AiPD: Autoinhibited Protein Database

Gene name	Ptpre (Ptpe)
Protein name	Receptor-type tyrosine-protein phosphatase epsilon
Names	Protein-tyrosine phosphatase epsilon, R-PTP-epsilon
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:19267
EC number	3.1.3.48: Phosphoric monoester hydrolases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

57-142 (Predicted disordered autoinhibitory region) PR

57-142 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-P49446-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs221569703	16	L>I	No	EVA
rs3388957664	18	R>*	No	EVA
rs243319874	24	D>Y	No	EVA
rs3397800000	57	L>I	No	EVA
rs3388955309	109	K>R	No	EVA
rs3388959089	110	K>N	No	EVA
rs259815482	111	F>Y	No	EVA
rs215287957	116	V>M	No	EVA
rs864263035	126	R>*	No	EVA
rs3388953994	146	I>L	No	EVA
rs229496129	149	T>S	No	EVA
rs3388957806	171	D>Y	No	EVA
rs215785275	172	H>L	No	EVA
rs3388951599	174	R>K	No	EVA
rs3412691992	191	A>V	No	EVA
rs3388944888	193	Y>*	No	EVA
rs3388955266	198	K>T	No	EVA
rs3388912901	199	E>G	No	EVA
rs3388959049	210	K>M	No	EVA
rs3388960338	262	V>I	No	EVA
rs3388938240	368	R>S	No	EVA
rs3388959386	375	Q>K	No	EVA
rs3388960356	378	Q>*	No	EVA
rs3388944863	414	H>L	No	EVA
rs3388950243	441	N>S	No	EVA
rs864265890	467	V>A	No	EVA
rs3388912875	477	F>L	No	EVA
rs3388957791	479	D>V	No	EVA
rs3388954025	481	I>F	No	EVA
rs3388954190	488	G>D	No	EVA
rs3388944897	500	G>R	No	EVA
rs3388954017	529	E>K	No	EVA
rs3388954251	563	I>M	No	EVA
rs3388927980	576	L>V	No	EVA

Type	Name	Position	InterPro Accession
domain	Tyrosine-specific protein phosphatase, PTPase domain	133 - 395	IPR000242-1
domain	Tyrosine-specific protein phosphatase, PTPase domain	424 - 690	IPR000242-2
domain	Tyrosine-specific protein phosphatases domain	313 - 384	IPR000387-1
domain	Tyrosine-specific protein phosphatases domain	604 - 679	IPR000387-2
domain	Protein-tyrosine phosphatase, catalytic	291 - 392	IPR003595-1
domain	Protein-tyrosine phosphatase, catalytic	585 - 687	IPR003595-2
active_site	Protein-tyrosine phosphatase, active site	332 - 342	IPR016130-1
active_site	Protein-tyrosine phosphatase, active site	627 - 637	IPR016130-2

		Description
EC Number	3.1.3.48	Phosphoric monoester hydrolases
Subcellular Localization	[Isoform 1]: Cell membrane; Single-pass type I membrane protein ;
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Name	Definition
identical protein binding	Binding to an identical protein or proteins.
protein tyrosine phosphatase activity	Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Name	Definition
negative regulation of insulin receptor signaling pathway	Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.
protein dephosphorylation	The process of removing one or more phosphoric residues from a protein.
regulation of mast cell activation	Any process that modulates the frequency, rate, or extent of mast cell activation.
transmembrane receptor protein tyrosine phosphatase signaling pathway	The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses protein tyrosine phosphatase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q13332	PTPRS	Receptor-type tyrosine-protein phosphatase S	Homo sapiens (Human)	PR
P10586	PTPRF	Receptor-type tyrosine-protein phosphatase F	Homo sapiens (Human)	PR
Q15262	PTPRK	Receptor-type tyrosine-protein phosphatase kappa	Homo sapiens (Human)	PR
P23468	PTPRD	Receptor-type tyrosine-protein phosphatase delta	Homo sapiens (Human)	PR
P28827	PTPRM	Receptor-type tyrosine-protein phosphatase mu	Homo sapiens (Human)	PR
P08575	PTPRC	Receptor-type tyrosine-protein phosphatase C	Homo sapiens (Human)	PR
P35822	Ptprk	Receptor-type tyrosine-protein phosphatase kappa	Mus musculus (Mouse)	PR
Q64487	Ptprd	Receptor-type tyrosine-protein phosphatase delta	Mus musculus (Mouse)	PR