Q27487

PR
Gene name
ctl-2
Protein name
Peroxisomal catalase 1
Names
Catalase-2
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_Y54G11A.5
EC number
1.11.1.6: Peroxidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-53 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q27487

Entry ID Method Resolution Chain Position Source
AF-Q27487-F1 Predicted AlphaFoldDB

No variants for Q27487

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q27487

No associated diseases with Q27487

4 regional properties for Q27487

Type Name Position InterPro Accession
binding_site Catalase haem-binding site 350 - 358 IPR002226
domain Catalase immune-responsive domain 431 - 490 IPR010582
domain Catalase core domain 24 - 408 IPR011614
active_site Catalase active site 60 - 76 IPR024708

Functions

Description
EC Number 1.11.1.6 Peroxidases
Subcellular Localization
  • Peroxisome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
peroxisome A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.

4 GO annotations of molecular function

Name Definition
catalase activity Catalysis of the reaction: 2 hydrogen peroxide = O2 + 2 H2O.
heme binding Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
metal ion binding Binding to a metal ion.
peroxidase activity Catalysis of the reaction: a donor + a peroxide = an oxidized donor + 2 H2O.

4 GO annotations of biological process

Name Definition
determination of adult lifespan The pathways that regulate the duration of the adult phase of the life-cycle of an animal.
hydrogen peroxide catabolic process The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2).
peroxisome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules.
response to hydrogen peroxide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q43206 CAT1 Catalase-1 Triticum aestivum (Wheat) PR
O97492 CAT Catalase Canis lupus familiaris (Dog) (Canis familiaris) PR
P17336 Cat Catalase Drosophila melanogaster (Fruit fly) PR
P18122 CAT1 Catalase isozyme 1 Zea mays (Maize) PR
P24270 Cat Catalase Mus musculus (Mouse) PR
P04762 Cat Catalase Rattus norvegicus (Rat) PR
Q0D9C4 CATB Catalase isozyme B Oryza sativa subsp japonica (Rice) PR
Q0E4K1 CATA Catalase isozyme A Oryza sativa subsp japonica (Rice) PR
O61235 ctl-1 Catalase-2 Caenorhabditis elegans PR
Q42547 CAT3 Catalase-3 Arabidopsis thaliana (Mouse-ear cress) PR
P25819 CAT2 Catalase-2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MPNDPSDNQL KTYKETYPKP QVITTSNGAP IYSKTAVLTA GRRGPMLMQD VVYMDEMAHF
70 80 90 100 110 120
DRERIPERVV HAKGAGAHGY FEVTHDISKY CKADIFNKVG KQTPLLIRFS TVGGESGSAD
130 140 150 160 170 180
TARDPRGFAI KFYTEEGNWD LVGNNTPIFF IRDPIHFPNF IHTQKRNPQT HLKDPNMIFD
190 200 210 220 230 240
FWLHRPEALH QVMFLFSDRG LPDGYRHMNG YGSHTFKMVN KDGKAIYVKF HFKPTQGVKN
250 260 270 280 290 300
LTVEKAGQLA SSDPDYSIRD LFNAIEKGDF PVWKMFIQVM TFEQAEKWEF NPFDVTKVWP
310 320 330 340 350 360
HGDYPLIEVG KMVLNRNPRN YFAEVEQSAF CPAHIVPGIE FSPDKMLQGR IFSYTDTHFH
370 380 390 400 410 420
RLGPNYIQLP VNCPYRSRAH NTQRDGAMAY DNQQHAPNFF PNSFNYGKTR PDVKDTTFPA
430 440 450 460 470 480
TGDVDRYESG DDNNYDQPRQ FWEKVLDTGA RERMCQNFAG PLGECHDFII KGMIDHFSKV
490
HPDFGARVKA LIQKQARSHI