AiPD: Autoinhibited Protein Database

Q13332

Gene name	PTPRS
Protein name	Receptor-type tyrosine-protein phosphatase S
Names	R-PTP-S, Receptor-type tyrosine-protein phosphatase sigma, R-PTP-sigma
Species	Homo sapiens (Human)
KEGG Pathway	hsa:5802
EC number	3.1.3.48: Phosphoric monoester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1655-1730 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1655-1730 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

7 structures for Q13332

Entry ID	Method	Resolution	Chain	Position	Source
2FH7	X-ray	200 A	A	1365-1948	PDB
2YD2	X-ray	255 A	A	30-244	PDB
2YD3	X-ray	230 A	A	30-235	PDB
2YD9	X-ray	260 A	A	30-334	PDB
4BPC	X-ray	210 A	A	1367-1948	PDB
4PBX	X-ray	315 A	A	30-614	PDB
AF-Q13332-F1	Predicted				AlphaFoldDB

985 variants for Q13332

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA9109009 rs140472977 RCV000791306	1586	V>M	Variant assessed as Somatic; 0.0 impact. NK-cell enteropathy [NCI-TCGA, ClinVar]	Yes	ClinGen ClinVar ESP ExAC NCI-TCGA TOPMed dbSNP gnomAD
TCGA novel	4	T>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs200430287	24	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1427468626	40	K>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1064293	48	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs777078756	49	V>C	Variant assessed as Somatic; 4.644e-05 impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	55	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	56	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs146675930	80	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1397380294	100	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	101	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs769916725	148	R>Q	Variant assessed as Somatic; 4.621e-05 impact. [NCI-TCGA]	No	NCI-TCGA
rs781304015	150	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs770043743	183	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs774744361	196	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1302269430	224	V>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	238	R>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	238	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs990860881	239	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs781664688	243	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1207603443	246	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	260	G>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	276	V>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	282	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1423516878	295	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	307	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1218428122	334	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	353	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	359	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs377318412	364	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1383575470	366	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	392	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs750721878	403	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	404	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1568465790	405	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1390768500 TCGA novel	414	S>A	Variant assessed as Somatic; impact. Variant assessed as Somatic; 4.705e-05 impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	414	S>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	425	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs754224013	429	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs919253826	429	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	429	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs760369713	431	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1237664443	431	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1405091584	435	A>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1205925337	445	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	446	Q>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	454	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	462	V>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs73545312	462	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs747170106	472	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	498	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1488811231	503	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1260947679	508	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs724159895	511	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	523	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	526	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1196402998	529	M>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs368361739	542	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs750655279	549	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	568	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs374725933	580	V>M	Variant assessed as Somatic; 4.62e-05 impact. [NCI-TCGA]	No	NCI-TCGA
rs775100072	593	R>C	Variant assessed as Somatic; 4.621e-05 impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	593	R>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs778054699	597	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs760549393	608	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1237159914	610	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1330682967 CA403517735	617	K>R		No	ClinGen TOPMed
CA9110167 rs777396253	618	P>L		No	ClinGen ExAC gnomAD
rs374621025 CA9110166	619	S>*		No	ClinGen ESP ExAC gnomAD
rs752226232 CA9110165	620	A>D		No	ClinGen ExAC gnomAD
rs766486140 CA9110161	621	P>H		No	ClinGen ExAC gnomAD
rs755108907	622	P>L	Variant assessed as Somatic; 6.512e-05 impact. [NCI-TCGA]	No	NCI-TCGA
rs1488250331 CA403517691	622	P>S		No	ClinGen TOPMed gnomAD
CA403517693 rs1488250331	622	P>T		No	ClinGen TOPMed gnomAD
rs760830146 CA9110156	624	D>G		No	ClinGen ExAC gnomAD
rs772048652 CA9110154	630	V>L		No	ClinGen ExAC TOPMed gnomAD
rs772048652 CA304606168	630	V>M		No	ClinGen ExAC TOPMed gnomAD
rs779378586 CA9110152	631	R>C		No	ClinGen ExAC TOPMed gnomAD
rs779378586 CA403517609	631	R>S		No	ClinGen ExAC TOPMed gnomAD
rs1216644787 CA403517582	633	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs771492236 CA9110151	635	I>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	636	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs868011195 CA304606167	640	R>C		No	ClinGen gnomAD
rs150939732 CA9110149	640	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed
CA9110148 rs755739102	641	P>L		No	ClinGen ExAC gnomAD
CA304606166 rs994725876	641	P>S		No	ClinGen TOPMed
CA304606165 rs1033036953	643	P>A		No	ClinGen Ensembl
CA9110145 rs754436545	643	P>L		No	ClinGen ExAC TOPMed gnomAD
rs766391106 CA9110143	644	P>A		No	ClinGen ExAC TOPMed gnomAD
CA9110142 rs758460182	644	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs766391106 CA304606164	644	P>S		No	ClinGen ExAC TOPMed gnomAD
CA403517485 rs766391106	644	P>T		No	ClinGen ExAC TOPMed gnomAD
CA9110138 rs760884281	646	T>M		No	ClinGen ExAC gnomAD
rs767837276 CA9110137 CA9110136	649	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC gnomAD NCI-TCGA
CA9110135 rs759529027	650	A>P		No	ClinGen ExAC gnomAD
TCGA novel	650	A>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA403517438 rs1220417036	652	V>L		No	ClinGen gnomAD
rs771403922 CA9110133	655	S>G		No	ClinGen ExAC gnomAD
rs200689431 CA9110132	657	R>C		No	ClinGen 1000Genomes ExAC gnomAD
CA403517403 rs1386910242	657	R>H		No	ClinGen TOPMed gnomAD
CA304606163 rs889829498	659	R>Q		No	ClinGen Ensembl
rs200771602 CA9110130	660	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs200771602 CA304606162	660	P>Q		No	ClinGen ExAC gnomAD
CA9110126 rs147784971	663	S>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs200172769 CA9110125	663	S>L		No	ClinGen ExAC TOPMed gnomAD
rs147784971 CA9110127	663	S>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA9110124 rs370707556	664	E>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA403517370 rs1484148894	664	E>Q		No	ClinGen gnomAD
rs1372364043 CA403517360	665	D>G		No	ClinGen TOPMed
rs1308508280 CA403517362	665	D>N		No	ClinGen TOPMed
CA403517347 rs1377623190	666	P>L		No	ClinGen TOPMed gnomAD
CA403517326 rs1355617947	669	K>E		No	ClinGen TOPMed
CA403517276 TCGA novel rs1599550265	673	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Ensembl
rs919758857 CA304606161	673	G>S		No	ClinGen TOPMed
rs759801187 CA9110119	674	I>M		No	ClinGen ExAC TOPMed gnomAD
rs1238574782 CA403517262	675	P>S		No	ClinGen gnomAD
rs1238574782 CA403517265	675	P>T		No	ClinGen gnomAD
rs376058028 CA9110117	676	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1313475733 CA403517220	680	Q>E		No	ClinGen gnomAD
CA403517213 rs1306570922	680	Q>H		No	ClinGen gnomAD
CA304606160 rs1036934835	684	E>K		No	ClinGen TOPMed gnomAD
rs1036934835 CA403517185	684	E>Q		No	ClinGen TOPMed gnomAD
rs1333782961 CA403517164	685	A>V		No	ClinGen gnomAD
TCGA novel	686	L>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs770401761 CA9110113	689	W>*		No	ClinGen ExAC gnomAD
rs568688962 CA9110110	693	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9110108 rs370330291	695	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA403517048 rs1240330020	696	T>I		No	ClinGen gnomAD
rs778710485 CA9110105	698	A>T		No	ClinGen ExAC TOPMed gnomAD
rs981031714 CA304606159	699	H>N		No	ClinGen Ensembl
CA9110103 rs753552451	701	E>G		No	ClinGen ExAC gnomAD
rs757257991 CA9110104	701	E>Q		No	ClinGen ExAC
rs147750933 CA9110102	703	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs945177819 CA403516984	704	P>L		No	ClinGen TOPMed gnomAD
rs945177819 CA304606158	704	P>R		No	ClinGen TOPMed gnomAD
CA403516976 rs1243032613	705	G>V		No	ClinGen gnomAD
CA403516968 rs1340279963	706	P>L		No	ClinGen gnomAD
CA304606157 rs1053912542	707	E>D		No	ClinGen TOPMed gnomAD
rs370338775 CA9110098	709	S>L		No	ClinGen ExAC TOPMed gnomAD
rs1420442830 CA403516932	710	P>S		No	ClinGen gnomAD
rs765642813 CA9110096	711	V>M		No	ClinGen ExAC TOPMed gnomAD
CA403516908 rs1367694603	713	V>I		No	ClinGen gnomAD
rs776822913 CA9110094	714	R>C		No	ClinGen ExAC TOPMed gnomAD
CA403516897 rs769069932	714	R>H		No	ClinGen ExAC gnomAD
rs769069932 CA9110093	714	R>P		No	ClinGen ExAC gnomAD
rs775268583 CA9110091	716	D>E		No	ClinGen ExAC TOPMed gnomAD
CA403516886 rs1488356054	716	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA403516876 rs1447785084	717	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA304606156 rs971664522	718	D>G		No	ClinGen TOPMed
