAD
CA353066743 rs1424461971	853	Q>H		No	ClinGen TOPMed
rs1434471249 CA353066775	855	V>I		No	ClinGen gnomAD
rs753326080 CA2425382	858	V>L		No	ClinGen ExAC gnomAD
rs754481569 CA2425383	859	C>Y		No	ClinGen ExAC gnomAD
CA2425384 rs778582066	860	N>S		No	ClinGen ExAC TOPMed gnomAD
CA2425385 rs747737086	861	G>C		No	ClinGen ExAC TOPMed gnomAD
rs1175613559 CA353066905	861	G>V		No	ClinGen TOPMed
rs1220916692 CA353066912	862	R>C		No	ClinGen gnomAD
rs1301892428 CA353066915	862	R>H		No	ClinGen TOPMed gnomAD
CA74708811 rs1030999467	863	E>D		No	ClinGen TOPMed gnomAD
CA353066957 rs1559698828	865	V>M		No	ClinGen Ensembl
rs1488392860 CA353066977	866	D>G		No	ClinGen TOPMed gnomAD
rs746860293 CA2425388	867	S>L		No	ClinGen ExAC gnomAD
rs1217638108 CA353066999 COSM123487	868	T>K	upper_aerodigestive_tract [Cosmic]	No	ClinGen cosmic curated TOPMed
rs144973019 CA353067008	869	T>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA2425391 rs144973019	869	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA2425390 rs776436857	869	T>S		No	ClinGen ExAC gnomAD
CA353067026 rs1283553487	870	S>L		No	ClinGen TOPMed
rs1193482971 CA353067036	871	S>L		No	ClinGen gnomAD
CA353067055 rs1559698909	873	L>G		No	ClinGen Ensembl

No associated diseases with Q14416

6 regional properties for Q14416

Type	Name	Position	InterPro Accession
domain	Receptor, ligand binding region	60 - 458	IPR001828
domain	GPCR, family 3, nine cysteines domain	496 - 546	IPR011500
domain	GPCR family 3, C-terminal	562 - 833	IPR017978
conserved_site	GPCR, family 3, conserved site	151 - 169	IPR017979-1
conserved_site	GPCR, family 3, conserved site	518 - 540	IPR017979-2
conserved_site	GPCR, family 3, conserved site	756 - 766	IPR017979-3

Functions

		Description
EC Number
Subcellular Localization	Cell membrane; Multi-pass membrane protein Synapse Cell projection, dendrite
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

8 GO annotations of cellular component

Name	Definition
anchoring junction	A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
astrocyte projection	A prolongation or process extending from the soma of an astrocyte and wrapping around neurons.
axon	The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
dendrite	A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
integral component of plasma membrane	The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of postsynaptic membrane	The component of the postsynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
presynaptic membrane	A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane.

6 GO annotations of molecular function

Name	Definition
adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	Combining with glutamate and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex to inhibit downstream adenylate cyclase activity.
calcium channel regulator activity	Modulates the activity of a calcium channel.
G protein-coupled receptor activity	Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
glutamate receptor activity	Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
group II metabotropic glutamate receptor activity	A G protein-coupled receptor that is activated by trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) and inhibits adenylate cyclase activity.
scaffold protein binding	Binding to a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.

13 GO annotations of biological process

Name	Definition
behavioral response to nicotine	Any process that results in a change in the behavior of an organism as a result of a nicotine stimulus.
chemical synaptic transmission	The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
G protein-coupled glutamate receptor signaling pathway	A G protein-coupled receptor signaling pathway initiated by glutamate binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.
gene expression	The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, translation and maturation for protein-coding genes.
glutamate homeostasis	Any process involved in the maintenance of an internal steady state of glutamate within an organism or cell.
glutamate secretion	The controlled release of glutamate by a cell. The glutamate is the most abundant excitatory neurotransmitter in the nervous system.
negative regulation of adenylate cyclase activity	Any process that stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase activity.
regulation of dopamine secretion	Any process that modulates the frequency, rate or extent of the regulated release of dopamine.
regulation of glutamate secretion	Any process that modulates the frequency, rate or extent of the controlled release of glutamate.
regulation of protein kinase B signaling	Any process that modulates the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
regulation of response to drug	Any process that modulates the frequency, rate or extent of response to drug.
regulation of synaptic transmission, glutamatergic	Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate.
response to cocaine	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant.

