AiPD: Autoinhibited Protein Database

P43378

Gene name	PTPN9
Protein name	Tyrosine-protein phosphatase non-receptor type 9
Names	Protein-tyrosine phosphatase MEG2, PTPase MEG2
Species	Homo sapiens (Human)
KEGG Pathway	hsa:5780
EC number	3.1.3.48: Phosphoric monoester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

234-352 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

234-352 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

8 structures for P43378

Entry ID	Method	Resolution	Chain	Position	Source
2PA5	X-ray	160 A	A/B	277-582	PDB
4GE2	X-ray	180 A	A/B	277-582	PDB
4GE5	X-ray	200 A	A/B	277-582	PDB
4GE6	X-ray	140 A	A/B	277-582	PDB
4ICZ	X-ray	190 A	A	277-582	PDB
6KZQ	X-ray	170 A	A	277-583	PDB
6L03	X-ray	208 A	A	277-583	PDB
AF-P43378-F1	Predicted				AlphaFoldDB

365 variants for P43378

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs111365423 CA272928255	2	E>V		No	ClinGen Ensembl
rs1237928997 CA393458492	3	P>H		No	ClinGen TOPMed
CA393458487 rs1595975683	4	A>P		No	ClinGen Ensembl
CA393458448 rs1284758946	8	R>G		No	ClinGen TOPMed gnomAD
rs1349007812 CA393458442	8	R>P		No	ClinGen Ensembl
CA393458445 rs1284758946	8	R>W		No	ClinGen TOPMed gnomAD
rs553966465 CA272928242	10	D>Y		No	ClinGen 1000Genomes TOPMed gnomAD
CA7668438 rs760850802	11	M>R		No	ClinGen ExAC TOPMed gnomAD
rs1253782595 CA393458419	11	M>V		No	ClinGen TOPMed gnomAD
rs1161089495 CA393458398	12	A>V		No	ClinGen gnomAD
CA393458389 rs1406642954	13	P>L		No	ClinGen TOPMed gnomAD
CA393458357 rs1595975649	16	T>I		No	ClinGen Ensembl
rs1260444481 CA393458349	17	P>R		No	ClinGen Ensembl
CA393458352 rs1158559646	17	P>S		No	ClinGen gnomAD
CA393458329 rs1555458060	19	E>*		No	ClinGen Ensembl
CA393458281 rs1444388765	21	Q>E		No	ClinGen TOPMed
CA7668421 rs369859591	22	A>V		No	ClinGen ESP ExAC gnomAD
CA7668420 rs755396738	23	T>A		No	ClinGen ExAC gnomAD
rs1220533901 CA393469687	24	K>E		No	ClinGen gnomAD
CA7668419 rs114063444	24	K>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7668417 rs375533645	28	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs937186808 CA272931724	30	I>T		No	ClinGen TOPMed gnomAD
rs1469606982 CA393469427	31	N>S		No	ClinGen gnomAD
rs1433936226 CA393469371	33	W>*		No	ClinGen gnomAD
CA393469378 rs1178706660	33	W>G		No	ClinGen gnomAD
rs1419116045 CA393469331	36	Q>E		No	ClinGen gnomAD
CA393469318 rs1184825046	36	Q>R		No	ClinGen gnomAD
CA272931717 rs920493765	38	N>K		No	ClinGen gnomAD
CA7668415 rs767473464	38	N>S		No	ClinGen ExAC TOPMed gnomAD
CA7668414 rs761905346	39	V>A		No	ClinGen ExAC gnomAD
CA272931711 rs1037662041	40	S>F		No	ClinGen Ensembl
CA393469177 rs1405039827	41	P>L		No	ClinGen TOPMed
CA393469129 rs1360568062	44	W>R		No	ClinGen TOPMed
CA393468977 rs1460823561	49	K>N		No	ClinGen gnomAD
CA393468986 rs1394582559	49	K>T		No	ClinGen TOPMed gnomAD
rs768801786 CA7668412	52	M>T		No	ClinGen ExAC TOPMed gnomAD
CA393468895 rs1212009842	53	A>P		No	ClinGen gnomAD
rs1163576337 CA393468864	54	R>G		No	ClinGen TOPMed gnomAD
rs1312376406 CA393468832	55	K>R		No	ClinGen gnomAD
rs745898435 CA7668411	58	V>G		No	ClinGen ExAC TOPMed gnomAD
rs114183309 CA7668410	60	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs538521905 CA7668409	60	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7668408 rs745765863	61	A>S		No	ClinGen ExAC TOPMed gnomAD