CA403516687 rs1374310303	722	A>T		No	ClinGen TOPMed
rs1393421847 CA403516685	722	A>V		No	ClinGen TOPMed
CA403516655 rs1360054733	727	V>A		No	ClinGen gnomAD
rs960841066 CA304605909	727	V>M		No	ClinGen TOPMed
TCGA novel	728	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1364091998 CA403516639	729	A>G		No	ClinGen TOPMed gnomAD
rs1599535237 CA403516644	729	A>T		No	ClinGen Ensembl
CA403516641 rs1364091998	729	A>V		No	ClinGen TOPMed gnomAD
rs1599535159 CA403516634	730	E>G		No	ClinGen Ensembl
rs1273151991 CA403516625	731	A>V		No	ClinGen TOPMed gnomAD
rs1328222592 CA403516607	734	A>D		No	ClinGen TOPMed gnomAD
TCGA novel	735	T>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1035485750 CA304605908	736	A>S		No	ClinGen TOPMed
rs1164098327 CA403516584	738	R>C		No	ClinGen TOPMed gnomAD
rs1254439512 CA403516583	738	R>H		No	ClinGen TOPMed
CA304605907 rs1004888859	745	A>T		No	ClinGen TOPMed gnomAD
rs1064295 CA304605906	745	A>V		No	ClinGen gnomAD
TCGA novel	746	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1195141314 CA403516529	747	G>D		No	ClinGen gnomAD
rs1246891588 CA403516531	747	G>S		No	ClinGen TOPMed gnomAD
rs1237963337 CA403516524	748	R>L		No	ClinGen gnomAD
rs1399739848 CA403516525	748	R>W		No	ClinGen TOPMed
CA403516507 rs1309771135	750	H>Q		No	ClinGen TOPMed gnomAD
rs769766853 CA9110063	752	Q>E		No	ClinGen ExAC gnomAD
rs1384894908 CA403516493	752	Q>H		No	ClinGen TOPMed
rs1477293906 CA403516495	752	Q>L		No	ClinGen gnomAD
CA403516488 rs1384706276	753	I>T		No	ClinGen Ensembl
rs1307585641 CA403516461	757	Q>R		No	ClinGen TOPMed
rs1305842029 CA403516449	759	H>Y		No	ClinGen gnomAD
rs1027605608 CA304605904	760	Y>F		No	ClinGen TOPMed
rs1038862962 CA304605901	762	R>C		No	ClinGen TOPMed gnomAD
rs1374294763 CA403516429	762	R>H		No	ClinGen TOPMed gnomAD
TCGA novel	762	R>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA304605902 rs1038862962	762	R>S		No	ClinGen TOPMed gnomAD
rs1442731364 CA403516424	763	M>L		No	ClinGen TOPMed gnomAD
rs1442731364 CA403516425	763	M>V		No	ClinGen TOPMed gnomAD
CA403516405 rs1356179565	765	G>A		No	ClinGen TOPMed gnomAD
rs780989941 CA9110061	766	A>T		No	ClinGen ExAC gnomAD
rs1174099281 CA403516386	768	A>G		No	ClinGen TOPMed
rs1175059175 CA403516389	768	A>P		No	ClinGen gnomAD
rs1437431875 CA403516382	769	R>C		No	ClinGen TOPMed gnomAD
CA9110060 rs542345642	771	P>L		No	ClinGen 1000Genomes ExAC gnomAD
rs1053239616 CA304605898	771	P>S		No	ClinGen TOPMed gnomAD
rs1481847293 CA403516363	772	P>L		No	ClinGen gnomAD
CA403516364 rs1481847293	772	P>Q		No	ClinGen gnomAD
rs1259120475 CA403516359	773	R>H		No	ClinGen gnomAD
rs746107616 CA9110059	777	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1298629875 CA403516321	778	M>I		No	ClinGen TOPMed
rs1599533520 CA403516309	780	A>V		No	ClinGen Ensembl
rs1303613614 CA403516308	781	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs898869635 CA304605873	784	W>R		No	ClinGen Ensembl
CA9110023 rs761681941	786	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA403516254 rs761681941	786	T>R		No	ClinGen ExAC TOPMed gnomAD
CA403516244 rs1390648362	788	D>H		No	ClinGen gnomAD
CA304605872 rs1015963134	789	T>M		No	ClinGen Ensembl
CA403516225 rs1417612381	791	E>K		No	ClinGen Ensembl
rs181439211 CA9110015	792	Y>H		No	ClinGen 1000Genomes ExAC gnomAD
rs765509959 CA9109972	793	E>Q		No	ClinGen ExAC gnomAD
CA403515889 rs1302269744	795	V>A		No	ClinGen TOPMed
rs1231581355 CA403515893	795	V>I		No	ClinGen TOPMed
CA403515876 rs1313547507	797	T>R		No	ClinGen gnomAD
CA9109971 rs369508635	798	N>D		No	ClinGen ESP ExAC gnomAD
CA403515851 rs1469389508	801	P>A		No	ClinGen gnomAD
CA9109968 rs747172851	802	E>D		No	ClinGen ExAC TOPMed gnomAD
rs202087387 CA403515833	804	A>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9109967 rs202087387	804	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9109966 rs772609224	804	A>V		No	ClinGen ExAC gnomAD
CA403515826 rs1599496062	805	Y>S		No	ClinGen Ensembl
CA9109963 rs756860719	807	I>L		No	ClinGen ExAC gnomAD
rs756860719 CA9109964	807	I>V		No	ClinGen ExAC gnomAD
CA9109962 rs748896771	808	T>M		No	ClinGen ExAC TOPMed gnomAD
rs748896771 CA304605334	808	T>R		No	ClinGen ExAC TOPMed gnomAD
CA9109960 rs755562182	810	A>T		No	ClinGen ExAC TOPMed gnomAD
CA403515795 rs1340374850	811	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1338543715 CA403515771	814	M>T		No	ClinGen gnomAD
rs755012048 CA9109957	815	K>R		No	ClinGen ExAC gnomAD
rs1159864455 CA403515662	817	D>N		No	ClinGen TOPMed
CA9109955 rs751437578	819	A>T		No	ClinGen ExAC TOPMed gnomAD
CA304605333 rs1023625190	820	R>C		No	ClinGen TOPMed gnomAD
CA403515642 rs1023625190	820	R>G		No	ClinGen TOPMed gnomAD
rs1012604149 CA304605332	820	R>H		No	ClinGen TOPMed gnomAD
CA403515627 rs1475868980	822	K>R		No	ClinGen gnomAD
rs776708266 CA9109953	826	V>I		No	ClinGen ExAC gnomAD
TCGA novel	830	G>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9109952 rs764444823	830	G>R		No	ClinGen ExAC gnomAD
CA9109951 rs538765384	831	A>T		No	ClinGen 1000Genomes ExAC gnomAD
rs1015526594 CA304605330	831	A>V		No	ClinGen TOPMed gnomAD
rs1205852773 CA403515290	834	G>S		No	ClinGen gnomAD
rs141070507 CA9109923	835	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9109922 rs746587534	835	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1169291996 CA403515265	837	T>I		No	ClinGen TOPMed
rs201908599 CA9109921	838	L>Q		No	ClinGen 1000Genomes ExAC gnomAD
CA403515247 rs758410040	839	S>*		No	ClinGen ExAC TOPMed gnomAD
rs758410040 CA9109920	839	S>L		No	ClinGen ExAC TOPMed gnomAD
CA403515228 rs1449294721	841	Q>*		No	ClinGen TOPMed
rs1305092282 CA403515197	843	T>N		No	ClinGen TOPMed
rs752927950 CA9109916	844	P>S		No	ClinGen ExAC gnomAD
rs1433614221 CA403515179	845	E>A		No	ClinGen gnomAD
rs759604875 CA403515183	845	E>K		No	ClinGen ExAC TOPMed gnomAD
rs759604875 CA9109914	845	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA403515165 rs1375643869	846	G>D		No	ClinGen gnomAD
rs766771400 CA9109912	849	L>Q		No	ClinGen ExAC gnomAD
CA403515118 rs1407721470	850	A>V		No	ClinGen gnomAD
rs763535247 CA9109911	851	R>C		No	ClinGen ExAC TOPMed gnomAD
rs199604489 CA9109910	851	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA9109909 RCV000754561 RCV002263956 rs199604489	851	R>L		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs115276698 CA304604938	853	E>A		No	ClinGen 1000Genomes TOPMed gnomAD
CA304604937 rs961564035	853	E>D		No	ClinGen TOPMed gnomAD
CA403515089 rs1239019907	853	E>K		No	ClinGen TOPMed
CA403515071 rs1263196047	854	P>L		No	ClinGen TOPMed
CA403515076 rs776422958	854	P>S		No	ClinGen ExAC gnomAD
CA9109907 rs776422958	854	P>T		No	ClinGen ExAC gnomAD
CA403515058 rs1214736605	855	P>L		No	ClinGen gnomAD
CA403515060 rs1214736605	855	P>R		No	ClinGen gnomAD
rs1173800965 CA403515035	858	T>A		No	ClinGen TOPMed
rs1173800965 CA403515037	858	T>P		No	ClinGen TOPMed
CA403515025 rs1224185745	859	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA9109904 rs200677865	859	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1167581020 CA403514994	861	D>A		No	ClinGen Ensembl
CA403515001 rs1413585604	861	D>N		No	ClinGen gnomAD
rs1314259486 CA403514984	862	Q>E		No	ClinGen gnomAD
rs1451171996 CA403514968	863	V>A		No	ClinGen gnomAD
TCGA novel	865	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA403514961 rs1160265804	865	G>S		No	ClinGen TOPMed gnomAD
CA9109900 rs371360214	867	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA403514945 rs1416280955	867	R>H		No	ClinGen TOPMed gnomAD
CA9109898 rs781357409	869	Q>*		No	ClinGen ExAC gnomAD
CA304604932 rs1028115213	869	Q>P		No	ClinGen TOPMed
CA9109897 rs151114416	872	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9109895 rs374591804	872	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs374591804 CA9109896	872	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA403514895 rs1488973838	873	E>A		No	ClinGen TOPMed
CA9109893 rs750931777	874	D>E		No	ClinGen ExAC TOPMed gnomAD
rs1478125902 CA403514869	875	S>W		No	ClinGen TOPMed
CA9109891 rs372181642	876	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA403514849 rs1294580214	877	P>L		No	ClinGen gnomAD
CA9109889 rs763791689	877	P>S		No	ClinGen ExAC gnomAD
CA403514853 rs763791689	877	P>T		No	ClinGen ExAC gnomAD
rs1428091133 CA403514840	878	L>P		No	ClinGen gnomAD
rs760436118 CA9109888	878	L>V		No	ClinGen ExAC TOPMed gnomAD
rs1332317323 CA403514820	880	T>N		No	ClinGen TOPMed gnomAD
rs771623625 CA9109886	881	L>V		No	ClinGen ExAC gnomAD
CA403514804 rs1568407818	882	E>*		No	ClinGen Ensembl
rs1322918895 CA403514792	883	F>L		No	ClinGen TOPMed
CA9109885 rs745426688	884	P>L		No	ClinGen ExAC TOPMed gnomAD
CA403514775 rs1164749059	884	P>S		No	ClinGen TOPMed gnomAD
CA9109884 rs774339890	885	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1168390637 CA403514769	885	P>T		No	ClinGen gnomAD
CA304604928 rs1007529586	887	E>K		No	ClinGen TOPMed gnomAD
CA9109881 rs148744813	889	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9109880 rs148744813	889	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs747248153 CA9109879	889	R>H		No	ClinGen ExAC gnomAD
rs780201997 CA9109878	890	Y>H		No	ClinGen ExAC gnomAD
CA9109877 rs375155482	891	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs765752538 CA9109875	892	A>T		No	ClinGen ExAC gnomAD
CA9109874 rs757862631	892	A>V		No	ClinGen ExAC gnomAD
CA304604926 rs748343733	893	S>L		No	ClinGen gnomAD
TCGA novel	894	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs754216245 CA9109873	894	G>V		No	ClinGen ExAC gnomAD
CA9109872 rs764560600	895	V>M		No	ClinGen ExAC TOPMed gnomAD
rs539486011 CA403514642	896	H>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9109871 rs550128751	896	H>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA403514631 rs1296988917	897	K>R		No	ClinGen gnomAD
rs1568407380 CA403514623	898	G>R		No	ClinGen Ensembl
rs370681168 CA9109868	899	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs909751365 CA304604925	899	A>V		No	ClinGen TOPMed
CA9109867 rs773778652	900	T>M		No	ClinGen ExAC gnomAD
rs1192744560 CA403514573	902	V>E		No	ClinGen TOPMed gnomAD
CA9109865 rs377203716	904	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1269321557 CA403514555	904	R>W		No	ClinGen TOPMed gnomAD
CA403514547 rs1479985617	905	L>F		No	ClinGen TOPMed gnomAD
CA403514532 rs1251374260	906	A>V		No	ClinGen gnomAD
CA403514521 rs200860780	907	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs200860780 CA9109863	907	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1020631416 CA304604923	908	R>Q		No	ClinGen TOPMed