8 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P41180	CASR	Extracellular calcium-sensing receptor	Homo sapiens (Human)	PR
O00222	GRM8	Metabotropic glutamate receptor 8	Homo sapiens (Human)	PR
Q9QYS2	Grm3	Metabotropic glutamate receptor 3	Mus musculus (Mouse)	PR
P47743	Grm8	Metabotropic glutamate receptor 8	Mus musculus (Mouse)	PR
Q3UVX5	Grm5	Metabotropic glutamate receptor 5	Mus musculus (Mouse)	PR
Q14BI2	Grm2	Metabotropic glutamate receptor 2	Mus musculus (Mouse)	PR
P31422	Grm3	Metabotropic glutamate receptor 3	Rattus norvegicus (Rat)	PR
P31421	Grm2	Metabotropic glutamate receptor 2	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MGSLLALLAL	LLLWGAVAEG	PAKKVLTLEG	DLVLGGLFPV	HQKGGPAEDC	GPVNEHRGIQ
70	80	90	100	110	120
RLEAMLFALD	RINRDPHLLP	GVRLGAHILD	SCSKDTHALE	QALDFVRASL	SRGADGSRHI
130	140	150	160	170	180
CPDGSYATHG	DAPTAITGVI	GGSYSDVSIQ	VANLLRLFQI	PQISYASTSA	KLSDKSRYDY
190	200	210	220	230	240
FARTVPPDFF	QAKAMAEILR	FFNWTYVSTV	ASEGDYGETG	IEAFELEARA	RNICVATSEK
250	260	270	280	290	300
VGRAMSRAAF	EGVVRALLQK	PSARVAVLFT	RSEDARELLA	ASQRLNASFT	WVASDGWGAL
310	320	330	340	350	360
ESVVAGSEGA	AEGAITIELA	SYPISDFASY	FQSLDPWNNS	RNPWFREFWE	QRFRCSFRQR
370	380	390	400	410	420
DCAAHSLRAV	PFEQESKIMF	VVNAVYAMAH	ALHNMHRALC	PNTTRLCDAM	RPVNGRRLYK
430	440	450	460	470	480
DFVLNVKFDA	PFRPADTHNE	VRFDRFGDGI	GRYNIFTYLR	AGSGRYRYQK	VGYWAEGLTL
490	500	510	520	530	540
DTSLIPWASP	SAGPLPASRC	SEPCLQNEVK	SVQPGEVCCW	LCIPCQPYEY	RLDEFTCADC
550	560	570	580	590	600
GLGYWPNASL	TGCFELPQEY	IRWGDAWAVG	PVTIACLGAL	ATLFVLGVFV	RHNATPVVKA
610	620	630	640	650	660
SGRELCYILL	GGVFLCYCMT	FIFIAKPSTA	VCTLRRLGLG	TAFSVCYSAL	LTKTNRIARI
670	680	690	700	710	720
FGGAREGAQR	PRFISPASQV	AICLALISGQ	LLIVVAWLVV	EAPGTGKETA	PERREVVTLR
730	740	750	760	770	780
CNHRDASMLG	SLAYNVLLIA	LCTLYAFKTR	KCPENFNEAK	FIGFTMYTTC	IIWLAFLPIF
790	800	810	820	830	840
YVTSSDYRVQ	TTTMCVSVSL	SGSVVLGCLF	APKLHIILFQ	PQKNVVSHRA	PTSRFGSAAA
850	860	870
RASSSLGQGS	GSQFVPTVCN	GREVVDSTTS	SL