P31422

PR
Gene name
Grm3 (Gprc1c, Mglur3)
Protein name
Metabotropic glutamate receptor 3
Names
mGluR3
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:24416
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

808-879 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

6 structures for P31422

Entry ID Method Resolution Chain Position Source
2E4U X-ray 235 A A/B 25-575 PDB
2E4V X-ray 240 A A/B 25-575 PDB
2E4W X-ray 240 A A/B 25-575 PDB
2E4X X-ray 275 A A/B 25-575 PDB
2E4Y X-ray 340 A A/B 25-575 PDB
AF-P31422-F1 Predicted AlphaFoldDB

No variants for P31422

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P31422

No associated diseases with P31422

6 regional properties for P31422

Type Name Position InterPro Accession
domain Receptor, ligand binding region 67 - 473 IPR001828
domain GPCR, family 3, nine cysteines domain 505 - 555 IPR011500
domain GPCR family 3, C-terminal 571 - 842 IPR017978
conserved_site GPCR, family 3, conserved site 157 - 175 IPR017979-1
conserved_site GPCR, family 3, conserved site 527 - 549 IPR017979-2
conserved_site GPCR, family 3, conserved site 765 - 775 IPR017979-3

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

12 GO annotations of cellular component

Name Definition
astrocyte projection A prolongation or process extending from the soma of an astrocyte and wrapping around neurons.
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
dendritic spine A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
glutamatergic synapse A synapse that uses glutamate as a neurotransmitter.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of postsynaptic membrane The component of the postsynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of presynaptic membrane The component of the presynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
neuron projection A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
postsynaptic density An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
postsynaptic membrane A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.
presynaptic membrane A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane.

4 GO annotations of molecular function

Name Definition
adenylate cyclase inhibiting G protein-coupled glutamate receptor activity Combining with glutamate and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex to inhibit downstream adenylate cyclase activity.
calcium channel regulator activity Modulates the activity of a calcium channel.
group II metabotropic glutamate receptor activity A G protein-coupled receptor that is activated by trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) and inhibits adenylate cyclase activity.
scaffold protein binding Binding to a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.

5 GO annotations of biological process

Name Definition
G protein-coupled glutamate receptor signaling pathway A G protein-coupled receptor signaling pathway initiated by glutamate binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.
gene expression The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, translation and maturation for protein-coding genes.
modulation of chemical synaptic transmission Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.
regulation of synaptic transmission, glutamatergic Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate.
sensory perception of pain The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O00222 GRM8 Metabotropic glutamate receptor 8 Homo sapiens (Human) PR
Q14416 GRM2 Metabotropic glutamate receptor 2 Homo sapiens (Human) PR
P41180 CASR Extracellular calcium-sensing receptor Homo sapiens (Human) PR
Q14BI2 Grm2 Metabotropic glutamate receptor 2 Mus musculus (Mouse) PR
P47743 Grm8 Metabotropic glutamate receptor 8 Mus musculus (Mouse) PR
Q3UVX5 Grm5 Metabotropic glutamate receptor 5 Mus musculus (Mouse) PR
Q9QYS2 Grm3 Metabotropic glutamate receptor 3 Mus musculus (Mouse) PR
P31421 Grm2 Metabotropic glutamate receptor 2 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MKMLTRLQIL MLALFSKGFL LSLGDHNFMR REIKIEGDLV LGGLFPINEK GTGTEECGRI
70 80 90 100 110 120
NEDRGIQRLE AMLFAIDEIN KDNYLLPGVK LGVHILDTCS RDTYALEQSL EFVRASLTKV
130 140 150 160 170 180
DEAEYMCPDG SYAIQENIPL LIAGVIGGSY SSVSIQVANL LRLFQIPQIS YASTSAKLSD
190 200 210 220 230 240
KSRYDYFART VPPDFYQAKA MAEILRFFNW TYVSTVASEG DYGETGIEAF EQEARLRNIC
250 260 270 280 290 300
IATAEKVGRS NIRKSYDSVI RELLQKPNAR VVVLFMRSDD SRELIAAANR VNASFTWVAS
310 320 330 340 350 360
DGWGAQESIV KGSEHVAYGA ITLELASHPV RQFDRYFQSL NPYNNHRNPW FRDFWEQKFQ
370 380 390 400 410 420
CSLQNKRNHR QVCDKHLAID SSNYEQESKI MFVVNAVYAM AHALHKMQRT LCPNTTKLCD
430 440 450 460 470 480
AMKILDGKKL YKEYLLKINF TAPFNPNKGA DSIVKFDTFG DGMGRYNVFN LQQTGGKYSY
490 500 510 520 530 540
LKVGHWAETL SLDVDSIHWS RNSVPTSQCS DPCAPNEMKN MQPGDVCCWI CIPCEPYEYL
550 560 570 580 590 600
VDEFTCMDCG PGQWPTADLS GCYNLPEDYI KWEDAWAIGP VTIACLGFLC TCIVITVFIK
610 620 630 640 650 660
HNNTPLVKAS GRELCYILLF GVSLSYCMTF FFIAKPSPVI CALRRLGLGT SFAICYSALL
670 680 690 700 710 720
TKTNCIARIF DGVKNGAQRP KFISPSSQVF ICLGLILVQI VMVSVWLILE TPGTRRYTLP
730 740 750 760 770 780
EKRETVILKC NVKDSSMLIS LTYDVVLVIL CTVYAFKTRK CPENFNEAKF IGFTMYTTCI
790 800 810 820 830 840
IWLAFLPIFY VTSSDYRVQT TTMCISVSLS GFVVLGCLFA PKVHIVLFQP QKNVVTHRLH
850 860 870
LNRFSVSGTA TTYSQSSAST YVPTVCNGRE VLDSTTSSL