rs370397015 CA9109862	908	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA403514493 rs1369452734	910	R>C		No	ClinGen gnomAD
CA403514491 rs1305417503	910	R>H	Variant assessed as Somatic; 7.506e-05 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA9109858 rs374643204	911	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs906063149 CA304604921	912	G>S		No	ClinGen TOPMed gnomAD
CA304604920 rs1014303618	913	L>P		No	ClinGen TOPMed gnomAD
CA304604919 rs1014303618	913	L>R		No	ClinGen TOPMed gnomAD
CA403514466 rs1354306749	913	L>V		No	ClinGen gnomAD
rs1379163672 CA403514451	915	E>K		No	ClinGen TOPMed gnomAD
rs527272427 CA304604918	916	E>A		No	ClinGen 1000Genomes TOPMed gnomAD
rs1394120193 CA403514431	916	E>K		No	ClinGen TOPMed
CA403514426 rs527272427	916	E>V		No	ClinGen 1000Genomes TOPMed gnomAD
rs1037036904 CA304604917	917	A>V		No	ClinGen TOPMed
CA403514407 rs1316753061	918	A>D		No	ClinGen TOPMed
rs1251215196 CA403514398	919	E>A		No	ClinGen gnomAD
TCGA novel	919	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs909875098 CA304604916	922	S>G		No	ClinGen TOPMed
CA403514353 rs1211174007	924	P>A		No	ClinGen gnomAD
rs370088739 CA9109854	924	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs956514858 CA403514323	926	D>E		No	ClinGen TOPMed
CA9109852 rs767176479	926	D>Y		No	ClinGen ExAC gnomAD
CA304604912 rs759129843	927	T>K		No	ClinGen ExAC TOPMed gnomAD
CA9109851 rs759129843	927	T>M		No	ClinGen ExAC TOPMed gnomAD
CA304604913 rs1030703866	927	T>S		No	ClinGen Ensembl
CA403514304 rs1478220397	928	P>L		No	ClinGen TOPMed
CA9109850 rs61729778	929	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA403514297 rs1313647555	929	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA403514296 rs1313647555	929	R>P		No	ClinGen TOPMed gnomAD
rs1416848107 CA403514294	930	G>S		No	ClinGen gnomAD
rs1402658601 CA403514279	931	H>P		No	ClinGen TOPMed
CA403514277 rs1202103155	931	H>Q		No	ClinGen gnomAD
rs1599468025 CA403514281	931	H>Y		No	ClinGen Ensembl
rs1156567371 CA403514270	932	P>L		No	ClinGen gnomAD
rs1156567371 CA403514266	932	P>R		No	ClinGen gnomAD
rs1364268470 CA403514256	933	Q>H		No	ClinGen gnomAD
rs1161310685 CA403514244	934	I>S		No	ClinGen gnomAD
CA304604909 rs1064296	935	L>V		No	ClinGen TOPMed gnomAD
CA9109848 rs762510209	937	A>V		No	ClinGen ExAC TOPMed gnomAD
CA403514215 rs1443767326	938	A>T		No	ClinGen gnomAD
CA304604906 rs182769562	940	N>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201435229 CA9109844	941	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs772298342 CA9109843	941	A>V		No	ClinGen ExAC TOPMed gnomAD
CA403514190 rs1293966082	942	S>L		No	ClinGen gnomAD
CA403514192 rs1285984808	942	S>P		No	ClinGen TOPMed
rs1014796224 CA304604905	944	G>R		No	ClinGen TOPMed gnomAD
rs895982467 CA304604904	945	T>A		No	ClinGen TOPMed gnomAD
rs1385418553 CA403514173	945	T>I		No	ClinGen TOPMed gnomAD
CA403514175 rs895982467	945	T>S		No	ClinGen TOPMed gnomAD
rs1385418553 CA403514174	945	T>S		No	ClinGen TOPMed gnomAD
CA9109838 rs778392508	946	V>I		No	ClinGen ExAC TOPMed gnomAD
CA9109835 rs781437725	949	R>C		No	ClinGen ExAC TOPMed gnomAD
CA403514151 rs1370939047	949	R>H		No	ClinGen gnomAD
CA403514131 rs1420265669	952	P>R		No	ClinGen TOPMed
rs749987801 CA9109830	954	V>L		No	ClinGen ExAC gnomAD
rs749987801 CA9109831	954	V>M		No	ClinGen ExAC gnomAD
rs1048404327 CA304604902	955	P>L		No	ClinGen TOPMed gnomAD
rs1385812531 CA403514117	955	P>S		No	ClinGen TOPMed
CA403514111 rs1337555183	956	A>G		No	ClinGen gnomAD
rs564427160 CA9109828	956	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs768350891 CA403514109	957	E>K		No	ClinGen ExAC TOPMed gnomAD
rs768350891 CA9109826	957	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA9109825 rs760578565	958	R>C		No	ClinGen ExAC TOPMed gnomAD
rs374990235 CA9109824	958	R>H		No	ClinGen ESP ExAC gnomAD
CA9109822 rs749356058	960	G>R		No	ClinGen ExAC TOPMed gnomAD
CA9109820 rs770291253	962	I>V		No	ClinGen ExAC TOPMed gnomAD
CA9109819 rs62113240	963	V>I		No	ClinGen ExAC gnomAD
CA403514067 rs1379482387	964	K>E		No	ClinGen TOPMed
CA403514062 rs1440176761	964	K>N		No	ClinGen TOPMed
CA304604899 rs915133073	966	T>M		No	ClinGen TOPMed
rs747443047 CA9109816	968	A>V		No	ClinGen ExAC gnomAD
rs758072738 CA9109814	969	V>M		No	ClinGen ExAC gnomAD
rs764731638 CA9109812	970	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA9109813 rs369041852	970	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA403514015 rs1272370030	972	A>V		No	ClinGen gnomAD
rs372440262 CA9109810	973	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA403514009 rs912026736	974	A>P		No	ClinGen TOPMed gnomAD
rs912026736 CA304604896	974	A>T		No	ClinGen TOPMed gnomAD
rs1369997087 CA403514005	974	A>V		No	ClinGen gnomAD
CA304604895 rs986697718	976	G>V		No	ClinGen TOPMed gnomAD
CA403513994 rs1410080119	977	P>T		No	ClinGen gnomAD
rs1171385518 CA403513983	978	A>V		No	ClinGen gnomAD
CA403513982 rs1028304582	979	R>*		No	ClinGen TOPMed gnomAD
CA304604894 rs1028304582	979	R>G		No	ClinGen TOPMed gnomAD
CA403513981 rs1193352037	979	R>Q		No	ClinGen gnomAD
CA403513966 rs1484090676	981	T>I		No	ClinGen TOPMed gnomAD
rs773355226 CA9109804	981	T>S		No	ClinGen ExAC gnomAD
CA403513967 rs1484090676	981	T>S		No	ClinGen TOPMed gnomAD
rs776974729 CA9109801	984	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1348958046 CA403513952	984	P>T		No	ClinGen gnomAD
rs747329678 CA9109799	985	A>G		No	ClinGen ExAC gnomAD
rs747329678 CA403513943	985	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs368886554 CA9109797	986	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA304604893 rs868294368	987	A>S		No	ClinGen gnomAD
rs756719219 CA9109794	989	P>L		No	ClinGen ExAC gnomAD
rs1359440247 CA403513922	989	P>S		No	ClinGen gnomAD
rs201357930 CA9109791	991	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA9109790 rs2230610	991	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs368236845 CA9109787	992	E>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs368236845 CA304604892	992	E>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA9109784 rs201423065	994	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9109783 rs370623380	994	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA403513889 rs1228933665	995	L>F		No	ClinGen gnomAD
VAR_035649 rs775778266 CA9109781	996	T>M	a colorectal cancer sample; somatic mutation [UniProt]	No	ClinGen UniProt ExAC TOPMed dbSNP gnomAD
CA403513873 rs1379393228	998	Q>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs746300376 CA9109779	998	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA304604890 rs936424649	999	G>S		No	ClinGen TOPMed
CA403513852 rs1416406546	1001	K>N		No	ClinGen gnomAD
rs770663085 CA9109777	1002	P>H		No	ClinGen ExAC TOPMed gnomAD
CA403513840 rs752695186	1003	D>E		No	ClinGen ExAC TOPMed gnomAD
CA9109774 rs756049037	1003	D>N		No	ClinGen ExAC TOPMed gnomAD
rs781335825 CA9109772	1004	T>A		No	ClinGen ExAC gnomAD
rs754813198 CA9109771	1004	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs762127352 CA9109768	1005	A>S		No	ClinGen ExAC gnomAD
CA9109767 rs753793633	1005	A>V		No	ClinGen ExAC gnomAD
rs1174340046 CA403513828	1006	Y>H		No	ClinGen TOPMed
TCGA novel	1007	D>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9109763 rs772609297	1007	D>E		No	ClinGen ExAC TOPMed gnomAD
rs943824465 CA304604888	1009	Q>*		No	ClinGen TOPMed gnomAD
rs943824465 CA304604889	1009	Q>K		No	ClinGen TOPMed gnomAD
rs1360908131 CA403513801	1010	V>L		No	ClinGen gnomAD
CA9109760 rs770446171	1011	R>*		No	ClinGen ExAC gnomAD
rs1392874652 CA403513796	1011	R>Q		No	ClinGen TOPMed gnomAD
rs777089062 CA9109758	1012	A>V		No	ClinGen ExAC gnomAD
rs1428131078 CA403513779	1014	T>A		No	ClinGen gnomAD
CA403513775 rs1391073074	1014	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA9109754 rs199829286	1015	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9109753 rs751272492	1015	R>H		No	ClinGen ExAC TOPMed gnomAD
CA304604886 rs751272492	1015	R>P		No	ClinGen ExAC TOPMed gnomAD
CA403513770 rs374799314	1016	R>P		No	ClinGen ExAC TOPMed gnomAD
CA9109751 rs374799314	1016	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA9109752 rs779903263	1016	R>W		No	ClinGen ExAC TOPMed gnomAD
CA403513750 rs1306524101	1020	P>T		No	ClinGen TOPMed gnomAD
rs1231013843 CA403513735	1022	S>G		No	ClinGen gnomAD
rs752821383 CA9109747	1023	P>A		No	ClinGen ExAC TOPMed gnomAD
CA403513726 rs1303233646	1023	P>L		No	ClinGen gnomAD
CA403513727 rs1303233646	1023	P>R		No	ClinGen gnomAD
rs752821383 CA9109748	1023	P>S		No	ClinGen ExAC TOPMed gnomAD
rs752821383 CA9109749	1023	P>T		No	ClinGen ExAC TOPMed gnomAD
rs202163446 CA9109745	1024	P>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs772912033 CA9109742	1024	P>H		No	ClinGen ExAC TOPMed gnomAD
rs772912033 CA9109743	1024	P>L		No	ClinGen ExAC TOPMed gnomAD
rs772912033 CA9109741	1024	P>R		No	ClinGen ExAC TOPMed gnomAD
CA9109744 rs202163446	1024	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs202163446 CA9109746	1024	P>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs374875451 CA9109737	1025	V>F		No	ClinGen ESP ExAC TOPMed
rs374875451 CA9109736	1025	V>I		No	ClinGen ESP ExAC TOPMed
rs756013055	1025	V>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs756013055	1025	V>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs746980740 CA9109733	1026	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA9109732 rs779918003	1026	R>H		No	ClinGen ExAC TOPMed gnomAD
CA9109730 rs745694014	1027	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA9109728 rs769764410	1028	R>G		No	ClinGen ExAC TOPMed gnomAD
CA9109727 rs752731468	1028	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs769764410 CA9109729	1028	R>W		No	ClinGen ExAC TOPMed gnomAD
CA9109726 rs767586201	1029	T>M		No	ClinGen ExAC TOPMed gnomAD
CA403513688 rs1206861930	1031	L>P		No	ClinGen TOPMed gnomAD
CA304604883 rs766862256	1032	R>G		No	ClinGen ExAC TOPMed gnomAD
RCV000912129 rs370399999 CA9109722	1032	R>Q		No	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
CA9109723 rs766862256	1032	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA403513678 rs1351187602	1033	D>E		No	ClinGen gnomAD
rs773496700 CA9109721	1033	D>N		No	ClinGen ExAC gnomAD
rs372067337 CA9109678	1036	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1270501015 CA403513642	1037	P>R		No	ClinGen Ensembl
CA9109676 rs759102109	1039	N>S		No	ClinGen ExAC gnomAD
CA403513611 rs1174993660	1041	K>M		No	ClinGen gnomAD
CA9109675 rs774267588	1042	V>M		No	ClinGen ExAC gnomAD
rs1211765615 CA403513602	1043	K>E		No	ClinGen gnomAD
rs1454313241 CA403513589	1044	M>I		No	ClinGen gnomAD
CA403513591 rs1329534234	1044	M>T		No	ClinGen TOPMed
