AiPD: Autoinhibited Protein Database

Gene name	CKA2
Protein name	Casein kinase II subunit alpha-2
Names	CK II, Casein kinase alpha 2, AtCKA2
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT3G50000
EC number	2.7.11.1: Protein-serine/threonine kinases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

11-114 (Predicted disordered autoinhibitory region) PR

11-114 (Predicted disordered autoinhibitory region)

cis-regPred

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q08466-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
ENSVATH00411897	17	L>F	No	1000Genomes
ENSVATH00411898	18	L>F	No	1000Genomes
ENSVATH06282963	19	C>W	No	1000Genomes
ENSVATH06282964	25	R>L	No	1000Genomes
ENSVATH14411346	26	A>T	No	1000Genomes
ENSVATH12673673	35	P>A	No	1000Genomes
tmp_3_18534595_A_G	37	T>A	No	1000Genomes
ENSVATH14411348	43	T>I	No	1000Genomes
ENSVATH12673705	53	F>L	No	1000Genomes
tmp_3_18534653_G_A	56	C>Y	No	1000Genomes
ENSVATH12673706	57	L>H	No	1000Genomes
ENSVATH14411349	58	D>E	No	1000Genomes
tmp_3_18534668_C_G	61	S>C	No	1000Genomes
tmp_3_18534673_G_A	63	A>T	No	1000Genomes
ENSVATH00411899	64	K>E	No	1000Genomes
tmp_3_18534685_C_T	67	L>F	No	1000Genomes
ENSVATH12673709	80	V>I	No	1000Genomes
tmp_3_18535084_A_G	126	N>D	No	1000Genomes
tmp_3_18535284_A_G	148	K>R	No	1000Genomes
tmp_3_18535442_T_A	201	Y>N	No	1000Genomes
ENSVATH14411354	209	L>F	No	1000Genomes
ENSVATH06282976	269	V>G	No	1000Genomes
ENSVATH14411357	286	M>L	No	1000Genomes
tmp_3_18536232_A_G	320	N>S	No	1000Genomes
ENSVATH14411359	324	N>D	No	1000Genomes
ENSVATH06282980	328	L>V	No	1000Genomes
tmp_3_18536288_G_A	339	G>R	No	1000Genomes
tmp_3_18536545_T_G	366	L>V	No	1000Genomes
tmp_3_18536587_G_C	380	A>P	No	1000Genomes

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q08466

		Description
EC Number	2.7.11.1	Protein-serine/threonine kinases
Subcellular Localization	Nucleus Nucleus, nucleolus	Enriched in the nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
protein kinase CK2 complex	A protein complex that possesses protein serine/threonine kinase activity, and contains two catalytic alpha subunits and two regulatory beta subunits. Protein kinase CK2 complexes are found in nearly every subcellular compartment, and can phosphorylate many protein substrates in addition to casein.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

Name	Definition
peptidyl-serine phosphorylation	The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
peptidyl-threonine phosphorylation	The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
regulation of cell cycle	Any process that modulates the rate or extent of progression through the cell cycle.
regulation of circadian rhythm	Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P19454	CKA2	Casein kinase II subunit alpha'	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
P15790	CKA1	Casein kinase II subunit alpha	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
P20427	CSNK2A2	Casein kinase II subunit alpha'	Bos taurus (Bovine)	PR
P21869		Casein kinase II subunit alpha'	Gallus gallus (Chicken)	PR
P19784	CSNK2A2	Casein kinase II subunit alpha'	Homo sapiens (Human)	PR
P68400	CSNK2A1	Casein kinase II subunit alpha	Homo sapiens (Human)	PR
O64816	CKA4	Casein kinase II subunit alpha-4, chloroplastic	Arabidopsis thaliana (Mouse-ear cress)	PR