Q641Z2

PR
Gene name
Ptpn9
Protein name
Tyrosine-protein phosphatase non-receptor type 9
Names
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:266611
EC number
3.1.3.48: Phosphoric monoester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

267-343 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q641Z2

Entry ID Method Resolution Chain Position Source
AF-Q641Z2-F1 Predicted AlphaFoldDB

No variants for Q641Z2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q641Z2

No associated diseases with Q641Z2

5 regional properties for Q641Z2

Type Name Position InterPro Accession
domain Tyrosine-specific protein phosphatase, PTPase domain 302 - 576 IPR000242
domain Tyrosine-specific protein phosphatases domain 481 - 565 IPR000387
domain CRAL-TRIO lipid binding domain 84 - 243 IPR001251
domain Protein-tyrosine phosphatase, catalytic 459 - 573 IPR003595
active_site Protein-tyrosine phosphatase, active site 513 - 523 IPR016130

Functions

Description
EC Number 3.1.3.48 Phosphoric monoester hydrolases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
neuron projection terminus The specialized, terminal region of a neuron projection such as an axon or a dendrite.

1 GO annotations of molecular function

Name Definition
protein tyrosine phosphatase activity Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

4 GO annotations of biological process

Name Definition
negative regulation of neuron projection development Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
peptidyl-tyrosine dephosphorylation The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine.
positive regulation of protein localization to plasma membrane Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.
protein dephosphorylation The process of removing one or more phosphoric residues from a protein.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P43378 PTPN9 Tyrosine-protein phosphatase non-receptor type 9 Homo sapiens (Human) PR
10 20 30 40 50 60
MEPATAPRPD MAPELTPEEE QATKQFLEEI NKWTVQYNVS PLSWNVAVKF LMARKFDVLR
70 80 90 100 110 120
AVELFHCYRE TRRKEGIVKL KPHEEPLRSE ILSGKFTILN VRDPTGASIA LFTARLHHPH
130 140 150 160 170 180
KSVQHVVLQA LFYLLDRAVD SFETQRNGLV FIYDMCGSNY ANFELDLGKK VLNLLKGAFP
190 200 210 220 230 240
ARLKKVLIVG APIWFRVPYS IISLLLKDKV RERIQILKTS EVTQHLPREC LPENLGGYIK
250 260 270 280 290 300
IDLATWNFQF LPQVNGHPDP FDEIILFSLP PALDWDSVHV PGPHAMTIQE LVDYVNTRQK
310 320 330 340 350 360
QGIYEEYEDI RRENPVGTFH CSMSPGNLEK NRYGDVPCLD QTRVKLTKRS GHTQTDYINA
370 380 390 400 410 420
SFMDGYKQKN AYIGTQGPLE NTYRDFWLMV WEQKVLVIVM TTRFEEGGRR KCGQYWPLEK
430 440 450 460 470 480
DSRIQFGFLT VTNLGVENMN HYKKTTLEIH NTEERQKRQV THFQFLSWPD YGVPSSAASL
490 500 510 520 530 540
IDFLRVVRSQ QSMAVGSLGA RSKGQCPEPP IVVHCSAGIG RTGTFCSLDI CLAQLEELGT
550 560 570 580 590
LNVFQTVSRM RTQRAFSIQT PEQYYFCYKA ILEFAEREGM VPSGHSLLAM DGQ