rs1337663643 CA403513585	1045	I>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs770895185 CA9109674	1049	S>A		No	ClinGen ExAC TOPMed gnomAD
CA403513544 rs146080105	1051	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA403513516 rs1219786363	1055	E>K		No	ClinGen Ensembl
CA9109672 rs772903486	1056	F>V		No	ClinGen ExAC gnomAD
rs768857484 CA9109671	1057	P>S		No	ClinGen ExAC gnomAD
rs747212154 CA403513490	1058	D>E		No	ClinGen ExAC TOPMed gnomAD
rs1599455730 CA403513497	1058	D>N		No	ClinGen Ensembl
CA9109669 rs780382156	1059	N>K		No	ClinGen ExAC gnomAD
rs1393807141 CA403513479	1060	Y>S		No	ClinGen TOPMed gnomAD
rs1195525448 CA403513450	1064	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA304604789 rs966517708	1064	T>P		No	ClinGen gnomAD
CA9109666 rs141765312	1065	P>A		No	ClinGen ESP ExAC gnomAD
CA9109665 rs779544389	1065	P>L		No	ClinGen ExAC gnomAD
TCGA novel	1067	K>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9109631 rs757962488	1069	Q>*		No	ClinGen ExAC gnomAD
CA403513405 rs1475035175	1069	Q>R		No	ClinGen TOPMed
CA9109629 rs138649939	1073	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs776516569 CA9109627	1075	L>M		No	ClinGen ExAC gnomAD
rs1212037871 CA403513352	1077	V>A		No	ClinGen gnomAD
rs767809989 CA9109626	1079	G>D		No	ClinGen ExAC TOPMed gnomAD
CA9109624 rs774511967	1080	R>C		No	ClinGen ExAC TOPMed gnomAD
rs771119355 CA9109623	1080	R>H		No	ClinGen ExAC TOPMed gnomAD
rs771119355 CA403513334	1080	R>L		No	ClinGen ExAC TOPMed gnomAD
rs1316669370 CA403513328	1081	T>I		No	ClinGen TOPMed
CA304604683 rs959828503	1082	T>I		No	ClinGen TOPMed
CA403513317 rs1300507338	1083	K>M		No	ClinGen TOPMed
CA403513306 rs1379503828	1085	L>F		No	ClinGen gnomAD
CA9109620 rs200191658	1087	T>M		No	ClinGen ExAC TOPMed gnomAD
CA403513230 rs1203670272	1096	N>D		No	ClinGen TOPMed
CA9109617 rs202061843	1096	N>S		No	ClinGen ExAC gnomAD
rs3202678 CA304604679	1097	F>L		No	ClinGen Ensembl
CA403513200 rs1164236147	1101	N>D		No	ClinGen gnomAD
rs377654164 CA9109615	1101	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA9109614 rs575201235	1102	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs765040102 CA9109612	1103	G>S		No	ClinGen ExAC gnomAD
rs1209147609 CA403513171	1105	S>N		No	ClinGen TOPMed
CA403513169 rs1249771341	1105	S>R		No	ClinGen TOPMed
CA304604677 rs544466481	1108	G>S		No	ClinGen gnomAD
CA9109608 rs201447856	1112	T>M	Variant assessed as Somatic; 0.0003238 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs769925793 CA9109605 RCV000754560	1115	A>T		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
CA403513094 rs1458048934	1117	T>S		No	ClinGen TOPMed
CA403513082 rs1341900869	1119	F>S		No	ClinGen TOPMed gnomAD
rs372506721 CA403513074	1120	N>I		No	ClinGen ExAC TOPMed gnomAD
rs372506721 CA9109603	1120	N>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs372506721 CA403513075	1120	N>T		No	ClinGen ExAC TOPMed gnomAD
rs748360435 CA304604676	1121	L>V		No	ClinGen ExAC TOPMed
CA9109600 rs769004088	1123	N>D		No	ClinGen ExAC TOPMed gnomAD
CA304604675 rs868694931	1124	G>D		No	ClinGen Ensembl
rs779660659 CA9109598	1124	G>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	1127	S>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs371881792 CA9109595	1128	V>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs371881792 CA9109594	1128	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs199805837 CA9109592	1129	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA403513017 rs1209240784	1130	P>S		No	ClinGen TOPMed
CA403512980 rs752585208	1135	D>E		No	ClinGen ExAC TOPMed gnomAD
rs755938901 CA9109591	1135	D>H		No	ClinGen ExAC gnomAD
rs755938901 CA403512984	1135	D>Y		No	ClinGen ExAC gnomAD
CA304604674 rs924348462	1136	G>D		No	ClinGen TOPMed gnomAD
CA9109589 rs140049694	1136	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA304604672 rs914037320	1139	M>T		No	ClinGen TOPMed
rs1231130806 CA403512958	1139	M>V		No	ClinGen gnomAD
rs866466115 CA304604671	1145	G>D		No	ClinGen TOPMed gnomAD
rs765371680 CA9109587	1145	G>R		No	ClinGen ExAC TOPMed gnomAD
rs765371680 CA9109586	1145	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1306330316 CA403512913	1146	Q>E		No	ClinGen gnomAD
rs1461372872 CA403512908	1146	Q>H		No	ClinGen TOPMed
TCGA novel	1147	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9109585 rs761866681	1148	P>H		No	ClinGen ExAC TOPMed gnomAD
CA9109582 rs760980604	1149	V>A		No	ClinGen ExAC gnomAD
CA9109583 rs147801733	1149	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	1152	Q>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs772064790 CA304604670	1152	Q>R		No	ClinGen gnomAD
CA9109549 rs781048317	1156	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1286194006 CA403512814	1158	M>I		No	ClinGen TOPMed
rs754772522 CA9109548	1162	R>C		No	ClinGen ExAC TOPMed gnomAD
rs746829913 CA403512791	1162	R>H		No	ClinGen ExAC gnomAD
rs746829913 CA9109547	1162	R>L		No	ClinGen ExAC gnomAD
CA304604581 rs910146505	1164	S>P		No	ClinGen TOPMed
rs1034131598 CA403512773	1165	R>H		No	ClinGen TOPMed gnomAD
rs1034131598 CA304604580	1165	R>P		No	ClinGen TOPMed gnomAD
CA403512771 rs1326503987	1166	G>R		No	ClinGen gnomAD
CA403512760 rs1465789831	1167	G>D		No	ClinGen gnomAD
rs1263912912 CA403512755	1168	Q>R		No	ClinGen gnomAD
CA9109546 rs779149362 CA403512745	1169	F>L		No	ClinGen ExAC TOPMed gnomAD
CA9109543 rs764176169	1172	P>L		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	1174	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA403512723 rs753240051	1174	G>R		No	ClinGen ExAC TOPMed gnomAD
rs753240051 CA9109541	1174	G>S		No	ClinGen ExAC TOPMed gnomAD
CA403512690 rs1384602128	1178	D>E		No	ClinGen gnomAD
rs774597513 CA9109538	1178	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1461228258 CA403512683	1179	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1389490950 CA403512689	1179	M>L		No	ClinGen TOPMed gnomAD
CA403512685 rs1163896977	1179	M>T		No	ClinGen TOPMed
rs1389490950 CA403512688	1179	M>V		No	ClinGen TOPMed gnomAD
CA403512672 rs762696876	1181	L>M		No	ClinGen ExAC TOPMed gnomAD
CA403512670 rs1388692315	1181	L>P		No	ClinGen gnomAD
CA9109536 rs762696876	1181	L>V		No	ClinGen ExAC TOPMed gnomAD
rs1168400719 CA403512659	1183	E>Q		No	ClinGen gnomAD
CA9109508 rs760546803	1185	I>L		No	ClinGen ExAC
rs1342415870 CA403512616	1187	D>G		No	ClinGen TOPMed
CA304604575 rs771853690	1190	R>P		No	ClinGen ExAC TOPMed gnomAD
rs771853690 CA9109506	1190	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1599436263 CA403512598	1190	R>W		No	ClinGen Ensembl
rs376266471 CA9109504	1192	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA403512575 rs1269111261	1194	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA9109503 rs115469963	1194	R>H	Variant assessed as Somatic; 0.0006238 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs1471312670 CA403512557	1197	R>Q		No	ClinGen gnomAD
CA9109501 rs781134304	1197	R>W		No	ClinGen ExAC TOPMed gnomAD
CA9109500 rs755452432	1199	S>L		No	ClinGen ExAC TOPMed gnomAD
CA403512540 rs1390942862	1200	R>C		No	ClinGen TOPMed
rs781371580 CA9109497	1200	R>H		No	ClinGen ExAC gnomAD
CA403512535 rs1204949982	1201	Q>*		No	ClinGen gnomAD
rs1440713936 CA403512531	1201	Q>H		No	ClinGen TOPMed gnomAD
CA304604573 rs957224661	1203	E>K		No	ClinGen TOPMed gnomAD
CA403512513 rs1377303300	1204	V>G		No	ClinGen TOPMed
CA9109496 rs750841016	1204	V>M		No	ClinGen ExAC gnomAD
rs142918634 CA403512504	1206	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA403512505 rs142918634	1206	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9109494 rs142918634	1206	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs764944959 CA9109495	1206	R>W		No	ClinGen ExAC TOPMed gnomAD
rs760302776 CA9109491	1209	I>V		No	ClinGen ExAC gnomAD
rs542361035 CA9109489	1212	R>C	Variant assessed as Somatic; 9.258e-05 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA9109488 rs375875548	1212	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs542361035 CA304604571	1212	R>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs769934024 CA9109486	1215	V>G		No	ClinGen ExAC gnomAD
CA9109487 rs774159488	1215	V>L		No	ClinGen ExAC TOPMed gnomAD
CA304604569 rs918842746	1217	P>L		No	ClinGen Ensembl
rs1265450607 CA403512429	1219	T>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs114904537 CA304604568	1221	H>N		No	ClinGen 1000Genomes
CA9109484 rs372619078	1222	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA9109483 rs768612717	1222	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA9109480 rs145842090	1224	D>N		No	ClinGen ESP ExAC gnomAD
rs779435853 CA403512389	1225	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs746169857 CA9109479	1225	Q>R		No	ClinGen ExAC gnomAD
TCGA novel	1226	K>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs757700265 CA403512376	1227	Q>P		No	ClinGen ExAC TOPMed gnomAD
rs757700265 CA9109477	1227	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA403512372 rs1176871419	1228	Y>N		No	ClinGen TOPMed
rs1433499108 CA403512356	1230	G>D		No	ClinGen gnomAD
CA9109475 rs202004674	1230	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA403512345 rs752222706	1232	D>H		No	ClinGen ExAC TOPMed gnomAD
CA9109473 rs752222706	1232	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs767400237 CA403512329	1234	R>P		No	ClinGen ExAC TOPMed gnomAD
CA9109472 rs767400237	1234	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA304604567 rs866165812	1234	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA9109471 rs759472181	1235	G>D		No	ClinGen ExAC TOPMed gnomAD
rs759472181 CA403512323	1235	G>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	1236	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9109470 rs200307602	1237	E>D		No	ClinGen 1000Genomes ExAC gnomAD
CA9109468 rs369971329	1239	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs201990407 CA9109466	1241	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs202091186 CA9109465	1241	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1220355220 CA403512217	1247	L>F		No	ClinGen gnomAD
rs116545788 CA9109461	1249	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs757534258 CA304604565	1251	Q>L		No	ClinGen ExAC TOPMed gnomAD
rs757534258 CA9109460	1251	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs1296936066 CA403512162	1252	K>E		No	ClinGen gnomAD
CA9109459 rs749715659	1253	S>G		No	ClinGen ExAC gnomAD
rs777238128 CA9109458	1253	S>N		No	ClinGen ExAC gnomAD
rs61743105 CA9109457	1253	S>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1405757941 CA403512135	1254	E>K		No	ClinGen TOPMed gnomAD