rs1567504061 CA393468586	62	I>M		No	ClinGen Ensembl
CA7668407 rs781132549	65	F>Y		No	ClinGen ExAC TOPMed gnomAD
CA7668406 rs146997520	68	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA393468374 rs1233526588	69	R>K		No	ClinGen Ensembl
CA393466886 rs1371430213	72	R>G		No	ClinGen gnomAD
rs771890256 CA7668385	72	R>L		No	ClinGen ExAC TOPMed gnomAD
CA272930019 rs771890256	72	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1366629650 CA393466799	76	G>R		No	ClinGen gnomAD
rs1366629650 CA393466802	76	G>S		No	ClinGen gnomAD
CA393466766 rs1166907039	78	V>I		No	ClinGen gnomAD
rs1010966122 CA272930004	81	K>N		No	ClinGen Ensembl
rs778660352 CA7668383	82	P>L		No	ClinGen ExAC gnomAD
CA7668382 rs756467948	83	H>D		No	ClinGen ExAC gnomAD
rs781566496 CA7668380	84	E>A		No	ClinGen ExAC
rs998964264 CA272929986	84	E>K		No	ClinGen TOPMed
rs751709167 CA7668378	88	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA7668377 rs141342401	88	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA7668376 rs147821578	91	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA393466443 rs1246087039	93	S>R		No	ClinGen gnomAD
CA7668374 rs150017042	98	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA7668373 rs759261267	99	L>V		No	ClinGen ExAC gnomAD
TCGA novel	100	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7668359 rs757748650	102	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1221340132 CA393466123	102	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs374568016 CA7668357	104	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA7668358 rs747532714	104	P>T		No	ClinGen ExAC gnomAD
rs1302021492 CA393466093	105	T>A		No	ClinGen gnomAD
rs1329409957 CA393466087	105	T>I		No	ClinGen TOPMed
CA7668356 rs758473931	107	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1390142423 CA393466064	109	I>T		No	ClinGen gnomAD
rs140490690 CA7668355	109	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA7668354 rs779059956	111	L>H		No	ClinGen ExAC gnomAD
rs755223048 CA7668353	113	T>S		No	ClinGen ExAC
TCGA novel	115	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1305256383 CA393465936	117	H>R		No	ClinGen TOPMed
CA7668351 rs766174800	120	H>D		No	ClinGen ExAC gnomAD
rs760497443 CA7668350	121	K>N		No	ClinGen ExAC gnomAD
CA7668349 rs376906988	125	H>P		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	127	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	129	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs773901742 CA7668346	130	A>D		No	ClinGen ExAC gnomAD
rs773901742 CA7668347	130	A>G		No	ClinGen ExAC gnomAD
CA393465561 rs142284706	133	Y>*		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	133	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs990105299 CA272929513	140	D>H		No	ClinGen Ensembl
CA7668326 rs762326530	142	F>I		No	ClinGen ExAC
CA7668325 rs775209859	143	E>D		No	ClinGen ExAC gnomAD
CA393463754 rs1342752736	145	Q>E		No	ClinGen gnomAD
CA393463679 rs1283579686	147	N>K		No	ClinGen gnomAD
CA393463617 rs1388099911	150	V>A		No	ClinGen TOPMed
CA393463624 rs761083078	150	V>L		No	ClinGen ExAC gnomAD
rs761083078 CA7668323	150	V>M		No	ClinGen ExAC gnomAD
