P20427

PR
Gene name
CSNK2A2
Protein name
Casein kinase II subunit alpha'
Names
CK II alpha'
Species
Bos taurus (Bovine)
KEGG Pathway
bta:282420
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-58 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

175-197 (Activation loop from InterPro)

Target domain

40-325 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for P20427

Entry ID Method Resolution Chain Position Source
AF-P20427-F1 Predicted AlphaFoldDB

No variants for P20427

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P20427

No associated diseases with P20427

3 regional properties for P20427

Type Name Position InterPro Accession
domain Protein kinase domain 40 - 325 IPR000719
active_site Serine/threonine-protein kinase, active site 153 - 165 IPR008271
binding_site Protein kinase, ATP binding site 46 - 69 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Nucleus
  • Cytoplasm
  • Interaction with SIRT6 prevents translocation into the nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

5 GO annotations of biological process

Name Definition
apoptotic process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of chromosome separation Any process that modulates the frequency, rate or extent of chromosome separation.
Wnt signaling pathway The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P21869 Casein kinase II subunit alpha' Gallus gallus (Chicken) PR
P19784 CSNK2A2 Casein kinase II subunit alpha' Homo sapiens (Human) PR
P68400 CSNK2A1 Casein kinase II subunit alpha Homo sapiens (Human) PR
O64816 CKA4 Casein kinase II subunit alpha-4, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
Q08466 CKA2 Casein kinase II subunit alpha-2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MPGPAARSRA RVYAEVNSLR SREYWDYEAH VPSWGNQDDY QLVRKLGRGK YSEVFEAINI
70 80 90 100 110 120
TNNERVVVKI LKPVKKKKIK REVKILENLR GGTNIIKLID TVKDPVSKTP ALVFEYINNT
130 140 150 160 170 180
DFKQLYQILT DFDIRFYMYE LLKALDYCHS KGIMHRDVKP HNVMIDHQQK KLRLIDWGLA
190 200 210 220 230 240
EFYHPAQEYN VRVASRYFKG PELLVDYQMY DYSLDMWSLG CMLASMIFRK EPFFHGQDNY
250 260 270 280 290 300
DQLVRIAKVL GTDELYGYLK KYHIDLDPHF NDILGQHSRK RWENFIHSEN RHLVSPEALD
310 320 330 340
LLDKLLRYDH QQRLTAKEAM EHPYFYPVVK EQSQPCADNA VLSSGLTAAR