CA9109454 rs139608745	1255	P>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs139608745 CA9109455	1255	P>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA403510979 rs1599430116	1256	T>P		No	ClinGen Ensembl
CA403510911 rs1156383212	1259	A>V		No	ClinGen gnomAD
CA403510903 rs1452566818	1260	S>N		No	ClinGen gnomAD
rs763526954 CA9109423	1261	P>A		No	ClinGen ExAC gnomAD
CA403510886 rs1161671874	1261	P>H		No	ClinGen TOPMed gnomAD
rs1239728663 CA403510840	1264	D>E		No	ClinGen TOPMed
CA304604505 rs867337946	1265	P>L		No	ClinGen Ensembl
rs1422453480 CA403510808	1267	Q>*		No	ClinGen gnomAD
rs748550727 CA9109420	1269	D>E		No	ClinGen ExAC TOPMed gnomAD
rs1221129890 CA403510774	1269	D>G		No	ClinGen TOPMed
rs761904835 CA304604502	1269	D>H		No	ClinGen ExAC TOPMed gnomAD
CA9109421 rs761904835	1269	D>N		No	ClinGen ExAC TOPMed gnomAD
CA403510732 rs1351608223	1271	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1204660130 CA403510739	1271	P>S		No	ClinGen gnomAD
CA304604500 rs776652526	1274	Q>H		No	ClinGen Ensembl
CA403510659 rs768318893	1276	I>M		No	ClinGen ExAC TOPMed gnomAD
rs146012732 CA9109417	1277	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs146012732 CA9109416	1277	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs750373156 CA9109414	1280	E>D		No	ClinGen ExAC gnomAD
rs757905971 CA9109415	1280	E>K		No	ClinGen ExAC gnomAD
rs1035903725 CA304604498	1282	G>E		No	ClinGen Ensembl
rs1385155560 CA403510489	1288	G>R		No	ClinGen gnomAD
rs1003437214 CA304604496	1291	L>V		No	ClinGen gnomAD
CA9109406 rs763007823	1293	V>M		No	ClinGen ExAC TOPMed gnomAD
rs773740248 CA9109405	1295	F>C		No	ClinGen ExAC
rs1446928503 CA403510384	1296	I>V		No	ClinGen gnomAD
rs762117575 CA9109403	1298	C>G		No	ClinGen ExAC TOPMed gnomAD
rs762117575 CA403510354	1298	C>S		No	ClinGen ExAC TOPMed gnomAD
CA304604494 rs1011549015	1299	I>L		No	ClinGen Ensembl
rs1330761136 CA403510338	1299	I>T		No	ClinGen TOPMed
rs376345440 CA304604492	1301	I>T		No	ClinGen TOPMed gnomAD
rs1312373726 CA403510292	1302	A>T		No	ClinGen gnomAD
rs149250405 CA9109402	1303	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA403510248 rs1246481445	1305	L>F		No	ClinGen gnomAD
rs773998457 CA9109373	1310	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA403510029 rs370343222	1311	D>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs370343222 CA9109370	1311	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA403510027 rs370343222	1311	D>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA9109368 rs747944058	1312	S>G		No	ClinGen ExAC gnomAD
rs780275846 CA9109367	1312	S>N		No	ClinGen ExAC gnomAD
CA9109340 rs374745287	1314	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs767763908 CA9109339	1314	R>H		No	ClinGen ExAC TOPMed gnomAD
rs760047878 CA9109338	1315	K>R		No	ClinGen ExAC gnomAD
CA9109336 rs766184946	1318	E>D		No	ClinGen ExAC gnomAD
rs751229657 CA9109337	1318	E>K		No	ClinGen ExAC gnomAD
rs762505033 CA9109335	1319	P>L		No	ClinGen ExAC gnomAD
rs762505033 CA403509879	1319	P>R		No	ClinGen ExAC gnomAD
rs1052009018 CA304604412	1319	P>S		No	ClinGen TOPMed gnomAD
CA9109334 rs772880114	1320	R>C		No	ClinGen ExAC gnomAD
CA304604411 rs936142250	1320	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs145751069 CA9109333	1323	C>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA403509852 rs1239121684	1324	L>V		No	ClinGen TOPMed
CA403509846 rs1310899689	1325	L>V		No	ClinGen TOPMed
rs370332631 CA9109331	1329	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA9109329 rs779055431	1331	A>G		No	ClinGen ExAC gnomAD
rs1361339357 CA403509807	1331	A>T		No	ClinGen TOPMed gnomAD
CA9109328 rs779055431	1331	A>V		No	ClinGen ExAC gnomAD
CA304604410 rs367722276	1333	H>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA TOPMed gnomAD
CA9109327 rs771170964	1334	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs749295712 CA9109326	1335	P>T		No	ClinGen ExAC gnomAD
rs1423783416 CA403509756	1339	V>M		No	ClinGen gnomAD
CA403509747 rs1366044529	1340	E>A		No	ClinGen gnomAD
rs1568388126 CA403509744	1340	E>D		No	ClinGen Ensembl
rs777724238 CA9109325	1341	M>I		No	ClinGen ExAC gnomAD
rs374679831 CA9109324	1342	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA9109323 rs753143589	1343	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs753143589 CA403509727	1343	R>G		No	ClinGen ExAC TOPMed gnomAD
CA9109321 rs201934952	1343	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
rs201934952 CA9109322	1343	R>L		No	ClinGen 1000Genomes ExAC gnomAD
CA403509724 rs1476169496	1344	I>V		No	ClinGen gnomAD
rs1266362648 CA403509710	1346	F>L		No	ClinGen gnomAD
CA304604182 rs908259585	1351	S>A		No	ClinGen Ensembl
rs1403235094 CA403508976	1352	G>D		No	ClinGen TOPMed gnomAD
CA403508952 rs1440592448	1354	R>G		No	ClinGen TOPMed
rs764987592 CA9109295	1355	S>I		No	ClinGen ExAC TOPMed gnomAD
rs764987592 CA304604181	1355	S>N		No	ClinGen ExAC TOPMed gnomAD
rs1469959251 CA403508916	1357	L>F		No	ClinGen gnomAD
TCGA novel	1357	L>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs865957699 CA304604180	1358	R>G		No	ClinGen Ensembl
CA9109293 rs753417682	1360	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA304604179 rs753417682	1360	P>Q		No	ClinGen ExAC TOPMed gnomAD
CA403508847 rs866147610	1361	G>E		No	ClinGen gnomAD
CA304604177 rs866147610	1361	G>V		No	ClinGen gnomAD
rs1460411052 CA403508831	1362	F>L		No	ClinGen gnomAD
CA403508790 rs1162516954	1364	F>L		No	ClinGen TOPMed
rs199585880 CA9109291	1364	F>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9109290 rs775461256	1365	E>A		No	ClinGen ExAC TOPMed gnomAD
rs955550206 CA304604176	1365	E>D		No	ClinGen TOPMed
rs1265626893 CA403508451	1367	M>I		No	ClinGen gnomAD
CA403508437 rs1285393473	1368	L>F		No	ClinGen TOPMed
CA304603999 rs1021700507	1369	S>R		No	ClinGen gnomAD
rs893878528 CA304603997	1370	H>P		No	ClinGen Ensembl
CA304603998 rs909186181	1370	H>Y		No	ClinGen TOPMed
CA9109258 rs760885887	1371	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA9109255 rs772736665	1372	P>L		No	ClinGen ExAC gnomAD
CA304603996 rs751670759	1373	I>T		No	ClinGen Ensembl
CA403508341 rs1210337335	1373	I>V		No	ClinGen gnomAD
CA403508311 rs1358436135	1375	I>V		No	ClinGen gnomAD
CA403508298 rs200850387	1376	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9109254 rs200850387	1376	A>T	Variant assessed as Somatic; 9.293e-05 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA403508294 rs1226089200	1377	D>N		No	ClinGen gnomAD
rs1340688664 CA403508269	1378	M>T		No	ClinGen gnomAD
CA403508254 rs373247829	1379	A>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA9109253 rs373247829	1379	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs558948003 CA9109251	1382	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
CA9109249 rs755603479	1383	E>K		No	ClinGen ExAC gnomAD
CA403508153 rs114166264	1384	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9109248 rs114166264	1384	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA403508161 rs1394993665	1384	R>W		No	ClinGen gnomAD
CA304603994 rs140530332	1388	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs267605547 CA9109246	1389	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1482164454 CA403507213	1391	L>I		No	ClinGen TOPMed gnomAD
rs1020485119 CA304603993	1392	K>R		No	ClinGen TOPMed gnomAD
CA9109245 rs369098162	1393	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	1398	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs374920205 CA9109217	1401	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA403507007 rs1455732532	1402	P>S		No	ClinGen TOPMed gnomAD
CA403507005 rs1455732532	1402	P>T		No	ClinGen TOPMed gnomAD
CA403506879 rs1379803911	1410	H>L		No	ClinGen gnomAD
CA403506881 rs1379803911	1410	H>R		No	ClinGen gnomAD
rs1364755919 CA403506852	1412	N>K		No	ClinGen gnomAD
rs201183797 CA9109214	1412	N>S		No	ClinGen 1000Genomes ExAC gnomAD
CA304603992 rs201183797	1412	N>T		No	ClinGen 1000Genomes ExAC gnomAD
CA9109212 rs773573468	1416	N>K		No	ClinGen ExAC gnomAD
rs1399239013 CA403506788	1418	P>A		No	ClinGen gnomAD
rs530579519 CA9109211	1418	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA403506762 rs1440179947	1421	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA403506760 rs1420232605	1421	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs768182732 CA9109208	1425	V>I		No	ClinGen ExAC gnomAD
rs768182732 CA403506709	1425	V>L		No	ClinGen ExAC gnomAD
CA304603990 rs976014452	1426	I>L		No	ClinGen TOPMed
CA9109206 rs114545401	1427	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9109205 rs114545401	1427	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA403506679 rs1283955648	1427	A>V		No	ClinGen TOPMed gnomAD
CA403506660 rs1217838563	1429	D>Y		No	ClinGen gnomAD
rs778834304 CA9109203	1430	H>Q		No	ClinGen ExAC TOPMed gnomAD
rs1356400067 CA403506641	1430	H>Y		No	ClinGen gnomAD
rs1064298 CA304603989	1431	S>F		No	ClinGen Ensembl
CA403506611 rs1379973129	1432	R>H		No	ClinGen gnomAD
rs190342971 CA9109199	1437	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9109198 rs751626412	1438	I>L		No	ClinGen ExAC TOPMed gnomAD
CA9109197 rs766847307	1438	I>T		No	ClinGen ExAC TOPMed gnomAD
rs528875239 CA403506432	1441	I>F		No	ClinGen 1000Genomes gnomAD
rs528875239 CA304603899	1441	I>L		No	ClinGen 1000Genomes gnomAD
rs747192109 CA9109162	1442	M>L		No	ClinGen ExAC TOPMed gnomAD
rs974923793 CA304603898	1442	M>T		No	ClinGen TOPMed gnomAD
rs747192109 CA9109161	1442	M>V		No	ClinGen ExAC TOPMed gnomAD
rs780295096 CA9109160	1443	G>S		No	ClinGen ExAC gnomAD
CA403506412 rs1328615941	1444	S>T		No	ClinGen TOPMed
rs1270305003 CA403506404	1445	D>G		No	ClinGen TOPMed
rs1426779255 CA403506385	1448	N>H		No	ClinGen gnomAD
rs192807174 CA9109155	1452	V>M		No	ClinGen 1000Genomes ExAC gnomAD
rs1031952638 CA304603897	1453	D>N		No	ClinGen TOPMed
CA403506341 rs1457749790	1454	G>C		No	ClinGen TOPMed gnomAD
CA403506343 rs1457749790	1454	G>S		No	ClinGen TOPMed gnomAD
CA403506333 rs1238817348	1455	Y>C		No	ClinGen gnomAD
rs752266796 CA9109152	1456	R>Q		No	ClinGen ExAC gnomAD
CA9109153 rs373940938	1456	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA9109151 rs4807697 VAR_047277	1457	C>R		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs4807697 CA403506326	1457	C>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs369756620 CA9109150	1457	C>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1221980061 CA403506309	1459	N>S		No	ClinGen gnomAD
CA9109148 rs189135288	1460	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs762790087 CA9109147	1460	A>V		No	ClinGen ExAC TOPMed gnomAD
CA403506294 rs1301896231	1461	Y>*		No	ClinGen gnomAD
rs930416291 CA304603896	1462	I>V		No	ClinGen TOPMed
