P18122

PR
Gene name
CAT1
Protein name
Catalase isozyme 1
Names
Species
Zea mays (Maize)
KEGG Pathway
EC number
1.11.1.6: Peroxidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-49 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P18122

Entry ID Method Resolution Chain Position Source
AF-P18122-F1 Predicted AlphaFoldDB

4 variants for P18122

Variant ID(s) Position Change Description Diseaes Association Provenance
157 A>V strain: cv. W64A [UniProt] No
211 S>T strain: cv. W64A [UniProt] No
329 S>I strain: cv. W64A [UniProt] No
483 P>A strain: cv. W64A [UniProt] No

No associated diseases with P18122

4 regional properties for P18122

Type Name Position InterPro Accession
binding_site Catalase haem-binding site 344 - 352 IPR002226
domain Catalase immune-responsive domain 423 - 483 IPR010582
domain Catalase core domain 18 - 401 IPR011614
active_site Catalase active site 54 - 70 IPR024708

Functions

Description
EC Number 1.11.1.6 Peroxidases
Subcellular Localization
  • Peroxisome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
peroxisome A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
catalase activity Catalysis of the reaction: 2 hydrogen peroxide = O2 + 2 H2O.
heme binding Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
metal ion binding Binding to a metal ion.

16 GO annotations of biological process

Name Definition
circadian rhythm Any biological process in an organism that recurs with a regularity of approximately 24 hours.
cold acclimation Any process that increases freezing tolerance of an organism in response to low, nonfreezing temperatures.
hydrogen peroxide catabolic process The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2).
regulation of cellular response to heat Any process that modulates the frequency, rate or extent of cellular response to heat.
response to abscisic acid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus.
response to absence of light Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an absence of light stimuli.
response to auxin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auxin stimulus.
response to cadmium ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
response to heat Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
response to hydrogen peroxide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
response to oxidative stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
response to reactive oxygen species Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
response to salicylic acid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salicylic acid stimulus.
response to salt Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus.
response to water deprivation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water.
response to xenobiotic stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.

10 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q43206 CAT1 Catalase-1 Triticum aestivum (Wheat) PR
P17336 Cat Catalase Drosophila melanogaster (Fruit fly) PR
P24270 Cat Catalase Mus musculus (Mouse) PR
P04762 Cat Catalase Rattus norvegicus (Rat) PR
Q0E4K1 CATA Catalase isozyme A Oryza sativa subsp japonica (Rice) PR
Q0D9C4 CATB Catalase isozyme B Oryza sativa subsp japonica (Rice) PR
Q27487 ctl-2 Peroxisomal catalase 1 Caenorhabditis elegans PR
O61235 ctl-1 Catalase-2 Caenorhabditis elegans PR
Q42547 CAT3 Catalase-3 Arabidopsis thaliana (Mouse-ear cress) PR
P25819 CAT2 Catalase-2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MDPYKHRPSS GSNSSFWTTN SGAPVWNNNS ALTVGQRGPI LLEDYHLIEK LAQFDRERIP
70 80 90 100 110 120
ERVVHARGAS AKGFFEVTHD VSHLTCADFL RAPGVQTPVI VRFSTVVHER GSPETLRDPR
130 140 150 160 170 180
GFAVKFYTRE GNFDLVGNNM PVFFIRDGMK FPDMVHAFKP NPKTNLQENW RIVDFFSHHP
190 200 210 220 230 240
ESLHMFTFLF DDVGIPLNYR HMEGFGVNTY SLINRDGKPH LVKFHWKPTC GVKCLLDNEA
250 260 270 280 290 300
VTVGGTCHSH ATKDLYDSIA AGNYPEWKLY IQTIDLDHED KFDFDPLDVT KTWPEDIIPL
310 320 330 340 350 360
QPVGRMVLNK NVDNFFAENE QIAFCPAISV PAIHYSDDKL LQTRIFSYAD TQRHRLGPNY
370 380 390 400 410 420
LMLPVNAPKC AHHNNHHDGF MNFMHRDEEV NYFPSRFDPA RHAEKVPIPP RVLTRCREKC
430 440 450 460 470 480
IIQKENNFKQ AGERYRSFDP ARQDRFIQRW VDALTHPRVT HEHRTIWISY WSQCDAALGQ
490
KLPSRLNLKP SM