rs1325317760	155	M>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA393463461 rs1334578051	157	G>D		No	ClinGen gnomAD
CA7668321 rs772606890	159	N>K		No	ClinGen ExAC gnomAD
CA7668320 rs371548349	160	Y>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs1169904099 CA393463401	161	A>S		No	ClinGen gnomAD
rs1277376034 CA393463377	162	N>S		No	ClinGen TOPMed
rs779240050 CA7668319	166	D>E		No	ClinGen ExAC gnomAD
CA272927272 rs372777107	166	D>Y		No	ClinGen ESP TOPMed
CA393463224 rs1381362325	170	K>Q		No	ClinGen TOPMed gnomAD
rs1474062695 CA393463157	173	N>H		No	ClinGen gnomAD
rs749260648 CA7668317	176	K>R		No	ClinGen ExAC TOPMed gnomAD
rs752320396 CA7668289	178	A>E		No	ClinGen ExAC gnomAD
rs764715102 CA7668288	182	R>C		No	ClinGen ExAC TOPMed gnomAD
rs754427368 CA7668287	182	R>H		No	ClinGen ExAC TOPMed gnomAD
CA7668285 rs140000948	183	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA393459004 rs1456334575	184	K>R		No	ClinGen TOPMed
CA272922956 rs905992844	185	K>N		No	ClinGen Ensembl
CA7668284 rs762260127	185	K>T		No	ClinGen ExAC gnomAD
rs1183352954 CA393458966	187	L>P		No	ClinGen gnomAD
CA393458923 rs1250554019	191	A>P		No	ClinGen TOPMed gnomAD
CA393458921 rs1250554019	191	A>S		No	ClinGen TOPMed gnomAD
CA7668282 rs764699404	191	A>V		No	ClinGen ExAC gnomAD
rs368001478 CA7668280	193	I>T		No	ClinGen ESP ExAC gnomAD
rs1244773383 CA393458868	195	F>V		No	ClinGen gnomAD
rs1320422354 CA393458853	196	R>Q		No	ClinGen gnomAD
CA7668279 rs770004306	198	P>S		No	ClinGen ExAC gnomAD
rs537929670 CA7668278	199	Y>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1411743297 CA393458803	200	S>Y		No	ClinGen gnomAD
CA393458794 rs1292997941	201	I>V		No	ClinGen gnomAD
CA7668276 rs771038986	203	S>T		No	ClinGen ExAC gnomAD
CA7668273 rs772106450	208	D>N		No	ClinGen ExAC gnomAD
rs748050343 CA7668272	209	K>E		No	ClinGen ExAC gnomAD
TCGA novel	210	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs929256343 CA272922894	211	R>Q		No	ClinGen TOPMed
rs370125636 CA7668271	211	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA393458643 rs1285264131	213	R>G		No	ClinGen TOPMed
CA393458641 rs1567492744	213	R>K		No	ClinGen Ensembl
CA393457288 rs1272764588	215	Q>R		No	ClinGen TOPMed
CA272921587 rs952416662	218	K>E		No	ClinGen TOPMed gnomAD
rs758717324 CA7668245	218	K>R		No	ClinGen ExAC gnomAD
CA393457200 rs1441610912	219	T>I		No	ClinGen gnomAD
rs1441610912 CA393457201	219	T>K		No	ClinGen gnomAD
rs753093738 CA7668244	220	S>F		No	ClinGen ExAC TOPMed gnomAD
rs765888385 CA7668243	223	T>M		No	ClinGen ExAC TOPMed gnomAD
CA393457109 rs1318329912	223	T>S		No	ClinGen gnomAD
rs1476259453 CA393457049	225	H>Q		No	ClinGen TOPMed
rs1240182518 CA393457058	225	H>R		No	ClinGen TOPMed
rs754031967 CA7668241	229	E>Q		No	ClinGen ExAC gnomAD
CA393456913 rs1194008529	231	L>V		No	ClinGen TOPMed
rs1449429317 CA393456856	233	E>G		No	ClinGen gnomAD
rs1416713349 CA393456882	233	E>K		No	ClinGen TOPMed
TCGA novel	234	N>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs889232276 CA272921538	234	N>Y		No	ClinGen TOPMed
rs760742888 CA7668239	236	G>D		No	ClinGen ExAC TOPMed gnomAD
CA393456747 rs1447877555	238	Y>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs530559093 CA7668236	239	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA393456703 rs1347370561	240	K>R		No	ClinGen gnomAD