CA403506284 rs1466270055	1463	A>S		No	ClinGen gnomAD
rs1274728310 CA403506275	1464	T>M		No	ClinGen TOPMed gnomAD
rs775641545 CA9109143	1466	G>A		No	ClinGen ExAC gnomAD
CA9109142 rs116660613	1467	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1255636453 CA403506248	1469	P>L		No	ClinGen gnomAD
CA9109139 rs757423838	1477	R>C		No	ClinGen ExAC gnomAD
CA304603895 rs532712500	1477	R>H		No	ClinGen gnomAD
CA9109138 rs749723623	1479	V>M		No	ClinGen ExAC gnomAD
rs778389901 CA9109137	1480	W>*		No	ClinGen ExAC TOPMed gnomAD
rs972894021 CA304603894	1481	E>G		No	ClinGen Ensembl
rs767215087 CA9109134	1483	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs376549612 CA9109136	1483	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1599387546 CA403506148	1484	S>A		No	ClinGen Ensembl
CA9109133 rs754694289	1484	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs765806159 CA9109131	1485	A>T		No	ClinGen ExAC TOPMed gnomAD
CA9109130 rs139132124	1485	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	1487	I>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1326918817 CA403506132	1487	I>V		No	ClinGen gnomAD
rs116515629 CA9109127	1488	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs776422333 CA9109126	1489	M>T		No	ClinGen ExAC gnomAD
CA9109125 rs768496731	1491	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA403506097 rs770889503	1492	R>L		No	ClinGen ExAC TOPMed gnomAD
CA9109122 rs770889503	1492	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs369295620 CA9109123	1492	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA403506092 rs1285057720	1493	L>R		No	ClinGen TOPMed
CA304603893 rs867284088	1494	E>G		No	ClinGen Ensembl
rs1218678810 CA403506084	1495	E>K		No	ClinGen gnomAD
CA403506063 rs1264309988	1497	S>L		No	ClinGen TOPMed gnomAD
rs748467965 CA9109118	1498	R>L		No	ClinGen ExAC TOPMed gnomAD
CA304603892 rs748467965	1498	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA403506061 rs1205787412	1498	R>W		No	ClinGen TOPMed
rs769120046 CA9109099	1499	I>S		No	ClinGen ExAC TOPMed gnomAD
CA403506035 rs61729768	1500	K>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA304603887 rs1036033572	1502	D>E		No	ClinGen Ensembl
rs368562196 CA9109096	1503	Q>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs939094664 CA304603886	1506	P>L		No	ClinGen Ensembl
CA304603885 rs928845139	1507	N>S		No	ClinGen gnomAD
rs778479954 CA9109094	1509	G>S		No	ClinGen ExAC gnomAD
rs147152459 CA9109092	1510	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs724159896 CA304603884	1511	E>K		No	ClinGen Ensembl
CA403505958 rs1197491728	1512	T>A		No	ClinGen gnomAD
CA304603883 rs760418863	1513	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs760418863 CA9109090	1513	Y>F		No	ClinGen ExAC TOPMed gnomAD
CA403505944 rs1568375584	1514	G>A		No	ClinGen Ensembl
rs116099658 CA403505947	1514	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9109088 rs116099658	1514	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs540902322 CA9109087	1516	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA403505926 rs1236009082	1517	Q>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA403505925 rs1375370905	1517	Q>R		No	ClinGen gnomAD
rs1308542151 CA403505916	1518	V>A		No	ClinGen gnomAD
rs773377919 CA9109086	1519	T>M		No	ClinGen ExAC TOPMed gnomAD
CA403505893 rs1166726276	1522	D>G		No	ClinGen TOPMed gnomAD
rs769320080 CA9109082	1525	E>K		No	ClinGen ExAC gnomAD
rs772384138 CA403505835	1531	V>F		No	ClinGen ExAC TOPMed gnomAD
rs772384138 CA9109079	1531	V>I		No	ClinGen ExAC TOPMed gnomAD
CA403505822 rs1177403750	1533	T>S		No	ClinGen gnomAD
CA9109074 CA403505814 rs533685228	1534	F>L		No	ClinGen ExAC TOPMed gnomAD
rs143481159 CA9109076	1534	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs527477754 CA9109075	1534	F>S		No	ClinGen 1000Genomes ExAC gnomAD
CA304603882 rs977538185	1535	S>F		No	ClinGen TOPMed gnomAD
rs754773533 CA9109070	1537	H>D		No	ClinGen ExAC gnomAD
CA304603880 rs747517599	1537	H>Q		No	ClinGen gnomAD
rs1483140281 CA403505801	1537	H>R		No	ClinGen gnomAD
rs750640223 CA9109069	1538	K>E		No	ClinGen ExAC gnomAD
rs757568361 CA304603599	1545	R>C		No	ClinGen ExAC TOPMed gnomAD
rs754177433 CA9109045	1545	R>H		No	ClinGen ExAC TOPMed gnomAD
rs757568361 CA9109046	1545	R>S		No	ClinGen ExAC TOPMed gnomAD
CA9109042 rs776015928	1546	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs369058883 CA9109040	1548	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA9109039 rs753499659	1548	R>H		No	ClinGen ExAC gnomAD
CA9109038 rs771340725	1549	Q>K		No	ClinGen ExAC gnomAD
TCGA novel	1552	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs182037655 CA9109036	1553	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs1191088838 CA403505007	1554	A>V		No	ClinGen TOPMed gnomAD
rs1248490430 CA403504987	1555	W>C		No	ClinGen gnomAD
rs1196839847 CA403504980	1556	P>L		No	ClinGen gnomAD
rs1258938541 CA403504977	1557	D>Y		No	ClinGen gnomAD
CA403504938 rs150241840	1560	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs150241840 CA9109029	1560	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA403504928 rs1368253825	1561	P>T		No	ClinGen gnomAD
CA403504911 rs1375587926	1562	E>A		No	ClinGen gnomAD
CA9109027 rs778163463	1562	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA9109025 rs752720358	1565	T>A		No	ClinGen ExAC gnomAD
CA9109024 rs768007031	1565	T>M		No	ClinGen ExAC gnomAD
CA403504863 rs1415481564	1566	P>S		No	ClinGen TOPMed gnomAD
CA403504824 rs1397448438	1569	A>D		No	ClinGen gnomAD
rs558410776 CA9109020	1572	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9109018 rs769362751	1572	R>Q		No	ClinGen ExAC gnomAD
CA9109019 rs558410776	1572	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1482411453 CA403504785	1573	R>G		No	ClinGen gnomAD
TCGA novel	1573	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1286819853 CA403504720	1577	C>*		No	ClinGen gnomAD
rs544938921 CA9109017	1577	C>R		No	ClinGen 1000Genomes ExAC gnomAD
rs1209168744 CA403504711	1578	N>S		No	ClinGen gnomAD
rs372226485 CA9109015	1579	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs372226485 CA9109016	1579	P>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1237948621 CA403504689	1580	P>S		No	ClinGen gnomAD
rs1352291696 CA403504667	1581	D>E		No	ClinGen gnomAD
rs1309412012 CA403504666	1582	A>T		No	ClinGen gnomAD
rs771943247 CA9109012	1582	A>V		No	ClinGen ExAC gnomAD
CA9109010 rs777981018	1583	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1449197300 CA403504642	1584	P>S		No	ClinGen gnomAD
CA304603594 rs1038424215	1585	I>T		No	ClinGen Ensembl
rs915320010 CA304603595	1585	I>V		No	ClinGen TOPMed
rs1380942206 CA403504608	1587	V>L		No	ClinGen gnomAD
CA9108972 rs571743236	1592	G>S		No	ClinGen ExAC TOPMed gnomAD
rs776677741 CA9108971	1595	R>C		No	ClinGen ExAC gnomAD
rs1385628370 CA403504477	1595	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA403504451 rs1355060495	1599	F>Y		No	ClinGen TOPMed
rs367918810 CA9108968	1601	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA9108966 rs151279682	1603	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA9108963 rs377564137	1604	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA9108964 rs377564137	1604	A>T	Variant assessed as Somatic; 4.656e-05 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA403504396 rs1431393078	1607	E>V		No	ClinGen gnomAD
rs148739536 CA9108960	1608	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA9108961 rs142364974	1608	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs1255744139 CA403504375	1611	P>S		No	ClinGen gnomAD
TCGA novel	1614	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs144570007 CA9108955	1617	V>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA9108956 rs144570007	1617	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1393306881 CA403504325	1618	Y>C		No	ClinGen TOPMed
CA403504305 rs1242977508	1621	V>L		No	ClinGen TOPMed
rs1242977508 CA403504307	1621	V>M		No	ClinGen TOPMed
rs775731386 CA9108951	1622	T>M		No	ClinGen ExAC TOPMed gnomAD
rs1057017143	1628	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs751085808	1643	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1330569020	1644	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1648	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1654	T>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1314953096	1659	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs749770933	1659	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs145108936	1710	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs753283232	1715	M>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1351895585	1721	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs768527095	1733	S>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1737	N>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs758652323	1752	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs762745270	1756	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1157608522	1766	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs779302415	1773	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs753489907	1774	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1778	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1477121983	1798	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs771577284	1798	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs773706905	1801	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1821	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs771526918	1834	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1269269717	1834	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1161731225	1837	R>W	Variant assessed as Somatic; 4.71e-05 impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1846	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs777398236	1847	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
RCV000901083 rs148478353	1852	S>L		No	ClinVar dbSNP
TCGA novel	1859	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1883	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs759155627	1884	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1477222866	1887	T>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs752031088	1899	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1903	E>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1290109580	1919	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1927	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1928	E>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1326058191	1935	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA

