O97492

PR
Gene name
CAT
Protein name
Catalase
Names
Species
Canis lupus familiaris (Dog) (Canis familiaris)
KEGG Pathway
cfa:403474
EC number
1.11.1.6: Peroxidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-53 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O97492

Entry ID Method Resolution Chain Position Source
AF-O97492-F1 Predicted AlphaFoldDB

3 variants for O97492

Variant ID(s) Position Change Description Diseaes Association Provenance
rs22611132 126 V>I No EVA
rs22611134 127 R>H No EVA
327 A>T acatalasemia; heat-labile [UniProt] No

No associated diseases with O97492

4 regional properties for O97492

Type Name Position InterPro Accession
binding_site Catalase haem-binding site 354 - 362 IPR002226
domain Catalase immune-responsive domain 436 - 496 IPR010582
domain Catalase core domain 28 - 413 IPR011614
active_site Catalase active site 64 - 80 IPR024708

Functions

Description
EC Number 1.11.1.6 Peroxidases
Subcellular Localization
  • Peroxisome matrix
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
catalase complex A protein-containing complex that is capable of catalase activity.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
peroxisomal membrane The lipid bilayer surrounding a peroxisome.
peroxisome A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.

8 GO annotations of molecular function

Name Definition
aminoacylase activity Catalysis of the reaction: an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid.
catalase activity Catalysis of the reaction: 2 hydrogen peroxide = O2 + 2 H2O.
enzyme binding Binding to an enzyme, a protein with catalytic activity.
heme binding Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
metal ion binding Binding to a metal ion.
NADP binding Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.
peroxisome targeting sequence binding Binding to a peroxisomal targeting sequence, a sequence of amino acids within a protein that acts as a signal for the localization of a protein into the peroxisome.
protein homodimerization activity Binding to an identical protein to form a homodimer.

13 GO annotations of biological process

Name Definition
aerobic respiration The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor.
cellular detoxification of hydrogen peroxide Any process that reduces or removes the toxicity of hydrogen peroxide in a cell. These include transport of hydrogen peroxide away from sensitive areas and to compartments or complexes whose purpose is sequestration.
cholesterol metabolic process The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.
hemoglobin metabolic process The chemical reactions and pathways involving hemoglobin, including its uptake and utilization.
hydrogen peroxide catabolic process The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2).
negative regulation of apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
negative regulation of NF-kappaB transcription factor activity Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.
positive regulation of cell division Any process that activates or increases the frequency, rate or extent of cell division.
positive regulation of NF-kappaB transcription factor activity Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
positive regulation of phosphatidylinositol 3-kinase signaling Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.
response to hydrogen peroxide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
triglyceride metabolic process The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins.
UV protection Any process in which an organism or cell protects itself from ultraviolet radiation (UV), which may also result in resistance to repeated exposure to UV.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P17336 Cat Catalase Drosophila melanogaster (Fruit fly) PR
P24270 Cat Catalase Mus musculus (Mouse) PR
P04762 Cat Catalase Rattus norvegicus (Rat) PR
Q0D9C4 CATB Catalase isozyme B Oryza sativa subsp japonica (Rice) PR
Q0E4K1 CATA Catalase isozyme A Oryza sativa subsp japonica (Rice) PR
Q27487 ctl-2 Peroxisomal catalase 1 Caenorhabditis elegans PR
O61235 ctl-1 Catalase-2 Caenorhabditis elegans PR
10 20 30 40 50 60
MADSRDPASD QMKLWKEQRA AQKPDVLTTG GGNPIGDKLN VMTAGPRGPL LVQDVVFTDE
70 80 90 100 110 120
MAHFDRERIP ERVVHAKGAG AFGYFEVTHD ITKYSKAKVF EHIGKRTPIA VRFSTVAGES
130 140 150 160 170 180
GSADTVRDPR GFAVKFYTED GNWDLVGNNT PIFFIRDAIL FPSFIHSQKR NPQTHLKDPD
190 200 210 220 230 240
MVWDFWSLRP ESLHQVSFLF SDRGIPDGHR HMNGYGSHTF KLVNAAGEAV YCKFHYKTDQ
250 260 270 280 290 300
GIKNLSVEDA ARLSHEDPDY GLRDLFNAIA TGNYPSWTFY IQVMTFSQAE TFPFNPFDLT
310 320 330 340 350 360
KIWPHQDYPL IPVGKLVLNR NPVNYFAEVE QMAFDPSNMP PGIEPSPDKM LQGRLFAYPD
370 380 390 400 410 420
THRHRLGPNY LQIPVNCPFR ARVANYQRDG PMCMLDNQGG APNYYPNSFS APEQQRCVLE
430 440 450 460 470 480
HSSQCSPDVQ RFNSANEDNV TQVRTFYLKV LGEEERKRLC ENIAGHLKDA QLFIQKKAVK
490 500 510 520
NFSDVHPDYG ARIQALLDKY NAEKPKNAIH TFMQHGSHLA AREKANL