rs774100050 CA7668235	241	I>T		No	ClinGen ExAC TOPMed gnomAD
CA7668231 rs769188751	244	A>G		No	ClinGen ExAC gnomAD
CA7668232 rs144459324	244	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1595956163 CA393456625	247	N>D		No	ClinGen Ensembl
CA393456586 rs1326871706	249	Q>L		No	ClinGen gnomAD
CA393456569 rs1333243473	250	F>L		No	ClinGen gnomAD
rs1393972245 CA393456538	253	Q>H		No	ClinGen gnomAD
CA393456526 rs1376859497	254	V>A		No	ClinGen gnomAD
TCGA novel	254	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1353811108 CA393456533	254	V>M		No	ClinGen TOPMed
CA7668230 rs146156674	255	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs144499352 CA7668228	256	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
CA393456434 rs1170216555	260	P>A		No	ClinGen TOPMed gnomAD
CA393456424 rs1350008531	261	F>V		No	ClinGen TOPMed
rs779410388 CA7668226	262	D>N		No	ClinGen ExAC TOPMed gnomAD
CA7668224 rs754307529	264	I>M		No	ClinGen ExAC gnomAD
rs766870073 CA7668223	265	I>F		No	ClinGen ExAC
CA7668221 rs373098861	265	I>M		No	ClinGen ESP ExAC gnomAD
rs1291261300 CA393456251	268	S>F		No	ClinGen gnomAD
rs767671900 CA393456229	269	L>P		No	ClinGen ExAC TOPMed gnomAD
rs767671900 CA7668220	269	L>R		No	ClinGen ExAC TOPMed gnomAD
CA7668219 rs762017100	270	P>L		No	ClinGen ExAC gnomAD
TCGA novel	270	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA272921475 rs890747262	271	P>L		No	ClinGen Ensembl
CA7668217 rs763887441	273	L>F		No	ClinGen ExAC TOPMed gnomAD
rs762666594 CA7668216	274	D>G		No	ClinGen ExAC TOPMed gnomAD
rs376495976 CA7668215	275	W>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs116470185 CA272921460	275	W>R		No	ClinGen 1000Genomes gnomAD
CA7668214 rs769718806	278	V>I		No	ClinGen ExAC gnomAD
CA393455967 rs1368586210	279	H>D		No	ClinGen TOPMed
CA7668213 rs745414592	281	P>L		No	ClinGen ExAC gnomAD
rs1028996748 CA272921445	283	P>T		No	ClinGen Ensembl
CA7668212 rs776203851	284	H>P		No	ClinGen ExAC gnomAD
rs770767796 CA7668211	285	A>G		No	ClinGen ExAC gnomAD
rs1368231884 CA393455707	286	M>I		No	ClinGen gnomAD
CA272921427 CA393455483 rs996540030	292	V>L		No	ClinGen TOPMed gnomAD
CA393455475 rs1161851120	293	D>N		No	ClinGen gnomAD
TCGA novel	295	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	295	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs559576371 CA272921406	297	A>D		No	ClinGen 1000Genomes gnomAD
CA272921421 rs560249411	297	A>T		No	ClinGen Ensembl
CA393455349 rs559576371	297	A>V		No	ClinGen 1000Genomes gnomAD
TCGA novel	298	R>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	299	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA393455175 rs1328117883	304	Y>*		No	ClinGen gnomAD
rs937767972 CA272921402	307	Y>*		No	ClinGen TOPMed
rs1312676573 CA393455080	308	E>D		No	ClinGen TOPMed
rs200342452 CA393455068	309	D>A		No	ClinGen ESP gnomAD
rs200342452 CA272921401	309	D>V		No	ClinGen ESP gnomAD
