Q14BI2
PR
Gene name |
Grm2 (Gprc1b, Mglur2) |
Protein name |
Metabotropic glutamate receptor 2 |
Names |
mGluR2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:108068 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q14BI2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q14BI2-F1 | Predicted | AlphaFoldDB |
24 variants for Q14BI2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389044245 | 33 | V>M | No | EVA | |
| rs3389067911 | 50 | C>G | No | EVA | |
| rs3389016215 | 60 | Q>H | No | EVA | |
| rs3389062855 | 71 | R>H | No | EVA | |
| rs224268309 | 83 | R>H | No | EVA | |
| rs3389062864 | 102 | A>V | No | EVA | |
| rs3389069566 | 104 | D>H | No | EVA | |
| rs3389048325 | 135 | A>S | No | EVA | |
| rs3400885247 | 262 | S>R | No | EVA | |
| rs3400644843 | 343 | P>H | No | EVA | |
| rs3400639102 | 344 | W>G | No | EVA | |
| rs3389069515 | 394 | N>D | No | EVA | |
| rs3389048510 | 410 | M>K | No | EVA | |
| rs237003114 | 463 | N>S | No | EVA | |
| rs30436152 | 494 | T>P | No | EVA | |
| rs3389044219 | 510 | K>R | No | EVA | |
| rs3413129008 | 567 | W>* | No | EVA | |
| rs3389065172 | 769 | T>I | No | EVA | |
| rs3389073468 | 799 | S>T | No | EVA | |
| rs3389044170 | 811 | A>G | No | EVA | |
| rs3389044170 | 811 | A>V | No | EVA | |
| rs248156538 | 847 | G>A | No | EVA | |
| rs248156538 | 847 | G>D | No | EVA | |
| rs3389016210 | 849 | G>E | No | EVA |
No associated diseases with Q14BI2
6 regional properties for Q14BI2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Receptor, ligand binding region | 74 - 477 | IPR001828 |
| domain | GPCR, family 3, nine cysteines domain | 512 - 562 | IPR011500 |
| domain | GPCR family 3, C-terminal | 577 - 857 | IPR017978 |
| conserved_site | GPCR, family 3, conserved site | 162 - 180 | IPR017979-1 |
| conserved_site | GPCR, family 3, conserved site | 534 - 556 | IPR017979-2 |
| conserved_site | GPCR, family 3, conserved site | 777 - 787 | IPR017979-3 |
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| astrocyte projection | A prolongation or process extending from the soma of an astrocyte and wrapping around neurons. |
| axon | The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. |
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| integral component of postsynaptic membrane | The component of the postsynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| presynaptic membrane | A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| adenylate cyclase inhibiting G protein-coupled glutamate receptor activity | Combining with glutamate and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex to inhibit downstream adenylate cyclase activity. |
| calcium channel regulator activity | Modulates the activity of a calcium channel. |
| group II metabotropic glutamate receptor activity | A G protein-coupled receptor that is activated by trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) and inhibits adenylate cyclase activity. |
| scaffold protein binding | Binding to a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes. |
11 GO annotations of biological process
| Name | Definition |
|---|---|
| behavioral response to nicotine | Any process that results in a change in the behavior of an organism as a result of a nicotine stimulus. |
| G protein-coupled glutamate receptor signaling pathway | A G protein-coupled receptor signaling pathway initiated by glutamate binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. |
| gene expression | The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, translation and maturation for protein-coding genes. |
| glutamate homeostasis | Any process involved in the maintenance of an internal steady state of glutamate within an organism or cell. |
| glutamate secretion | The controlled release of glutamate by a cell. The glutamate is the most abundant excitatory neurotransmitter in the nervous system. |
| regulation of dopamine secretion | Any process that modulates the frequency, rate or extent of the regulated release of dopamine. |
| regulation of glutamate secretion | Any process that modulates the frequency, rate or extent of the controlled release of glutamate. |
| regulation of protein kinase B signaling | Any process that modulates the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. |
| regulation of response to drug | Any process that modulates the frequency, rate or extent of response to drug. |
| regulation of synaptic transmission, glutamatergic | Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. |
| response to cocaine | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O00222 | GRM8 | Metabotropic glutamate receptor 8 | Homo sapiens (Human) | PR |
| P41180 | CASR | Extracellular calcium-sensing receptor | Homo sapiens (Human) | PR |
| Q14416 | GRM2 | Metabotropic glutamate receptor 2 | Homo sapiens (Human) | PR |
| P47743 | Grm8 | Metabotropic glutamate receptor 8 | Mus musculus (Mouse) | PR |
| Q9QYS2 | Grm3 | Metabotropic glutamate receptor 3 | Mus musculus (Mouse) | PR |
| Q3UVX5 | Grm5 | Metabotropic glutamate receptor 5 | Mus musculus (Mouse) | PR |
| P31422 | Grm3 | Metabotropic glutamate receptor 3 | Rattus norvegicus (Rat) | PR |
| P31421 | Grm2 | Metabotropic glutamate receptor 2 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MESLLRFLAL | LLLRGAVAEG | PAKKVLTLEG | DLVLGGLFPV | HQKGGPAEEC | GPVNEHRGIQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RLEAMLFALD | RINRDPHLLP | GVRLGAHILD | SCSKDTHALE | QALDFVRASL | SRGADGSRHI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| CPDGSYATLS | DAPTAITGVI | GGSYSDVSIQ | VANLLRLFQI | PQISYASTSA | KLSDKSRYDY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FARTVPPDFF | QAKAMAEILR | FFNWTYVSTV | ASEGDYGETG | IEAFELEARA | RNICVATSEK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VGRAMSRAAF | EGVVRALLQK | PSARVAVLFT | RSEDARELLA | ATQRLNASFT | WVASDGWGAL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ESVVAGSERA | AEGAITIELA | SYPISDFASY | FQNLDPWNNS | RNPWFREFWE | ERFRCSFRQR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DCAAHSLRAV | PFEQESKIMF | VVNAVYAMAH | ALHNMHRALC | PNTTRLCDAM | RPVNGRRLYK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DFVLNVKFDA | PFRPADTDDE | VRFDRFGDGI | GRYNIFTYLR | AGNGRYRYQK | VGYWAEGLTL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DTSIIPWASP | SAGTLPASRC | SEPCLQNEVK | SVQPGEVCCW | LCIPCQPYEY | RLDEFTCADC |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GLGYWPNASL | TGCFELPQEY | IRWGDAWAVG | PVTIACLGAL | ATLFVLGVFV | RHNATPVVKA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SGRELCYILL | GGVFLCYCMT | FIFIAKPSTA | VCTLRRLGLG | TAFSVCYSAL | LTKTNRIARI |
| 670 | 680 | 690 | 700 | 710 | 720 |
| FGGAREGAQR | PRFISPASQV | AICLALISGQ | LLIVAAWLVV | EAPGIGKETA | PERREVVTLR |
| 730 | 740 | 750 | 760 | 770 | 780 |
| CNHRDASMLG | SLAYNVLLIA | LCTLYAFKTR | KCPENFNEAK | FIGFTMYTTC | IIWLAFLPIF |
| 790 | 800 | 810 | 820 | 830 | 840 |
| YVTSSDYRVQ | TTTMCVSVSL | SGSVVLGCLF | APKLHIILFQ | PQKNVVSHRA | PTSRFGSAAP |
| 850 | 860 | 870 | |||
| RASANLGQGS | GSQLVPTVCN | GREVVDSTTS | SL |