P35822

PR
Gene name
Ptprk (Ptpk)
Protein name
Receptor-type tyrosine-protein phosphatase kappa
Names
Protein-tyrosine phosphatase kappa, R-PTP-kappa
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:19272
EC number
3.1.3.48: Phosphoric monoester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

790-901 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P35822

Entry ID Method Resolution Chain Position Source
AF-P35822-F1 Predicted AlphaFoldDB

35 variants for P35822

Variant ID(s) Position Change Description Diseaes Association Provenance
rs46969210 27 L>H No EVA
rs3400789685 41 P>L No EVA
rs3389097705 58 H>Y No EVA
rs13463066 64 P>S No EVA
rs3389086420 176 S>N No EVA
rs3389067584 392 P>S No EVA
rs3389097668 405 I>S No EVA
rs3389093304 477 S>G No EVA
rs3389093058 489 P>S No EVA
rs3389072104 532 S>P No EVA
rs3389097641 536 A>V No EVA
rs37184126 538 P>S No EVA
rs3389103814 556 V>E No EVA
rs3389037174 592 A>V No EVA
rs3389072089 610 T>S No EVA
rs3389095582 673 L>F No EVA
rs3389095594 733 A>S No EVA
rs3389090133 734 T>I No EVA
rs3389093229 757 S>G No EVA
rs3389097658 764 I>F No EVA
rs3406006137 796 H>Y No EVA
rs3389095733 858 V>I No EVA
rs3389095508 880 R>G No EVA
rs3389086435 887 H>R No EVA
rs3389086474 896 S>I No EVA
rs3401002343 911 S>* No EVA
rs3400994797 915 D>E No EVA
rs3401093049 927 R>L No EVA
rs3389067627 1125 V>G No EVA
rs3389037154 1204 R>Q No EVA
rs3389093308 1225 M>I No EVA
rs3389095526 1275 D>V No EVA
rs3389060687 1288 I>N No EVA
rs3389072137 1292 N>S No EVA
rs3389080498 1375 Q>* No EVA

No associated diseases with P35822

15 regional properties for P35822

Type Name Position InterPro Accession
domain Tyrosine-specific protein phosphatase, PTPase domain 898 - 1161 IPR000242-1
domain Tyrosine-specific protein phosphatase, PTPase domain 1190 - 1455 IPR000242-2
domain Tyrosine-specific protein phosphatases domain 1079 - 1150 IPR000387-1
domain Tyrosine-specific protein phosphatases domain 1367 - 1444 IPR000387-2
domain MAM domain 30 - 193 IPR000998
domain Protein-tyrosine phosphatase, catalytic 1057 - 1158 IPR003595-1
domain Protein-tyrosine phosphatase, catalytic 1347 - 1452 IPR003595-2
domain Immunoglobulin subtype 200 - 288 IPR003599
domain Fibronectin type III 290 - 388 IPR003961-1
domain Fibronectin type III 389 - 475 IPR003961-2
domain Fibronectin type III 487 - 594 IPR003961-3
domain Immunoglobulin-like domain 195 - 280 IPR007110
domain Immunoglobulin I-set 200 - 277 IPR013098
active_site Protein-tyrosine phosphatase, active site 1098 - 1108 IPR016130-1
active_site Protein-tyrosine phosphatase, active site 1392 - 1402 IPR016130-2

Functions

Description
EC Number 3.1.3.48 Phosphoric monoester hydrolases
Subcellular Localization
  • Membrane; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

11 GO annotations of cellular component

Name Definition
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
cell junction A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella.
cell surface The external part of the cell wall and/or plasma membrane.
cell-cell junction A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects.
dendrite A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
leading edge membrane The portion of the plasma membrane surrounding the leading edge of a motile cell.
neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
photoreceptor outer segment The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
beta-catenin binding Binding to a catenin beta subunit.
gamma-catenin binding Binding to catenin complex gamma subunit.
protein kinase binding Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
protein tyrosine phosphatase activity Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