No associated diseases with Q13332

27 regional properties for Q13332

Type	Name	Position	InterPro Accession
domain	Tyrosine-specific protein phosphatase, PTPase domain	1392 - 1650	IPR000242-1
domain	Tyrosine-specific protein phosphatase, PTPase domain	1679 - 1941	IPR000242-2
domain	Tyrosine-specific protein phosphatases domain	1568 - 1639	IPR000387-1
domain	Tyrosine-specific protein phosphatases domain	1857 - 1930	IPR000387-2
domain	Protein-tyrosine phosphatase, catalytic	1546 - 1647	IPR003595-1
domain	Protein-tyrosine phosphatase, catalytic	1835 - 1938	IPR003595-2
domain	Immunoglobulin subtype 2	45 - 114	IPR003598-1
domain	Immunoglobulin subtype 2	147 - 223	IPR003598-2
domain	Immunoglobulin subtype 2	257 - 318	IPR003598-3
domain	Immunoglobulin subtype	39 - 125	IPR003599-1
domain	Immunoglobulin subtype	141 - 235	IPR003599-2
domain	Immunoglobulin subtype	251 - 329	IPR003599-3
domain	Fibronectin type III	332 - 424	IPR003961-1
domain	Fibronectin type III	427 - 523	IPR003961-2
domain	Fibronectin type III	525 - 616	IPR003961-3
domain	Fibronectin type III	618 - 718	IPR003961-4
domain	Fibronectin type III	720 - 831	IPR003961-5
domain	Fibronectin type III	832 - 930	IPR003961-6
domain	Fibronectin type III	929 - 1033	IPR003961-7
domain	Fibronectin type III	1034 - 1120	IPR003961-8
domain	Immunoglobulin-like domain	33 - 123	IPR007110-1
domain	Immunoglobulin-like domain	135 - 233	IPR007110-2
domain	Immunoglobulin-like domain	245 - 327	IPR007110-3
domain	Immunoglobulin I-set	33 - 124	IPR013098-1
domain	Immunoglobulin I-set	245 - 328	IPR013098-2
active_site	Protein-tyrosine phosphatase, active site	1587 - 1597	IPR016130-1
active_site	Protein-tyrosine phosphatase, active site	1878 - 1888	IPR016130-2