CA7668209 rs777502335	311	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs893813224 CA272921396	312	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs146356869 CA7668208	312	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs146356869 CA393454976	312	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs541229442 CA7668206	313	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA7668207 rs541229442	313	E>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7668205 rs149279759	314	N>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs370139184 CA7668203	316	V>A		No	ClinGen ExAC TOPMed gnomAD
rs757267318 CA7668202	321	C>Y		No	ClinGen ExAC gnomAD
rs1595956094 CA393454707	322	S>C		No	ClinGen Ensembl
CA393454701 rs1256412687	323	M>L		No	ClinGen TOPMed
CA7668189 rs780462038	324	S>Y		No	ClinGen ExAC gnomAD
CA7668187 rs774808504	325	P>L		No	ClinGen ExAC gnomAD
CA7668188 rs770259983	325	P>S		No	ClinGen ExAC gnomAD
CA7668186 rs781608991	326	G>*		No	ClinGen ExAC gnomAD
CA393449011 rs781608991	326	G>R		No	ClinGen ExAC gnomAD
rs1372318614 CA393448984	328	L>V		No	ClinGen gnomAD
CA272910278 rs200903438	329	E>K		No	ClinGen 1000Genomes
TCGA novel	332	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1370988548 CA393448912	333	Y>S		No	ClinGen TOPMed
CA7668185 rs757356597	339	L>P		No	ClinGen ExAC gnomAD
rs1175564642 CA393448753	345	K>Q		No	ClinGen gnomAD
rs778014922 CA7668183	347	T>A		No	ClinGen ExAC gnomAD
TCGA novel	349	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs758645507 CA7668182	349	R>P		No	ClinGen ExAC TOPMed gnomAD
CA393448696 rs758645507	349	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1484731220 CA393448685	350	S>I		No	ClinGen gnomAD
CA7668181 rs192954004	352	H>R		No	ClinGen 1000Genomes ExAC gnomAD
CA7668180 rs765097713	354	Q>E		No	ClinGen ExAC gnomAD
CA393445149 rs1212416571	357	Y>D		No	ClinGen gnomAD
CA393445070 rs1273270542	359	N>S		No	ClinGen gnomAD
CA393444662 rs758355506	368	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA393444643 rs1247300943	369	K>*		No	ClinGen TOPMed
rs1036032774 CA272902939	370	N>S		No	ClinGen TOPMed
rs778963922 CA7668161	373	I>T		No	ClinGen ExAC gnomAD
CA7668162 rs752970552	373	I>V		No	ClinGen ExAC gnomAD
rs868267683 CA272900087	378	P>L		No	ClinGen Ensembl
rs779982140 CA7668139	381	N>K		No	ClinGen ExAC TOPMed gnomAD
CA7668135 rs767314169	383	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA7668136 rs750389235	383	Y>H		No	ClinGen ExAC gnomAD
rs756811878 CA7668134	384	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs186045366 CA7668133	384	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA393440628 rs1255330227	390	V>A		No	ClinGen gnomAD
CA393440642 rs1467509950	390	V>I		No	ClinGen gnomAD
TCGA novel	391	W>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1013135078 CA393440556	394	K>*		No	ClinGen TOPMed gnomAD
rs1013135078 CA272900051	394	K>Q		No	ClinGen TOPMed gnomAD
rs1250526505 CA393439991	396	L>W		No	ClinGen gnomAD
rs760990870 CA7668127	403	R>C		No	ClinGen ExAC gnomAD
rs773793387 CA7668126	403	R>H		No	ClinGen ExAC gnomAD
rs1255523419 CA393482570	405	E>K		No	ClinGen gnomAD
rs757841659 CA7668113	407	G>V		No	ClinGen ExAC gnomAD
CA7668110 rs761078819	408	G>S		No	ClinGen ExAC gnomAD
rs768137697 CA7668108	412	C>G		No	ClinGen ExAC gnomAD
CA272915718 rs760155067	413	G>S		No	ClinGen Ensembl
rs547836130 CA7668107	414	Q>H		No	ClinGen 1000Genomes ExAC gnomAD
rs1368877291 CA393482350	414	Q>R		No	ClinGen gnomAD
CA393482224 rs1383601489	419	E>G		No	ClinGen gnomAD