15 GO annotations of biological process

Name Definition
cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
cell migration The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
cellular response to reactive oxygen species Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
cellular response to UV Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
focal adhesion assembly The aggregation and bonding together of a set of components to form a focal adhesion, a complex of intracellular signaling and structural proteins that provides a structural link between the internal actin cytoskeleton and the ECM, and also function as a locus of signal transduction activity.
negative regulation of cell cycle Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle.
negative regulation of cell migration Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
negative regulation of cell population proliferation Any process that stops, prevents or reduces the rate or extent of cell proliferation.
negative regulation of DNA-templated transcription Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
negative regulation of keratinocyte proliferation Any process that decreases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population.
neuron projection development The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
protein dephosphorylation The process of removing one or more phosphoric residues from a protein.
protein localization to cell surface A process in which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
transforming growth factor beta receptor signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q13332 PTPRS Receptor-type tyrosine-protein phosphatase S Homo sapiens (Human) PR
P10586 PTPRF Receptor-type tyrosine-protein phosphatase F Homo sapiens (Human) PR
P23468 PTPRD Receptor-type tyrosine-protein phosphatase delta Homo sapiens (Human) PR
P08575 PTPRC Receptor-type tyrosine-protein phosphatase C Homo sapiens (Human) PR
P28827 PTPRM Receptor-type tyrosine-protein phosphatase mu Homo sapiens (Human) PR
Q15262 PTPRK Receptor-type tyrosine-protein phosphatase kappa Homo sapiens (Human) PR
P49446 Ptpre Receptor-type tyrosine-protein phosphatase epsilon Mus musculus (Mouse) PR
Q64487 Ptprd Receptor-type tyrosine-protein phosphatase delta Mus musculus (Mouse) PR
10 20 30 40 50 60
MDVAAAALPA FVALWLLYPW PLLGSALGQF SAGGCTFDDG PGACDYHQDL YDDFEWVHVS
70 80 90 100 110 120
AQEPHYLPPE MPQGSYMVVD SSNHDPGEKA RLQLPTMKEN DTHCIDFSYL LYSQKGLNPG
130 140 150 160 170 180
TLNILVRVNK GPLANPIWNV TGFTGRDWLR AELAVSTFWP NEYQVIFEAE VSGGRSGYIA
190 200 210 220 230 240
IDDIQVLSYP CDKSPHFLRL GDVEVNAGQN ATFQCIATGR DAVHNKLWLQ RRNGEDIPVA
250 260 270 280 290 300
QTKNINHRRF AASFRLQEVT KTDQDLYRCV TQSERGSGVS NFAQLIVREP PRPIAPPQLL
310 320 330 340 350 360
GVGPTYLLIQ LNANSIIGDG PIILKEVEYR MTSGSWTETH AVNAPTYKLW HLDPDTEYEI
370 380 390 400 410 420
RVLLTRPGEG GTGLPGPPLI TRTKCAEPMR TPKTLKIAEI QARRIAVDWE SLGYNITRCH
430 440 450 460 470 480
TFNVTICYHY FRGHNESRAD CLDMDPKAPQ HVVNHLPPYT NVSLKMILTN PEGRKESEET
490 500 510 520 530 540
IIQTDEDVPG PVPVKSLQGT SFENKIFLNW KEPLEPNGII TQYEVSYSSI RSFDPAVPVA
550 560 570 580 590 600
GPPQTVSNLW NSTHHVFMHL HPGTTYQFFI RASTVKGFGP ATAINVTTNI SAPSLPDYEG
610 620 630 640 650 660
VDASLNETAT TITVLLRPAQ AKGAPISAYQ IVVEQLHPHR TKREAGAMEC YQVPVTYQNA
670 680 690 700 710 720
LSGGAPYYFA AELPPGNLPE PAPFTVGDNR TYKGFWNPPL APRKGYNIYF QAMSSVEKET
730 740 750 760 770 780
KTQCVRIATK AAATEEPEVI PDPAKQTDRV VKIAGISAGI LVFILLLLVV IVIVKKSKLA
790 800 810 820 830 840
KKRKDAMGNT RQEMTHMVNA MDRSYADQST LHAEDPLSLT FMDQHNFSPR LPNDPLVPTA
850 860 870 880 890 900
VLDENHSATA ESSRLLDVPR YLCEGTESPY QTGQLHPAIR VADLLQHINL MKTSDSYGFK
910 920 930 940 950 960
EEYESFFEGQ SASWDVAKKD QNRAKNRYGN IIAYDHSRVI LQPVEDDPSS DYINANYIDI
970 980 990 1000 1010 1020
WLYRDGYQRP SHYIATQGPV HETVYDFWRM VWQEQSACIV MVTNLVEVGR VKCYKYWPDD
1030 1040 1050 1060 1070 1080
TEVYGDFKVT CVEMEPLAEY VVRTFTLERR GYNEIREVKQ FHFTGWPDHG VPYHATGLLS
1090 1100 1110 1120 1130 1140
FIRRVKLSNP PSAGPIVVHC SAGAGRTGCY IVIDIMLDMA EREGVVDIYN CVKALRSRRI
1150 1160 1170 1180 1190 1200
NMVQTEEQYI FIHDAILEAC LCGETAIPVC EFKAAYFDMI RIDSQTNSSH LKDEFQTLNS
1210 1220 1230 1240 1250 1260
VTPRLQAEDC SIACLPRNHD KNRFMDMLPP DRCLPFLITI DGESSNYINA ALMDSYRQPA
1270 1280 1290 1300 1310 1320
AFIVTQYPLP NTVKDFWRLV YDYGCTSIVM LNEVDLSQGC PQYWPEEGML RYGPIQVECM
1330 1340 1350 1360 1370 1380
SCSMDCDVIN RIFRICNLTR PQEGYLMVQQ FQYLGWASHR EVPGSKRSFL KLILQVEKWQ
1390 1400 1410 1420 1430 1440
EECEEGEGRT IIHCLNGGGR SGMFCAIGIV VEMVKRQNVV DVFHAVKTLR NSKPNMVEAP
1450
EQYRFCYDVA LEYLESS