Functions

		Description
EC Number	3.1.3.48	Phosphoric monoester hydrolases
Subcellular Localization	Cell membrane ; Single-pass type I membrane protein Cell projection, axon Perikaryon Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane Synapse, synaptosome Postsynaptic density Cell projection, neuron projection Cell projection, growth cone	Is rapidly internalized when dendritic cells are stimulated with the TLR9 ligand cytidine-phosphate-guanosine (CpG) (PubMed:26231120) Detected in a punctate pattern along neurites and axon growth cones (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

10 GO annotations of cellular component

Name	Definition
anchoring junction	A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
axon	The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
growth cone	The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
integral component of plasma membrane	The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of postsynaptic density membrane	The component of the postsynaptic density membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of synaptic vesicle membrane	The component of the synaptic vesicle membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
perikaryon	The portion of the cell soma (neuronal cell body) that excludes the nucleus.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

5 GO annotations of molecular function

Name	Definition
chondroitin sulfate binding	Binding to chondroitin sulfate, a glycosaminoglycan made up of two alternating monosaccharides: D-glucuronic acid (GlcA) and N-acetyl-D-galactosamine (GalNAc).
heparan sulfate proteoglycan binding	Binding to a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit.
heparin binding	Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
phosphoprotein phosphatase activity	Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity.
protein tyrosine phosphatase activity	Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

11 GO annotations of biological process

Name	Definition
negative regulation of axon extension	Any process that stops, prevents, or reduces the frequency, rate or extent of axon outgrowth.
negative regulation of axon regeneration	Any process that stops, prevents, or reduces the frequency, rate or extent of axon regeneration.
negative regulation of collateral sprouting	Any process that stops, prevents, or reduces the frequency, rate or extent of collateral sprouting.
negative regulation of dendritic spine development	Any process that decreases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure.
negative regulation of interferon-alpha production	Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-alpha production.
negative regulation of interferon-beta production	Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-beta production.
negative regulation of neuron projection development	Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
negative regulation of toll-like receptor 9 signaling pathway	Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 9 signaling pathway.
peptidyl-tyrosine dephosphorylation	The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine.
protein dephosphorylation	The process of removing one or more phosphoric residues from a protein.
synaptic membrane adhesion	The attachment of presynaptic membrane to postsynaptic membrane via adhesion molecules that are at least partially embedded in the plasma membrane.

9 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P08575	PTPRC	Receptor-type tyrosine-protein phosphatase C	Homo sapiens (Human)	PR
P28827	PTPRM	Receptor-type tyrosine-protein phosphatase mu	Homo sapiens (Human)	PR
Q15262	PTPRK	Receptor-type tyrosine-protein phosphatase kappa	Homo sapiens (Human)	PR
P10586	PTPRF	Receptor-type tyrosine-protein phosphatase F	Homo sapiens (Human)	PR
P23468	PTPRD	Receptor-type tyrosine-protein phosphatase delta	Homo sapiens (Human)	PR
P43378	PTPN9	Tyrosine-protein phosphatase non-receptor type 9	Homo sapiens (Human)	PR
P49446	Ptpre	Receptor-type tyrosine-protein phosphatase epsilon	Mus musculus (Mouse)	PR
Q64487	Ptprd	Receptor-type tyrosine-protein phosphatase delta	Mus musculus (Mouse)	PR
P35822	Ptprk	Receptor-type tyrosine-protein phosphatase kappa	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MAPTWGPGMV	SVVGPMGLLV	VLLVGGCAAE	EPPRFIKEPK	DQIGVSGGVA	SFVCQATGDP
70	80	90	100	110	120
KPRVTWNKKG	KKVNSQRFET	IEFDESAGAV	LRIQPLRTPR	DENVYECVAQ	NSVGEITVHA
130	140	150	160	170	180
KLTVLREDQL	PSGFPNIDMG	PQLKVVERTR	TATMLCAASG	NPDPEITWFK	DFLPVDPSAS
190	200	210	220	230	240
NGRIKQLRSE	TFESTPIRGA	LQIESSEETD	QGKYECVATN	SAGVRYSSPA	NLYVRELREV
250	260	270	280	290	300
RRVAPRFSIL	PMSHEIMPGG	NVNITCVAVG	SPMPYVKWMQ	GAEDLTPEDD	MPVGRNVLEL
310	320	330	340	350	360
TDVKDSANYT	CVAMSSLGVI	EAVAQITVKS	LPKAPGTPMV	TENTATSITI	TWDSGNPDPV
370	380	390	400	410	420
SYYVIEYKSK	SQDGPYQIKE	DITTTRYSIG	GLSPNSEYEI	WVSAVNSIGQ	GPPSESVVTR
430	440	450	460	470	480
TGEQAPASAP	RNVQARMLSA	TTMIVQWEEP	VEPNGLIRGY	RVYYTMEPEH	PVGNWQKHNV
490	500	510	520	530	540
DDSLLTTVGS	LLEDETYTVR	VLAFTSVGDG	PLSDPIQVKT	QQGVPGQPMN	LRAEARSETS
550	560	570	580	590	600
ITLSWSPPRQ	ESIIKYELLF	REGDHGREVG	RTFDPTTSYV	VEDLKPNTEY	AFRLAARSPQ
610	620	630	640	650	660
GLGAFTPVVR	QRTLQSKPSA	PPQDVKCVSV	RSTAILVSWR	PPPPETHNGA	LVGYSVRYRP
670	680	690	700	710	720
LGSEDPEPKE	VNGIPPTTTQ	ILLEALEKWT	QYRITTVAHT	EVGPGPESSP	VVVRTDEDVP
730	740	750	760	770	780
SAPPRKVEAE	ALNATAIRVL	WRSPAPGRQH	GQIRGYQVHY	VRMEGAEARG	PPRIKDVMLA
790	800	810	820	830	840
DAQWETDDTA	EYEMVITNLQ	PETAYSITVA	AYTMKGDGAR	SKPKVVVTKG	AVLGRPTLSV
850	860	870	880	890	900
QQTPEGSLLA	RWEPPAGTAE	DQVLGYRLQF	GREDSTPLAT	LEFPPSEDRY	TASGVHKGAT
910	920	930	940	950	960
YVFRLAARSR	GGLGEEAAEV	LSIPEDTPRG	HPQILEAAGN	ASAGTVLLRW	LPPVPAERNG
970	980	990	1000	1010	1020
AIVKYTVAVR	EAGALGPARE	TELPAAAEPG	AENALTLQGL	KPDTAYDLQV	RAHTRRGPGP
1030	1040	1050	1060	1070	1080
FSPPVRYRTF	LRDQVSPKNF	KVKMIMKTSV	LLSWEFPDNY	NSPTPYKIQY	NGLTLDVDGR
1090	1100	1110	1120	1130	1140
TTKKLITHLK	PHTFYNFVLT	NRGSSLGGLQ	QTVTAWTAFN	LLNGKPSVAP	KPDADGFIMV
1150	1160	1170	1180	1190	1200
YLPDGQSPVP	VQSYFIVMVP	LRKSRGGQFL	TPLGSPEDMD	LEELIQDISR	LQRRSLRHSR
1210	1220	1230	1240	1250	1260
QLEVPRPYIA	ARFSVLPPTF	HPGDQKQYGG	FDNRGLEPGH	RYVLFVLAVL	QKSEPTFAAS
1270	1280	1290	1300	1310	1320
PFSDPFQLDN	PDPQPIVDGE	EGLIWVIGPV	LAVVFIICIV	IAILLYKNKP	DSKRKDSEPR
1330	1340	1350	1360	1370	1380
TKCLLNNADL	APHHPKDPVE	MRRINFQTPD	SGLRSPLREP	GFHFESMLSH	PPIPIADMAE
1390	1400	1410	1420	1430	1440
HTERLKANDS	LKLSQEYESI	DPGQQFTWEH	SNLEVNKPKN	RYANVIAYDH	SRVILQPIEG
1450	1460	1470	1480	1490	1500
IMGSDYINAN	YVDGYRCQNA	YIATQGPLPE	TFGDFWRMVW	EQRSATIVMM	TRLEEKSRIK
1510	1520	1530	1540	1550	1560
CDQYWPNRGT	ETYGFIQVTL	LDTIELATFC	VRTFSLHKNG	SSEKREVRQF	QFTAWPDHGV
1570	1580	1590	1600	1610	1620
PEYPTPFLAF	LRRVKTCNPP	DAGPIVVHCS	AGVGRTGCFI	VIDAMLERIK	PEKTVDVYGH
1630	1640	1650	1660	1670	1680
VTLMRSQRNY	MVQTEDQYSF	IHEALLEAVG	CGNTEVPARS	LYAYIQKLAQ	VEPGEHVTGM
1690	1700	1710	1720	1730	1740
ELEFKRLANS	KAHTSRFISA	NLPCNKFKNR	LVNIMPYEST	RVCLQPIRGV	EGSDYINASF
1750	1760	1770	1780	1790	1800
IDGYRQQKAY	IATQGPLAET	TEDFWRMLWE	NNSTIVVMLT	KLREMGREKC	HQYWPAERSA
1810	1820	1830	1840	1850	1860
RYQYFVVDPM	AEYNMPQYIL	REFKVTDARD	GQSRTVRQFQ	FTDWPEQGVP	KSGEGFIDFI
1870	1880	1890	1900	1910	1920
GQVHKTKEQF	GQDGPISVHC	SAGVGRTGVF	ITLSIVLERM	RYEGVVDIFQ	TVKMLRTQRP
1930	1940
AMVQTEDEYQ	FCYQAALEYL	GSFDHYAT