TCGA novel	419	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs774862716 CA393482158	421	D>E		No	ClinGen ExAC TOPMed gnomAD
CA272915707 rs979297605	422	S>F		No	ClinGen TOPMed gnomAD
rs763085113 CA7668104	423	R>Q		No	ClinGen ExAC gnomAD
CA7668105 rs768858532	423	R>W		No	ClinGen ExAC gnomAD
rs138474126 CA7668103	424	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7668102 rs770114056	425	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA7668101 rs745713152	425	R>L		No	ClinGen ExAC TOPMed gnomAD
CA393482091 rs745713152	425	R>P		No	ClinGen ExAC TOPMed gnomAD
CA393482089 rs745713152	425	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1338413537 CA393481939	431	V>M		No	ClinGen TOPMed
TCGA novel	433	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA393481878 rs1429366646	433	N>S		No	ClinGen gnomAD
CA7668099 rs370582138	436	V>M		No	ClinGen ExAC TOPMed gnomAD
CA393481740 rs1263917869	439	M>V		No	ClinGen TOPMed
CA272915652 rs961245487	441	H>Q		No	ClinGen TOPMed
CA393481561 rs777730659	442	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA7668097 rs777730659	442	Y>F		No	ClinGen ExAC TOPMed gnomAD
CA7668096 rs150528240	446	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs552177179 CA7668095	446	T>M		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	448	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1292215154 CA393481308	451	N>H		No	ClinGen gnomAD
rs1412531654 CA393481294	451	N>S		No	ClinGen gnomAD
CA393481251 rs1453114485	452	T>I		No	ClinGen TOPMed gnomAD
CA7668071 rs751926493	455	R>L		No	ClinGen ExAC TOPMed gnomAD
rs751926493 CA7668070	455	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA7668072 rs779716989	455	R>W	Variant assessed as Somatic; 4.622e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1019576408 CA272915281	456	Q>*		No	ClinGen Ensembl
CA7668069 rs764734452	456	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs370340509 CA7668068	458	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs1007808448 CA272915279	458	R>H		No	ClinGen TOPMed gnomAD
rs1216667988 CA393480950	459	Q>*		No	ClinGen TOPMed
rs752879409 CA7668067	464	Q>H		No	ClinGen ExAC gnomAD
CA393480766 rs1183972897	465	F>L		No	ClinGen gnomAD
CA393480633 rs1458139337	470	D>Y		No	ClinGen gnomAD
CA7668065 rs369309692	471	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs369309692 CA7668066	471	Y>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1215206811 CA393480192	481	I>T		No	ClinGen TOPMed gnomAD
CA393480029 rs1280766894	485	R>K		No	ClinGen gnomAD
rs772988079 CA7668061	489	N>T		No	ClinGen ExAC TOPMed gnomAD
CA393479705 rs1370851647	494	A>S		No	ClinGen gnomAD
rs1439473723 CA393479696	495	V>M		No	ClinGen TOPMed
rs748092690 CA7668059	498	M>T		No	ClinGen ExAC gnomAD
rs1317983377 CA393479552	499	G>A		No	ClinGen gnomAD
rs774206319 CA7668058	499	G>R		No	ClinGen ExAC gnomAD
rs748783045 CA393479512	500	A>E		No	ClinGen ExAC TOPMed gnomAD
rs563208732 CA7668057	500	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7668056 rs748783045	500	A>V		No	ClinGen ExAC TOPMed gnomAD
CA7668055 rs372830341	501	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA272915169 rs747400123	501	R>H		No	ClinGen TOPMed gnomAD
rs747400123 CA393479490	501	R>L		No	ClinGen TOPMed gnomAD
rs747441557 CA7668053	502	S>C		No	ClinGen ExAC gnomAD
rs747441557 CA7668054	502	S>F		No	ClinGen ExAC gnomAD
rs747441557 CA393479459	502	S>Y		No	ClinGen ExAC gnomAD
CA393479388 rs1469707293	504	G>R		No	ClinGen gnomAD
TCGA novel	507	P>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1454206583 CA393479241	508	E>G		No	ClinGen TOPMed
CA393479172 rs758775634	511	I>L		No	ClinGen ExAC gnomAD
rs753290383 CA7668049	511	I>T		No	ClinGen ExAC gnomAD
rs758775634 CA7668050	511	I>V		No	ClinGen ExAC gnomAD
CA393479081 rs1240176520	514	H>L		No	ClinGen gnomAD
rs116225300 CA7668047	517	A>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1595943983 CA393478849	522	T>A		No	ClinGen Ensembl
CA7668030 rs748504854	527	S>L		No	ClinGen ExAC gnomAD
CA393478385 rs1353701489	529	D>G		No	ClinGen gnomAD
CA393478319 rs1475979959	531	C>F		No	ClinGen gnomAD
rs755506201 CA7668029	533	A>S		No	ClinGen ExAC gnomAD
CA7668028 rs755506201	533	A>T		No	ClinGen ExAC gnomAD
rs1331042963 CA393478164	535	L>P		No	ClinGen TOPMed
rs780198245 CA7668025	540	T>I		No	ClinGen ExAC TOPMed gnomAD
CA7668022 rs767676254	541	L>F		No	ClinGen ExAC gnomAD
TCGA novel	543	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1308356455 CA393477860	544	F>L		No	ClinGen TOPMed
rs1194006527 CA393477832	545	Q>H		No	ClinGen gnomAD
CA272914607 rs963719922	546	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
TCGA novel	548	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA393477716 rs1264582051	549	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA7668020 rs367823360	549	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA393477460 rs1251181454	557	S>G		No	ClinGen gnomAD
CA7668018 rs762931038	557	S>R		No	ClinGen ExAC gnomAD
rs1030951288 CA272914583	560	T>N		No	ClinGen Ensembl
CA272914581 rs1025470079	561	P>L		No	ClinGen TOPMed
CA393477305 rs1259088932	562	E>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA7668015 rs759071179	564	Y>D		No	ClinGen ExAC gnomAD
rs1266673527 CA393477136	567	C>Y		No	ClinGen TOPMed
CA393477097 rs776474331	568	Y>*		No	ClinGen ExAC gnomAD
rs1396618018 CA393477087	569	K>*		No	ClinGen TOPMed gnomAD
rs1396618018 CA393477089	569	K>Q		No	ClinGen TOPMed gnomAD
rs770680191 CA7668013	569	K>R		No	ClinGen ExAC TOPMed gnomAD
CA7668009 rs779323296	575	A>P		No	ClinGen ExAC TOPMed gnomAD
CA393476909 rs779323296	575	A>T		No	ClinGen ExAC TOPMed gnomAD
CA7668008 rs768845597	577	K>E		No	ClinGen ExAC gnomAD
rs1171085127 CA393476835	577	K>M		No	ClinGen TOPMed gnomAD
CA272914520 rs752153208	577	K>N		No	ClinGen TOPMed gnomAD
CA7668007 rs749809514	580	M>I		No	ClinGen ExAC gnomAD
rs1402526433 CA393476723	581	V>I		No	ClinGen TOPMed
rs1402526433 CA393476721	581	V>L		No	ClinGen TOPMed
CA393476684 rs1415138873	583	S>P		No	ClinGen gnomAD
rs1012051899 CA272914506	588	L>M		No	ClinGen Ensembl
CA393476558 rs1356314926	588	L>P		No	ClinGen gnomAD
rs1249194516 CA393476527	589	A>T		No	ClinGen gnomAD
CA393476490 rs1481891165	590	V>M		No	ClinGen gnomAD
CA7668002 rs757462800	591	E>A		No	ClinGen ExAC gnomAD
rs1345626725 CA393476447	591	E>D		No	ClinGen TOPMed
CA7668003 rs757462800	591	E>G		No	ClinGen ExAC gnomAD
rs1213408029 CA393476419	592	S>R		No	ClinGen gnomAD

No associated diseases with P43378

6 regional properties for P43378

Type	Name	Position	InterPro Accession
domain	Tyrosine-specific protein phosphatase, PTPase domain	302 - 576	IPR000242
domain	Tyrosine-specific protein phosphatases domain	481 - 565	IPR000387
domain	CRAL-TRIO lipid binding domain	84 - 243	IPR001251
domain	Protein-tyrosine phosphatase, catalytic	459 - 573	IPR003595
domain	CRAL/TRIO, N-terminal domain	43 - 68	IPR011074
active_site	Protein-tyrosine phosphatase, active site	513 - 523	IPR016130

Functions

		Description
EC Number	3.1.3.48	Phosphoric monoester hydrolases
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
neuron projection terminus	The specialized, terminal region of a neuron projection such as an axon or a dendrite.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.

2 GO annotations of molecular function

Name	Definition
non-membrane spanning protein tyrosine phosphatase activity	Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate.
protein tyrosine phosphatase activity	Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

4 GO annotations of biological process

Name	Definition
negative regulation of neuron projection development	Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
peptidyl-tyrosine dephosphorylation	The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine.
positive regulation of protein localization to plasma membrane	Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.
protein dephosphorylation	The process of removing one or more phosphoric residues from a protein.

7 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P08575	PTPRC	Receptor-type tyrosine-protein phosphatase C	Homo sapiens (Human)	PR
P28827	PTPRM	Receptor-type tyrosine-protein phosphatase mu	Homo sapiens (Human)	PR
Q15262	PTPRK	Receptor-type tyrosine-protein phosphatase kappa	Homo sapiens (Human)	PR
P10586	PTPRF	Receptor-type tyrosine-protein phosphatase F	Homo sapiens (Human)	PR
P23468	PTPRD	Receptor-type tyrosine-protein phosphatase delta	Homo sapiens (Human)	PR
Q13332	PTPRS	Receptor-type tyrosine-protein phosphatase S	Homo sapiens (Human)	PR
Q641Z2	Ptpn9	Tyrosine-protein phosphatase non-receptor type 9	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MEPATAPRPD	MAPELTPEEE	QATKQFLEEI	NKWTVQYNVS	PLSWNVAVKF	LMARKFDVLR
70	80	90	100	110	120
AIELFHSYRE	TRRKEGIVKL	KPHEEPLRSE	ILSGKFTILN	VRDPTGASIA	LFTARLHHPH
130	140	150	160	170	180
KSVQHVVLQA	LFYLLDRAVD	SFETQRNGLV	FIYDMCGSNY	ANFELDLGKK	VLNLLKGAFP
190	200	210	220	230	240
ARLKKVLIVG	APIWFRVPYS	IISLLLKDKV	RERIQILKTS	EVTQHLPREC	LPENLGGYVK
250	260	270	280	290	300
IDLATWNFQF	LPQVNGHPDP	FDEIILFSLP	PALDWDSVHV	PGPHAMTIQE	LVDYVNARQK
310	320	330	340	350	360
QGIYEEYEDI	RRENPVGTFH	CSMSPGNLEK	NRYGDVPCLD	QTRVKLTKRS	GHTQTDYINA
370	380	390	400	410	420
SFMDGYKQKN	AYIGTQGPLE	NTYRDFWLMV	WEQKVLVIVM	TTRFEEGGRR	KCGQYWPLEK
430	440	450	460	470	480
DSRIRFGFLT	VTNLGVENMN	HYKKTTLEIH	NTEERQKRQV	THFQFLSWPD	YGVPSSAASL
490	500	510	520	530	540
IDFLRVVRNQ	QSLAVSNMGA	RSKGQCPEPP	IVVHCSAGIG	RTGTFCSLDI	CLAQLEELGT
550	560	570	580	590
LNVFQTVSRM	RTQRAFSIQT	PEQYYFCYKA	ILEFAEKEGM	VSSGQNLLAV	ESQ